LOCUS       NM_013135               4622 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus RAS p21 protein activator 1 (Rasa1), mRNA.
ACCESSION   NM_013135
VERSION     NM_013135.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4622)
  AUTHORS   Liu,Y., Zhou,P., Wang,F., Zhang,X., Yang,D., Hong,L. and Ruan,D.
  TITLE     Inhibition of lncRNA SNHG8 plays a protective role in
            hypoxia-ischemia-reoxygenation-induced myocardial injury by
            regulating miR-335 and RASA1 expression
  JOURNAL   Mol Med Rep 24 (2) (2021)
   PUBMED   34165173
  REMARK    GeneRIF: Inhibition of lncRNA SNHG8 plays a protective role in
            hypoxia-ischemia-reoxygenation-induced myocardial injury by
            regulating miR-335 and RASA1 expression.
REFERENCE   2  (bases 1 to 4622)
  AUTHORS   Lundby,A., Franciosa,G., Emdal,K.B., Refsgaard,J.C., Gnosa,S.P.,
            Bekker-Jensen,D.B., Secher,A., Maurya,S.R., Paul,I., Mendez,B.L.,
            Kelstrup,C.D., Francavilla,C., Kveiborg,M., Montoya,G., Jensen,L.J.
            and Olsen,J.V.
  TITLE     Oncogenic Mutations Rewire Signaling Pathways by Switching Protein
            Recruitment to Phosphotyrosine Sites
  JOURNAL   Cell 179 (2), 543-560 (2019)
   PUBMED   31585087
REFERENCE   3  (bases 1 to 4622)
  AUTHORS   Queiros,A.M., Eschen,C., Fliegner,D., Kararigas,G., Dworatzek,E.,
            Westphal,C., Sanchez Ruderisch,H. and Regitz-Zagrosek,V.
  TITLE     Sex- and estrogen-dependent regulation of a miRNA network in the
            healthy and hypertrophied heart
  JOURNAL   Int J Cardiol 169 (5), 331-338 (2013)
   PUBMED   24157234
REFERENCE   4  (bases 1 to 4622)
  AUTHORS   Durrington,H.J., Firth,H.V., Patient,C., Belham,M., Jayne,D.,
            Burrows,N., Morrell,N.W. and Chilvers,E.R.
  TITLE     A novel RASA1 mutation causing capillary malformation-arteriovenous
            malformation (CM-AVM) presenting during pregnancy
  JOURNAL   Am J Med Genet A 161A (7), 1690-1694 (2013)
   PUBMED   23687085
REFERENCE   5  (bases 1 to 4622)
  AUTHORS   Wang,J. and Ruan,K.
  TITLE     miR-335 is involved in the rat epididymal development by targeting
            the mRNA of RASA1
  JOURNAL   Biochem Biophys Res Commun 402 (2), 222-227 (2010)
   PUBMED   20933506
  REMARK    GeneRIF: miR-335 can be involved in the epididymal development by
            affecting the expression of RASA1.
REFERENCE   6  (bases 1 to 4622)
  AUTHORS   Nakagawa,Y., Purushotham,K.R., Wang,P.L., Fischer,J.E., Dunn,W.A.,
            Schneyer,C.A. and Humphreys-Beher,M.G.
  TITLE     Alterations in the subcellular distribution of p21ras-GTPase
            activating protein in proliferating rat acinar cells
  JOURNAL   Biochem Biophys Res Commun 187 (2), 1172-1179 (1992)
   PUBMED   1382416
REFERENCE   7  (bases 1 to 4622)
  AUTHORS   Fujita-Yoshigaki,J., Shirouzu,M., Koide,H., Nishimura,S. and
            Yokoyama,S.
  TITLE     Identification of amino acid residues of Ras protein that are
            essential for signal-transducing activity but not for enhancement
            of GTPase activity by GAP
  JOURNAL   FEBS Lett 294 (3), 187-190 (1991)
   PUBMED   1756860
REFERENCE   8  (bases 1 to 4622)
  AUTHORS   Moran,M.F., Polakis,P., McCormick,F., Pawson,T. and Ellis,C.
  TITLE     Protein-tyrosine kinases regulate the phosphorylation, protein
            interactions, subcellular distribution, and activity of p21ras
            GTPase-activating protein
  JOURNAL   Mol Cell Biol 11 (4), 1804-1812 (1991)
   PUBMED   2005883
REFERENCE   9  (bases 1 to 4622)
  AUTHORS   Brott,B.K., Decker,S., Shafer,J., Gibbs,J.B. and Jove,R.
  TITLE     GTPase-activating protein interactions with the viral and cellular
            Src kinases
  JOURNAL   Proc Natl Acad Sci U S A 88 (3), 755-759 (1991)
   PUBMED   1704131
REFERENCE   10 (bases 1 to 4622)
  AUTHORS   Gibbs,J.B., Marshall,M.S., Scolnick,E.M., Dixon,R.A. and Vogel,U.S.
  TITLE     Modulation of guanine nucleotides bound to Ras in NIH3T3 cells by
            oncogenes, growth factors, and the GTPase activating protein (GAP)
  JOURNAL   J Biol Chem 265 (33), 20437-20442 (1990)
   PUBMED   2122974
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Oct 3, 2022 this sequence version replaced NM_013135.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.6246.1,
                                           SRR26643292.7189.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760400 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-969               JAXUCZ010000002.1  17675193-17676161   c
            970-1122            JAXUCZ010000002.1  17635285-17635437   c
            1123-1258           JAXUCZ010000002.1  17634137-17634272   c
            1259-1329           JAXUCZ010000002.1  17633174-17633244   c
            1330-1447           JAXUCZ010000002.1  17632208-17632325   c
            1448-1479           JAXUCZ010000002.1  17631501-17631532   c
            1480-1532           JAXUCZ010000002.1  17627640-17627692   c
            1533-1683           JAXUCZ010000002.1  17625014-17625164   c
            1684-1762           JAXUCZ010000002.1  17621297-17621375   c
            1763-1883           JAXUCZ010000002.1  17613509-17613629   c
            1884-2040           JAXUCZ010000002.1  17612619-17612775   c
            2041-2128           JAXUCZ010000002.1  17609409-17609496   c
            2129-2206           JAXUCZ010000002.1  17608594-17608671   c
            2207-2364           JAXUCZ010000002.1  17607106-17607263   c
            2365-2441           JAXUCZ010000002.1  17606712-17606788   c
            2442-2614           JAXUCZ010000002.1  17605437-17605609   c
            2615-2774           JAXUCZ010000002.1  17605021-17605180   c
            2775-2917           JAXUCZ010000002.1  17603769-17603911   c
            2918-3033           JAXUCZ010000002.1  17602519-17602634   c
            3034-3120           JAXUCZ010000002.1  17601672-17601758   c
            3121-3188           JAXUCZ010000002.1  17599844-17599911   c
            3189-3277           JAXUCZ010000002.1  17597772-17597860   c
            3278-3355           JAXUCZ010000002.1  17596642-17596719   c
            3356-3490           JAXUCZ010000002.1  17595157-17595291   c
            3491-4622           JAXUCZ010000002.1  17593136-17594267   c
FEATURES             Location/Qualifiers
     source          1..4622
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q11"
     gene            1..4622
                     /gene="Rasa1"
                     /gene_synonym="GAP; GAPX; p120GAP; Rasa; rasGAP"
                     /note="RAS p21 protein activator 1"
                     /db_xref="GeneID:25676"
                     /db_xref="RGD:3537"
     exon            1..969
                     /gene="Rasa1"
                     /gene_synonym="GAP; GAPX; p120GAP; Rasa; rasGAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             458..3574
                     /gene="Rasa1"
                     /gene_synonym="GAP; GAPX; p120GAP; Rasa; rasGAP"
                     /note="GTPase-activating protein; RAS p21 protein
                     activator (GTPase activating protein) 1"
                     /codon_start=1
                     /product="ras GTPase-activating protein 1"
                     /protein_id="NP_037267.2"
                     /db_xref="GeneID:25676"
                     /db_xref="RGD:3537"
                     /translation="MMAAEAGSEEGGPATAGTGGAAATGSSAYTAACRVKLPAAPPMA
                     VAPCPGLADTDLAAALGGGAASGSGFLGTGPVSGVLGGAALTGGAAAGVAGAAAAGPA
                     GDIALIKGTLSLPAETLGPGGGFPPLPPPPLLPPLGSGLGTVDEGDSLDGPEYEEEEV
                     AIPLTAPPTNQWYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQTNVV
                     NHFRIIAMCGDYYIGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAPPEPVEDRRRVR
                     AILPYTKVPDTDEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREE
                     DPHEGKIWFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKI
                     CPTPNNQFMMGGRYYNSIGDIIDHYRKEQIVEGYYLKEPVPMQDQGQVLNDTVDGKEI
                     YNTIRRKTKDAFYKNIVKKGYLLKKGKGKRWKNLYFILEGSDAQLIYFESEKRATKPK
                     GLIDLSVCSVYVVHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAF
                     CSLRKSSPGTSNKRLRQVSSLVLHIEEAHKLPVKHFTNPYCNIYLNSVQVAKTHAREG
                     QNPVWSEEFVFDDLPPDINRFEITLSNKTKKSKDPDILFMRCQLSRLQKGHATDEWFL
                     LSSHIPLKGIEPGSLRVRARYSMEKIMPEEEYSEFKELILQKELHVVYALSHVCGQDR
                     TLLASILLKIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATAT
                     QFVHHALKDSILKIMESKQSCELSPSKLEKNEDVNTNLAHLLSILSELVEKIFMASEI
                     LPPTLRYIYGCLQKSVQHKWPTNNTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPS
                     PIAARTLTLVAKSVQNLANLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELP
                     DTTEHSRTDLSRDLAALHEICVAHSDELRTLSNERGVQQHVLKKLLAITELLQQKQNQ
                     YTKTNDVR"
     exon            970..1122
                     /gene="Rasa1"
                     /gene_synonym="GAP; GAPX; p120GAP; Rasa; rasGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1258
                     /gene="Rasa1"
                     /gene_synonym="GAP; GAPX; p120GAP; Rasa; rasGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1329
                     /gene="Rasa1"
                     /gene_synonym="GAP; GAPX; p120GAP; Rasa; rasGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1447
                     /gene="Rasa1"
                     /gene_synonym="GAP; GAPX; p120GAP; Rasa; rasGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1479
                     /gene="Rasa1"
                     /gene_synonym="GAP; GAPX; p120GAP; Rasa; rasGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1532
                     /gene="Rasa1"
                     /gene_synonym="GAP; GAPX; p120GAP; Rasa; rasGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1683
                     /gene="Rasa1"
                     /gene_synonym="GAP; GAPX; p120GAP; Rasa; rasGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1762
                     /gene="Rasa1"
                     /gene_synonym="GAP; GAPX; p120GAP; Rasa; rasGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1883
                     /gene="Rasa1"
                     /gene_synonym="GAP; GAPX; p120GAP; Rasa; rasGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..2040
                     /gene="Rasa1"
                     /gene_synonym="GAP; GAPX; p120GAP; Rasa; rasGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2041..2128
                     /gene="Rasa1"
                     /gene_synonym="GAP; GAPX; p120GAP; Rasa; rasGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2129..2206
                     /gene="Rasa1"
                     /gene_synonym="GAP; GAPX; p120GAP; Rasa; rasGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2364
                     /gene="Rasa1"
                     /gene_synonym="GAP; GAPX; p120GAP; Rasa; rasGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2365..2441
                     /gene="Rasa1"
                     /gene_synonym="GAP; GAPX; p120GAP; Rasa; rasGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2442..2614
                     /gene="Rasa1"
                     /gene_synonym="GAP; GAPX; p120GAP; Rasa; rasGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2615..2774
                     /gene="Rasa1"
                     /gene_synonym="GAP; GAPX; p120GAP; Rasa; rasGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2775..2917
                     /gene="Rasa1"
                     /gene_synonym="GAP; GAPX; p120GAP; Rasa; rasGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2918..3033
                     /gene="Rasa1"
                     /gene_synonym="GAP; GAPX; p120GAP; Rasa; rasGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3034..3120
                     /gene="Rasa1"
                     /gene_synonym="GAP; GAPX; p120GAP; Rasa; rasGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3121..3188
                     /gene="Rasa1"
                     /gene_synonym="GAP; GAPX; p120GAP; Rasa; rasGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3189..3277
                     /gene="Rasa1"
                     /gene_synonym="GAP; GAPX; p120GAP; Rasa; rasGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3278..3355
                     /gene="Rasa1"
                     /gene_synonym="GAP; GAPX; p120GAP; Rasa; rasGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3356..3490
                     /gene="Rasa1"
                     /gene_synonym="GAP; GAPX; p120GAP; Rasa; rasGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3491..4622
                     /gene="Rasa1"
                     /gene_synonym="GAP; GAPX; p120GAP; Rasa; rasGAP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagatgagg ctgcggcggc cgcggcacca gcagcccctg gggtggctgc ggtgggggcg
       61 gccggaaccc cggtgttgag gcgcggcggc ggcggccgag gcggcgctgc ctcagccgct
      121 gcagcgggct tcccttcctc tttagcgtag ccaggaagtt tggcgcccct gtgcatgtgt
      181 gcgcgtgagt gtgggtgtgc gcggcgagac tcgcctagcg tttctgcagg cgccgggctt
      241 ttttgcccgc gtcgcttccc gtaagcaagc cagcgctgcg gagcttgggc tgtggcccgg
      301 ggagggggcg cggcggcggg cgctctcctt ttgttgttgt ttcctctgcc tggagagctg
      361 aagggggacg cgcctgggtg gggcggctcg cagcccgggc ctggtggccc ccggggctcc
      421 cgggcggcgg ggtagctagg ggagagcggg cttcaacatg atggcggccg aggcgggcag
      481 tgaggaaggc ggcccggcga ccgcggggac cggcggcgcc gcggccacgg gctccagcgc
      541 ctacacagca gcgtgccggg taaagttacc cgcggcccct ccgatggcag tcgccccgtg
      601 tcctgggctg gcggacaccg acctggctgc ggccctcggt gggggagccg cgtcggggtc
      661 cgggttcctg gggaccgggc cggtgtctgg tgtcctgggg ggcgccgcgc tgaccggcgg
      721 tgctgcagct ggcgtggcgg gtgctgcagc cgctggacct gccggagaca tcgctctcat
      781 caaggggact ctctctctgc ctgctgagac tctcgggccg ggcggcggat tccctcctct
      841 gccgcctcct cctctgttgc ctcctttggg ctccggtctg gggacagtgg atgaaggtga
      901 ctccttggat ggaccagaat acgaggagga agaggtggcc ataccgctga ccgcacctcc
      961 aactaaccag tggtatcatg gaaaacttga tagaactata gcagaagaac gcctcaggca
     1021 ggcagggaaa tctggaagct accttataag agagagtgat cggaggccag ggtcctttgt
     1081 actttcattt cttagccaga caaatgttgt caatcatttt aggattattg ctatgtgtgg
     1141 tgattactac attggtggaa ggcgtttttc ttcactctca gacctaatag gatattacag
     1201 tcacgtttct tgtttactta aaggagaaaa attactctac ccagttgcac caccagagcc
     1261 agtagaagat agaagacgtg tacgagccat tctgccctac acaaaagtac cagacactga
     1321 tgaaataagt ttcttaaagg gagatatgtt cattgttcac aatgagttag aagatggatg
     1381 gatgtgggtt acaaacctaa gaacagatga gcaaggcctt attgttgagg acctagtgga
     1441 agaggtgggc cgagaagaag atccacacga aggcaaaata tggttccatg ggaagatttc
     1501 caaacaagaa gcttataatt tattaatgac agttggccaa gtctgcagct ttcttgtgag
     1561 gccctcagat aatactcctg gagattattc cctgtatttt cggaccaatg aaaatatcca
     1621 gcgatttaaa atttgtccaa cacctaacaa tcagttcatg atgggaggcc gctattataa
     1681 cagtattggg gacatcatag accactatcg gaaagaacag attgttgaag gctattatct
     1741 taaggaacct gtaccaatgc aggatcaagg acaagtactc aatgacactg tggatgggaa
     1801 ggaaatctat aatacaattc gtcgtaaaac aaaggatgca ttttataaaa atattgttaa
     1861 aaaaggttat cttctgaaga agggcaaagg aaaacgttgg aaaaatttat attttatctt
     1921 agagggcagt gatgcccaac ttatttattt tgaaagtgaa aaacgagcta caaaaccaaa
     1981 agggctaata gatctcagtg tatgttctgt ctacgttgtc catgatagtc tcttcggcag
     2041 gccaaactgt tttcagatag tcgttcagca ctttagtgaa gaacattaca tcttttactt
     2101 tgcaggagaa actccagaac aagcagagga ttggatgaaa ggcctgcaag cattttgcag
     2161 tttacggaaa agtagcccag ggacatctaa taaacgcctt cgtcaggtca gcagccttgt
     2221 attacatatt gaagaagctc ataaactacc agtaaaacac ttcactaatc catattgtaa
     2281 catctacttg aatagtgtcc aagtagcaaa aactcatgca agggaggggc aaaacccagt
     2341 atggtcagag gagtttgtct ttgatgatct tcctcctgac atcaatagat ttgaaatcac
     2401 acttagtaat aaaacaaaga aaagtaaaga tccagatatc ttatttatgc gttgccagtt
     2461 gagcaggtta cagaaaggac atgccacaga tgaatggttt ctgctaagtt ctcatatacc
     2521 actaaaaggt attgaaccag gatctctgcg tgttcgagca cgatactcta tggaaaaaat
     2581 catgccagaa gaagagtaca gtgaatttaa agagcttata ctgcagaagg aacttcacgt
     2641 agtctatgct ctatcacacg tatgtggaca agaccgaaca ctactggcca gcatcctact
     2701 gaaaatattt cttcatgaaa agcttgagtc attgttgtta tgcacactaa atgacagaga
     2761 gataagtatg gaagatgaag ccactaccct atttcgagct acaacacttg cgagtacctt
     2821 gatggagcag tacatgaaag ccacggccac gcagtttgtt catcatgctt tgaaagactc
     2881 cattttaaag ataatggaaa gcaagcaatc atgtgagtta agtccatcaa agttagaaaa
     2941 aaatgaagat gtgaacacta atttagcaca cctattgagc atactttcag agcttgtgga
     3001 gaaaatattc atggcttcag aaatacttcc accgacactg agatatattt atgggtgttt
     3061 acagaaatca gttcagcata agtggcctac aaataacacc atgagaacac gagttgttag
     3121 tggttttgtt tttcttcggc ttatctgccc agctatcctg aatccacgga tgtttaatat
     3181 catctcagat tctccatctc ctattgctgc aagaacactg acattagtgg ctaaatctgt
     3241 gcagaattta gcaaatcttg tggaatttgg agctaaggag ccttatatgg aaggtgtcaa
     3301 tccattcatc aaaagtaata aacatcgcat gatcatgttt ttagatgaac ttgggaatgt
     3361 acctgagctt ccggacacta cagaacattc tagaactgac ctgtctcgtg acttagcagc
     3421 attgcatgag atttgtgtag ctcattcaga tgaactgaga acactcagta atgagcgtgg
     3481 tgtacagcag catgtactga aaaagcttct ggcaataaca gaactgcttc aacaaaagca
     3541 aaaccagtat acaaaaacca atgatgtcag gtagcagccc ggtgttctgc atggattcgg
     3601 catgcccaac gtggtaattc acatcaccat gtctcctttg ctcttgccaa aaagaaaaac
     3661 aaaataataa agagagaaag aaaaaaaata gcacaccttt ccacattcca gtgatgtgtg
     3721 agctatgcaa gcaaaaaccc aagactgctg gagagtaact gccagcacct ctgtaagcta
     3781 tctgtgcaga atattgtgca ctttttccac atggaatctt taccaaactc tgagccttgg
     3841 tgtacaggtc acccttaaca acagcaaaaa cgctgactga cgtgtcttaa actttgaaaa
     3901 tatattttca gtatattcaa ttgccaaagt tttgctgtct cggaaaagga actatgaaat
     3961 caactgacaa gaaaactcat cctattgaca acagaattta actggatcac agacagttct
     4021 tactgcaatt tcttctttat aaacatgacc atttgactgt tcactgaatt tatttgtatt
     4081 tacagtttcc agagtttgac attataatag gaacaatctt gctatatact ttttaaaaat
     4141 accgtgctct tctttccgga attgttgaaa gacaatatat gaaatggatg actctattgc
     4201 tcatcagctt tattttttaa acacaccact tattttgttg gaattgtcaa agactgtact
     4261 tagatcccat gcttttgtta aaatgtttac aacagtaaat agtttaaatt caataaatat
     4321 tattggtcat tgtaccaatt attgcatgtt acccacttga ccattgtata gattgctgat
     4381 gtgtctttta tgtttaaaca aactgctaga atacttttgt caattctaag atggtttttg
     4441 ttatctctga ttatgcagac aacctcatca gccacttaac aacttacata tctttcaatt
     4501 tgtacttgtt tttcctgctg gaaatttagt ttgtatagtt catctgctcc tgtgtatgta
     4561 tttttgtgtg aagtattcac aagggttaag ttaaaataaa ctaagggata gcttgcataa
     4621 tt
//
