LOCUS       NM_001105777            2122 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus arginyl-tRNA synthetase 1 (Rars1), mRNA.
ACCESSION   NM_001105777 XM_001065238 XM_213276
VERSION     NM_001105777.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2122)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2122)
  AUTHORS   Fu,Y., Kim,Y., Jin,K.S., Kim,H.S., Kim,J.H., Wang,D., Park,M.,
            Jo,C.H., Kwon,N.H., Kim,D., Kim,M.H., Jeon,Y.H., Hwang,K.Y., Kim,S.
            and Cho,Y.
  TITLE     Structure of the ArgRS-GlnRS-AIMP1 complex and its implications for
            mammalian translation
  JOURNAL   Proc Natl Acad Sci U S A 111 (42), 15084-15089 (2014)
   PUBMED   25288775
REFERENCE   3  (bases 1 to 2122)
  AUTHORS   Fu,R., Fan,Y.Z., Fan,Y.C. and Zhao,H.Y.
  TITLE     Expression of arginyl-tRNA synthetase in rats with focal cerebral
            ischemia
  JOURNAL   J Huazhong Univ Sci Technolog Med Sci 34 (2), 172-175 (2014)
   PUBMED   24710927
  REMARK    GeneRIF: The expression levels of ArgRS mRNA and protein in
            ischemic penumbra varied with ischemic time, suggesting that the
            energy metabolism of brain cells in penumbra changed dynamically
            after ischemia to ensure the endogenous self-protection of the body
REFERENCE   4  (bases 1 to 2122)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 2122)
  AUTHORS   Yannay-Cohen,N., Carmi-Levy,I., Kay,G., Yang,C.M., Han,J.M.,
            Kemeny,D.M., Kim,S., Nechushtan,H. and Razin,E.
  TITLE     LysRS serves as a key signaling molecule in the immune response by
            regulating gene expression
  JOURNAL   Mol Cell 34 (5), 603-611 (2009)
   PUBMED   19524539
REFERENCE   6  (bases 1 to 2122)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 2122)
  AUTHORS   Shultz,M.A., Zhang,L., Gu,Y.Z., Baker,G.L., Fannuchi,M.V.,
            Padua,A.M., Gurske,W.A., Morin,D., Penn,S.G., Jovanovich,S.B.,
            Plopper,C.G. and Buckpitt,A.R.
  TITLE     Gene expression analysis in response to lung toxicants: I.
            Sequencing and microarray development
  JOURNAL   Am J Respir Cell Mol Biol 30 (3), 296-310 (2004)
   PUBMED   12947022
REFERENCE   8  (bases 1 to 2122)
  AUTHORS   Kim,J.Y., Kang,Y.S., Lee,J.W., Kim,H.J., Ahn,Y.H., Park,H., Ko,Y.G.
            and Kim,S.
  TITLE     p38 is essential for the assembly and stability of macromolecular
            tRNA synthetase complex: implications for its physiological
            significance
  JOURNAL   Proc Natl Acad Sci U S A 99 (12), 7912-7916 (2002)
   PUBMED   12060739
REFERENCE   9  (bases 1 to 2122)
  AUTHORS   Ko,Y.G., Kang,Y.S., Kim,E.K., Park,S.G. and Kim,S.
  TITLE     Nucleolar localization of human methionyl-tRNA synthetase and its
            role in ribosomal RNA synthesis
  JOURNAL   J Cell Biol 149 (3), 567-574 (2000)
   PUBMED   10791971
REFERENCE   10 (bases 1 to 2122)
  AUTHORS   Van Dang,C., Glinski,R.L., Gainey,P.C. and Hilderman,R.H.
  TITLE     Physical and biochemical characterization of a purified
            arginyl-tRNA synthetase-lysyl-tRNA-synthetase complex from rat
            liver
  JOURNAL   Biochemistry 21 (8), 1959-1966 (1982)
   PUBMED   7082655
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB313613.1, CF110623.1 and BF420005.1.
            
            On Oct 24, 2007 this sequence version replaced NM_001105777.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC161929.1, SRR8487226.134187.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-585               CB313613.1         4-588
            586-2095            CF110623.1         65-1574
            2096-2122           BF420005.1         1-27                c
FEATURES             Location/Qualifiers
     source          1..2122
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..2122
                     /gene="Rars1"
                     /gene_synonym="Rars"
                     /note="arginyl-tRNA synthetase 1"
                     /db_xref="GeneID:287191"
                     /db_xref="RGD:1309215"
     exon            1..66
                     /gene="Rars1"
                     /gene_synonym="Rars"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..2004
                     /gene="Rars1"
                     /gene_synonym="Rars"
                     /EC_number="6.1.1.19"
                     /note="arginyl-tRNA synthetase, cytoplasmic; argRS"
                     /codon_start=1
                     /product="arginine--tRNA ligase, cytoplasmic"
                     /protein_id="NP_001099247.2"
                     /db_xref="GeneID:287191"
                     /db_xref="RGD:1309215"
                     /translation="MDGLVAQCSARLLQQEKEIKSLTAEIDRLKNCSYLEASPSLEQL
                     REENLKLKYRLNILRRSLQAERKRPTKNMININSRLQELFGCAIKAAYPDLENPPLVV
                     TPSQQPKFGDYQCNSAMGISQMLKAKEQKVSPREIAENITKHLPNNEYIDRVEIAGPG
                     FINVHLRKDFVSEQLTNLLVNGVQLPVLGENEKVIVDFSSPNIAKEMHVGHLRSTIIG
                     ESMSRLFEFAGYNVLRLNHVGDWGTQFGMLIAHLQDKFPDYLTVSPPIGDLQAFYKES
                     KKRFDTEEEFKKRAYECVVLLQSKNPDIMKAWNLICDVSREEFNKIYDALDITLIERG
                     ESFYQDRMKDIVKEFEDKGFVQVDDGRKIVFVPGCSVPLTIVKSDGGYTYDTSDLAAI
                     KQRLFEEKANKIIYVVDNGQATHFQTVFAAAQMIGWYDPKVTRVAHVGFGVVLGEDKK
                     KFKTRSGETVRLMDLLEEGLRRSMDKLKEKERDKVLTEEELKAAQTSVAYGCIKYADL
                     SHNRLNDYVFSFDKMLDDRGNTAAYLLYAFTRIRSIARLANIDEEMLQRAARETKIIL
                     DHEKEWKLGRCILRFPEILQKILDDLFLHTLCDYIYELATTFTEFYDSCYCVEKDRQT
                     GKVLKVNMWRMLLCEAVAAVMAKGFDILGIKPVQRM"
     exon            67..201
                     /gene="Rars1"
                     /gene_synonym="Rars"
                     /inference="alignment:Splign:2.1.0"
     exon            202..390
                     /gene="Rars1"
                     /gene_synonym="Rars"
                     /inference="alignment:Splign:2.1.0"
     exon            391..499
                     /gene="Rars1"
                     /gene_synonym="Rars"
                     /inference="alignment:Splign:2.1.0"
     exon            500..600
                     /gene="Rars1"
                     /gene_synonym="Rars"
                     /inference="alignment:Splign:2.1.0"
     exon            601..722
                     /gene="Rars1"
                     /gene_synonym="Rars"
                     /inference="alignment:Splign:2.1.0"
     exon            723..843
                     /gene="Rars1"
                     /gene_synonym="Rars"
                     /inference="alignment:Splign:2.1.0"
     exon            844..973
                     /gene="Rars1"
                     /gene_synonym="Rars"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1078
                     /gene="Rars1"
                     /gene_synonym="Rars"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1257
                     /gene="Rars1"
                     /gene_synonym="Rars"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1367
                     /gene="Rars1"
                     /gene_synonym="Rars"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1473
                     /gene="Rars1"
                     /gene_synonym="Rars"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1646
                     /gene="Rars1"
                     /gene_synonym="Rars"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1894
                     /gene="Rars1"
                     /gene_synonym="Rars"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..2105
                     /gene="Rars1"
                     /gene_synonym="Rars"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtgagtcg ctgacgaaag gatggacggt ctggtggctc agtgctccgc gcggttgctg
       61 cagcaggaaa aggagattaa atctctgact gctgagatcg accggctgaa gaactgtagt
      121 tacttagaag cttctccaag tttggaacag ttacgagaag aaaatttaaa attgaagtat
      181 aggctgaata ttcttcgaag gagtcttcag gcagaaagga aaaggccgac taagaacatg
      241 atcaacatca acagtcgcct gcaggagctc ttcggctgtg ccattaaggc tgcgtatcca
      301 gacttggaga accctcccct ggtcgtaaca ccaagtcagc agcccaagtt tggagactat
      361 caatgtaata gcgccatggg tatttctcag atgctcaagg caaaggagca gaaggttagt
      421 cctagagaaa ttgccgaaaa cattaccaaa cacctgccaa acaacgagta catcgacagg
      481 gttgaaattg cgggtcccgg tttcatcaat gtgcacctga gaaaggactt tgtgtcagaa
      541 cagttaacca atctcctagt gaatggagtt caactacctg tgcttggaga aaatgaaaag
      601 gtgatagttg acttctcctc tcccaacata gctaaggaga tgcacgttgg ccacctcagg
      661 tcaaccatca taggagaaag tatgagccgc ctctttgagt ttgcaggata caacgtgcta
      721 aggttaaacc acgtaggaga ctgggggacc cagtttggca tgctcatcgc tcacctgcag
      781 gataagtttc cagattatct gacagtttca cctcctattg gggatcttca ggccttttat
      841 aaggaatcta agaagaggtt tgataccgag gaggagttta agaagcgagc ctatgagtgt
      901 gttgttttgc tgcagagtaa aaacccagat atcatgaaag cctggaatct catctgtgat
      961 gtgtccaggg aagagtttaa taaaatctat gatgcactgg acatcacttt gatagaaaga
     1021 ggagaatcct tctatcaaga taggatgaag gatattgtaa aggaatttga agataaaggg
     1081 tttgtgcagg tggatgatgg caggaaaatt gtgttcgtgc ctgggtgttc tgtaccatta
     1141 acaatagtga aatcagatgg gggctacact tacgacacct ctgacctggc tgccatcaaa
     1201 cagaggctat ttgaagaaaa agcaaataag attatttatg tggtggacaa tggacaagct
     1261 acacacttcc agacagtatt tgctgctgct caaatgattg gttggtatga ccctaaagtt
     1321 actcgagtgg cccacgttgg atttggtgtg gtcctaggag aagacaagaa gaaatttaaa
     1381 acacgttcag gtgaaactgt gcgcctcatg gacctgctgg aagaaggact gagacggtcc
     1441 atggacaagc tgaaggagaa agagagagac aaggtcttaa ctgaagagga gttgaaggca
     1501 gctcagacat ccgttgcata tggctgcatc aaatacgccg acctttctca taatcgcctg
     1561 aatgactacg tcttctcctt tgataagatg ctggacgaca gagggaacac agctgcctac
     1621 ctactgtacg ccttcaccag aatcaggtcc attgcacgcc tggccaatat cgatgaggaa
     1681 atgctgcaga gagcagctcg ggaaaccaag atcattttgg accacgagaa ggagtggaaa
     1741 ctgggacggt gcattttacg gttccccgaa atcctacaga agatcttaga tgacctgttt
     1801 ctccacactc tgtgtgatta catttatgag ctagcaacca ctttcacaga gttctatgac
     1861 agctgctact gtgtggagaa agatcggcag actgggaaag tgctgaaggt gaacatgtgg
     1921 cggatgctcc tgtgtgaagc cgtagctgct gtcatggcca aaggcttcga tatactggga
     1981 ataaagcccg tccagaggat gtagcccccc aagatcgggg actgttttta ccaaagtaga
     2041 cgttactact gttcgctttt tcaacaatca tgtggacaca aatagtaaag gaattttcat
     2101 aactaaaaaa aaaaaaaaaa aa
//
