LOCUS       NM_001013427             765 bp    mRNA    linear   ROD 02-JUL-2023
DEFINITION  Rattus norvegicus retinoic acid receptor responder 2 (Rarres2),
            mRNA.
ACCESSION   NM_001013427 XM_216142
VERSION     NM_001013427.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 765)
  AUTHORS   Wabel E, Orr A, Flood ED, Thompson JM, Xie H, Demireva EY,
            Abolibdeh B, Honke Hulbert D, Mullick AE, Garver H, Fink GD, Kung
            TA and Watts SW.
  TITLE     Chemerin is resident to vascular tunicas and contributes to
            vascular tone
  JOURNAL   Am J Physiol Heart Circ Physiol 325 (1), H172-H186 (2023)
   PUBMED   37294893
  REMARK    GeneRIF: Chemerin is resident to vascular tunicas and contributes
            to vascular tone.
REFERENCE   2  (bases 1 to 765)
  AUTHORS   Quan XZ, Ye JH, Yang XZ and Xie Y.
  TITLE     HOXA9-induced chemerin signals through CMKLR1/AMPK/TXNIP/NLRP3
            pathway to induce pyroptosis of trophoblasts and aggravate
            preeclampsia
  JOURNAL   Exp Cell Res 408 (2), 112802 (2021)
   PUBMED   34461109
  REMARK    GeneRIF: HOXA9-induced chemerin signals through
            CMKLR1/AMPK/TXNIP/NLRP3 pathway to induce pyroptosis of
            trophoblasts and aggravate preeclampsia.
REFERENCE   3  (bases 1 to 765)
  AUTHORS   Samy DM, Mostafa DK, Abdelmonsif DA, Ismail CA and Hassaan PS.
  TITLE     Crosstalk of hypothalamic chemerin, histamine, and AMPK in diet-and
            olanzapine-induced obesity in rats
  JOURNAL   Life Sci 284, 119897 (2021)
   PUBMED   34450172
  REMARK    GeneRIF: Crosstalk of hypothalamic chemerin, histamine, and AMPK in
            diet-and olanzapine-induced obesity in rats.
REFERENCE   4  (bases 1 to 765)
  AUTHORS   Omori A, Goshima M, Kakuda C, Kodama T, Otani K, Okada M and
            Yamawaki H.
  TITLE     Chemerin-9-induced contraction was enhanced through the
            upregulation of smooth muscle chemokine-like receptor 1 in isolated
            pulmonary artery of pulmonary arterial hypertensive rats
  JOURNAL   Pflugers Arch 472 (3), 335-342 (2020)
   PUBMED   31965243
  REMARK    GeneRIF: Chemerin-9-induced contraction was enhanced through the
            upregulation of smooth muscle chemokine-like receptor 1 in isolated
            pulmonary artery of pulmonary arterial hypertensive rats.
REFERENCE   5  (bases 1 to 765)
  AUTHORS   Ferland DJ, Garver H, Contreras GA, Fink GD and Watts SW.
  TITLE     Chemerin contributes to in vivo adipogenesis in a location-specific
            manner
  JOURNAL   PLoS One 15 (2), e0229251 (2020)
   PUBMED   32092101
  REMARK    GeneRIF: demonstrate chemerin's adipokine potential in vivo and
            identify it as fat depot location-specific.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 765)
  AUTHORS   Wu Y and Smas CM.
  TITLE     Wdnm1-like, a new adipokine with a role in MMP-2 activation
  JOURNAL   Am J Physiol Endocrinol Metab 295 (1), E205-E215 (2008)
   PUBMED   18492766
REFERENCE   7  (bases 1 to 765)
  AUTHORS   Takahashi M, Takahashi Y, Takahashi K, Zolotaryov FN, Hong KS,
            Kitazawa R, Iida K, Okimura Y, Kaji H, Kitazawa S, Kasuga M and
            Chihara K.
  TITLE     Chemerin enhances insulin signaling and potentiates
            insulin-stimulated glucose uptake in 3T3-L1 adipocytes
  JOURNAL   FEBS Lett 582 (5), 573-578 (2008)
   PUBMED   18242188
REFERENCE   8  (bases 1 to 765)
  AUTHORS   Goralski KB, McCarthy TC, Hanniman EA, Zabel BA, Butcher EC, Parlee
            SD, Muruganandan S and Sinal CJ.
  TITLE     Chemerin, a novel adipokine that regulates adipogenesis and
            adipocyte metabolism
  JOURNAL   J Biol Chem 282 (38), 28175-28188 (2007)
   PUBMED   17635925
REFERENCE   9  (bases 1 to 765)
  AUTHORS   Wittamer V, Franssen JD, Vulcano M, Mirjolet JF, Le Poul E,
            Migeotte I, Brezillon S, Tyldesley R, Blanpain C, Detheux M,
            Mantovani A, Sozzani S, Vassart G, Parmentier M and Communi D.
  TITLE     Specific recruitment of antigen-presenting cells by chemerin, a
            novel processed ligand from human inflammatory fluids
  JOURNAL   J Exp Med 198 (7), 977-985 (2003)
   PUBMED   14530373
REFERENCE   10 (bases 1 to 765)
  AUTHORS   Nagpal S, Patel S, Jacobe H, DiSepio D, Ghosn C, Malhotra M, Teng
            M, Duvic M and Chandraratna RA.
  TITLE     Tazarotene-induced gene 2 (TIG2), a novel retinoid-responsive gene
            in skin
  JOURNAL   J Invest Dermatol 109 (1), 91-95 (1997)
   PUBMED   9204961
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC091177.1.
            
            On Apr 20, 2005 this sequence version replaced XM_216142.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091177.1, CF115064.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..765
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..765
                     /gene="Rarres2"
                     /note="retinoic acid receptor responder 2"
                     /db_xref="GeneID:297073"
                     /db_xref="RGD:1309874"
     exon            1..59
                     /gene="Rarres2"
                     /inference="alignment:Splign:2.1.0"
     exon            60..262
                     /gene="Rarres2"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..574
                     /gene="Rarres2"
                     /note="chemerin; retinoic acid receptor responder protein
                     2; retinoic acid receptor responder (tazarotene induced)
                     2"
                     /codon_start=1
                     /product="retinoic acid receptor responder protein 2
                     precursor"
                     /protein_id="NP_001013445.1"
                     /db_xref="GeneID:297073"
                     /db_xref="RGD:1309874"
                     /translation="MKCLLISLALWLGTADIHGTELELSETQRRGLQVALEEFHRHPP
                     VQWAFQEIGVDSADDLFFSAGTFVRLEFKLQQTSCLKKDWKKPECTIKPNGRKRKCLA
                     CIKLDPKGKVLGRMVHCPILKQGPQQEPQESQCSKIAQAGEDSRIYFFPGQFAFSRAL
                     QSK"
     exon            263..367
                     /gene="Rarres2"
                     /inference="alignment:Splign:2.1.0"
     exon            368..463
                     /gene="Rarres2"
                     /inference="alignment:Splign:2.1.0"
     exon            464..585
                     /gene="Rarres2"
                     /inference="alignment:Splign:2.1.0"
     exon            586..681
                     /gene="Rarres2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttcgaggaa ccacacagaa aagggcctct ctaaagcaac gaacctgata tttttcaagg
       61 accataggac taaagcaaag ccatgaagtg cctgctgatc tccctggccc tatggctggg
      121 cacagcggac atacacggga cagagcttga gctcagcgag acacagcgca gaggcctgca
      181 ggtggctctg gaggagttcc acagacaccc gcctgtgcag tgggccttcc aggagatcgg
      241 tgtggacagt gctgatgacc tgttcttctc agctggcacc tttgtgaggc tggaatttaa
      301 gctccagcag accagctgcc tgaagaagga ctggaaaaag ccagagtgta caatcaaacc
      361 aaatgggagg aagcggaaat gcctggcctg catcaaactg gaccccaagg gtaaagttct
      421 aggccggatg gtccactgcc caatactgaa gcaagggcct cagcaggagc ctcaggaatc
      481 ccagtgcagt aagatagcac aggccggcga ggactcccgc atctacttct tccctgggca
      541 gtttgccttc tccagggctc tacaatccaa ataagccctg gacagggttt catcttactt
      601 cctgtacagc cgtggcggta cccaccatat ggcctcccaa agactttcaa ctccaggcta
      661 ataaaactgt tcctttccaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
      721 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
