LOCUS       NM_001135250            2720 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus retinoic acid receptor, gamma (Rarg), transcript
            variant 2, mRNA.
ACCESSION   NM_001135250
VERSION     NM_001135250.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2720)
  AUTHORS   Chee,L.C., Hendy,J., Purton,L.E. and McArthur,G.A.
  TITLE     The granulocyte-colony stimulating factor receptor (G-CSFR)
            interacts with retinoic acid receptors (RARs) in the regulation of
            myeloid differentiation
  JOURNAL   J Leukoc Biol 93 (2), 235-243 (2013)
   PUBMED   23136256
REFERENCE   2  (bases 1 to 2720)
  AUTHORS   Feng,Y., Yu,Y.M., Yin,M.Z., Hong,L. and Cai,W.
  TITLE     Ectopic expression of retinoic acid receptors and change of
            myocardial structure in the offspring heart with vitamin A
            deficiency
  JOURNAL   J Nutr Sci Vitaminol (Tokyo) 58 (5), 309-318 (2012)
   PUBMED   23327965
  REMARK    GeneRIF: We showed that the embryo hearts from vitamin A
            insufficient groups exhibited ultrastructural changes and
            significantly lowe expression of GATA-4, RARalpha and gamma, and
            higher expression of RXRalpha and beta.
REFERENCE   3  (bases 1 to 2720)
  AUTHORS   Terao,M., Fratelli,M., Kurosaki,M., Zanetti,A., Guarnaccia,V.,
            Paroni,G., Tsykin,A., Lupi,M., Gianni,M., Goodall,G.J. and
            Garattini,E.
  TITLE     Induction of miR-21 by retinoic acid in estrogen receptor-positive
            breast carcinoma cells: biological correlates and molecular targets
  JOURNAL   J Biol Chem 286 (5), 4027-4042 (2011)
   PUBMED   21131358
REFERENCE   4  (bases 1 to 2720)
  AUTHORS   Latasa,M.J., Ituero,M., Moran-Gonzalez,A., Aranda,A. and
            Cosgaya,J.M.
  TITLE     Retinoic acid regulates myelin formation in the peripheral nervous
            system
  JOURNAL   Glia 58 (12), 1451-1464 (2010)
   PUBMED   20648638
REFERENCE   5  (bases 1 to 2720)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   6  (bases 1 to 2720)
  AUTHORS   Lopes da Silva,S., Van Horssen,A.M., Chang,C. and Burbach,J.P.
  TITLE     Expression of nuclear hormone receptors in the rat supraoptic
            nucleus
  JOURNAL   Endocrinology 136 (5), 2276-2283 (1995)
   PUBMED   7720676
REFERENCE   7  (bases 1 to 2720)
  AUTHORS   Lohnes,D., Mark,M., Mendelsohn,C., Dolle,P., Dierich,A., Gorry,P.,
            Gansmuller,A. and Chambon,P.
  TITLE     Function of the retinoic acid receptors (RARs) during development
            (I). Craniofacial and skeletal abnormalities in RAR double mutants
  JOURNAL   Development 120 (10), 2723-2748 (1994)
   PUBMED   7607067
REFERENCE   8  (bases 1 to 2720)
  AUTHORS   Sylvester,I. and Scholer,H.R.
  TITLE     Regulation of the Oct-4 gene by nuclear receptors
  JOURNAL   Nucleic Acids Res 22 (6), 901-911 (1994)
   PUBMED   8152920
REFERENCE   9  (bases 1 to 2720)
  AUTHORS   Rochette-Egly,C., Lutz,Y., Saunders,M., Scheuer,I., Gaub,M.P. and
            Chambon,P.
  TITLE     Retinoic acid receptor gamma: specific immunodetection and
            phosphorylation
  JOURNAL   J Cell Biol 115 (2), 535-545 (1991)
   PUBMED   1655807
REFERENCE   10 (bases 1 to 2720)
  AUTHORS   Giguere,V., Shago,M., Zirngibl,R., Tate,P., Rossant,J. and
            Varmuza,S.
  TITLE     Identification of a novel isoform of the retinoic acid receptor
            gamma expressed in the mouse embryo
  JOURNAL   Mol Cell Biol 10 (5), 2335-2340 (1990)
   PUBMED   2157970
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at an
            alternate start codon, compared to variant 1. The encoded isoform
            (2) has a distinct N-terminus and is longer than isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.508500.1,
                                           SRR26360194.2308071.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN16676784,
                                           SAMN16676785 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-445               JAXUCZ010000007.1  135257361-135257805 c
            446-594             JAXUCZ010000007.1  135252769-135252917 c
            595-736             JAXUCZ010000007.1  135252036-135252177 c
            737-897             JAXUCZ010000007.1  135251260-135251420 c
            898-1074            JAXUCZ010000007.1  135250996-135251172 c
            1075-1279           JAXUCZ010000007.1  135250526-135250730 c
            1280-1438           JAXUCZ010000007.1  135249949-135250107 c
            1439-2720           JAXUCZ010000007.1  135246427-135247708 c
FEATURES             Location/Qualifiers
     source          1..2720
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..2720
                     /gene="Rarg"
                     /note="retinoic acid receptor, gamma"
                     /db_xref="GeneID:685072"
                     /db_xref="RGD:1583230"
     exon            1..445
                     /gene="Rarg"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..1638
                     /gene="Rarg"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="retinoic acid receptor gamma isoform 2"
                     /protein_id="NP_001128722.1"
                     /db_xref="GeneID:685072"
                     /db_xref="RGD:1583230"
                     /translation="MLALPLPPPGAGHCGGRRGNGLRVLGVLAPSFSPSRVAMYDCME
                     SFVPGPRRLYGAAGPGAGLLRRATGSSCFAGLESFAWAQPASLQSVETQSTSSEEMVP
                     SSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCI
                     INKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGPPDNYELSPQLEELIT
                     KVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLP
                     GFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPL
                     TDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYA
                     RRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEMFE
                     DDSSKPGPHPKASSEDEAPGSQGKRGQSPQPDQGP"
     exon            446..594
                     /gene="Rarg"
                     /inference="alignment:Splign:2.1.0"
     exon            595..736
                     /gene="Rarg"
                     /inference="alignment:Splign:2.1.0"
     exon            737..897
                     /gene="Rarg"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1074
                     /gene="Rarg"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1279
                     /gene="Rarg"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1438
                     /gene="Rarg"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..2720
                     /gene="Rarg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 catccctcta ggctctgctt ttacaaaagg tctccacaga gctagctgcc taggcaccct
       61 aagtgaggca gacggaggca gaagctagct tcgccttcgc gccccgccca gtccctttcc
      121 cttgctgggg atccccctct tccccgccca ccccttaccc cccatggatc tcagcgccct
      181 atgctagccc tccccctccc ccctccagga gcggggcact gcggggggag gagggggaat
      241 gggctgcggg tccttggtgt tctagcaccc agtttctctc caagccgggt cgcgatgtac
      301 gactgcatgg aatcgtttgt cccgggtccg cgacggctgt atggggcggc cgggcccggg
      361 gccggcttgc tacgcagagc cactggcagc tcctgtttcg ccggacttga gtcttttgcc
      421 tgggcacagc ctgccagtct acaatccgtg gagactcaga gcaccagctc cgaggagatg
      481 gtgcccagct ctccctcacc cccaccacct cctcgggtct ataagccgtg ctttgtatgc
      541 aacgacaagt cttccggcta ccactatggg gtcagctcct gcgaaggctg caagggcttc
      601 ttcagacgca gcatccagaa aaacatggtg tatacgtgtc accgtgacaa aaactgtatc
      661 atcaacaagg taaccaggaa tcggtgccag tactgccggc tgcaaaagtg tttcgaagtg
      721 ggcatgtcca aggaagctgt aaggaatgac cggaacaaga agaaaaagga ggtaaaggaa
      781 gaaggcccac cagacaacta cgaactgagt ccacagttag aggagctcat caccaaggtc
      841 agcaaagccc accaggagac tttcccctca ctctgccagc tgggcaagta caccacgaac
      901 tccagcgcag atcaccgggt gcaactggac ctggggctgt gggacaagtt cagtgagctg
      961 gccaccaaat gcatcatcaa gattgtggag tttgcgaagc ggctgcctgg ttttacagga
     1021 ctcagcattg ctgaccagat cacgctgctc aaggccgcct gcctggacat cctaatgcta
     1081 cggatctgta caaggtatac cccagagcaa gacaccatga cattctcgga tgggctgacc
     1141 ctgaaccgaa cccagatgca caatgctggc tttgggcccc ttacagacct cgtcttcgcc
     1201 tttgcggggc agctcctgcc cttggagatg gatgacacgg agactgggct gcttagtgct
     1261 atctgcctca tctgtggaga ccgaatggac ctggaagaac ccgagaaggt ggacaagctg
     1321 caggagcccc tgttggaagc cctaaggctt tatgcccggc gacggagacc cagccaacca
     1381 tacatgtttc caaggatgct catgaaaatc acagacctcc ggggcatcag caccaaggga
     1441 gcagaaagag ctataaccct caagatggag attccaggcc cgatgccccc cctgatccga
     1501 gagatgctgg agaaccctga gatgtttgag gacgactcct cgaagcctgg cccccacccc
     1561 aaggcttcca gtgaggatga agctccaggg agccagggaa aacggggcca aagtccccaa
     1621 cctgaccagg gcccctgacc tacccaactg tggggttggg ccccaggcag cagactgacc
     1681 atttcccaga taccgccagt gactggggga ggacctgccc cgcccactcc ccaccctttc
     1741 aagagctcgt tgttttgcca aagtttctag gggtgcctgt gttcatccct gtcctgttct
     1801 aactggctcc ctctacagtc ccaagggact gccgcgcacc tacccgaaga gccgagccgg
     1861 agaaggggct agcctgggtc tagactctaa aatctcagca ctgcctttca gattcaggcc
     1921 acaggttccc cacgcaagag gaagccccgc cttcccatag ccctttcctc tgccaggtgc
     1981 ttgggcctct gggagcaaac aggaacacta gagaccaaaa ggggggccct ggggagggct
     2041 gagcccaccc ttgcgcccca ccctgagcgc ctgacgccgc gtgatgaaac tgcctcgctc
     2101 agtgccctct gtgccccatc ctaatcctcc tgccaggtgt aggggcaggc tggggcctgc
     2161 atttctgggg tggggcctga gggagaaggg agaaatgtga gcccattctg tacctctgct
     2221 gaagtacggc actcatcctg ggccctccat tttataagcc tctcccttac tcctgtcgcg
     2281 tgccttggcc tcccgccctc ataaacgcca tcaggcaggg ccctcctaca ctacagaggg
     2341 gccaggggtc cctctcctag tgccttctac ccttgacccc cccagagcag cttggccccg
     2401 gggaggggag atgctgctta gctgatccca ccctgaccca gaggaaggcc tctatttatt
     2461 tattagcttt tgtttacacc ctggaatgac cccttcctcc aggggtcttg ggagggggag
     2521 cccagggcct ctgtgacccc cctcctttct ttccccaagc ccccagttta tatttagctg
     2581 ccaaataaga ttcttgcagg ctcccccttt tctctggggg gttagggtgc tgtcccctcc
     2641 cctctgttta catctcctac cccgctgttc gcatattgct gagttttcta tttttgcaaa
     2701 ataaagtgat ggaaactcaa
//
