LOCUS       NM_031529               3092 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus retinoic acid receptor, beta (Rarb), mRNA.
ACCESSION   NM_031529 XM_001059523 XM_223843
VERSION     NM_031529.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3092)
  AUTHORS   Tan,M., Yang,T., Liu,H., Xiao,L., Li,C., Zhu,J., Chen,J. and Li,T.
  TITLE     Maternal vitamin A deficiency impairs cholinergic and nitrergic
            neurons, leading to gastrointestinal dysfunction in rat offspring
            via RARbeta
  JOURNAL   Life Sci 264, 118688 (2021)
   PUBMED   33130074
  REMARK    GeneRIF: Maternal vitamin A deficiency impairs cholinergic and
            nitrergic neurons, leading to gastrointestinal dysfunction in rat
            offspring via RARbeta.
REFERENCE   2  (bases 1 to 3092)
  AUTHORS   Walter,R.F.H., Rozynek,P., Casjens,S., Werner,R., Mairinger,F.D.,
            Speel,E.J.M., Zur Hausen,A., Meier,S., Wohlschlaeger,J.,
            Theegarten,D., Behrens,T., Schmid,K.W., Bruning,T. and Johnen,G.
  TITLE     Methylation of L1RE1, RARB, and RASSF1 function as possible
            biomarkers for the differential diagnosis of lung cancer
  JOURNAL   PLoS One 13 (5), e0195716 (2018)
   PUBMED   29851970
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3092)
  AUTHORS   Kettunen,E., Hernandez-Vargas,H., Cros,M.P., Durand,G., Le
            Calvez-Kelm,F., Stuopelyte,K., Jarmalaite,S., Salmenkivi,K.,
            Anttila,S., Wolff,H., Herceg,Z. and Husgafvel-Pursiainen,K.
  TITLE     Asbestos-associated genome-wide DNA methylation changes in lung
            cancer
  JOURNAL   Int J Cancer 141 (10), 2014-2029 (2017)
   PUBMED   28722770
REFERENCE   4  (bases 1 to 3092)
  AUTHORS   Wu,H., Meng,S., Xu,Q., Wang,X., Wang,J., Gong,R., Song,Y., Duan,Y.
            and Zhang,Y.
  TITLE     Gene expression profiling of lung adenocarcinoma in Xuanwei, China
  JOURNAL   Eur J Cancer Prev 25 (6), 508-517 (2016)
   PUBMED   26695082
REFERENCE   5  (bases 1 to 3092)
  AUTHORS   Shirai,T., Shichi,Y., Sato,M., Tanioka,Y., Furusho,T., Ota,T.,
            Tadokoro,T., Suzuki,T., Kobayashi,K. and Yamamoto,Y.
  TITLE     High dietary fat-induced obesity in Wistar rats and type 2 diabetes
            in nonobese Goto-Kakizaki rats differentially affect retinol
            binding protein 4 expression and vitamin A metabolism
  JOURNAL   Nutr Res 36 (3), 262-270 (2016)
   PUBMED   26923513
  REMARK    GeneRIF: RARbeta in the kidney, which was induced in a retinoic
            acid-dependent manner, was downregulated by 90% in nonobese
            Goto-Kakizaki rats.
REFERENCE   6  (bases 1 to 3092)
  AUTHORS   Reboul,P., George,P., Louisot,P. and Broquet,P.
  TITLE     Study of retinoic acid effect upon retinoic acid receptors beta
            (RAR-beta) in C6 cultured glioma cells
  JOURNAL   Biochem Mol Biol Int 36 (5), 1097-1105 (1995)
   PUBMED   7581005
REFERENCE   7  (bases 1 to 3092)
  AUTHORS   Lohnes,D., Mark,M., Mendelsohn,C., Dolle,P., Dierich,A., Gorry,P.,
            Gansmuller,A. and Chambon,P.
  TITLE     Function of the retinoic acid receptors (RARs) during development
            (I). Craniofacial and skeletal abnormalities in RAR double mutants
  JOURNAL   Development 120 (10), 2723-2748 (1994)
   PUBMED   7607067
REFERENCE   8  (bases 1 to 3092)
  AUTHORS   Nagpal,S., Zelent,A. and Chambon,P.
  TITLE     RAR-beta 4, a retinoic acid receptor isoform is generated from
            RAR-beta 2 by alternative splicing and usage of a CUG initiator
            codon
  JOURNAL   Proc Natl Acad Sci U S A 89 (7), 2718-2722 (1992)
   PUBMED   1313565
REFERENCE   9  (bases 1 to 3092)
  AUTHORS   Rochette-Egly,C., Lutz,Y., Saunders,M., Scheuer,I., Gaub,M.P. and
            Chambon,P.
  TITLE     Retinoic acid receptor gamma: specific immunodetection and
            phosphorylation
  JOURNAL   J Cell Biol 115 (2), 535-545 (1991)
   PUBMED   1655807
REFERENCE   10 (bases 1 to 3092)
  AUTHORS   Mattei,M.G., Riviere,M., Krust,A., Ingvarsson,S., Vennstrom,B.,
            Islam,M.Q., Levan,G., Kautner,P., Zelent,A., Chambon,P. et al.
  TITLE     Chromosomal assignment of retinoic acid receptor (RAR) genes in the
            human, mouse, and rat genomes
  JOURNAL   Genomics 10 (4), 1061-1069 (1991)
   PUBMED   1655630
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On or before Aug 17, 2012 this sequence version replaced
            XM_223843.6, XM_001059523.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.35984.1,
                                           SRR26360194.2114121.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-696               JAXUCZ010000015.1  11336392-11337087
            697-845             JAXUCZ010000015.1  11363486-11363634
            846-987             JAXUCZ010000015.1  11402301-11402442
            988-1148            JAXUCZ010000015.1  11466167-11466327
            1149-1325           JAXUCZ010000015.1  11475128-11475304
            1326-1530           JAXUCZ010000015.1  11477669-11477873
            1531-1689           JAXUCZ010000015.1  11478637-11478795
            1690-3092           JAXUCZ010000015.1  11480635-11482037
FEATURES             Location/Qualifiers
     source          1..3092
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p16"
     gene            1..3092
                     /gene="Rarb"
                     /note="retinoic acid receptor, beta"
                     /db_xref="GeneID:24706"
                     /db_xref="RGD:3535"
     exon            1..696
                     /gene="Rarb"
                     /inference="alignment:Splign:2.1.0"
     CDS             540..1886
                     /gene="Rarb"
                     /codon_start=1
                     /product="retinoic acid receptor beta"
                     /protein_id="NP_113717.1"
                     /db_xref="GeneID:24706"
                     /db_xref="RGD:3535"
                     /translation="MFDCMDVLSVSPGQILDFYTASPSSCMLQEKALKACLSGFTQAE
                     WQHRHTAQSIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCK
                     GFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKK
                     EPSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLW
                     DKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDT
                     MTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQD
                     LEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLK
                     MEIPGSMPPLIQEMLENSEGHEPLTPNSSGNTAEHSPSVSPSSVETSGVSQSPLLQ"
     exon            697..845
                     /gene="Rarb"
                     /inference="alignment:Splign:2.1.0"
     exon            846..987
                     /gene="Rarb"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1148
                     /gene="Rarb"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1325
                     /gene="Rarb"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1530
                     /gene="Rarb"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1689
                     /gene="Rarb"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..3092
                     /gene="Rarb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttgaaggtt agcagcccgg gaagggttca ccgaaagttc actcgcatat attaggcaat
       61 tcaatctttc attccgtgtg acagaagtgg taggaagtga gctgctccga ggcaggaggg
      121 tctattcttt gccaaagggg gggaccagag ttcccgtgcg ccgcggccgc aggactggga
      181 tgccgaggac gcgagccacc cgggcagggc gcgtctgggc accggcgggg taggacccgc
      241 gcgctcccgg aggcctgcgc gggcgtcgcc tggaagggag aacttgggat cggtgcggga
      301 acccccgccc cggctggatc ggccgagcga gcctggaaaa tggtaaatga tcatttggat
      361 caattacagg cttttagctg gcttgtctgt cataattcat gattcggggc tgggaaaaag
      421 accaacagcc tacgtgccaa aaaaggggca gagtttgatg gagttcgtgg acttttctgt
      481 gcggctcgcc tccacaccta gaggataagc acttttgcag agcgcggtgc ggagagatca
      541 tgtttgactg tatggatgtt ctgtcagtga gtcccgggca gatcctggat ttctacaccg
      601 cgagcccgtc ctcctgcatg ctgcaggaga aggctctcaa agcctgcctc agtggattca
      661 cccaggccga atggcagcac cggcatactg ctcaatccat cgagacacag agtaccagct
      721 ctgaggagct cgtcccgagc cccccatctc cacttccgcc gcctcgggtg tacaagccct
      781 gcttcgtctg ccaggacaag tcatcgggct accactatgg cgtcagtgcc tgcgagggct
      841 gcaagggctt tttccgacga agcattcaga agaacatgat ctacacttgc caccgggata
      901 agaactgcgt tattaacaag gtcactagga atcgatgcca gtactgccgc ctgcagaagt
      961 gctttgaagt gggcatgtcc aaagagtctg tcaggaatga caggaacaag aaaaagaagg
     1021 agccttcaaa gcaggagtgc acagagagct atgagatgac agcggagctg gatgacctca
     1081 ccgagaagat ccggaaagcc caccaggaaa cctttccctc actctgccag ctgggtaaat
     1141 acaccacgaa ttccagtgct gaccaccggg tccgattgga cctgggcctc tgggacaaat
     1201 tcagtgagct ggccaccaag tgcattatta agatcgtgga gttcgccaag cgtctgccgg
     1261 gcttcacggg cctgaccatc gcagaccaga tcaccctgct caaggccgcc tgcttggaca
     1321 tcctgattct cagaatttgt accaggtata ccccagagca agacaccatg actttctctg
     1381 atggccttac cctaaatcga actcagatgc acaatgctgg cttcggtcct ctgactgacc
     1441 ttgtgttcac ctttgccaac cagctcctgc ctttggaaat ggatgacaca gaaacaggtc
     1501 ttctcagtgc catctgctta atctgtggag accgccagga ccttgaggaa ccaacaaaag
     1561 tagacaagct ccaagagccg ctgctggaag cactaaagat ttacattaga aaacgacggc
     1621 ccagcaagcc ccacatgttt ccaaagatct taatgaaaat cacggatctc cgcagcatca
     1681 gcgccaaagg tgcagaacgt gtaattacct tgaaaatgga aattcctgga tcgatgccac
     1741 ctctcattca ggaaatgctg gagaattctg aaggacatga acccttgacc cccaattcca
     1801 gtgggaatac agcagagcac agtcccagcg tgtcccccag ctcagtggag accagtggag
     1861 tgagccagtc cccgctgctg cagtgagaca cctcagcgaa agcagacatt ccccgggacc
     1921 ctcagttcca aattgaaaat gcaaggaaaa catttttact gctgcttagt ttttgaactg
     1981 aaatgttaaa ctcaaaaagg accaagaagt tttcatatgt atcaatatat attccttact
     2041 gtgtaacttg cctagaaata caaacttttc aaattctgaa aatcagccat ttcatgccac
     2101 cagaatctag tttaaagctt ctactttcct ctctgaacag tcaagatgca tggcagagac
     2161 ccagttgaga tgatttagcc ctggttaagt ttctgaagac tttgtacata cagaagtacg
     2221 gctctgttct ttctatactg tatgttggtg ctttcttttg tcttgcatac tcaataacca
     2281 agacaccaag gttatggagc agaccactgt acatccactg tacgtcttgc tttcatgaat
     2341 gacaaggcct catggtaagg aaccaggacc tttgtccagt acaggataag actaaagaca
     2401 tgctggttta agtggtgtgg aagcttctcc ttgctttttg atgctctcaa gctgcatcct
     2461 ttctcttatg ttgcccagat agagtatacc acttcactgc actacagaaa ggaattctgt
     2521 gtcagtgtaa ctgccagttc agttaatcca atgtcattgt tcaattgcta atgtcacttt
     2581 aaactaaaag tggtttgttc cttgatgaca caactaccga aggaaaaaat ctgcagtcat
     2641 gatagcctcc aaggcaaaag cactgtccag tgttagtaaa tgtgtttacc tgttcacaag
     2701 ccattggaga gatatcacag gataatcagc agccttgtct gccatctgga ctctagcagc
     2761 ccagtgtcct tcctgactca ggcctgatcc tggattcccc agacttgaag cttgagggtg
     2821 tgggcagtgg cctcctctgg ccttgttcaa tcactatgat gcagactgac agcagtggga
     2881 gactgagtgg ttgacagact caagtgtcgg gttctgagtt ctcatgtaag cactagtgga
     2941 actttcattg tttttgatat attagcaaag gtctgtgcta taccactggc tgtttgtaca
     3001 ttgagacggt ttaacagtgc tttctatgtt catatactgt ttaccttttt ccatggagtc
     3061 tcctggcaaa gaataaatat atttatttta aa
//
