LOCUS       NP_001386657             412 aa            linear   ROD 29-MAR-2024
DEFINITION  43 kDa receptor-associated protein of the synapse isoform 1 [Rattus
            norvegicus].
ACCESSION   NP_001386657 XP_006234590
VERSION     NP_001386657.1
DBSOURCE    REFSEQ: accession NM_001399728.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 412)
  AUTHORS   Chen,P.J., Martinez-Pena Y Valenzuela,I., Aittaleb,M. and
            Akaaboune,M.
  TITLE     AChRs Are Essential for the Targeting of Rapsyn to the Postsynaptic
            Membrane of NMJs in Living Mice
  JOURNAL   J Neurosci 36 (21), 5680-5685 (2016)
   PUBMED   27225759
REFERENCE   2  (residues 1 to 412)
  AUTHORS   Witzemann,V., Chevessier,F., Pacifici,P.G. and Yampolsky,P.
  TITLE     The neuromuscular junction: selective remodeling of synaptic
            regulators at the nerve/muscle interface
  JOURNAL   Mech Dev 130 (6-8), 402-411 (2013)
   PUBMED   23032192
  REMARK    Review article
REFERENCE   3  (residues 1 to 412)
  AUTHORS   Sigoillot,S.M., Bourgeois,F., Lambergeon,M., Strochlic,L. and
            Legay,C.
  TITLE     ColQ controls postsynaptic differentiation at the neuromuscular
            junction
  JOURNAL   J Neurosci 30 (1), 13-23 (2010)
   PUBMED   20053883
REFERENCE   4  (residues 1 to 412)
  AUTHORS   Francolini,M., Brunelli,G., Cambianica,I., Barlati,S., Barbon,A.,
            La Via,L., Guarneri,B., Boroni,F., Lanzillotta,A., Baiguera,C.,
            Ettorre,M., Buffelli,M., Spano,P., Clementi,F. and Pizzi,M.
  TITLE     Glutamatergic reinnervation and assembly of glutamatergic synapses
            in adult rat skeletal muscle occurs at cholinergic endplates
  JOURNAL   J Neuropathol Exp Neurol 68 (10), 1103-1115 (2009)
   PUBMED   19918122
REFERENCE   5  (residues 1 to 412)
  AUTHORS   Martinez-Martinez,P., Phernambucq,M., Steinbusch,L., Schaeffer,L.,
            Berrih-Aknin,S., Duimel,H., Frederik,P., Molenaar,P., De Baets,M.H.
            and Losen,M.
  TITLE     Silencing rapsyn in vivo decreases acetylcholine receptors and
            augments sodium channels and secondary postsynaptic membrane
            folding
  JOURNAL   Neurobiol Dis 35 (1), 14-23 (2009)
   PUBMED   19344765
REFERENCE   6  (residues 1 to 412)
  AUTHORS   Weatherbee,S.D., Anderson,K.V. and Niswander,L.A.
  TITLE     LDL-receptor-related protein 4 is crucial for formation of the
            neuromuscular junction
  JOURNAL   Development 133 (24), 4993-5000 (2006)
   PUBMED   17119023
REFERENCE   7  (residues 1 to 412)
  AUTHORS   Moransard,M., Borges,L.S., Willmann,R., Marangi,P.A., Brenner,H.R.,
            Ferns,M.J. and Fuhrer,C.
  TITLE     Agrin regulates rapsyn interaction with surface acetylcholine
            receptors, and this underlies cytoskeletal anchoring and clustering
  JOURNAL   J Biol Chem 278 (9), 7350-7359 (2003)
   PUBMED   12486121
  REMARK    GeneRIF: rapsyn binds to acetylcholine receptor at the cell
            surface, and its recruitment is induced by agrin
            GeneRIF: rapsyn binds to AChR at the cell surface, and its
            recruitment is induced by agrin.
REFERENCE   8  (residues 1 to 412)
  AUTHORS   Marchand,S., Devillers-Thiery,A., Pons,S., Changeux,J.P. and
            Cartaud,J.
  TITLE     Rapsyn escorts the nicotinic acetylcholine receptor along the
            exocytic pathway via association with lipid rafts
  JOURNAL   J Neurosci 22 (20), 8891-8901 (2002)
   PUBMED   12388596
REFERENCE   9  (residues 1 to 412)
  AUTHORS   Terrado,J., Burgess,R.W., DeChiara,T., Yancopoulos,G., Sanes,J.R.
            and Kato,A.C.
  TITLE     Motoneuron survival is enhanced in the absence of neuromuscular
            junction formation in embryos
  JOURNAL   J Neurosci 21 (9), 3144-3150 (2001)
   PUBMED   11312299
REFERENCE   10 (residues 1 to 412)
  AUTHORS   Noakes,P.G., Phillips,W.D., Hanley,T.A., Sanes,J.R. and Merlie,J.P.
  TITLE     43K protein and acetylcholine receptors colocalize during the
            initial stages of neuromuscular synapse formation in vivo
  JOURNAL   Dev Biol 155 (1), 275-280 (1993)
   PUBMED   8416841
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Jan 13, 2022 this sequence version replaced XP_006234590.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.12010.1,
                                           SRR26643287.8362.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..412
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     Protein         1..412
                     /product="43 kDa receptor-associated protein of the
                     synapse isoform 1"
                     /note="43 kDa receptor-associated protein of the synapse;
                     nicotinic acetylcholine receptor-associated 46K protein;
                     receptor-associated protein of the synapse, 43 kDa"
                     /calculated_mol_wt=46153
     Region          1..80
                     /region_name="SNAP"
                     /note="Soluble N-ethylmaleimide-sensitive factor (NSF)
                     Attachment Protein family; cl24038"
                     /db_xref="CDD:451671"
     Region          9..348
                     /region_name="LapB"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; COG2956"
                     /db_xref="CDD:442196"
     Site            order(127..128,131..132,134,164,167..168,171..172,
                     174..175,198,210..211,214..215,218)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          127..151
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          156..192
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          197..234
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          246..274
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          360..404
                     /region_name="RING-H2_Rapsyn"
                     /note="RING finger, H2 subclass, found in 43 kDa
                     receptor-associated protein of the synapse (Rapsyn) and
                     similar proteins; cd16478"
                     /db_xref="CDD:438141"
     CDS             1..412
                     /gene="Rapsn"
                     /gene_synonym="rapsyn"
                     /coded_by="NM_001399728.1:184..1422"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:362161"
                     /db_xref="RGD:1311592"
ORIGIN      
        1 mgqdqtkqqi ekglqlyqsn qtekalqvwm kvlekgsdlv grfrvlgclv tahsemgryk
       61 emlkfavvqi dtareledad fllesylnla rsneklcefh ktisycktcl glpgtragaq
      121 lggqvslsmg naflglslfq kalesfekal ryahnnddtm lecrvccslg sfyaqvkdye
      181 kalffpckaa elvndygkgw slkyramsqy hmavayrllg hlgsamecce esmkialqhg
      241 drplqalcll cfadihrsrg dletafpryd samsimteig nrlgqvhvll gvakcwiark
      301 vldkaldaie kaqdlaeevg nklsqlklhc lsegicrskg lqrelrahvv rfhecveete
      361 lycglcgesi geknsrlqal pcshifhlrc lqnngtrscp ncrrssmkpg fv
//
