LOCUS       NM_001108798            7305 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus Ras association (RalGDS/AF-6) and pleckstrin
            homology domains 1 (Raph1), mRNA.
ACCESSION   NM_001108798 XM_001070281 XM_343579
VERSION     NM_001108798.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7305)
  AUTHORS   Michael,M., Vehlow,A., Navarro,C. and Krause,M.
  TITLE     c-Abl, Lamellipodin, and Ena/VASP proteins cooperate in dorsal
            ruffling of fibroblasts and axonal morphogenesis
  JOURNAL   Curr Biol 20 (9), 783-791 (2010)
   PUBMED   20417104
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Jul 27, 2011 this sequence version replaced NM_001108798.1.
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data. There are no rat transcripts representing this gene; the
            genomic coordinates used for the transcript record were predicted
            based on mouse transcript alignments and on full-length homologous
            protein alignment with mouse NP_001230057.1 and human NP_998754.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-199               JAXUCZ010000009.1  69483821-69484019   c
            200-319             JAXUCZ010000009.1  69455033-69455152   c
            320-425             JAXUCZ010000009.1  69447155-69447260   c
            426-934             JAXUCZ010000009.1  69445122-69445630   c
            935-1012            JAXUCZ010000009.1  69424248-69424325   c
            1013-1172           JAXUCZ010000009.1  69423557-69423716   c
            1173-1294           JAXUCZ010000009.1  69422455-69422576   c
            1295-1360           JAXUCZ010000009.1  69421243-69421308   c
            1361-1504           JAXUCZ010000009.1  69420192-69420335   c
            1505-1615           JAXUCZ010000009.1  69419112-69419222   c
            1616-1714           JAXUCZ010000009.1  69417031-69417129   c
            1715-1835           JAXUCZ010000009.1  69416251-69416371   c
            1836-1978           JAXUCZ010000009.1  69412196-69412338   c
            1979-7305           JAXUCZ010000009.1  69403496-69408822   c
FEATURES             Location/Qualifiers
     source          1..7305
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q32"
     gene            1..7305
                     /gene="Raph1"
                     /note="Ras association (RalGDS/AF-6) and pleckstrin
                     homology domains 1"
                     /db_xref="GeneID:363239"
                     /db_xref="RGD:1308387"
     exon            1..199
                     /gene="Raph1"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..4000
                     /gene="Raph1"
                     /codon_start=1
                     /product="ras-associated and pleckstrin homology
                     domains-containing protein 1"
                     /protein_id="NP_001102268.2"
                     /db_xref="GeneID:363239"
                     /db_xref="RGD:1308387"
                     /translation="MEQLSDEEIDHGAEEDSDKEDQDLDKMFGAWLGELDRLTQSLDS
                     DKPKEPVKRSPLRQETNMANFSYRFSIYNLNEALNQGETVDLDALMADLCSIEQELSS
                     VGSGNSKRQVTEPKVAQKLPASRHTSKHGTLRGVSSSSTRTTRPPHANYSLDDITAQL
                     EQASLSMDEAAQQSAVEDAKPPATNQHRRTASAGTVSDAEVRSVSNSSRSSITSAASS
                     MDSLDIDKVTRPQELDLTAHQGKPITEEEQAAKLKAEKIRVALEKIKEAQVKKLVIRV
                     HMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGYSLDWSLVETISELQMERIFEDHENL
                     VENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLLGKKETAEMADRNKEVLLEECFCG
                     SSVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYVPKGKAKVSRDLVCFLQLDHVN
                     VYYGQDYRNKYKAPTDCCLALKHPQIQKKSQYIKYLCCDDARTLHQWVNGIRIAKYGK
                     QLYTNYQEALKRTESAYDWTSLSSSSIKSGSSSSSIPESQSNHSNQSDSGVSDTLPSG
                     HIRSQSTVSSIFSEAWKRGTQLEESSKARMESMNRSYTSLMPPLSPQTKIITPYTASQ
                     PSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPSSGSAATMFVKYSTITRLQNAAQHSG
                     TLFKSPAPSAMQPLPLASQSKAQIVVPPNGVIPPPPPPPPPPTPGSAMAQLKPVPCAP
                     SLPQFSPQPPPLKIHQVQHLPQAAPPTPPAAPLIPATVPPQAPPKPLVTIPPSASTKM
                     VSPVVAQAVPPTPAPPVPPTKKQPVFPVSHIPPTPPVQPTPHPPPTLPKQQSFGVKPP
                     PSPLSPVPSVVKQMASQFPPPPTPPPVDSQPLKPLPASVTPQSPPAVKAKPKWQPSSI
                     PAPSPDFPPPPPESSLVFPPPPPPAPVPPPPPPPPPPPPPPPVSPMASPTPDKGGSPG
                     KKTSKMSSPGGKKPPPTPQRNSSIKSGSCAEHPEPKRPSVDSLVSKFAPPAESGSPSK
                     ETPPPPAAPPKPGKLHLSGVNLPGIHQQGILSAKPSVLSGRGKDAVVEFPSPPSDSDF
                     PPPPPEIELPLPPIEIPAVFSGNTSPKVAVVNPQPQLWSKTSVKKAPPPTRPKRNDST
                     RLTQADISEQPAMTTVVPQVPTSPKSSLSVQPGFLADLNRTLQRKSITRHGSLSSSRM
                     SRAEPTATMDDMALPPPPPELLSDQQKAGFGGSHISGYATLRRGPPPAPPKRDQNTKL
                     SRDW"
     exon            200..319
                     /gene="Raph1"
                     /inference="alignment:Splign:2.1.0"
     exon            320..425
                     /gene="Raph1"
                     /inference="alignment:Splign:2.1.0"
     exon            426..934
                     /gene="Raph1"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1012
                     /gene="Raph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1172
                     /gene="Raph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1294
                     /gene="Raph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1360
                     /gene="Raph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1504
                     /gene="Raph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1615
                     /gene="Raph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1714
                     /gene="Raph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1835
                     /gene="Raph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..1978
                     /gene="Raph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..7305
                     /gene="Raph1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggccgacc cgcccagttc ccgccgacgc ccgctctgtg ggtcggtcag tcagtcaccg
       61 agcgcgcgcc gcgggagctg cggtcgctct cagcgttcgg gagaggagcg tcgcgcctgg
      121 cgaggcggca gcggcggctg gagggcgcga gcagctgctg cctagcgcgg ggctccggga
      181 gggccgaggg gctgccgcga tggagcaact atctgatgaa gagattgacc atggtgcaga
      241 agaagacagt gacaaggaag atcaggacct ggacaaaatg tttggggcct ggcttgggga
      301 gctggacaga cttactcaga gtttggattc tgacaagccc aaagaaccag tgaaaagatc
      361 tcctcttcgc caggaaacaa atatggccaa cttttcttac cgtttctcca tatacaactt
      421 gaatgaagct ctgaatcagg gtgagactgt ggatctggac gccctgatgg ccgatctctg
      481 ctctatagag caggagctca gcagtgttgg ctcaggaaat agtaagcgcc aagtcacaga
      541 acccaaagtt gctcagaagc tacctgctag ccgacataca tcaaaacatg gtaccctgag
      601 aggagtgtca tcttcctcta ctagaacaac taggcctccg catgctaact actccctgga
      661 tgacatcact gcacagttag aacaggcttc cttgagcatg gacgaggctg ctcagcagtc
      721 tgcagtagaa gatgctaagc ctcccgcaac aaaccagcac agaaggaccg catcagcagg
      781 caccgtgagt gacgccgaag tgcgctccgt tagcaactcc tcccggtcga gcatcacttc
      841 tgcggcctcc agcatggatt ctctggatat tgacaaagtc acacgccctc aagaactgga
      901 tttgacagca caccagggaa agccaattac tgaggaagaa caggcagcaa aactgaaagc
      961 tgagaagatc cgagttgctc tggagaaaat taaagaggct caagtgaaaa agctggtgat
     1021 cagggtccac atgtctgatg acagttctaa aacaatgatg gtggatgaga gacagacagt
     1081 gagacaagtg ctggataacc tgatggacaa atctcactgt ggctacagtt tagactggtc
     1141 gctggtggag acaatttctg agttacaaat ggaaagaatc tttgaagacc atgaaaactt
     1201 ggttgaaaat cttcttaatt ggacaagaga cagccaaaat aagcttatat ttatggagcg
     1261 tatagaaaaa tatgcacttt ttaaaaaccc ccagaattac cttctaggga aaaaggaaac
     1321 ggctgagatg gcagacagaa acaaagaagt gctgttagag gaatgttttt gtggaagttc
     1381 tgtaactgtc ccagaaattg aaggagtcct ttggttgaaa gatgatggca agaagtcctg
     1441 gaaaaagcgt tattttctct tgcgagcatc tggtatctac tatgtcccta aagggaaagc
     1501 aaaggtatct cgggatctag tgtgctttct ccagctggat catgtaaatg tatactatgg
     1561 gcaggactat cggaacaaat acaaagcacc cacagactgc tgtctggcct taaagcaccc
     1621 acagatccag aagaagtctc agtacatcaa gtacctttgt tgtgatgatg caaggaccct
     1681 gcatcagtgg gtcaatggga tccgcattgc caagtatggg aagcagctct acacgaatta
     1741 ccaagaagcc ttgaagagga cagagtcagc ttatgattgg acctctttat ccagctccag
     1801 cattaaatcc ggatccagtt cttccagtat cccagagtct cagtccaatc actctaatca
     1861 gtctgacagt ggagtgtctg acaccctgcc ctccggacac atccgctccc aaagtactgt
     1921 gagctctatc ttctcggaag cctggaagcg aggcactcag ttggaagagt ccagcaaggc
     1981 cagaatggag tctatgaatc ggtcctacac ttcacttatg ccccccctgt cccctcaaac
     2041 taagatcatc actccctata ctgcctcaca accttcacca cctctgcctc ctcctccacc
     2101 accacctcct cctcctccac ctccaccacc accacctcct cctcctctcc ccagccagtc
     2161 tgcaccatct tcaggctcag cagccaccat gtttgtcaag tacagcacaa tcaccaggct
     2221 gcagaatgca gctcagcatt cagggaccct gtttaagtct ccagcaccat cagcgatgca
     2281 gcctcttcct ttggcttcac agtccaaggc tcaaattgtg gtgcccccca atggagttat
     2341 tcctccaccc cctcctcctc ccccaccccc aacccccggc tcagccatgg cccagttaaa
     2401 gccagtgcca tgtgccccat ccctaccaca gttcagcccc caacctccac ccctgaagat
     2461 tcatcaggtt cagcatcttc ctcaggcagc ccctcctaca cccccagcag ctcctctcat
     2521 ccctgcaact gtgccacctc aagcaccccc taaacctctg gtgaccattc ctccttcagc
     2581 cagcacaaag atggtgtcac cagtagtagc acaagctgta ccacctaccc ctgcacctcc
     2641 agtgccccca acaaagaaac agccagtatt ccctgtttct cacattccac ccactccccc
     2701 tgtccagcct accccacatc ccccaccaac actacccaag cagcagagct ttggggtgaa
     2761 gccacccccc tctccactgt cccctgtgcc ctcagttgtg aagcagatgg ccagtcagtt
     2821 tccaccccct cccactcctc ctcctgtgga ctctcagccc ctaaaacctc tcccagcaag
     2881 tgtcacccca cagtcccctc ctgcagtaaa agcaaaaccc aaatggcagc ccagttcaat
     2941 ccctgcccct tctccagatt tccctcctcc ccctcctgaa agcagcctgg tatttcctcc
     3001 accacctcct ccagccccag tcccaccacc accaccacca ccacctccac caccaccacc
     3061 accaccagtg tcacctatgg cttcacctac ccctgacaaa ggtggatctc caggcaaaaa
     3121 gacaagtaag atgtccagcc ctggggggaa gaaaccaccc ccaaccccgc agcgcaactc
     3181 cagcattaag tccggcagtt gtgcagagca ccctgagccc aagcgaccct cggtagacag
     3241 tctagtcagc aagtttgcac cgccagcaga atcagggtct cccagcaagg agaccccacc
     3301 acctcctgca gcacccccca aacctgggaa actacacctt tctggagtca acctccctgg
     3361 aatccatcag caagggattt tgtcggcaaa accctctgtt ctaagtgggc gtggaaagga
     3421 cgccgtggtg gaatttccat ctccaccatc tgattctgac tttccacccc ctcctcctga
     3481 aatagagctt cctctacccc ctatcgagat tccagctgtc ttctccggga acacctcccc
     3541 aaaagtggca gttgttaatc ctcagccaca gctatggtct aaaacatcag tgaagaaggc
     3601 ccctccacct acccggccca aacgcaatga tagtacccgt ctcactcaag ctgacatctc
     3661 tgaacagcca gcgatgacca cagttgtgcc acaagtgccc acttctccta aatccagcct
     3721 tagcgtccag cctggattcc tagctgatct caacaggaca ctgcagcgca agtctatcac
     3781 acggcatggc tccctctcct cctcacgtat gtctagagca gaacccacag ccacaatgga
     3841 cgacatggca ctacccccac caccaccaga actgctgtct gaccagcaga aagctggctt
     3901 tggaggtagt catatttcag gctatgcaac attgcgaaga ggaccccctc ccgcccctcc
     3961 taaaagagac cagaatacta agctctcaag agactggtag ccacaagaca ttttcatgct
     4021 atctataatc agttctacaa tcagttcatc tgatcatctg tgaatccagg tgttcagagc
     4081 ctcctgatat gttattcagg tagtgtccag ctgtgtgtgt gggtttgtgt gtatatgtgc
     4141 tgcatgtgtg tacatggatg tacacacagc tatacagaca gtgtgtatat acatatgtat
     4201 acatctatgt gtatatatac agagaactga ttctatttat tccttctgcc tcctaatcca
     4261 aatatggagt tttgtatatt ttgggtggaa gaagacatag gaggggatat gttgtcactt
     4321 aaaacttgtc tagtgtatgg attggaccaa atactagaag gtatttcctg tgtctatcca
     4381 cgtgccacct atctgtgcat gtgttatagg agatgggcag tttctcagct agagtgtatc
     4441 atcagaatgt ttggtgtact gatagggctt ttttctctat ttctcccagt ttttcccagt
     4501 tcactggatt tagaactgct tgactgacac ttaaatacta catgtaaagg ggcactttac
     4561 atcagggaaa ctattataca gaatgggtaa acagtgcagg aaagggagtg gttgtaaatg
     4621 ggaaagtcat ggccgttcta gttgcagtac tgccatgacc ccagccacat ctaagatgtc
     4681 ttcacaggta agctttgtgt ccacagcaca aggaatattt aatgttatga tctgggctac
     4741 cttcagtact gtcttgcaaa gcttcatcaa cttggcttta tgattcttgc tttattgtga
     4801 atgtccagta cacattgtaa tgtactgttc agttatgtct tcgggtcaca atcatcttca
     4861 tatatagtgt gtgcattcat agacatttga atacatgaat agtctgagta tgaaatatat
     4921 accctgtgcc cagtttggtt cattattata aagacagtcg cctgctgcaa tgcctccttt
     4981 acaaattgtt ctatgagaaa gaaagaaaaa actaaactgg cccctgtaca gatatctttg
     5041 atgaagttac aatgcaaaga atccatctgg gaatgggatt gtcatgaaca aaaagtttcc
     5101 ataatttcat ccatagctag tggagctgct aagacctttg tttgctattc acagctcaag
     5161 tgtagagatt tttataagtg accagatgtt ctgatggagc agtgtcacag tccagtgaca
     5221 gtaagtgaca cactggctat gcaaaggcag ctaggcaaac cttggctgca ctgctcctat
     5281 tctgtgtgct tttggtatga gaagtgtgtg ctcatcaact tagagtgacc ttagagctag
     5341 ctattttaag aggataaaaa ctggccatcc caccaattac aagtgaacat gtcttgtaaa
     5401 gaaaggctgc ctactaaaaa aataaccagt gccaaatgca atcttttggt cctgtccctc
     5461 aaagagaaag cggctgcaat ggatctgggc caagactcac tagagagcat agtatttgta
     5521 ctacttcgtc ataaagacgt gcgagtggca cccttgtcac atctgcagcc actgttcagt
     5581 gccgtcacac attaggaagg aaaaagacca tttaagtcat tgtatttttt aaaacccaac
     5641 ttaaggaaat ttattgaatc tttcaaattg ttcaccaagt atttatgctt gatattccta
     5701 tgatgaaatg acctttaaca tactgaattg ttagtttcaa caaacacaac aaatgcagtc
     5761 aatctgagta cagaggccaa gccccactga ggctgggaga agtgctgctt ccctgtgctt
     5821 atcaacctgt ggctctacgt tcaagagagt ggatccggtt atccccagta ttactttttt
     5881 ctttttaaat taaaccagat gaaacaattt aagatttcct tgagtggaaa aatatgtact
     5941 tccggtctat attaagccct aaatcaatag ccttctcttt ttttccagtg tggatttcat
     6001 gggaattctt aagacatcct gagctatgac ttctgtttta ttgtcatggg agggcagata
     6061 actttgaaaa ccagtaatgc caaaaaaatg agagagcagt aactacccat ttctaactcg
     6121 catgacagca cccagtttct ttatatttct caaagataat agctgttaat ttttttttaa
     6181 aaaaggtgat acatcgcaat cttttttttt tttttttttt aggtgacaca ttccaatctt
     6241 tgtttttagc tgcctagagt gtttgaaggt tgtgctgagg tgtagtcttg ttgcttctct
     6301 gtctctgatg tgtttgttca tggacaagac ccactgccag acaacactgg ttctgtgcct
     6361 tctctcactg ccctttgctt ggcagctcca gcttacatgg ctttttaggc cagtgaaagg
     6421 cacccagagg ctgcctggac tgactagtga atagggtgaa ggaccttccc ctgagggcag
     6481 aacaggtgct tttcagaact ggtgactagc tttttgacaa ccttaatttt tactatataa
     6541 gtaatctcaa gagtctctag tgctgaagct ttggcaccaa ctctgaaggg cagcagaaaa
     6601 ccacactcca gctcacagct gttagaacgc tcgtctacgt gaatctcacc accttggctt
     6661 ttactcccag gagatttaca tgctcatttg aaggggagaa aattaatttt taagatgtcc
     6721 actcacagat aactagattt ttttcaatat ctgaactttt taacctgaga aagatggctg
     6781 tatcttacag attatcaaaa agacattttc atcagataat taaaactaat aaagatgact
     6841 gtgggttttt tttaagtcct tcaaaattaa ggtgctccta ccccatggat ggcatatctt
     6901 gcaaagggct aagaactgtt ttgggttcct tttgtgttac tttgatgtta taaataatgt
     6961 tgaatttgtc taaacaggat tgagaggtca cagggtaaca attccaaaat tcagattaac
     7021 agaggtttca gaacctggat ttgttcatca gactttgaac tgaacatatt gtcacctttg
     7081 ctattcaaaa ccaattttat gttacaaaca caaggcagtg tttaatcaag taaaaaaatt
     7141 catgcaaata tttccatgta tcttcagaaa tcagaaacag cattataact gatgtaatcc
     7201 cagattctac gctagcttac taattaaaat aatggtcctc tatggttagg tgacaatttc
     7261 taataaaata ggtaaaaata cctttcttta ttaaaaaaat ccctt
//
