LOCUS       NM_001395143            6339 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus Rap guanine nucleotide exchange factor 5
            (Rapgef5), transcript variant 2, mRNA.
ACCESSION   NM_001395143 XM_039112595
VERSION     NM_001395143.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6339)
  AUTHORS   Bithell,A., Alberta,J., Hornby,F., Stiles,C.D. and Williams,B.P.
  TITLE     Expression of the guanine nucleotide exchange factor, mr-gef, is
            regulated during the differentiation of specific subsets of
            telencephalic neurons
  JOURNAL   Brain Res Dev Brain Res 146 (1-2), 107-118 (2003)
   PUBMED   14643017
REFERENCE   2  (bases 1 to 6339)
  AUTHORS   Rebhun,J.F., Castro,A.F. and Quilliam,L.A.
  TITLE     Identification of guanine nucleotide exchange factors (GEFs) for
            the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction
  JOURNAL   J Biol Chem 275 (45), 34901-34908 (2000)
   PUBMED   10934204
REFERENCE   3  (bases 1 to 6339)
  AUTHORS   Ichiba,T., Hoshi,Y., Eto,Y., Tajima,N. and Kuraishi,Y.
  TITLE     Characterization of GFR, a novel guanine nucleotide exchange factor
            for Rap1
  JOURNAL   FEBS Lett 457 (1), 85-89 (1999)
   PUBMED   10486569
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Jun 4, 2021 this sequence version replaced XM_039112595.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.26769.1,
                                           SRR26643298.37473.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-306               JAXUCZ010000006.1  144588162-144588467
            307-357             JAXUCZ010000006.1  144630807-144630857
            358-464             JAXUCZ010000006.1  144632738-144632844
            465-586             JAXUCZ010000006.1  144636960-144637081
            587-755             JAXUCZ010000006.1  144638444-144638612
            756-822             JAXUCZ010000006.1  144649403-144649469
            823-871             JAXUCZ010000006.1  144668277-144668325
            872-948             JAXUCZ010000006.1  144701251-144701327
            949-1074            JAXUCZ010000006.1  144714435-144714560
            1075-1193           JAXUCZ010000006.1  144744455-144744573
            1194-1282           JAXUCZ010000006.1  144745029-144745117
            1283-1361           JAXUCZ010000006.1  144770275-144770353
            1362-1506           JAXUCZ010000006.1  144775286-144775430
            1507-1604           JAXUCZ010000006.1  144776366-144776463
            1605-1635           JAXUCZ010000006.1  144779304-144779334
            1636-1714           JAXUCZ010000006.1  144780370-144780448
            1715-1864           JAXUCZ010000006.1  144782745-144782894
            1865-1962           JAXUCZ010000006.1  144787210-144787307
            1963-2085           JAXUCZ010000006.1  144789672-144789794
            2086-2264           JAXUCZ010000006.1  144791736-144791914
            2265-2355           JAXUCZ010000006.1  144802928-144803018
            2356-2406           JAXUCZ010000006.1  144805893-144805943
            2407-2494           JAXUCZ010000006.1  144807254-144807341
            2495-2559           JAXUCZ010000006.1  144812777-144812841
            2560-2614           JAXUCZ010000006.1  144816695-144816749
            2615-6339           JAXUCZ010000006.1  144819184-144822908
FEATURES             Location/Qualifiers
     source          1..6339
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q33"
     gene            1..6339
                     /gene="Rapgef5"
                     /gene_synonym="Mrgef; RGD1562891; rMR-GEF"
                     /note="Rap guanine nucleotide exchange factor 5"
                     /db_xref="GeneID:362799"
                     /db_xref="RGD:1561668"
     exon            1..306
                     /gene="Rapgef5"
                     /gene_synonym="Mrgef; RGD1562891; rMR-GEF"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..2733
                     /gene="Rapgef5"
                     /gene_synonym="Mrgef; RGD1562891; rMR-GEF"
                     /note="isoform 2 is encoded by transcript variant 2;
                     MR-GEF; M-Ras-regulated Rap GEF; Rap guanine nucleotide
                     exchange factor (GEF) 5; guanine nucleotide exchange
                     factor for Rap1-like"
                     /codon_start=1
                     /product="rap guanine nucleotide exchange factor 5 isoform
                     2"
                     /protein_id="NP_001382072.1"
                     /db_xref="GeneID:362799"
                     /db_xref="RGD:1561668"
                     /translation="MAVGSVKMQPPCESPALASAAPAEGPLRRSPSAREPEREPTAAS
                     LRPRLRDLPALLRSGLTLRRKRSAAGARTLSRRISNPYLDHSPSQIYGENSSCAGRAL
                     RNIIILQAADLVKDRVNLKGFYRRSCVGSELVDWLLEHCPFVQCRSMAIGVWQLLLDM
                     GIMSSVDQHLYFQDNYVFYQFSSDECSYLYCEFEREEEWQKGVKLLLELVHLIPARAG
                     ICDLSHQKAEDSEESSDEILARLTSAVQRELAAVIALKARKSAIEQDDENTDKHVTVT
                     EANDDAPDPQAGVMCKLQERDDIGRIELVHKLARENCQFLQTDKKEPEKSEQQDDEVT
                     MVQVKDQGQSVLVLKKVASCGPAPTTGSAESDARYVVVSGTPEKILEHLLNDLHLAEV
                     QHKETETLLDDFLLTYTVFMTTDDLCQALLRHYSAKKYQGEEENSDVPCRKRKVLHLV
                     SQWISLYKDWLHEDEHSKMFLKTIYRNVLDDVYEYPILEKELKEFQKILGMHRRHTVD
                     EYSPQKKNKALFHQFSLKENWLQHRGTVAETEEIFCHVYVTEHSYISVKAKVSSTAQE
                     ILKVVAEKLQRAEEDLALVAIMFSGEKHEFQPNDLAISKSLEASGRIYVYRKDLADTL
                     NPFAENEESQQRSMRILGMNTWDLALELMSFDWSLFNSIHEQELIYFTFSRQGSGEHT
                     VNLSLLLQRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIAAHCKAQQNLNSFFAIVM
                     GLNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRDAFKKMKPPKIPFMPL
                     LLKDVTFIHEGNKTFLDNLVNFEKLHMIADTVRTLRHCRTNQFGSDMSPKEQQELKSY
                     VNHLYVIDSQQALFELSHRLEPRA"
     exon            307..357
                     /gene="Rapgef5"
                     /gene_synonym="Mrgef; RGD1562891; rMR-GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            358..464
                     /gene="Rapgef5"
                     /gene_synonym="Mrgef; RGD1562891; rMR-GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            465..586
                     /gene="Rapgef5"
                     /gene_synonym="Mrgef; RGD1562891; rMR-GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            587..755
                     /gene="Rapgef5"
                     /gene_synonym="Mrgef; RGD1562891; rMR-GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            756..822
                     /gene="Rapgef5"
                     /gene_synonym="Mrgef; RGD1562891; rMR-GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            823..871
                     /gene="Rapgef5"
                     /gene_synonym="Mrgef; RGD1562891; rMR-GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            872..948
                     /gene="Rapgef5"
                     /gene_synonym="Mrgef; RGD1562891; rMR-GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1074
                     /gene="Rapgef5"
                     /gene_synonym="Mrgef; RGD1562891; rMR-GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1193
                     /gene="Rapgef5"
                     /gene_synonym="Mrgef; RGD1562891; rMR-GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1282
                     /gene="Rapgef5"
                     /gene_synonym="Mrgef; RGD1562891; rMR-GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1361
                     /gene="Rapgef5"
                     /gene_synonym="Mrgef; RGD1562891; rMR-GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1506
                     /gene="Rapgef5"
                     /gene_synonym="Mrgef; RGD1562891; rMR-GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1604
                     /gene="Rapgef5"
                     /gene_synonym="Mrgef; RGD1562891; rMR-GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1635
                     /gene="Rapgef5"
                     /gene_synonym="Mrgef; RGD1562891; rMR-GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1714
                     /gene="Rapgef5"
                     /gene_synonym="Mrgef; RGD1562891; rMR-GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1864
                     /gene="Rapgef5"
                     /gene_synonym="Mrgef; RGD1562891; rMR-GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..1962
                     /gene="Rapgef5"
                     /gene_synonym="Mrgef; RGD1562891; rMR-GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1963..2085
                     /gene="Rapgef5"
                     /gene_synonym="Mrgef; RGD1562891; rMR-GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..2264
                     /gene="Rapgef5"
                     /gene_synonym="Mrgef; RGD1562891; rMR-GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2265..2355
                     /gene="Rapgef5"
                     /gene_synonym="Mrgef; RGD1562891; rMR-GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2356..2406
                     /gene="Rapgef5"
                     /gene_synonym="Mrgef; RGD1562891; rMR-GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2407..2494
                     /gene="Rapgef5"
                     /gene_synonym="Mrgef; RGD1562891; rMR-GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2495..2559
                     /gene="Rapgef5"
                     /gene_synonym="Mrgef; RGD1562891; rMR-GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2560..2614
                     /gene="Rapgef5"
                     /gene_synonym="Mrgef; RGD1562891; rMR-GEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2615..6339
                     /gene="Rapgef5"
                     /gene_synonym="Mrgef; RGD1562891; rMR-GEF"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtctcgccc tctcgctgcc ttgcgaaggc gcggaggcga gcgcggagga gagcagcctc
       61 gggcgccgcc gcaaccgtca gggcatcagg atggcggtgg gctctgtcaa gatgcagccg
      121 ccgtgcgaga gcccggccct ggcttcggcg gccccggccg aggggcccct gcgccgcagc
      181 ccgagcgccc gggagccgga gcgcgagccg accgccgcgt ctctgcggcc gcgcctcagg
      241 gacctgcctg cgctgctgcg gagcgggctc acgctgcgga ggaagcggag cgccgccggg
      301 gcccggactc tctcaagaag aatttccaat ccataccttg accatagtcc ttctcagatt
      361 tatggagaga attcttcttg tgcaggaaga gcattgagga atattattat ccttcaggca
      421 gctgacctgg taaaggacag agtgaatctc aaggggtttt acaggagaag ctgcgtgggg
      481 tcagagctgg tcgactggct cctggaacac tgtccttttg tccagtgtcg atctatggcc
      541 attggggtct ggcagctcct actggacatg gggattatgt catcagtgga ccagcatctc
      601 tactttcagg ataactatgt tttctaccag ttctcctcgg atgaatgcag ctacctgtac
      661 tgtgaatttg aaagagagga agaatggcaa aagggagtga agcttttact ggagcttgtg
      721 cacctcattc ctgcgagagc tggcatctgt gacctttctc accagaaagc ggaagactcg
      781 gaagaaagca gcgatgaaat ccttgctcga ctgacatctg cggtgcagag ggagctagcg
      841 gctgttattg ctttgaaagc aaggaagtct gcaatcgaac aagatgatga aaacactgac
      901 aaacacgtaa ccgtgacaga ggctaatgac gacgccccgg atcctcaggc tggggtgatg
      961 tgtaagcttc aagagagaga tgatatcgga cgtattgagc tggtccacaa gctggcaaga
     1021 gagaactgtc agtttttaca gacagacaaa aaagaaccgg agaagtcgga acagcaagat
     1081 gatgaagtga cgatggttca ggttaaagac caaggccaga gtgtgctggt gctgaagaaa
     1141 gttgcaagct gtggcccagc ccccaccacg gggagcgcgg agagcgacgc gagatatgtg
     1201 gtggtgtctg ggaccccgga gaagatcttg gagcaccttt tgaatgactt acacctggca
     1261 gaggttcagc acaaagaaac agaaacactc cttgatgact tcctcctcac gtatacggta
     1321 ttcatgacaa ccgatgactt gtgccaggcg ctgttaagac actattctgc taagaagtat
     1381 caaggggaag aagaaaactc agatgtccct tgtcggaagc gcaaggtctt acatctggtt
     1441 tcccagtgga tttctctgta caaggactgg ctgcatgaag atgagcactc aaagatgttt
     1501 ctaaagacca tatacaggaa tgtgctggat gacgtctatg aatatccgat ccttgagaaa
     1561 gagctgaagg agtttcagaa gatactgggc atgcaccgcc gtcacactgt tgatgaatac
     1621 tcaccacaga agaagaataa agccctcttc catcaattca gtcttaagga gaactggctc
     1681 cagcatagag gaactgtggc cgaaacagag gaaatttttt gccacgtgta tgtgacggag
     1741 cactcctaca tcagtgtgaa ggcaaaagtt tctagtacag cccaggagat cctgaaggtt
     1801 gtggccgaga agctgcagcg tgccgaagag gatctggctc tggtggccat tatgttctct
     1861 ggagaaaagc atgaatttca gccaaatgac ttggccattt ccaaatccct ggaggcatct
     1921 ggtcggatat acgtctaccg gaaagatctg gctgacactt tgaatccttt tgcagaaaat
     1981 gaggaatccc agcaaaggtc gatgaggatt ttggggatga acacttggga ccttgctctg
     2041 gaattaatga gttttgattg gagtctgttc aattcaatcc acgagcaaga actcatctac
     2101 ttcacattca gcagacaggg gagcggagag cacactgtga acctcagcct tctgctccag
     2161 agatgtaacg aggtccagct ctgggtggcc acggagattc tgctctgcag ccagctaggc
     2221 aagcgcgtgc agctggtgaa aaaattcatc aagattgctg ctcactgcaa agcccagcag
     2281 aacctaaact ccttctttgc catcgtgatg ggtctcaaca ccgcctctgt cagccggctg
     2341 tcacagacct gggagaaaat tcctgggaag tttaagaaac ttttctctga acttgagagt
     2401 ttaacggatc cttccctaaa ccacaaggcc tacagggatg cattcaaaaa gatgaagccg
     2461 ccaaaaatcc ctttcatgcc cttactgctt aaagatgtaa catttattca tgaaggaaat
     2521 aaaacattcc tggataatct tgtcaatttt gaaaagctgc acatgatcgc agatactgtc
     2581 cgaaccctga gacactgcag gactaaccag tttggaagcg acatgtctcc aaaggagcag
     2641 caagagctga agtcctatgt caaccacctg tatgtcatcg acagccagca agccctgttc
     2701 gagctctctc acaggctgga gcctcgagcc tgagctgcgc cagtccgtcc tgcatctgca
     2761 acactttaga gcaagggaag gctccattga gcatgttgct tcctgtaaga aaagaggtcg
     2821 ctgagtttta tcagcaaacc atgagacaag tgcaggaaag ccagccaatg cactttcagg
     2881 aagtgacacg tcagccacca gaggcgggag agctccccca ctgctgtcag ggagaagaca
     2941 ggagacagag catccttgga acagggtcct ccttgggacg gctatttcat tccagtccaa
     3001 gtttcagctt acgacgtgcc agcatcagga ggagattgtt catatggcgg gaaggactgt
     3061 cactctgtct gcccacccta ctgctgattg gctgcctgct caccttgttg ccgattggct
     3121 gttcagagac cggaacaccc ctgaaccagc aagggcatct ccaaatgtcc caggaagagg
     3181 agaggcctct gttgctataa acttagcatc accctggagg gcacgtcctt ctgtgcaaat
     3241 gagaaatgcc tggcacacac ttcctttgca tccacaatca ttgaccaacg tatacacaga
     3301 tgaactagtt cacgctccac tgacgcactt ctgtaagcaa ggtagcctgg gtttctcatc
     3361 caataaggag cttggcgtcg ttcagtttct atgaactttc tttacgtata tcgtcatttg
     3421 ttgttgagtg caattttcag aaaaacacag ggccaggact gtggggtgct cagtgttagc
     3481 ttactggggt gacggaattt ccagtgtctg cactctggtg tctgatggag ccttggcgtc
     3541 cgacactaac tactccgcca ggctccctgc ctacaggatg cagaacatca gcccacgagg
     3601 gaggtgagtg agtgaagctg agtatctgaa gcttaacagt tagcttgcta gactcagtga
     3661 ttgaaaagta tccagagatg cctaaagtct cacttacatg gggagtcaga gccccgtagt
     3721 ctacttccca agtaaagcca gagtctttct gcaatttgcc tttcaccttc ttattctttg
     3781 tttttataaa ttgggcctca tataccaaat aaggcctctt ggaattctga aggactcgtt
     3841 agaggatctc cctgaatcct cgagtaagag aaaagcttgc ggttaaaaca agcccactct
     3901 cccaccagct agatactagt tccttcgctg tgcgcaaatc cccatctgag tatttggtct
     3961 gtgcatctct agtcttgagt atgggtatgc cattcacatc cctgggaatc ggggggcagg
     4021 gactgggtcc acccagacct gcttcctact ctcctcagca cctggttctc attctcatta
     4081 ctaaggtctg agctatgccc gttgccacct gacttcctga gagctatgct gttccctggt
     4141 cttgggacca gtgagcctga gacactgcta aaaggaacca tatgctttca gagagattgc
     4201 atccgatcta gcatgtaaaa ttttagctct ataaacttac agggggttat agaaacactc
     4261 caactgaggg tgattcactc agaaaatgtt tctcgggtct gagggctggt gcatgagacc
     4321 agagccacag aaccagggag agcaagctgt cttgatgtgt agacaagcac aacctctgag
     4381 gacagtacac acttacagca caaacacgcg tgtcttccct ccaagctagc aactgagagc
     4441 ggggctagtg tatcatagca gctcattttg acattgtctg tattaactct acattgcctc
     4501 aagcagagcc ttacctttag agctcattgt agatggagat ctgtttcagt ggaacactgt
     4561 ctgtctagac tccagctcag ctgggctgca caagtcacat ctgcatcgtg cttagcacac
     4621 ttaagagaac tctgcagggc acgaatggga atagccctgg agaacatggg gtgaggctgc
     4681 ttgtccctcc aaagcaaaaa gccggatggg atttattttc ccatcctgta tacggaatat
     4741 ctaaaaaatc tctaaatcct tctcaacttt aacacctgtt gctagggatt tctcagtcag
     4801 cagatttagg aacttcagac gcttcacagt ctcttaaatc taaaatagga aaagttcagg
     4861 atggtcagac cctgttttca caggaagcgc ttctgaagga agccaagccc tgtataggtg
     4921 tccacagggg tggacactcc catgcatggg atgactccct tccttctcca aagcctcccg
     4981 ggtgtctaac taaggtctct tccagttctc ctttgggttt ttgtgatttc atgggtctcc
     5041 attccctccc tcgatcccat ataattagca tctccatcag tgagtgatac ctggccctcg
     5101 aggggttctt tgggtctttg gattctgttc ctgcaaagca gatttgcttg caagttccta
     5161 cccgagtcag aacacaggtc catctaggga aagtcatgga gtttccaaac atttcaaagg
     5221 atttgcctcc aagtgtgaac ttgccgaatg aatggttgcc atagcacacg gtgtaaccca
     5281 cactctacct tttctggtat ccttagttgc gttgagaata aatacctttt cctactccag
     5341 tatctacacg cgggcagtgt ggcacatact ttgaatttag aggcatgagc ataaagtccc
     5401 accctctgag tctgtaggga ggtatttcac agttgggccg tcgttttgag tgaggaagtg
     5461 gggtatggcc ccgtggctgc ttatgtagac tttttatccc agagctcctg tggctgcctg
     5521 agcaccagcc ctgtggtttt gtacacacaa aacctgaaaa cacaaaaaca cgtgcacagc
     5581 aaagcctgaa ccaaatggca caacccacac aagcttatca gaattgggca aaacccatta
     5641 agcttagaag acaagggcca ctgtagctgt ccagcgtaga acttcttctc aacttcaaag
     5701 acatgtcctt gaaatttcag cccactcatt actgagtggg cccgttttgc tctagggaaa
     5761 acacattttg aaaattgcca aaaagtcgga agaaatgtac tactgtataa agcaaagctg
     5821 tatatactaa gtaagcattt ttagcagagg aatatttatt tgcatagcct atttatttgt
     5881 attcgtatca cgctgttatt aaacatcagg atgaaatcaa tgaccagaag caaggactct
     5941 tgcctttgga cgtctcattg cttaggactg ccatgatgct gtcagcttgg gataacaatt
     6001 agaagataga aagcccacag gccgggcatc tacctaactt ctcagggact acacctcgta
     6061 gttttccacc attataagag ctggtaaata tgaaacattc gttgacttac cagactgcca
     6121 ttgacagtgt ttgatttttt tttctcatag ttcatgctct ctgcctctgt gtatatgact
     6181 gtgctgtgta tttatcaaag taggaagcaa taatttatat gtaaaaaaaa tggccaagca
     6241 atataaggtt aaaacttacg taagtaacca ttaccttatc ttgtattttc aagtgttttt
     6301 taaatctgct tttccaaata taacactatg ttaaacata
//
