LOCUS       NM_001100642            3205 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Rattus norvegicus Rap guanine nucleotide exchange factor 4
            (Rapgef4), mRNA.
ACCESSION   NM_001100642 XM_001060956
VERSION     NM_001100642.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3205)
  AUTHORS   Boileve,A., Romito,O., Hof,T., Levallois,A., Brard,L., d'Hers,S.,
            Fouchet,A., Simard,C., Guinamard,R., Brette,F. and Salle,L.
  TITLE     EPAC1 and 2 inhibit K+ currents via PLC/PKC and NOS/PKG pathways in
            rat ventricular cardiomyocytes
  JOURNAL   Am J Physiol Cell Physiol 327 (3), C557-C570 (2024)
   PUBMED   38985989
  REMARK    GeneRIF: EPAC1 and 2 inhibit K[+] currents via PLC/PKC and NOS/PKG
            pathways in rat ventricular cardiomyocytes.
REFERENCE   2  (bases 1 to 3205)
  AUTHORS   Xie,Z., Penzes,P. and Srivastava,D.P.
  TITLE     Exchange protein directly activated by cAMP 2 is required for
            corticotropin-releasing hormone-mediated spine loss
  JOURNAL   Eur J Neurosci 50 (7), 3108-3114 (2019)
   PUBMED   31199033
  REMARK    GeneRIF: Exchange protein directly activated by cAMP 2 is required
            for corticotropin-releasing hormone-mediated spine loss.
            Review article
REFERENCE   3  (bases 1 to 3205)
  AUTHORS   Kozhevnikova,L.M., Tsorin,I.B., Stolyaruk,V.N., Sukhanova,I.F.,
            Vititnova,M.B., Nikiforova,T.D., Kolik,L.G. and Kryzhanovskii,S.A.
  TITLE     Epac Proteins and Calmodulin as Possible Arrhythmogenesis Trigger
            in Alcoholic Cardiomyopathy
  JOURNAL   Bull Exp Biol Med 165 (5), 613-616 (2018)
   PUBMED   30225708
  REMARK    GeneRIF: Epac1/Epac2 and CaM can play a key role in
            arrhythmogenesis development under conditions of alcoholic
            cardiomyopathy.
REFERENCE   4  (bases 1 to 3205)
  AUTHORS   Emery,A.C., Xu,W., Eiden,M.V. and Eiden,L.E.
  TITLE     Guanine nucleotide exchange factor Epac2-dependent activation of
            the GTP-binding protein Rap2A mediates cAMP-dependent growth arrest
            in neuroendocrine cells
  JOURNAL   J Biol Chem 292 (29), 12220-12231 (2017)
   PUBMED   28546426
  REMARK    GeneRIF: Data suggest that Rap2A is the obligate effector for Epac2
            in mediating growth arrest and reversal of neurite extension
            through activation of MAP kinase signaling via protein
            phosphorylation/farnesylation in neuroendocrine cells. (Rap2A = RAS
            oncogene family member Rap2A; Epac2 = guanine nucleotide exchange
            factor Epac2)
REFERENCE   5  (bases 1 to 3205)
  AUTHORS   Sun,W., Jiao,W., Huang,Y., Li,R., Zhang,Z., Wang,J. and Lei,T.
  TITLE     Exchange proteins directly activated by cAMP induce the
            proliferation of rat anterior pituitary GH3 cells via the
            activation of extracellular signal-regulated kinase
  JOURNAL   Biochem Biophys Res Commun 485 (2), 355-359 (2017)
   PUBMED   28216156
  REMARK    GeneRIF: Rap guanine nucleotide exchange factors Epac1 and Epac2
            induces the phosphorylation of extracellular signal-regulated
            kinases ERK1/2 in pituitary tumor GH3 cells.
REFERENCE   6  (bases 1 to 3205)
  AUTHORS   Bacchelli,E., Blasi,F., Biondolillo,M., Lamb,J.A., Bonora,E.,
            Barnby,G., Parr,J., Beyer,K.S., Klauck,S.M., Poustka,A.,
            Bailey,A.J., Monaco,A.P. and Maestrini,E.
  CONSRTM   International Molecular Genetic Study of Autism Consortium (IMGSAC)
  TITLE     Screening of nine candidate genes for autism on chromosome 2q
            reveals rare nonsynonymous variants in the cAMP-GEFII gene
  JOURNAL   Mol Psychiatry 8 (11), 916-924 (2003)
   PUBMED   14593429
REFERENCE   7  (bases 1 to 3205)
  AUTHORS   Fujimoto,K., Shibasaki,T., Yokoi,N., Kashima,Y., Matsumoto,M.,
            Sasaki,T., Tajima,N., Iwanaga,T. and Seino,S.
  TITLE     Piccolo, a Ca2+ sensor in pancreatic beta-cells. Involvement of
            cAMP-GEFII.Rim2. Piccolo complex in cAMP-dependent exocytosis
  JOURNAL   J Biol Chem 277 (52), 50497-50502 (2002)
   PUBMED   12401793
REFERENCE   8  (bases 1 to 3205)
  AUTHORS   Kashima,Y., Miki,T., Shibasaki,T., Ozaki,N., Miyazaki,M., Yano,H.
            and Seino,S.
  TITLE     Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated
            insulin secretion
  JOURNAL   J Biol Chem 276 (49), 46046-46053 (2001)
   PUBMED   11598134
REFERENCE   9  (bases 1 to 3205)
  AUTHORS   Ozaki,N., Shibasaki,T., Kashima,Y., Miki,T., Takahashi,K., Ueno,H.,
            Sunaga,Y., Yano,H., Matsuura,Y., Iwanaga,T., Takai,Y. and Seino,S.
  TITLE     cAMP-GEFII is a direct target of cAMP in regulated exocytosis
  JOURNAL   Nat Cell Biol 2 (11), 805-811 (2000)
   PUBMED   11056535
REFERENCE   10 (bases 1 to 3205)
  AUTHORS   Kawasaki,H., Springett,G.M., Mochizuki,N., Toki,S., Nakaya,M.,
            Matsuda,M., Housman,D.E. and Graybiel,A.M.
  TITLE     A family of cAMP-binding proteins that directly activate Rap1
  JOURNAL   Science 282 (5397), 2275-2279 (1998)
   PUBMED   9856955
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 16, 2019 this sequence version replaced XM_001060956.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB031229.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               JAXUCZ010000003.1  77217047-77217182
            137-279             JAXUCZ010000003.1  77278041-77278183
            280-368             JAXUCZ010000003.1  77281347-77281435
            369-515             JAXUCZ010000003.1  77297347-77297493
            516-588             JAXUCZ010000003.1  77388994-77389066
            589-608             JAXUCZ010000003.1  77392797-77392816
            609-662             JAXUCZ010000003.1  77426330-77426383
            663-769             JAXUCZ010000003.1  77426698-77426804
            770-891             JAXUCZ010000003.1  77429658-77429779
            892-1075            JAXUCZ010000003.1  77431389-77431572
            1076-1160           JAXUCZ010000003.1  77449000-77449084
            1161-1221           JAXUCZ010000003.1  77449563-77449623
            1222-1298           JAXUCZ010000003.1  77451301-77451377
            1299-1445           JAXUCZ010000003.1  77451719-77451865
            1446-1561           JAXUCZ010000003.1  77453934-77454049
            1562-1650           JAXUCZ010000003.1  77459095-77459183
            1651-1729           JAXUCZ010000003.1  77461484-77461562
            1730-1880           JAXUCZ010000003.1  77475548-77475698
            1881-1969           JAXUCZ010000003.1  77477536-77477624
            1970-2000           JAXUCZ010000003.1  77478317-77478347
            2001-2079           JAXUCZ010000003.1  77478540-77478618
            2080-2226           JAXUCZ010000003.1  77478979-77479125
            2227-2324           JAXUCZ010000003.1  77480902-77480999
            2325-2450           JAXUCZ010000003.1  77485557-77485682
            2451-2629           JAXUCZ010000003.1  77486087-77486265
            2630-2720           JAXUCZ010000003.1  77489199-77489289
            2721-2771           JAXUCZ010000003.1  77492903-77492953
            2772-2859           JAXUCZ010000003.1  77493718-77493805
            2860-2924           JAXUCZ010000003.1  77494220-77494284
            2925-2979           JAXUCZ010000003.1  77505420-77505474
            2980-3205           JAXUCZ010000003.1  77508720-77508945
FEATURES             Location/Qualifiers
     source          1..3205
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q23"
     gene            1..3205
                     /gene="Rapgef4"
                     /gene_synonym="CAMP-GEFII; CAMPS; Cgef2; Epac2"
                     /note="Rap guanine nucleotide exchange factor 4"
                     /db_xref="GeneID:252857"
                     /db_xref="RGD:621886"
     exon            1..136
                     /gene="Rapgef4"
                     /gene_synonym="CAMP-GEFII; CAMPS; Cgef2; Epac2"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..3107
                     /gene="Rapgef4"
                     /gene_synonym="CAMP-GEFII; CAMPS; Cgef2; Epac2"
                     /note="epac 2; exchange factor directly activated by cAMP
                     2; exchange protein directly activated by cAMP 2;
                     cAMP-regulated guanine nucleotide exchange factor II; Rap
                     guanine nucleotide exchange factor (GEF) 4"
                     /codon_start=1
                     /product="rap guanine nucleotide exchange factor 4"
                     /protein_id="NP_001094112.1"
                     /db_xref="GeneID:252857"
                     /db_xref="RGD:621886"
                     /translation="MVAAHAAHSPSSAEWIACLDKRPLERSSEDVDIIFTRLKGVKAF
                     ERFHPNLLRQICLCSYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAV
                     TICTLGIGTAFGESILDNTPRHATIVTRENSELLRIEQEDFKALWEKYRQYMAGLLAP
                     PYGVMETGSNNDRIPDKENTPLIEPHVPLRPAHTITKVPSEKILRAGKILRIAILSRA
                     PHMIRDRKYHLKTYRQCCVGTELVDWMIQQTSCVHSRTQAVGMWQVLLEDGVLNHVDQ
                     ERHFQDKYLFYRFLDDEHEDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRK
                     PPGQRTADDLEIIYDELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGT
                     SWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDK
                     EDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKI
                     LEHFLETIRLEPSLNEATDSVLNDFVMMHCVFMPNTQLCPALVAHYHAQPSQGTEQER
                     MDYALNNKRRVIRLVLQWAAMYGDLLQEDDVAMAFLEEFYVSVSDDARMMVAFKEQLA
                     ELEKTVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCIDHTYT
                     TIRVPVAASVKEVISAVADKLGSGEGLIIVKMNSGGEKVVLKPNDVSVFTTLTINGRL
                     FACPREQFDSLTPLPEQEGPTTGTVGTFELMSSKDLAYQMTTYDWELFNCVHELELIY
                     HTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKE
                     YKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTAA
                     KLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPD
                     AAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP"
     exon            137..279
                     /gene="Rapgef4"
                     /gene_synonym="CAMP-GEFII; CAMPS; Cgef2; Epac2"
                     /inference="alignment:Splign:2.1.0"
     exon            280..368
                     /gene="Rapgef4"
                     /gene_synonym="CAMP-GEFII; CAMPS; Cgef2; Epac2"
                     /inference="alignment:Splign:2.1.0"
     exon            369..515
                     /gene="Rapgef4"
                     /gene_synonym="CAMP-GEFII; CAMPS; Cgef2; Epac2"
                     /inference="alignment:Splign:2.1.0"
     exon            516..588
                     /gene="Rapgef4"
                     /gene_synonym="CAMP-GEFII; CAMPS; Cgef2; Epac2"
                     /inference="alignment:Splign:2.1.0"
     exon            589..608
                     /gene="Rapgef4"
                     /gene_synonym="CAMP-GEFII; CAMPS; Cgef2; Epac2"
                     /inference="alignment:Splign:2.1.0"
     exon            609..662
                     /gene="Rapgef4"
                     /gene_synonym="CAMP-GEFII; CAMPS; Cgef2; Epac2"
                     /inference="alignment:Splign:2.1.0"
     exon            663..769
                     /gene="Rapgef4"
                     /gene_synonym="CAMP-GEFII; CAMPS; Cgef2; Epac2"
                     /inference="alignment:Splign:2.1.0"
     exon            770..891
                     /gene="Rapgef4"
                     /gene_synonym="CAMP-GEFII; CAMPS; Cgef2; Epac2"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1075
                     /gene="Rapgef4"
                     /gene_synonym="CAMP-GEFII; CAMPS; Cgef2; Epac2"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1160
                     /gene="Rapgef4"
                     /gene_synonym="CAMP-GEFII; CAMPS; Cgef2; Epac2"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1221
                     /gene="Rapgef4"
                     /gene_synonym="CAMP-GEFII; CAMPS; Cgef2; Epac2"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1298
                     /gene="Rapgef4"
                     /gene_synonym="CAMP-GEFII; CAMPS; Cgef2; Epac2"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1445
                     /gene="Rapgef4"
                     /gene_synonym="CAMP-GEFII; CAMPS; Cgef2; Epac2"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1561
                     /gene="Rapgef4"
                     /gene_synonym="CAMP-GEFII; CAMPS; Cgef2; Epac2"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1650
                     /gene="Rapgef4"
                     /gene_synonym="CAMP-GEFII; CAMPS; Cgef2; Epac2"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1729
                     /gene="Rapgef4"
                     /gene_synonym="CAMP-GEFII; CAMPS; Cgef2; Epac2"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1880
                     /gene="Rapgef4"
                     /gene_synonym="CAMP-GEFII; CAMPS; Cgef2; Epac2"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..1969
                     /gene="Rapgef4"
                     /gene_synonym="CAMP-GEFII; CAMPS; Cgef2; Epac2"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2000
                     /gene="Rapgef4"
                     /gene_synonym="CAMP-GEFII; CAMPS; Cgef2; Epac2"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2079
                     /gene="Rapgef4"
                     /gene_synonym="CAMP-GEFII; CAMPS; Cgef2; Epac2"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2226
                     /gene="Rapgef4"
                     /gene_synonym="CAMP-GEFII; CAMPS; Cgef2; Epac2"
                     /inference="alignment:Splign:2.1.0"
     exon            2227..2324
                     /gene="Rapgef4"
                     /gene_synonym="CAMP-GEFII; CAMPS; Cgef2; Epac2"
                     /inference="alignment:Splign:2.1.0"
     exon            2325..2450
                     /gene="Rapgef4"
                     /gene_synonym="CAMP-GEFII; CAMPS; Cgef2; Epac2"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2629
                     /gene="Rapgef4"
                     /gene_synonym="CAMP-GEFII; CAMPS; Cgef2; Epac2"
                     /inference="alignment:Splign:2.1.0"
     exon            2630..2720
                     /gene="Rapgef4"
                     /gene_synonym="CAMP-GEFII; CAMPS; Cgef2; Epac2"
                     /inference="alignment:Splign:2.1.0"
     exon            2721..2771
                     /gene="Rapgef4"
                     /gene_synonym="CAMP-GEFII; CAMPS; Cgef2; Epac2"
                     /inference="alignment:Splign:2.1.0"
     exon            2772..2859
                     /gene="Rapgef4"
                     /gene_synonym="CAMP-GEFII; CAMPS; Cgef2; Epac2"
                     /inference="alignment:Splign:2.1.0"
     exon            2860..2924
                     /gene="Rapgef4"
                     /gene_synonym="CAMP-GEFII; CAMPS; Cgef2; Epac2"
                     /inference="alignment:Splign:2.1.0"
     exon            2925..2979
                     /gene="Rapgef4"
                     /gene_synonym="CAMP-GEFII; CAMPS; Cgef2; Epac2"
                     /inference="alignment:Splign:2.1.0"
     exon            2980..3205
                     /gene="Rapgef4"
                     /gene_synonym="CAMP-GEFII; CAMPS; Cgef2; Epac2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgcgggag cccgccggga ggcgcgcggg aggtggccgc ggcccggggc caccgtgcgc
       61 tgctgcccaa catggttgct gcgcacgctg cacactctcc gtcctcggcc gagtggatcg
      121 cctgcctgga taaaaggccg ttggagcgat ctagtgaaga tgtggacata attttcacgc
      181 ggctgaaagg agttaaagct tttgagagat ttcacccaaa cctccttcgt cagatttgtt
      241 tatgcagtta ctatgagaac ctggagaaag gaatcacact gtttcgacaa ggggacattg
      301 gaaccaactg gtatgctgtc ctagctgggt ctttggatgt taaagtgtct gagaccagca
      361 gtcaccagga tgcggtgacc atctgtaccc tgggaattgg gacagccttt ggagagtcca
      421 ttctcgacaa cacacctcgt catgcaacca ttgttaccag agagaacagt gagctcctcc
      481 gtatcgagca ggaagacttt aaggcactat gggagaaata ccgacagtat atggccggac
      541 ttctggctcc tccctatggt gttatggaaa cgggctctaa caatgacagg attccggaca
      601 aggagaatac acctctcatt gaacctcacg ttcctctccg ccctgctcac accattacca
      661 aggtcccttc agagaagatc ctcagagctg gaaaaatttt gcgaattgcc attctctctc
      721 gagcacccca catgataaga gacagaaaat accacctaaa gacatacaga caatgctgtg
      781 ttgggactga gctggtagac tggatgatac agcagacgtc ctgtgttcac tcccggactc
      841 aagctgttgg catgtggcaa gtcttgctgg aagatggcgt cctcaaccac gtggaccagg
      901 agcgccattt ccaagataaa tatttatttt atcgatttct ggatgacgag catgaggatg
      961 cccctttgcc tactgaggag gagaagaagg agtgcgatga agagctccag gacaccatgc
     1021 tgctgctgtc acaaatgggc cctgacgccc acatgagaat gatcctgcga aaaccacctg
     1081 gccagaggac tgcagatgac ctagagatta tctacgacga actccttcat attaaagcct
     1141 tatcccatct ttctaccaca gtgaaacggg agttagcagg tgttctcatt tttgagtctc
     1201 acgccaaagg aggaactgtg ttgtttaacc agggggaaga aggtacctcc tggtacatca
     1261 ttctgaaagg atccgtgaat gtagtcattt atggcaaggg tgtggtctgc accctgcatg
     1321 agggagatga ctttggcaag ttagctctgg tgaacgatgc tccgagagct gcatccattg
     1381 ttcttcggga agataattgt cacttcctaa gagttgacaa ggaagacttc aatcggattc
     1441 tgagggacgt tgaggcgaat acagtcagac ttaaagaaca tgaccaagat gtcttggtac
     1501 tggagaaggt cccagcaggg aacagagctt ctaatcaagg aaactcacag cctcagcaaa
     1561 agtatactgt gatgtcagga acacctgaaa agattttaga gcattttcta gaaacaatac
     1621 gccttgagcc atctttgaat gaagcaacag attcagtttt aaatgacttc gttatgatgc
     1681 actgtgtttt tatgccaaac acccagcttt gccccgccct cgtggcccat taccacgcac
     1741 agccttctca aggtacagaa caggagagaa tggattacgc cctcaacaac aagaggcggg
     1801 tcatccgcct ggttctgcaa tgggcagcca tgtatggtga tcttctccaa gaagacgacg
     1861 tggccatggc tttcctggag gagttctatg tgtctgtatc agatgatgca cggatgatgg
     1921 tcgccttcaa ggagcagctg gctgagctgg agaagactgt caaacagatc tcagaagacg
     1981 caaaagctcc acagaagaag cacaaggtgc ttttgcagca gtttaataca ggtgacgaga
     2041 gggcccagaa gcgtcagccg attcgtggct ctgatgaggt tttgttcaag gtctactgca
     2101 ttgaccacac ctataccacc atccgagtgc ctgtagccgc ctcggtgaag gaagtcatca
     2161 gtgcagtagc agacaaactt ggctctgggg aaggcctgat cattgtcaag atgaactctg
     2221 gaggagaaaa ggtggtgctc aaacctaatg atgtttcagt atttacgacg ctcaccatta
     2281 atggacgcct gtttgcctgc ccgcgagagc aattcgactc actgactccc ttgccagaac
     2341 aggagggccc gaccactggg acagtgggga cgtttgaact gatgagctcg aaagacttgg
     2401 cgtaccagat gacaacgtat gactgggaac tcttcaactg tgtgcacgag ctggagctaa
     2461 tctaccacac atttggaagg cataatttta aaaagaccac agcaaacttg gatttgttcc
     2521 tgaggagatt taatgaaatt cagttttggg ttgtcactga gatctgcctt tgttcccagc
     2581 tcagcaaacg tgttcagctt ttgaaaaaat ttatcaagat agcggctcac tgcaaggagt
     2641 acaaaaacct gaattccttc ttcgccatcg tcatggggct cagtaacgtg gctgtgagcc
     2701 gcctggcatt aacatgggag aaactgccga gcaagtttaa gaagttctat gcggagtttg
     2761 agagcttaat ggatccttcc agaaatcaca gggcgtacag gctgacagca gctaaactgg
     2821 agccccccct catccctttc atgcccttgc ttattaaaga tatgacattt actcatgagg
     2881 ggaacaagac attcattgac aatctagtaa actttgaaaa aatgcgcatg attgcaaata
     2941 ctgccagaac ggtgcgctac tacaggagcc agccattcaa tccggatgct gctcaagcta
     3001 ataagaacca tcaggatgtc cggagttatg tacggcaatt aaatgtgatt gacaaccaga
     3061 gaactttatc acagatgtca cacagattag agcctcgcag gccatagaca tctgcagtgc
     3121 ccagagtgat gctccgtctc cagtccacaa tctttcaaaa gatgctgtgt atgctactac
     3181 tgactgtgtt gctactagag aattc
//
