LOCUS       XM_039079830            4780 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus Rap guanine nucleotide exchange factor
            3 (Rapgef3), transcript variant X3, mRNA.
ACCESSION   XM_039079830
VERSION     XM_039079830.1
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051342.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_039079830.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4780
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..4780
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /note="Rap guanine nucleotide exchange factor 3; Derived
                     by automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 6 ESTs, 22 Proteins, and 100% coverage of the
                     annotated genomic feature by RNAseq alignments, including
                     8 samples with support for all annotated introns"
                     /db_xref="GeneID:59326"
                     /db_xref="RGD:621869"
     CDS             1480..4200
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /codon_start=1
                     /product="rap guanine nucleotide exchange factor 3 isoform
                     X3"
                     /protein_id="XP_038935758.1"
                     /db_xref="GeneID:59326"
                     /db_xref="RGD:621869"
                     /translation="MTEGTGLTPLTNSEGSLDFRVSLEQATTEHVHKAGKLLYRHLLA
                     TYPTLIRDRKYHLRLHRQCCSGRELVDGILALGLGVHSRSQAVGICQVLLDEGALCHV
                     KHDWTFQDRDAQFYRFPGPEPQPAGTHDVEEELVEAMALLSQRGPDALLTVALRKSPG
                     QRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWY
                     IIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIILRENNCHFLRVDKQDF
                     NRIIKDVEAKTMRLEEHGKVVLVLERTSQGAGPSRPPTPGRNRYTVMSGTPEKILELL
                     LEAMRPDSSAHDPTETFLSDFLLTHSVFMPCTQLFAALLHHFHVEPSEPAGGSEQERS
                     TYICNKRQQILRLVSRWVALYSPMLRSDPVATSFLQKLSDLVSRDTRLSNLLREQYPE
                     RRRHHRLENGCGNVSPQTKAPPHTPELVMCCMFPSVTSPQDAGLDVRDLLLLHVEQSC
                     ETEAPEKARNAPVWFPNHEEPLPSSAGAIRVGDKVPYDICRPDHSVLTLHLPVTASVR
                     EVMAALAHEDHWTKGQVLVKVNSAGDVVGLQPDARGVATSLGLNERIFVVDPQEVHEL
                     TPHPEQLGPTLGSSEMLDLVSAKDLAGQLTEHDWNLFNRIHQVELIHYVLGPQHLRDV
                     TTANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAV
                     MFGLSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLALTKLSPPVIPFM
                     PLLLKDMTFIHEGNHTLVENLINFEKMRMMARAVRMLHHCRSHSTAPLSPLRSRVSHI
                     HEDSQASRISTCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELEP"
ORIGIN      
        1 tggagtggag cccctgcttg cccctctctc cctgggtctt tctaataggg gttgggggtg
       61 ggaggagact cgtcctaccc ctcatcccta ctcaggctcc gggtcactgt ggtagttcct
      121 gctgggatct agccggctgg aacccgccct ccttttcaag gctgcaatta cttgtgagct
      181 tcctgtccct cccaggcttg gagaagctag gtagggggtg ggagaaggtc agttaccagg
      241 acaatgaggt cactggggaa tctcttggga tcttaagttg gagagggtgg agaagtcctc
      301 tccagtctct ttctccccta agacctcaga aaggaaggac cagattgtac gggaagctgg
      361 acacatgaag gttgggactg ttggagtgtg aagggggtca aaggtctgga agcaaagccc
      421 tcctctgcca gatatggggg caatgtgctt aggtttctag gaataacgta tttggctttt
      481 agggctagag accactgttc cccatctttc taccatgccc ctcctgatgg gtggagcaag
      541 atagattgaa ccttttgtgc ctgtgcttcg gaagctctct gacccccttg gaggctgcat
      601 gtcttggctc tttttttttt tttttttttt tttttggttc tttttttccg gagctgggga
      661 ccgaacccaa ggccttgcgc ttcctaggca agcgctctac cactgagcta aatccccaac
      721 cccatgtctt ggctctctta tggctcatta gattcatgaa gtgttcctgt gaggcagcaa
      781 gtgccagcag ggcatgtgca tgcacggggt gaagagggtg aaccagagtc caggaaggca
      841 ggcctgggca gtttaggcta cacctccctc tttagaaaac ccaggggaaa gtgggttcac
      901 cttctgaaga agatttagtt catcagagac caggacaaga gaaaaagaag gcagggtagc
      961 tcaggggggt gggggtgggg ctcgcagcca gatgtagaga ggactttctg actatggcta
     1021 aggcagtata gcaatggggc gaaaacagct ttgaaaaaga tgtgggagag atgaggtctt
     1081 gtactatatg tgggaacaaa aaaggctcag ggtgaccttg gctggcccca caggtgcaaa
     1141 caagactgga cagtttgggg ggggggagtg tttctaatct ccaaatcaaa tccgtccaaa
     1201 tgatggcagt ggctaagagt cacagtactt gtgtcccgtg ccttatgaca gcttcatctt
     1261 tgtcatacta aatatgctca caacagcctg gtgggaccag tcccagtggt ttcatcttcc
     1321 agatgtgaag agggaggcac agagaggtca agcagctggt gaagggctgc acagctgctg
     1381 agtggctgag ctgcgtttta tacccaagat ctacctgcag aatacctccg acaccctcgt
     1441 gtccctgctc catgcacaac ctggcctagg accttagcca tgaccgaagg aactggtctg
     1501 acgccactta ccaacagtga gggctccctg gacttcagag tgagcctgga gcaggccacc
     1561 acagagcatg tgcacaaggc cgggaagctc ctgtaccgtc atctcttggc aacgtaccct
     1621 accctcatcc gagacagaaa ataccatctg cgactacatc ggcagtgctg ctctggccgg
     1681 gagctagtgg atgggatctt ggctctgggt cttggggtcc actcacggag ccaagctgtg
     1741 ggcatctgcc aggtgttgct ggatgagggt gccctttgcc atgtaaaaca tgactggacc
     1801 ttccaggacc gagacgccca attctacaga ttccctggac cggagcccca gcctgcagga
     1861 actcatgacg tggaagagga gcttgttgag gcaatggccc tactctccca gcgagggcct
     1921 gatgccctac tcactgttgc actccggaag tccccgggtc agcgtacaga tgaagagctg
     1981 gacctcatct tcgaggagct gctacatatc aaggcggtgg ctcacctttc taactcggtg
     2041 aaacgggaac tagctgctgt tctgctcttt gaaccacaca gcaaggcagg aactgtgttg
     2101 ttcagccagg gggacaaggg tacctcatgg tacattatct ggaagggatc tgtcaatgtg
     2161 gtgacccatg gcaaggggct ggtgaccacg ttgcacgagg gagatgactt tggacagctg
     2221 gctctggtga acgacgcacc tcgagcagcc accatcatcc ttcgagaaaa taactgtcac
     2281 tttctgcgtg tggacaagca ggacttcaac cgcatcatca aggatgtgga agcaaaaacc
     2341 atgagactgg aagaacacgg caaagtggtg ttagttttgg agagaacctc tcagggtgct
     2401 ggcccttccc gccctccgac cccaggcagg aaccgatata cggtaatgtc tggcacccca
     2461 gagaaaatcc tagaactcct gttggaggct atgagaccgg attccagtgc tcatgaccca
     2521 acagagacat tcctcagtga cttcctgctg acgcacagtg tcttcatgcc ctgcacacag
     2581 ctctttgccg ccctcctgca ccacttccac gtggagccat cagagcctgc cgggggcagc
     2641 gagcaggaac gcagcaccta catctgcaac aagaggcagc agattctgcg tctggtcagc
     2701 cggtgggtgg ccctctacag ccccatgctc cgctcagatc ccgtggccac cagcttcctc
     2761 cagaaactct cagacctggt gagcagagat acccgactta gcaacttgct gagggaacag
     2821 tatccggaga gacggcgaca ccacaggttg gagaatggct gtgggaatgt atctcctcag
     2881 accaaggctc ctccccacac gccagaactt gtgatgtgtt gtatgttccc atcggtcacg
     2941 tccccccagg atgcagggct ggacgtgaga gacttgcttc ttctgcatgt ggagcagagc
     3001 tgtgaaacag aagcacctga gaaagcccgg aatgcacctg tttggtttcc taaccatgag
     3061 gaacccctcc caagcagcgc tggggccatc cgagtcgggg acaaagtccc ctatgatatc
     3121 tgcagacccg accactcggt gctgaccctg cacctgccgg tgacagcctc cgtgagggaa
     3181 gtgatggcag ctttggccca tgaggaccac tggaccaagg ggcaggtgct ggtaaaggtc
     3241 aattctgccg gtgatgtcgt tggcttgcag ccagatgccc gcggtgtggc cacatccctg
     3301 gggctcaatg agcggatctt tgttgtcgac ccacaggaag tgcacgagct gaccccacac
     3361 cctgagcagc tggggcccac tctgggttct tctgagatgc tggacctagt gagtgccaag
     3421 gacctggcag gccagctcac agagcatgac tggaacctct tcaacaggat ccaccaggtg
     3481 gagctgatcc actatgtact gggcccccag cacctgcggg acgtcaccac tgcaaacctg
     3541 gagcgcttca tgcgacgctt caacgagctg cagtactggg tggccaccga actctgtctc
     3601 tgcccggttc ctggcccccg ggctcagcta ctccggaagt tcatcaagct ggcagcccac
     3661 ctcaaggagc agaagaatct caactctttc tttgcggtca tgtttggcct cagcaactcg
     3721 gccatcagcc gcctggccca cacctgggag cgtctgcccc ataaagtacg gaagctgtac
     3781 tcggccctgg aaaggttgct ggacccttcc tggaaccacc gagtgtaccg attggctctc
     3841 accaagctct ctcctcctgt catccctttc atgcccctgc tactcaaaga catgaccttc
     3901 atccatgaag ggaaccacac actggtagaa aacctcatca actttgagaa gatgcgaatg
     3961 atggccagag ccgtgcggat gctccaccac tgccgaagcc acagcaccgc gcctctatca
     4021 ccactcagaa gccgggtttc ccacatccac gaggacagcc aggcatcaag aatctccaca
     4081 tgttccgagc agtccctgag cacccggagt ccagccagca cctgggctta tgtccagcag
     4141 ctgaaggtca ttgacaacca gcgggaactg tcccgcctct cccgggaact ggaaccatga
     4201 ggaaggactg gctggagcag gcacttctct cagagaaagc cagagcctgt gcaaccaaga
     4261 ggtccagagg ccagccacag ctgggcaggg ctctccacag agcggactca aggccctgga
     4321 gtgggcagtg tcgaggcagc tgtcctctgt gatgactgtc agctgtgaag atctttgatg
     4381 ttcacggcca aggaaaaggg gccattgagg ccccagaggg gtaggagagc tgggaggtgc
     4441 aggactctgg ttcagtagag agccctccca ccgggctttc tgcatgtctg tatgtctgta
     4501 catgcagctg tgctgtccat ggatgccagg ccctgtgctt gttttcacag gagccagcga
     4561 gctcacatct gcatggggtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgag
     4621 cactgggtgg tgccttgcct gggagagggt ggggagttct gctattctca ccacacatct
     4681 gagataaaca gctgggtgtg ggcagagccg ctgcctagag tggtggtccc tgtggagttg
     4741 tattgttccc ataaattaac aaagatatgt gtgttctgca
//
