LOCUS       NM_021690               3355 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Rattus norvegicus Rap guanine nucleotide exchange factor 3
            (Rapgef3), mRNA.
ACCESSION   NM_021690
VERSION     NM_021690.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3355)
  AUTHORS   Boileve,A., Romito,O., Hof,T., Levallois,A., Brard,L., d'Hers,S.,
            Fouchet,A., Simard,C., Guinamard,R., Brette,F. and Salle,L.
  TITLE     EPAC1 and 2 inhibit K+ currents via PLC/PKC and NOS/PKG pathways in
            rat ventricular cardiomyocytes
  JOURNAL   Am J Physiol Cell Physiol 327 (3), C557-C570 (2024)
   PUBMED   38985989
  REMARK    GeneRIF: EPAC1 and 2 inhibit K[+] currents via PLC/PKC and NOS/PKG
            pathways in rat ventricular cardiomyocytes.
REFERENCE   2  (bases 1 to 3355)
  AUTHORS   Huang,S., Shi,C., Liu,F., Si,Y., Shen,D., Yang,L., Gao,Y. and
            Liao,Y.
  TITLE     Activation of Epac in the BLA disrupts reconsolidation and
            attenuates heroin-seeking behaviour
  JOURNAL   Addict Biol 28 (10), e13330 (2023)
   PUBMED   37753572
  REMARK    GeneRIF: Activation of Epac in the BLA disrupts reconsolidation and
            attenuates heroin-seeking behaviour.
REFERENCE   3  (bases 1 to 3355)
  AUTHORS   Sitzia,C., Vianello,E., Dozio,E., Kalousova,M., Zima,T.,
            Brizzola,S., Roccabianca,P., Tedeschi,G., Lamont,J., Tacchini,L.
            and Corsi-Romanelli,M.M.
  TITLE     Unveiling IL-33/ST2 Pathway Unbalance in Cardiac Remodeling Due to
            Obesity in Zucker Fatty Rats
  JOURNAL   Int J Mol Sci 24 (3), 1991 (2023)
   PUBMED   36768322
  REMARK    GeneRIF: Unveiling IL-33/ST2 Pathway Unbalance in Cardiac
            Remodeling Due to Obesity in Zucker Fatty Rats.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3355)
  AUTHORS   Huang,S.T., Chen,B.B., Song,Z.J., Tang,H.L., Hua,R. and Zhang,Y.M.
  TITLE     Unraveling the role of Epac1-SOCS3 signaling in the development of
            neonatal-CRD-induced visceral hypersensitivity in rats
  JOURNAL   CNS Neurosci Ther 28 (9), 1393-1408 (2022)
   PUBMED   35702948
  REMARK    GeneRIF: Unraveling the role of Epac1-SOCS3 signaling in the
            development of neonatal-CRD-induced visceral hypersensitivity in
            rats.
REFERENCE   5  (bases 1 to 3355)
  AUTHORS   Wang,X., Zhang,Y., Yang,Y., Zhang,W., Luo,L., Han,F., Guan,H.,
            Tao,K. and Hu,D.
  TITLE     Curcumin pretreatment protects against hypoxia/reoxgenation injury
            via improvement of mitochondrial function, destabilization of
            HIF-1alpha and activation of Epac1-Akt pathway in rat bone marrow
            mesenchymal stem cells
  JOURNAL   Biomed Pharmacother 109, 1268-1275 (2019)
   PUBMED   30551377
  REMARK    GeneRIF: Activation of Epac1-Akt signaling pathway.
REFERENCE   6  (bases 1 to 3355)
  AUTHORS   Weissman,J.T., Ma,J.N., Essex,A., Gao,Y. and Burstein,E.S.
  TITLE     G-protein-coupled receptor-mediated activation of rap GTPases:
            characterization of a novel Galphai regulated pathway
  JOURNAL   Oncogene 23 (1), 241-249 (2004)
   PUBMED   14712229
REFERENCE   7  (bases 1 to 3355)
  AUTHORS   Lin,S.L., Johnson-Farley,N.N., Lubinsky,D.R. and Cowen,D.S.
  TITLE     Coupling of neuronal 5-HT7 receptors to activation of
            extracellular-regulated kinase through a protein kinase
            A-independent pathway that can utilize Epac
  JOURNAL   J Neurochem 87 (5), 1076-1085 (2003)
   PUBMED   14622088
  REMARK    GeneRIF: Over-expression of Epac1 enhanced 5-HT7 nicotinic
            receptor-mediated activation of ERK proceeding through
            cAMP-dependent pathways utilizing cAMP-guanine nucleotide exchange
            factors rather than protein kinase A
REFERENCE   8  (bases 1 to 3355)
  AUTHORS   Laroche-Joubert,N., Marsy,S., Michelet,S., Imbert-Teboul,M. and
            Doucet,A.
  TITLE     Protein kinase A-independent activation of ERK and H,K-ATPase by
            cAMP in native kidney cells: role of Epac I
  JOURNAL   J Biol Chem 277 (21), 18598-18604 (2002)
   PUBMED   11897793
REFERENCE   9  (bases 1 to 3355)
  AUTHORS   Konu,O., Kane,J.K., Barrett,T., Vawter,M.P., Chang,R., Ma,J.Z.,
            Donovan,D.M., Sharp,B., Becker,K.G. and Li,M.D.
  TITLE     Region-specific transcriptional response to chronic nicotine in rat
            brain
  JOURNAL   Brain Res 909 (1-2), 194-203 (2001)
   PUBMED   11478936
REFERENCE   10 (bases 1 to 3355)
  AUTHORS   Kawasaki,H., Springett,G.M., Mochizuki,N., Toki,S., Nakaya,M.,
            Matsuda,M., Housman,D.E. and Graybiel,A.M.
  TITLE     A family of cAMP-binding proteins that directly activate Rap1
  JOURNAL   Science 282 (5397), 2275-2279 (1998)
   PUBMED   9856955
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 26, 2020 this sequence version replaced NM_021690.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U78167.1, BC107667.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-289               JAXUCZ010000007.1  130776528-130776816 c
            290-343             JAXUCZ010000007.1  130771083-130771136 c
            344-450             JAXUCZ010000007.1  130770888-130770994 c
            451-572             JAXUCZ010000007.1  130770593-130770714 c
            573-741             JAXUCZ010000007.1  130770050-130770218 c
            742-826             JAXUCZ010000007.1  130769409-130769493 c
            827-887             JAXUCZ010000007.1  130768674-130768734 c
            888-964             JAXUCZ010000007.1  130768511-130768587 c
            965-1111            JAXUCZ010000007.1  130768191-130768337 c
            1112-1224           JAXUCZ010000007.1  130767738-130767850 c
            1225-1313           JAXUCZ010000007.1  130767356-130767444 c
            1314-1392           JAXUCZ010000007.1  130767022-130767100 c
            1393-1552           JAXUCZ010000007.1  130766671-130766830 c
            1553-1635           JAXUCZ010000007.1  130766500-130766582 c
            1636-1675           JAXUCZ010000007.1  130765950-130765989 c
            1676-1757           JAXUCZ010000007.1  130763691-130763772 c
            1758-1904           JAXUCZ010000007.1  130763243-130763389 c
            1905-2002           JAXUCZ010000007.1  130760446-130760543 c
            2003-2128           JAXUCZ010000007.1  130759928-130760053 c
            2129-2310           JAXUCZ010000007.1  130759671-130759852 c
            2311-2401           JAXUCZ010000007.1  130759314-130759404 c
            2402-2452           JAXUCZ010000007.1  130759159-130759209 c
            2453-2540           JAXUCZ010000007.1  130758283-130758370 c
            2541-2605           JAXUCZ010000007.1  130757877-130757941 c
            2606-2660           JAXUCZ010000007.1  130757109-130757163 c
            2661-2732           JAXUCZ010000007.1  130756943-130757014 c
            2733-3355           JAXUCZ010000007.1  130754946-130755568 c
FEATURES             Location/Qualifiers
     source          1..3355
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..3355
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /note="Rap guanine nucleotide exchange factor 3"
                     /db_xref="GeneID:59326"
                     /db_xref="RGD:621869"
     exon            1..289
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..2851
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /note="epac 1; cAMP-GEFI; exchange factor directly
                     activated by cAMP 1; exchange protein directly activated
                     by cAMP 1; cAMP-regulated guanine nucleotide exchange
                     factor I (cAMP-GEFI); Rap guanine nucleotide exchange
                     factor (GEF) 3"
                     /codon_start=1
                     /product="rap guanine nucleotide exchange factor 3"
                     /protein_id="NP_067722.2"
                     /db_xref="GeneID:59326"
                     /db_xref="RGD:621869"
                     /translation="MVLKRMHRPRCCSYQLVFEHRRPSCIQGLRWTPLTNSEGSLDFR
                     VSLEQATTEHVHKAGKLLYRHLLATYPTLIRDRKYHLRLHRQCCSGRELVDGILALGL
                     GVHSRSQAVGICQVLLDEGALCHVKHDWTFQDRDAQFYRFPGPEPQPAGTHDVEEELV
                     EAMALLSQRGPDALLTVALRKSPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAV
                     LLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVND
                     APRAATIILRENNCHFLRVDKQDFNRIIKDVEAKTMRLEEHGKVVLVLERTSQGAGPS
                     RPPTPGRNRYTVMSGTPEKILELLLEAMRPDSSAHDPTETFLSDFLLTHSVFMPCTQL
                     FAALLHHFHVEPSEPAGGSEQERSTYICNKRQQILRLVSRWVALYSPMLRSDPVATSF
                     LQKLSDLVSRDTRLSNLLREQYPERRRHHRLENGCGNVSPQTKARNAPVWFPNHEEPL
                     PSSAGAIRVGDKVPYDICRPDHSVLTLHLPVTASVREVMAALAHEDHWTKGQVLVKVN
                     SAGDVVGLQPDARGVATSLGLNERIFVVDPQEVHELTPHPEQLGPTLGSSEMLDLVSA
                     KDLAGQLTEHDWNLFNRIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVATE
                     LCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHK
                     VRKLYSALERLLDPSWNHRVYRLALTKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLI
                     NFEKMRMMARAVRMLHHCRSHSTAPLSPLRSRVSHIHEDSQASRISTCSEQSLSTRSP
                     ASTWAYVQQLKVIDNQRELSRLSRELEP"
     exon            290..343
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            344..450
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            451..572
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            573..741
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            742..826
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            827..887
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            888..964
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1111
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1224
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1313
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1392
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1552
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1635
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1675
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1757
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1904
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..2002
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..2128
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            2129..2310
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            2311..2401
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            2402..2452
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            2453..2540
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            2541..2605
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            2606..2660
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            2661..2732
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
     exon            2733..3355
                     /gene="Rapgef3"
                     /gene_synonym="Epac"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgctaagcct ggggtggtgg taggaaggtc cagctcctcc ggccgatggc tgtccacttt
       61 cctcccccca tcacaggtca gctggccagg tgagaaccac tggcaggtgg gcccagctgt
      121 ggtggagagt ccagctgtgg gggcaccgca ggtgggaggt ctcccggacg tggttccgga
      181 gggcacgctg ctcaatatgg tgctgaagag aatgcaccgt ccccggtgct gctcttacca
      241 gctagtgttc gagcaccggc gcccaagctg catccaggga cttcgctgga cgccacttac
      301 caacagtgag ggctccctgg acttcagagt gagcctggag caggccacca cagagcatgt
      361 gcacaaggcc gggaagctcc tgtaccgtca tctcttggca acgtacccta ccctcatccg
      421 agacagaaaa taccatctgc gactacatcg gcagtgctgc tctggccggg agctagtgga
      481 tgggatcttg gctctgggtc ttggggtcca ctcacggagc caagctgtgg gcatctgcca
      541 ggtgttgctg gatgagggtg ccctttgcca tgtaaaacat gactggacct tccaggaccg
      601 agacgcccaa ttctacagat tccctggacc ggagccccag cctgcaggaa ctcatgacgt
      661 ggaagaggag cttgttgagg caatggccct actctcccag cgagggcctg atgccctact
      721 cactgttgca ctccggaagt ccccgggtca gcgtacagat gaagagctgg acctcatctt
      781 cgaggagctg ctacatatca aggcggtggc tcacctttct aactcggtga aacgggaact
      841 agctgctgtt ctgctctttg aaccacacag caaggcagga actgtgttgt tcagccaggg
      901 ggacaagggt acctcatggt acattatctg gaagggatct gtcaatgtgg tgacccatgg
      961 caaggggctg gtgaccacgt tgcacgaggg agatgacttt ggacagctgg ctctggtgaa
     1021 cgacgcacct cgagcagcca ccatcatcct tcgagaaaat aactgtcact ttctgcgtgt
     1081 ggacaagcag gacttcaacc gcatcatcaa ggatgtggaa gcaaaaacca tgagactgga
     1141 agaacacggc aaagtggtgt tagttttgga gagaacctct cagggtgctg gcccttcccg
     1201 ccctccgacc ccaggcagga accgatatac ggtaatgtct ggcaccccag agaaaatcct
     1261 agaactcctg ttggaggcta tgagaccgga ttccagtgct catgacccaa cagagacatt
     1321 cctcagtgac ttcctgctga cgcacagtgt cttcatgccc tgcacacagc tctttgccgc
     1381 cctcctgcac cacttccacg tggagccatc agagcctgcc gggggcagcg agcaggaacg
     1441 cagcacctac atctgcaaca agaggcagca gattctgcgt ctggtcagcc ggtgggtggc
     1501 cctctacagc cccatgctcc gctcagatcc cgtggccacc agcttcctcc agaaactctc
     1561 agacctggtg agcagagata cccgacttag caacttgctg agggaacagt atccggagag
     1621 acggcgacac cacaggttgg agaatggctg tgggaatgta tctcctcaga ccaaggcccg
     1681 gaatgcacct gtttggtttc ctaaccatga ggaacccctc ccaagcagcg ctggggccat
     1741 ccgagtcggg gacaaagtcc cctatgatat ctgcagaccc gaccactcgg tgctgaccct
     1801 gcacctgccg gtgacagcct ccgtgaggga agtgatggca gctttggccc atgaggacca
     1861 ctggaccaag gggcaggtgc tggtaaaggt caattctgcc ggtgatgtcg ttggcttgca
     1921 gccagatgcc cgcggtgtgg ccacatccct ggggctcaat gagcggatct ttgttgtcga
     1981 cccacaggaa gtgcacgagc tgaccccaca ccctgagcag ctggggccca ctctgggttc
     2041 ttctgagatg ctggacctag tgagtgccaa ggacctggca ggccagctca cagagcatga
     2101 ctggaacctc ttcaacagga tccaccaggt ggagctgatc cactatgtac tgggccccca
     2161 gcacctgcgg gacgtcacca ctgcaaacct ggagcgcttc atgcgacgct tcaacgagct
     2221 gcagtactgg gtggccaccg aactctgtct ctgcccggtt cctggccccc gggctcagct
     2281 actccggaag ttcatcaagc tggcagccca cctcaaggag cagaagaatc tcaactcttt
     2341 ctttgcggtc atgtttggcc tcagcaactc ggccatcagc cgcctggccc acacctggga
     2401 gcgtctgccc cataaagtac ggaagctgta ctcggccctg gaaaggttgc tggacccttc
     2461 ctggaaccac cgagtgtacc gattggctct caccaagctc tctcctcctg tcatcccttt
     2521 catgcccctg ctactcaaag acatgacctt catccatgaa gggaaccaca cactggtaga
     2581 aaacctcatc aactttgaga agatgcgaat gatggccaga gccgtgcgga tgctccacca
     2641 ctgccgaagc cacagcaccg cgcctctatc accactcaga agccgggttt cccacatcca
     2701 cgaggacagc caggcatcaa gaatctccac atgttccgag cagtccctga gcacccggag
     2761 tccagccagc acctgggctt atgtccagca gctgaaggtc attgacaacc agcgggaact
     2821 gtcccgcctc tcccgggaac tggaaccatg aggaaggact ggctggagca ggcacttctc
     2881 tcagagaaag ccagagcctg tgcaaccaag aggtccagag gccagccaca gctgggcagg
     2941 gctctccaca gagcggactc aaggccctgg agtgggcagt gtcgaggcag ctgtcctctg
     3001 tgatgactgt cagctgtgaa gatctttgat gttcacggcc aaggaaaagg ggccattgag
     3061 gccccagagg ggtaggagag ctgggaggtg caggactctg gttcagtaga gagccctccc
     3121 accgggcttt ctgcatgtct gtatgtctgt acatgcagct gtgctgtcca tggatgccag
     3181 gccctgtgct tgttttcaca ggagccagcg agctcacatc tgcatggggt gtgtgtgtgt
     3241 gtgtgtgtgt gtgtgtgtgt gtgtgtgtga gcactgggtg gtgccttgcc tgggagaggg
     3301 tggggagttc tgctattctc accacacatc tgagataaac agctgggtgt gggca
//
