LOCUS       XM_008761684            9111 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus Rap guanine nucleotide exchange factor
            1 (Rapgef1), transcript variant X10, mRNA.
ACCESSION   XM_008761684
VERSION     XM_008761684.3
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051338.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_008761684.4.
            
            On Jan 21, 2021 this sequence version replaced XM_008761684.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9111
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..9111
                     /gene="Rapgef1"
                     /note="Rap guanine nucleotide exchange factor 1; Derived
                     by automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 39 ESTs, 5 long SRA reads, 1 Protein, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 22 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:63881"
                     /db_xref="RGD:619793"
     CDS             3144..6812
                     /gene="Rapgef1"
                     /codon_start=1
                     /product="rap guanine nucleotide exchange factor 1 isoform
                     X10"
                     /protein_id="XP_008759906.2"
                     /db_xref="GeneID:63881"
                     /db_xref="RGD:619793"
                     /translation="MGNAIEKQKPLRQSHLCPWKQDSQRSHLSSFTMKLMDKFHSPKI
                     KRTPSKKGKPAEVSKTPEKPVSKEARDRFLPEGYPIPLDLEQQAVEFMSTSAVDSRSQ
                     RQKNLCWLEEKEKEVVSALRYFKTIVDKMAIDKKVLEMLPGSASKVLEAILPLVQTDP
                     RIQHSSALSSCYSRVYQSLANLIRWSDQVMLEGVNSEDKEMVTTVKGVIKAVLDGVKE
                     LVRLTIEKQGRPSPTSPVKPSSPASKPDGQPELPLTEREMEILNKTSVSPSTELLPDS
                     TSEEVAPPKPPLPGIRVVDNSPPALPPKKRQSAPSPTRVAVVAPMSRAVSGSSLPVGI
                     NRQDFDVECYTQRRLSGGSRSCGGESPRLSPCSSTGKLSRSDEQLSSLDRDSGQCSRN
                     TSCETLDHYDPDYEFLQQDLSNADQTPPQAACNLSPLPESMGESGPPFVGYSFQLPLG
                     SCLQQDGQQTDTPPALPEKKRRSAVSQTTDSSGCRVSYERHPSQYDNISEDDLQNPAQ
                     PVSYPPFAAILPFQQGASSTPVEFVGDFSVPESAGDPEKPPPLPEKKNKHMLAYMQLL
                     EDYSEPQPSMFYQTPQSEHIYQQKNKMLMEVYGFSDSFCGSDSTQELAPPPALPPKQR
                     QLQASYAASSFSVSHCVQQTKVAFTPEDGSAAQGLSVSVSNSFLNRHGSLPVPSYKSV
                     FRSYSQDFMPHHQASVQPFLPPTSSSSPHFPPVHASQSSDLAVPTVSSPPPSTVDGPL
                     SSSQDSSFHGNPVRLPSETSFTDSEPPSGKDGHPRDLSVSSASGKDSRENGERSPKSL
                     DALESAQSEEEVDELSLIDHNEIMARLTLKQEGDDGPDVRGGSGDILLVHATETDRKD
                     LVLYCEAFLTTYRTFISPEELIKKLQCRYEKFSPFADTFKKRVSKNTFFVLVRVVDEL
                     CLVELTEEILKLLMELVFRLVCSGELSLARVLRKNILDKVDQKKLLRCAHSDQPLAAR
                     GVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEH
                     FNNMSYWVRSVIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRR
                     LEWQRQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPD
                     YIDGKVNFSKRWQQFNILDSMRCFQQVHYEIRRNDDIINFFNDFSDHLAEEALWELSL
                     KIKPRNITRRKTDREEKT"
ORIGIN      
        1 cacttttgtc tcacagttca ctggtcagaa gcacactgac tagtgtgctt agaccaggcc
       61 agctgccctc caaagccagt ttctgccacc gtccttcctc tctggacagg aggagacgag
      121 ctttttacta ggcaaagatg aagtgggagg gggatggata aggacttctt agtagctgtg
      181 tgtgagagag aagctgatcg agtctgcttg gcctctgctc ttctgagtat gtgtttgggg
      241 gtttctagca ctgtcttcat tcaagaagca actgataacc caaggcctag ttgtctggtt
      301 ggagtcagca tgtactccca gtgccttctg gtgtttgtgg gacatgggga agtatggcct
      361 tgttggctgt gaatagagcc ttccactctg gtgcactgac tttagtttgc ttcggttttc
      421 gagacagggt ttctcttgca ctagccgtaa ctgctctggg atcatcctcc ttcagtctgg
      481 caagtgctga aatcattggc tggagcggcc atgtccaggt gtcattcaga ttttgattcg
      541 tcctgtgagt gtctcctgtc atatccctgc atgggaatgt cagccggtct tgactaacag
      601 catatttact gtttgtgatg tttctgggta cactttctcg gcaattcagg aggaaccctt
      661 taaaaaagac tcctcagctc gtctccctgc cccactggag agcacaggtt tgagtcatat
      721 gaaaccaggg cttgaagaag ccaccaagtc ctcaagtaac atatgctctt gagaaagtct
      781 ctttgctggt gccatcagtg ggtgtgttgt gtggaactta ggttcgtttg ctcatggaaa
      841 ccccactacc agagtgacag ttcagaaaca gcaggtcaga acccgagccc agctctgtat
      901 acattttgct gctgttgttg ttgttgttgt tgttgttgtt gttgttgttg ttgctgctac
      961 tgtgtgagtg tgggcctgca aatgctgtaa aagaagagag cacgtcacgg ggcatgtgtg
     1021 actgccaaag ggcaactttg aagctctcct tccatcacgg atttctgggg gtcaaatgca
     1081 ggtactcctg aagcacccac cgcacagatc ctgagcccag ggctgtaact ggcatgttct
     1141 gtggtgtctg catcagtgac tttctagacc aggaggagca gtactgatgt gccactccca
     1201 gggcagaggc cctgcgtggg ctctggctgg cttccgtgtg gctaactgtt ctaatgtggg
     1261 gacactggga ctcctcactg gttcattcct tccccgatcc gtctgcatct gtgtatcaga
     1321 gttgccgagc ccactcactc catggcagtt cttcctgctg ggcagtgcat aaatgatttg
     1381 ccgaacggtg ataaagtaaa actttctcta agtaaagatg ttacaatgca ggttccaacc
     1441 agagcctctc agatgtgtta gtttgaacat actttaacct gcacatagcc tgtaagaagc
     1501 cagttcaagt agtgtatttg tagctaaaac ttgtagaaaa ggtgttcagg tgtttaatga
     1561 gaaggagaca gatgaagtta ttccagatca tcaaaaggat tagatggtta gcaggtagct
     1621 gactagcagc ttgctgagcc gcacagatgc gggcttttac ccttggcctg tccactgttg
     1681 gttgcactat gacttaggtg ggggtctgtg cagtgaggga aacaggatcc tctcatctct
     1741 tctcattcct gcagcaacct tggaaagatg aactgggtac acttagtttt gccaagtttg
     1801 gaagttcaga ctgtgatttt ctgaagtgct ttctatattg atggaggaaa acccagtacc
     1861 caaagatctc ggagagattt agagaggcca ttctcccagg ctagctgggg cagctccaga
     1921 gttgtaaaga agactaagcc tctctggttc taagggttct aaggccttgt gggtgttgtc
     1981 ttaagtctat ttccattcgc ttccatgcca ttgccaccca gcttcacaga gcatgtctgc
     2041 tgtgtaccac tggctaacct ggagccaggg ctttcccacc tcacctgcta tatagagtct
     2101 gaggttagga gacagtcgtg aggaacatgc accaagtctt ctcaagtggc tctggtccaa
     2161 acaaggcagc agagggggcg gggtgtggtg tgtccacttg gcagacaggg aaactaaggc
     2221 tgctgggttc atggacaaca gcagtggcag agctggggtt gaagctctgg ctgggcccag
     2281 atctggcaag cttaccctga tgcctctgag ccgcatttct acctcctact gtggggcctg
     2341 aaatacatta gacttagccc ccctccccca ccatggtttc tcctttcttt tttgcccagg
     2401 cttcatgccc ttgttttctt ccagcaaacc aggtgccacc ttctccagca gaactgttat
     2461 ccaaatggag tgggccttag gtctccgagt gcacacctta taggtggaat tggcattttg
     2521 actcctatca cttgcatctg agtgcgcccc cgcccgcccc ggagccacag tattaatgag
     2581 atcagtcttg tttcctctga ccatgtcatg ggtctgcaaa tgagacttta aatagaagat
     2641 gtgacagatg ggtctgtgca ggtttcttca ctgcatacaa tagaatggac catcttgact
     2701 ttcagctcct gggttaccac tgcctactct tcccctcagg aaagcagcag ggccaggagc
     2761 acagcccatt ccctagtccc tgctgagcta gtgagtagtg atgtcaaagg aagcaaaggg
     2821 ctgcttaata tagtggatta cagaacccac cggtagggca gggcggtggg gcagggcggt
     2881 gaggcagggc cggaacagcc ctttcttcta gtttcctccc aggacctcta aagaatttga
     2941 aaggcaggag gctgagatgt tttagagtga cagagttcct gctttcctga gggtgtggca
     3001 gccctcctgg agctctgcct gaggctgctg ggtcattggg ttaacctaga gatgagtccc
     3061 ctttcagcca gtgtcttggt tcttactgtc attcggtgaa gatgtctggg ctgggaaagg
     3121 tgctgtgatc tgctggcttt aggatgggca atgccattga aaaacagaag cccctgagac
     3181 aaagccatct gtgcccctgg aaacaagact ctcagcgctc tcatctctcc tccttcacca
     3241 tgaagctgat ggacaaattc cactctccta aaatcaagag aacaccatcc aagaagggaa
     3301 agccagctga ggtgtcgaag actcctgaga agcctgtgag caaagaggca agagacagat
     3361 ttctaccaga gggctaccct atccccttgg atctggagca gcaggcagta gaatttatgt
     3421 ccaccagtgc tgtggattcc aggtctcaga ggcagaagaa cctgtgctgg ctggaggaga
     3481 aagagaagga ggttgtcagt gccttgcgct actttaagac cattgtggac aaaatggcca
     3541 ttgataagaa ggttctggag atgctcccgg ggtcagccag caaggtgctg gaggccatct
     3601 tacccctggt gcagactgac cctcggatcc agcacagctc agccctctcc tcttgctata
     3661 gccgagtgta ccagagcctt gccaacctta tccgctggtc tgaccaggtg atgctcgagg
     3721 gtgtgaactc agaagataag gagatggtga cgactgtgaa gggtgtcatc aaagctgtgc
     3781 tggatggagt gaaggaactg gtgaggctaa ccattgagaa gcaaggccgg ccatcaccaa
     3841 caagcccagt gaagcccagt tccccagcca gcaagcctga tggccagcct gagctccctc
     3901 tgacagaacg agaaatggag attctgaaca agacaagtgt gtcaccatcc actgaactgc
     3961 tcccagactc caccagtgaa gaggttgcgc cccccaagcc ccctttacct ggcatccggg
     4021 tggttgataa cagtccacca gcattaccac ccaagaaaag gcaatctgct ccatccccta
     4081 cccgggtggc tgtggtagcc cccatgagtc gtgctgtcag tggctccagt ttgcctgttg
     4141 gaatcaatag gcaggacttt gatgttgaat gttacaccca gaggcgcctg tcaggaggca
     4201 gccgctcctg tggtggtgaa tctcctcgcc tgtccccctg cagcagtaca ggcaagctca
     4261 gccggtcaga cgagcagctg tcctccctag acagggatag cgggcagtgc tcacggaaca
     4321 caagctgtga aacactagat cactatgacc ccgactatga attcctccag caagacctct
     4381 ccaatgcaga ccagacccct ccacaggcag cctgtaacct cagcccactg ccggagtcca
     4441 tgggggagtc tgggccccca tttgttggct actctttcca gctgcctctg ggcagctgtc
     4501 tccagcagga tggacagcag acagatactc cacctgccct tcctgagaag aagcgtagga
     4561 gcgcagtctc ccagaccacg gacagctctg gctgcagggt gtcctatgag cgacacccct
     4621 cacagtatga caacatctca gaagatgatc tgcagaaccc agcccagcct gtgtcctacc
     4681 cgccctttgc tgctatcctg ccctttcagc agggagcttc ttccacccct gttgagtttg
     4741 tgggtgattt cagtgttcct gagtcagccg gtgacccaga aaagccacct cctctaccag
     4801 agaagaaaaa caaacacatg ctggcctaca tgcaactgct ggaggactac tcagagccac
     4861 agccctccat gttctaccag acaccgcaga gtgagcacat ctaccagcag aagaacaaga
     4921 tgctcatgga ggtctatggc ttcagcgact ccttctgtgg tagtgactcc acgcaggagc
     4981 tggcccctcc acccgctttg ccccccaagc agcggcagct gcaggcctcc tatgctgctt
     5041 cttccttctc tgtctcccac tgtgtccagc aaactaaagt ggccttcacc cccgaggacg
     5101 gcagtgccgc tcagggcctc agtgtatccg tgtctaactc ctttctcaac cggcacggca
     5161 gcttgcctgt gccctcgtac aaatctgtgt ttaggtctta ctcccaggac ttcatgcctc
     5221 accaccaagc ctccgtccaa cctttccttc cgcctacctc ctcttcctct ccacatttcc
     5281 cacctgtcca cgcgtcccag agctcggact tagcggtgcc caccgtaagc agtccgcctc
     5341 ccagcaccgt ggacgggcct ctctcgtctt ctcaggacag cagctttcat gggaaccctg
     5401 tccgccttcc ttccgaaacc tctttcactg actcggaacc gccatctggg aaggacggac
     5461 atcccagaga tctttcggtc agcagtgcat ctgggaagga cagcagagaa aatggggaga
     5521 ggtccccgaa gtcactggat gctctggagt cagcccagtc agaagaggaa gtggatgaac
     5581 tgtccctcat tgaccacaat gaaatcatgg ccaggctgac actcaagcaa gagggtgatg
     5641 atggaccaga tgttcgtgga ggttcaggag acatcttact ggtccatgct actgagacag
     5701 acagaaaaga cctggtcctg tactgtgaag ccttcctgac cacctacaga accttcatca
     5761 gccccgagga gctcatcaag aagctgcagt gccggtacga gaagttctct ccctttgctg
     5821 acacattcaa gaagcgagtg agcaagaaca cattcttcgt gctggtgcgg gtggtggacg
     5881 agctctgcct ggtggagctg acagaggaga tcctgaagct gctgatggag ctagtcttcc
     5941 gcctagtgtg cagtggagag ctcagcttgg ccagggtact ccgaaagaac attctggaca
     6001 aggtggacca gaagaagctg ctcaggtgtg cccattccga ccagcctttg gcagccaggg
     6061 gtgttgcagc caggccagga accttgcatg atttccacag ccacgagata gctgaacagc
     6121 tgacactgct ggatgccgag cttttctata agatagagat tcccgaagtt ttgctttggg
     6181 ccaaagagca gaatgaagag aagagcccca atctgaccca gttcacagag cacttcaaca
     6241 acatgtccta ctgggtgcgg tccgtcatca tgctgcagga gaaggcccag gaccgggaga
     6301 ggctgctcct gaagttcatc aagatcatga agcacctgcg caagctcaac aatttcaact
     6361 cctacctggc catcctctcc gcactggact cggcccccat ccgcagactg gagtggcagc
     6421 gacagacctc agagggcctg gctgagtact gcacgttgat tgacagctca tcctccttcc
     6481 gagcctaccg ggctgccctc tcagaggtgg aacctccatg tatcccatac ctaggtttga
     6541 tcctgcaaga cctgacgttc gtccacctgg gaaacccaga ctacatagac gggaaggtca
     6601 acttctccaa gcggtggcag cagttcaaca tcctggacag catgcgctgt ttccagcagg
     6661 tgcactatga aatccggaga aacgacgaca tcataaactt cttcaatgac ttcagcgacc
     6721 acctggccga ggaagcccta tgggaactct ctctgaagat caagcctagg aacataacaa
     6781 ggcggaaaac agaccgtgaa gagaagacct aggagcaggc tggctgtgag gatgctcaag
     6841 cagccaggag aggacctgga ccgtcccagc ctcagagcct gtccatggct tggctgtgtg
     6901 gcagcaccga gtctgccggc cggtttcctg cctccttccc tatggctaaa gccccagggt
     6961 tcacagtgag ctggctggca ggcctcagga ctggcttgtg tactggtggc ccctggtctg
     7021 gttttgtttt ctgttttctg tcgatgctcc gtcctgttcc ctactgtccc ctccaacagg
     7081 gagcagaaga aacctgagca gcagaccagg ggagtggctg gcttccttcc tccctcccaa
     7141 ggctgtcttt gccttcttaa gtggcagata agtagaggcc ccacccaggc cccttgggta
     7201 gaccgccctc cagggtacct ggagccagag gagatagggc tgggaggtgg aagaaggaga
     7261 aaagggccac agcaggcatc tttcactgtc catttcctgc cttttagaca tggaggatga
     7321 ggatgtcgac ctggcgtgaa agtatcatgg gataggcagc agccagagct gacacttgtc
     7381 acagtactgg ccccagccct gtcctgccag gcatggtcca ccaaggctca cctgctggac
     7441 tgacagcagc accagttgca ccttccaccc tgttgcccca ccactgtcca gccccagccc
     7501 agcccacatc agcggttctc tggggatcag gaacaggagg cagaagggag agttcatgct
     7561 gagctggggc caaggctatg cttccaagtg gctcagagag tgaggatctt tagtgaccta
     7621 gggagaggca agcagcctct ccgtgcttgc tgtgtgcctt aaatgccatc tcctgttcct
     7681 tccagcctgg ggcttccctc ctcctgtgcc ccacccctgg cagccagcag ggtcctgggc
     7741 cctttttgct ccctgggaat gtctcctgtt cccaaggcta aagaagccta ggatgtgagg
     7801 cctccagggg ctcctgattc cagacaggtg gcagagccac ccctgctgct gaggttgaca
     7861 atctgttcag ggctcaggac tgggatctcc ctggccatgg tcccacggcc tcactgtagg
     7921 ctgattggca gggtgcaggt cagaatgcag aggtgctgct ggccctgcac catccctcca
     7981 gttcaggttt gcatggacag gcaccctcat cttctggtca tggggcttgg ccaagtggat
     8041 cccaggattt ctgtgcttcc cagcccagtc gtcagagcag aagaaaagac agcagcagct
     8101 gctggccggg tactaatttg aaacagctgt cactctgaac ccttcctggg ttggtttttt
     8161 gttttgtttt tgtttttaaa gcagctttta tcaaataaga actataggac cctcttctgt
     8221 ttatttgtgc tgtaaataga aaggggacat ctgtaaacag ccccttggcc agctccctct
     8281 ggcagcagcc ggtactggat tgtttatgga gcgtttgtgg agtcaggctt gtgaacagtc
     8341 gcgtgggtct ttggtgtgtt cctcttttac aggtcctttc atttcagtct ttgctcctac
     8401 ttgctgtcct tcaccagctc taggtgctgc tgtgtgcgag tggggaacac tgtgcacacg
     8461 gggtctttcc tcccagcgct ttagaggccc ctgcagcctc cctctgtagc acaggccaac
     8521 ataggcccag cctactggtg ctgcagccaa cagagcggct ctgtggtctg tgtctactgg
     8581 ttcccaaaca tgagctggct agaaaggaag gctctccttc cagaccagaa aagccaggcc
     8641 ctcctacaat cctgggagcc ttaggcagac taagtcaagg gccagggcac gtctggagtt
     8701 tctgtgtggg gatgttgagg tgcgatgtgt gggtttaact tattagccag caggcttccc
     8761 cagtcacctg cctctggctg cggctgagcc cagtgttccc gcagcctggc ttccacatgt
     8821 ctgtttttta ggggtggggg gctgggagag ctgtgaagat gggtctttat agatatacta
     8881 agcagcatgg acaattcggt tcccagcaga ggccagccct tacctgtgga tatggtctga
     8941 ccaaggctag ggcaagcaaa caccatgtct gactgaccct taagtctccc agtgtggcac
     9001 tgtaatataa ccccccactc acctgtctga caatgcatct tcctacagac agaacagcgc
     9061 gcaactttta tatgaaagaa aaataaacag acaaaagccc gtctgatgcc a
//
