LOCUS       XM_006233902            8686 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus Rap guanine nucleotide exchange factor
            1 (Rapgef1), transcript variant X19, mRNA.
ACCESSION   XM_006233902
VERSION     XM_006233902.4
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051338.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_006233902.5.
            
            On Jan 21, 2021 this sequence version replaced XM_006233902.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8686
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..8686
                     /gene="Rapgef1"
                     /note="Rap guanine nucleotide exchange factor 1; Derived
                     by automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 39 ESTs, 6 long SRA reads, 4 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 62 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:63881"
                     /db_xref="RGD:619793"
     CDS             3133..6387
                     /gene="Rapgef1"
                     /codon_start=1
                     /product="rap guanine nucleotide exchange factor 1 isoform
                     X19"
                     /protein_id="XP_006233964.1"
                     /db_xref="GeneID:63881"
                     /db_xref="RGD:619793"
                     /translation="MGNAIEKQKPLRQSHLCPWKQDSQRSHLSSFTMKLMDKFHSPKI
                     KRTPSKKGKPAEVSKTPEKPVSKEARDRFLPEGYPIPLDLEQQAVEFMSTSAVDSRSQ
                     RQKNLCWLEEKEKEVVSALRYFKTIVDKMAIDKKVLEMLPGSASKVLEAILPLVQTDP
                     RIQHSSALSSCYSRVYQSLANLIRWSDQVMLEGVNSEDKEMVTTVKGVIKAVLDGVKE
                     LVRLTIEKQGRPSPTSPVKPSSPASKPDGQPELPLTEREMEILNKTSVSPSTELLPDS
                     TSEEVAPPKPPLPGIRVVDNSPPALPPKKRQSAPSPTRVAVVAPMSRAVSGSSLPVGI
                     NRQDFDVECYTQRRLSGGSRSCGGESPRLSPCSSTGKLSRSDEQLSSLDRDSGQCSRN
                     TSCETLDHYDPDYEFLQQDLSNADQTPPQAACNLSPLPESMGESGPPFVGYSFQLPLG
                     SCLQQDGQQTDTPPALPEKKRRSAVSQTTDSSGCRVSYERHPSQYDNISEDDLQNPAQ
                     PVSYPPFAAILPFQQGASSTPVEFVGDFSVPESAGDPEKPPPLPEKKNKHMLAYMQLL
                     EDYSEPQPSMFYQTPQSEHIYQQKNKMLMEVYGFSDSFCGSDSTQELAPPPALPPKQR
                     QLEPPSGKDGHPRDLSVSSASGKDSRENGERSPKSLDALESAQSEEEVDELSLIDHNE
                     IMARLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLVLYCEAFLTTYRTFISPEELI
                     KKLQCRYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVELTEEILKLLMELVFRLVC
                     SGELSLARVLRKNILDKVDQKKLLRCAHSDQPLAARGVAARPGTLHDFHSHEIAEQLT
                     LLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSVIMLQEKAQDRE
                     RLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQRQTSEGLAEYCTLIDSSS
                     SFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRWQQFNILDSMR
                     CFQQVHYEIRRNDDIINFFNDFSDHLAEEALWELSLKIKPRNITRRKTDREEKT"
ORIGIN      
        1 cacagttcac tggtcagaag cacactgact agtgtgctta gaccaggcca gctgccctcc
       61 aaagccagtt tctgccaccg tccttcctct ctggacagga ggagacgagc tttttactag
      121 gcaaagatga agtgggaggg ggatggataa ggacttctta gtagctgtgt gtgagagaga
      181 agctgatcga gtctgcttgg cctctgctct tctgagtatg tgtttggggg tttctagcac
      241 tgtcttcatt caagaagcaa ctgataaccc aaggcctagt tgtctggttg gagtcagcat
      301 gtactcccag tgccttctgg tgtttgtggg acatggggaa gtatggcctt gttggctgtg
      361 aatagagcct tccactctgg tgcactgact ttagtttgct tcggttttcg agacagggtt
      421 tctcttgcac tagccgtaac tgctctggga tcatcctcct tcagtctggc aagtgctgaa
      481 atcattggct ggagcggcca tgtccaggtg tcattcagat tttgattcgt cctgtgagtg
      541 tctcctgtca tatccctgca tgggaatgtc agccggtctt gactaacagc atatttactg
      601 tttgtgatgt ttctgggtac actttctcgg caattcagga ggaacccttt aaaaaagact
      661 cctcagctcg tctccctgcc ccactggaga gcacaggttt gagtcatatg aaaccagggc
      721 ttgaagaagc caccaagtcc tcaagtaaca tatgctcttg agaaagtctc tttgctggtg
      781 ccatcagtgg gtgtgttgtg tggaacttag gttcgtttgc tcatggaaac cccactacca
      841 gagtgacagt tcagaaacag caggtcagaa cccgagccca gctctgtata cattttgctg
      901 ctgttgttgt tgttgttgtt gttgttgttg ttgttgttgt tgctgctact gtgtgagtgt
      961 gggcctgcaa atgctgtaaa agaagagagc acgtcacggg gcatgtgtga ctgccaaagg
     1021 gcaactttga agctctcctt ccatcacgga tttctggggg tcaaatgcag gtactcctga
     1081 agcacccacc gcacagatcc tgagcccagg gctgtaactg gcatgttctg tggtgtctgc
     1141 atcagtgact ttctagacca ggaggagcag tactgatgtg ccactcccag ggcagaggcc
     1201 ctgcgtgggc tctggctggc ttccgtgtgg ctaactgttc taatgtgggg acactgggac
     1261 tcctcactgg ttcattcctt ccccgatccg tctgcatctg tgtatcagag ttgccgagcc
     1321 cactcactcc atggcagttc ttcctgctgg gcagtgcata aatgatttgc cgaacggtga
     1381 taaagtaaaa ctttctctaa gtaaagatgt tacaatgcag gttccaacca gagcctctca
     1441 gatgtgttag tttgaacata ctttaacctg cacatagcct gtaagaagcc agttcaagta
     1501 gtgtatttgt agctaaaact tgtagaaaag gtgttcaggt gtttaatgag aaggagacag
     1561 atgaagttat tccagatcat caaaaggatt agatggttag caggtagctg actagcagct
     1621 tgctgagccg cacagatgcg ggcttttacc cttggcctgt ccactgttgg ttgcactatg
     1681 acttaggtgg gggtctgtgc agtgagggaa acaggatcct ctcatctctt ctcattcctg
     1741 cagcaacctt ggaaagatga actgggtaca cttagttttg ccaagtttgg aagttcagac
     1801 tgtgattttc tgaagtgctt tctatattga tggaggaaaa cccagtaccc aaagatctcg
     1861 gagagattta gagaggccat tctcccaggc tagctggggc agctccagag ttgtaaagaa
     1921 gactaagcct ctctggttct aagggttcta aggccttgtg ggtgttgtct taagtctatt
     1981 tccattcgct tccatgccat tgccacccag cttcacagag catgtctgct gtgtaccact
     2041 ggctaacctg gagccagggc tttcccacct cacctgctat atagagtctg aggttaggag
     2101 acagtcgtga ggaacatgca ccaagtcttc tcaagtggct ctggtccaaa caaggcagca
     2161 gagggggcgg ggtgtggtgt gtccacttgg cagacaggga aactaaggct gctgggttca
     2221 tggacaacag cagtggcaga gctggggttg aagctctggc tgggcccaga tctggcaagc
     2281 ttaccctgat gcctctgagc cgcatttcta cctcctactg tggggcctga aatacattag
     2341 acttagcccc cctcccccac catggtttct cctttctttt ttgcccaggc ttcatgccct
     2401 tgttttcttc cagcaaacca ggtgccacct tctccagcag aactgttatc caaatggagt
     2461 gggccttagg tctccgagtg cacaccttat aggtggaatt ggcattttga ctcctatcac
     2521 ttgcatctga gtgcgccccc gcccgccccg gagccacagt attaatgaga tcagtcttgt
     2581 ttcctctgac catgtcatgg gtctgcaaat gagactttaa atagaagatg tgacagatgg
     2641 gtctgtgcag gtttcttcac tgcatacaat agaatggacc atcttgactt tcagctcctg
     2701 ggttaccact gcctactctt cccctcagga aagcagcagg gccaggagca cagcccattc
     2761 cctagtccct gctgagctag tgagtagtga tgtcaaagga agcaaagggc tgcttaatat
     2821 agtggattac agaacccacc ggtagggcag ggcggtgggg cagggcggtg aggcagggcc
     2881 ggaacagccc tttcttctag tttcctccca ggacctctaa agaatttgaa aggcaggagg
     2941 ctgagatgtt ttagagtgac agagttcctg ctttcctgag ggtgtggcag ccctcctgga
     3001 gctctgcctg aggctgctgg gtcattgggt taacctagag atgagtcccc tttcagccag
     3061 tgtcttggtt cttactgtca ttcggtgaag atgtctgggc tgggaaaggt gctgtgatct
     3121 gctggcttta ggatgggcaa tgccattgaa aaacagaagc ccctgagaca aagccatctg
     3181 tgcccctgga aacaagactc tcagcgctct catctctcct ccttcaccat gaagctgatg
     3241 gacaaattcc actctcctaa aatcaagaga acaccatcca agaagggaaa gccagctgag
     3301 gtgtcgaaga ctcctgagaa gcctgtgagc aaagaggcaa gagacagatt tctaccagag
     3361 ggctacccta tccccttgga tctggagcag caggcagtag aatttatgtc caccagtgct
     3421 gtggattcca ggtctcagag gcagaagaac ctgtgctggc tggaggagaa agagaaggag
     3481 gttgtcagtg ccttgcgcta ctttaagacc attgtggaca aaatggccat tgataagaag
     3541 gttctggaga tgctcccggg gtcagccagc aaggtgctgg aggccatctt acccctggtg
     3601 cagactgacc ctcggatcca gcacagctca gccctctcct cttgctatag ccgagtgtac
     3661 cagagccttg ccaaccttat ccgctggtct gaccaggtga tgctcgaggg tgtgaactca
     3721 gaagataagg agatggtgac gactgtgaag ggtgtcatca aagctgtgct ggatggagtg
     3781 aaggaactgg tgaggctaac cattgagaag caaggccggc catcaccaac aagcccagtg
     3841 aagcccagtt ccccagccag caagcctgat ggccagcctg agctccctct gacagaacga
     3901 gaaatggaga ttctgaacaa gacaagtgtg tcaccatcca ctgaactgct cccagactcc
     3961 accagtgaag aggttgcgcc ccccaagccc cctttacctg gcatccgggt ggttgataac
     4021 agtccaccag cattaccacc caagaaaagg caatctgctc catcccctac ccgggtggct
     4081 gtggtagccc ccatgagtcg tgctgtcagt ggctccagtt tgcctgttgg aatcaatagg
     4141 caggactttg atgttgaatg ttacacccag aggcgcctgt caggaggcag ccgctcctgt
     4201 ggtggtgaat ctcctcgcct gtccccctgc agcagtacag gcaagctcag ccggtcagac
     4261 gagcagctgt cctccctaga cagggatagc gggcagtgct cacggaacac aagctgtgaa
     4321 acactagatc actatgaccc cgactatgaa ttcctccagc aagacctctc caatgcagac
     4381 cagacccctc cacaggcagc ctgtaacctc agcccactgc cggagtccat gggggagtct
     4441 gggcccccat ttgttggcta ctctttccag ctgcctctgg gcagctgtct ccagcaggat
     4501 ggacagcaga cagatactcc acctgccctt cctgagaaga agcgtaggag cgcagtctcc
     4561 cagaccacgg acagctctgg ctgcagggtg tcctatgagc gacacccctc acagtatgac
     4621 aacatctcag aagatgatct gcagaaccca gcccagcctg tgtcctaccc gccctttgct
     4681 gctatcctgc cctttcagca gggagcttct tccacccctg ttgagtttgt gggtgatttc
     4741 agtgttcctg agtcagccgg tgacccagaa aagccacctc ctctaccaga gaagaaaaac
     4801 aaacacatgc tggcctacat gcaactgctg gaggactact cagagccaca gccctccatg
     4861 ttctaccaga caccgcagag tgagcacatc taccagcaga agaacaagat gctcatggag
     4921 gtctatggct tcagcgactc cttctgtggt agtgactcca cgcaggagct ggcccctcca
     4981 cccgctttgc cccccaagca gcggcagctg gaaccgccat ctgggaagga cggacatccc
     5041 agagatcttt cggtcagcag tgcatctggg aaggacagca gagaaaatgg ggagaggtcc
     5101 ccgaagtcac tggatgctct ggagtcagcc cagtcagaag aggaagtgga tgaactgtcc
     5161 ctcattgacc acaatgaaat catggccagg ctgacactca agcaagaggg tgatgatgga
     5221 ccagatgttc gtggaggttc aggagacatc ttactggtcc atgctactga gacagacaga
     5281 aaagacctgg tcctgtactg tgaagccttc ctgaccacct acagaacctt catcagcccc
     5341 gaggagctca tcaagaagct gcagtgccgg tacgagaagt tctctccctt tgctgacaca
     5401 ttcaagaagc gagtgagcaa gaacacattc ttcgtgctgg tgcgggtggt ggacgagctc
     5461 tgcctggtgg agctgacaga ggagatcctg aagctgctga tggagctagt cttccgccta
     5521 gtgtgcagtg gagagctcag cttggccagg gtactccgaa agaacattct ggacaaggtg
     5581 gaccagaaga agctgctcag gtgtgcccat tccgaccagc ctttggcagc caggggtgtt
     5641 gcagccaggc caggaacctt gcatgatttc cacagccacg agatagctga acagctgaca
     5701 ctgctggatg ccgagctttt ctataagata gagattcccg aagttttgct ttgggccaaa
     5761 gagcagaatg aagagaagag ccccaatctg acccagttca cagagcactt caacaacatg
     5821 tcctactggg tgcggtccgt catcatgctg caggagaagg cccaggaccg ggagaggctg
     5881 ctcctgaagt tcatcaagat catgaagcac ctgcgcaagc tcaacaattt caactcctac
     5941 ctggccatcc tctccgcact ggactcggcc cccatccgca gactggagtg gcagcgacag
     6001 acctcagagg gcctggctga gtactgcacg ttgattgaca gctcatcctc cttccgagcc
     6061 taccgggctg ccctctcaga ggtggaacct ccatgtatcc catacctagg tttgatcctg
     6121 caagacctga cgttcgtcca cctgggaaac ccagactaca tagacgggaa ggtcaacttc
     6181 tccaagcggt ggcagcagtt caacatcctg gacagcatgc gctgtttcca gcaggtgcac
     6241 tatgaaatcc ggagaaacga cgacatcata aacttcttca atgacttcag cgaccacctg
     6301 gccgaggaag ccctatggga actctctctg aagatcaagc ctaggaacat aacaaggcgg
     6361 aaaacagacc gtgaagagaa gacctaggag caggctggct gtgaggatgc tcaagcagcc
     6421 aggagaggac ctggaccgtc ccagcctcag agcctgtcca tggcttggct gtgtggcagc
     6481 accgagtctg ccggccggtt tcctgcctcc ttccctatgg ctaaagcccc agggttcaca
     6541 gtgagctggc tggcaggcct caggactggc ttgtgtactg gtggcccctg gtctggtttt
     6601 gttttctgtt ttctgtcgat gctccgtcct gttccctact gtcccctcca acagggagca
     6661 gaagaaacct gagcagcaga ccaggggagt ggctggcttc cttcctccct cccaaggctg
     6721 tctttgcctt cttaagtggc agataagtag aggccccacc caggcccctt gggtagaccg
     6781 ccctccaggg tacctggagc cagaggagat agggctggga ggtggaagaa ggagaaaagg
     6841 gccacagcag gcatctttca ctgtccattt cctgcctttt agacatggag gatgaggatg
     6901 tcgacctggc gtgaaagtat catgggatag gcagcagcca gagctgacac ttgtcacagt
     6961 actggcccca gccctgtcct gccaggcatg gtccaccaag gctcacctgc tggactgaca
     7021 gcagcaccag ttgcaccttc caccctgttg ccccaccact gtccagcccc agcccagccc
     7081 acatcagcgg ttctctgggg atcaggaaca ggaggcagaa gggagagttc atgctgagct
     7141 ggggccaagg ctatgcttcc aagtggctca gagagtgagg atctttagtg acctagggag
     7201 aggcaagcag cctctccgtg cttgctgtgt gccttaaatg ccatctcctg ttccttccag
     7261 cctggggctt ccctcctcct gtgccccacc cctggcagcc agcagggtcc tgggcccttt
     7321 ttgctccctg ggaatgtctc ctgttcccaa ggctaaagaa gcctaggatg tgaggcctcc
     7381 aggggctcct gattccagac aggtggcaga gccacccctg ctgctgaggt tgacaatctg
     7441 ttcagggctc aggactggga tctccctggc catggtccca cggcctcact gtaggctgat
     7501 tggcagggtg caggtcagaa tgcagaggtg ctgctggccc tgcaccatcc ctccagttca
     7561 ggtttgcatg gacaggcacc ctcatcttct ggtcatgggg cttggccaag tggatcccag
     7621 gatttctgtg cttcccagcc cagtcgtcag agcagaagaa aagacagcag cagctgctgg
     7681 ccgggtacta atttgaaaca gctgtcactc tgaacccttc ctgggttggt tttttgtttt
     7741 gtttttgttt ttaaagcagc ttttatcaaa taagaactat aggaccctct tctgtttatt
     7801 tgtgctgtaa atagaaaggg gacatctgta aacagcccct tggccagctc cctctggcag
     7861 cagccggtac tggattgttt atggagcgtt tgtggagtca ggcttgtgaa cagtcgcgtg
     7921 ggtctttggt gtgttcctct tttacaggtc ctttcatttc agtctttgct cctacttgct
     7981 gtccttcacc agctctaggt gctgctgtgt gcgagtgggg aacactgtgc acacggggtc
     8041 tttcctccca gcgctttaga ggcccctgca gcctccctct gtagcacagg ccaacatagg
     8101 cccagcctac tggtgctgca gccaacagag cggctctgtg gtctgtgtct actggttccc
     8161 aaacatgagc tggctagaaa ggaaggctct ccttccagac cagaaaagcc aggccctcct
     8221 acaatcctgg gagccttagg cagactaagt caagggccag ggcacgtctg gagtttctgt
     8281 gtggggatgt tgaggtgcga tgtgtgggtt taacttatta gccagcaggc ttccccagtc
     8341 acctgcctct ggctgcggct gagcccagtg ttcccgcagc ctggcttcca catgtctgtt
     8401 ttttaggggt ggggggctgg gagagctgtg aagatgggtc tttatagata tactaagcag
     8461 catggacaat tcggttccca gcagaggcca gcccttacct gtggatatgg tctgaccaag
     8521 gctagggcaa gcaaacacca tgtctgactg acccttaagt ctcccagtgt ggcactgtaa
     8581 tataaccccc cactcacctg tctgacaatg catcttccta cagacagaac agcgcgcaac
     8641 ttttatatga aagaaaaata aacagacaaa agcccgtctg atgcca
//
