LOCUS       NM_133410                552 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus RAP2B, member of RAS oncogene family (Rap2b),
            mRNA.
ACCESSION   NM_133410
VERSION     NM_133410.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 552)
  AUTHORS   Monteiro,A.C., Sumagin,R., Rankin,C.R., Leoni,G., Mina,M.J.,
            Reiter,D.M., Stehle,T., Dermody,T.S., Schaefer,S.A., Hall,R.A.,
            Nusrat,A. and Parkos,C.A.
  TITLE     JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c
            and regulate epithelial barrier function
  JOURNAL   Mol Biol Cell 24 (18), 2849-2860 (2013)
   PUBMED   23885123
REFERENCE   2  (bases 1 to 552)
  AUTHORS   Gloerich,M., ten Klooster,J.P., Vliem,M.J., Koorman,T.,
            Zwartkruis,F.J., Clevers,H. and Bos,J.L.
  TITLE     Rap2A links intestinal cell polarity to brush border formation
  JOURNAL   Nat Cell Biol 14 (8), 793-801 (2012)
   PUBMED   22797597
REFERENCE   3  (bases 1 to 552)
  AUTHORS   Hussain,N.K., Hsin,H., Huganir,R.L. and Sheng,M.
  TITLE     MINK and TNIK differentially act on Rap2-mediated signal
            transduction to regulate neuronal structure and AMPA receptor
            function
  JOURNAL   J Neurosci 30 (44), 14786-14794 (2010)
   PUBMED   21048137
  REMARK    GeneRIF: MINK interaction with Rap2 plays a critical role in
            maintaining the morphological integrity of dendrites and synaptic
            transmission.
REFERENCE   4  (bases 1 to 552)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   5  (bases 1 to 552)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 552)
  AUTHORS   Uechi,Y., Bayarjargal,M., Umikawa,M., Oshiro,M., Takei,K.,
            Yamashiro,Y., Asato,T., Endo,S., Misaki,R., Taguchi,T. and
            Kariya,K.
  TITLE     Rap2 function requires palmitoylation and recycling endosome
            localization
  JOURNAL   Biochem Biophys Res Commun 378 (4), 732-737 (2009)
   PUBMED   19061864
REFERENCE   7  (bases 1 to 552)
  AUTHORS   Canobbio,I., Trionfini,P., Guidetti,G.F., Balduini,C. and Torti,M.
  TITLE     Targeting of the small GTPase Rap2b, but not Rap1b, to lipid rafts
            is promoted by palmitoylation at Cys176 and Cys177 and is required
            for efficient protein activation in human platelets
  JOURNAL   Cell Signal 20 (9), 1662-1670 (2008)
   PUBMED   18582561
REFERENCE   8  (bases 1 to 552)
  AUTHORS   Kukimoto-Niino,M., Takagi,T., Akasaka,R., Murayama,K.,
            Uchikubo-Kamo,T., Terada,T., Inoue,M., Watanabe,S., Tanaka,A.,
            Hayashizaki,Y., Kigawa,T., Shirouzu,M. and Yokoyama,S.
  TITLE     Crystal structure of the RUN domain of the RAP2-interacting protein
            x
  JOURNAL   J Biol Chem 281 (42), 31843-31853 (2006)
   PUBMED   16928684
REFERENCE   9  (bases 1 to 552)
  AUTHORS   Greco,F., Ciana,A., Pietra,D., Balduini,C., Minetti,G. and Torti,M.
  TITLE     Rap2, but not Rap1 GTPase is expressed in human red blood cells and
            is involved in vesiculation
  JOURNAL   Biochim Biophys Acta 1763 (3), 330-335 (2006)
   PUBMED   16540189
REFERENCE   10 (bases 1 to 552)
  AUTHORS   Paganini,S., Guidetti,G.F., Catricala,S., Trionfini,P., Panelli,S.,
            Balduini,C. and Torti,M.
  TITLE     Identification and biochemical characterization of Rap2C, a new
            member of the Rap family of small GTP-binding proteins
  JOURNAL   Biochimie 88 (3-4), 285-295 (2006)
   PUBMED   16213650
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF386786.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AF386786.1, DV216028.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..552
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q31"
     gene            1..552
                     /gene="Rap2b"
                     /note="RAP2B, member of RAS oncogene family"
                     /db_xref="GeneID:170923"
                     /db_xref="RGD:620591"
     CDS             1..552
                     /gene="Rap2b"
                     /EC_number="3.6.5.2"
                     /codon_start=1
                     /product="ras-related protein Rap-2b"
                     /protein_id="NP_596901.1"
                     /db_xref="GeneID:170923"
                     /db_xref="RGD:620591"
                     /translation="MREYKVVVLGSGGVGKSALTVQFVTGSFIEKYDPTIEDFYRKEI
                     EVDSSPSVLEILDTAGTEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIR
                     VKRYERVPMILVGNKVDLEGEREVSYGEGKALAEEWSCPFMETSAKNKASVDELFAEI
                     VRQMNYAAQPNGDEGCCSACVIL"
     exon            1..552
                     /gene="Rap2b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgagagagt acaaagtggt ggtactgggc tcgggtggcg tgggcaagtc cgcgctcacc
       61 gtgcagttcg taacaggttc cttcatcgag aagtacgacc caaccatcga agacttttac
      121 cgcaaggaga tcgaggtgga ttcgtcgccg tcggttctgg agatcctgga caccgcgggc
      181 acggagcagt tcgcttccat gcgggacctg tacatcaaga atggccaggg cttcatcctc
      241 gtctacagcc tggtcaacca gcagagcttc caggacatca agcccatgcg ggaccagatc
      301 atccgcgtga aacggtacga gcgcgtaccc atgatcctgg taggcaacaa ggtggacctg
      361 gagggcgaac gtgaggtctc ctatggcgag ggcaaggccc tggccgagga gtggagctgc
      421 cccttcatgg aaacatcggc caaaaacaaa gcctcagtgg atgagctatt cgcagagatc
      481 gtgaggcaga tgaactacgc ggcacagccc aacggcgacg agggctgctg ctcggcctgc
      541 gtgatcctgt ga
//
