LOCUS       NM_053741                491 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus RAP2A, member of RAS oncogene family (Rap2a),
            mRNA.
ACCESSION   NM_053741
VERSION     NM_053741.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Hu Y, Hong XY, Yang XF, Ma RH, Wang X, Zhang JF, Feng Q, Li XG, Sun
            DS, Li X, Wan HL, Li T, Wang Q, Ke D, Wang JZ and Liu GP.
  TITLE     Inflammation-dependent ISG15 upregulation mediates MIA-induced
            dendrite damages and depression by disrupting NEDD4/Rap2A signaling
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1865 (6), 1477-1489 (2019)
   PUBMED   30826466
  REMARK    GeneRIF: The data revealed that maternal immune activation impedes
            offspring's dendrite development and causes depressive like
            behaviors by upregulating ISG15 and suppressing NEDD4/Rap2A
            signaling.
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Emery AC, Xu W, Eiden MV and Eiden LE.
  TITLE     Guanine nucleotide exchange factor Epac2-dependent activation of
            the GTP-binding protein Rap2A mediates cAMP-dependent growth arrest
            in neuroendocrine cells
  JOURNAL   J Biol Chem 292 (29), 12220-12231 (2017)
   PUBMED   28546426
  REMARK    GeneRIF: Data suggest that Rap2A is the obligate effector for Epac2
            in mediating growth arrest and reversal of neurite extension
            through activation of MAP kinase signaling via protein
            phosphorylation/farnesylation in neuroendocrine cells. (Rap2A = RAS
            oncogene family member Rap2A; Epac2 = guanine nucleotide exchange
            factor Epac2)
REFERENCE   3  (bases 1 to 491)
  AUTHORS   Gloerich M, ten Klooster JP, Vliem MJ, Koorman T, Zwartkruis FJ,
            Clevers H and Bos JL.
  TITLE     Rap2A links intestinal cell polarity to brush border formation
  JOURNAL   Nat Cell Biol 14 (8), 793-801 (2012)
   PUBMED   22797597
REFERENCE   4  (bases 1 to 491)
  AUTHORS   Kawabe H, Neeb A, Dimova K, Young SM Jr, Takeda M, Katsurabayashi
            S, Mitkovski M, Malakhova OA, Zhang DE, Umikawa M, Kariya K,
            Goebbels S, Nave KA, Rosenmund C, Jahn O, Rhee J and Brose N.
  TITLE     Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls
            neurite development
  JOURNAL   Neuron 65 (3), 358-372 (2010)
   PUBMED   20159449
REFERENCE   5  (bases 1 to 491)
  AUTHORS   Uechi Y, Bayarjargal M, Umikawa M, Oshiro M, Takei K, Yamashiro Y,
            Asato T, Endo S, Misaki R, Taguchi T and Kariya K.
  TITLE     Rap2 function requires palmitoylation and recycling endosome
            localization
  JOURNAL   Biochem Biophys Res Commun 378 (4), 732-737 (2009)
   PUBMED   19061864
REFERENCE   6  (bases 1 to 491)
  AUTHORS   Taira K, Umikawa M, Takei K, Myagmar BE, Shinzato M, Machida N,
            Uezato H, Nonaka S and Kariya K.
  TITLE     The Traf2- and Nck-interacting kinase as a putative effector of
            Rap2 to regulate actin cytoskeleton
  JOURNAL   J Biol Chem 279 (47), 49488-49496 (2004)
   PUBMED   15342639
REFERENCE   7  (bases 1 to 491)
  AUTHORS   Machida N, Umikawa M, Takei K, Sakima N, Myagmar BE, Taira K,
            Uezato H, Ogawa Y and Kariya K.
  TITLE     Mitogen-activated protein kinase kinase kinase kinase 4 as a
            putative effector of Rap2 to activate the c-Jun N-terminal kinase
  JOURNAL   J Biol Chem 279 (16), 15711-15714 (2004)
   PUBMED   14966141
REFERENCE   8  (bases 1 to 491)
  AUTHORS   Menetrey J and Cherfils J.
  TITLE     Structure of the small G protein Rap2 in a non-catalytic complex
            with GTP
  JOURNAL   Proteins 37 (3), 465-473 (1999)
   PUBMED   10591105
REFERENCE   9  (bases 1 to 491)
  AUTHORS   Cherfils J, Menetrey J, Le Bras G, Janoueix-Lerosey I, de Gunzburg
            J, Garel JR and Auzat I.
  TITLE     Crystal structures of the small G protein Rap2A in complex with its
            substrate GTP, with GDP and with GTPgammaS
  JOURNAL   EMBO J 16 (18), 5582-5591 (1997)
   PUBMED   9312017
REFERENCE   10 (bases 1 to 491)
  AUTHORS   Lerosey I, Chardin P, de Gunzburg J and Tavitian A.
  TITLE     The product of the rap2 gene, member of the ras superfamily.
            Biochemical characterization and site-directed mutagenesis
  JOURNAL   J Biol Chem 266 (7), 4315-4321 (1991)
   PUBMED   1900290
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY037826.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AY037826.1, AA957571.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q24"
     gene            1..491
                     /gene="Rap2a"
                     /note="RAP2A, member of RAS oncogene family"
                     /db_xref="GeneID:114560"
                     /db_xref="RGD:620590"
     exon            1..491
                     /gene="Rap2a"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..323
                     /gene="Rap2a"
                     /EC_number="3.6.5.2"
                     /note="rap2A-like protein; RAS related protein 2a inverted
                     question mark"
                     /codon_start=1
                     /product="ras-related protein Rap-2a"
                     /protein_id="NP_446193.1"
                     /db_xref="GeneID:114560"
                     /db_xref="RGD:620590"
                     /translation="MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEI
                     EVDSSPSVLEILDTAGTEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIR
                     VKR"
ORIGIN      
        1 ggacgatgcg cgagtacaaa gtggtggtgc tgggctcggg cggggtaggc aaatccgccc
       61 tgaccgtgca gttcgtgacc ggcaccttca ttgagaaata cgaccccacc atcgaggact
      121 tctaccgcaa ggagatcgag gtggactcgt cgccttcggt gttggagatc ctggacacgg
      181 cgggcaccga gcagttcgcg tccatgcggg acctgtacat caagaacggc cagggcttca
      241 tcctggtcta cagcctggtc aaccagcaga gcttccagga tatcaagccc atgcgggacc
      301 agatcatccg cgtgaagcgg tgagcagagc ggggcgcacg ggggctcggt ggctgcggcg
      361 atcccggtcc ctggctcgcc tgggctacac cacctccttc cggggctcag acttgcgggc
      421 tttgtttcac aagtaaaatt gggcagcccg ttaaccccca gctcagccct ttgtctctag
      481 gacgttggta g
//
