LOCUS       NM_001415062            3728 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus Rap1 GTPase-GDP dissociation stimulator 1
            (Rap1gds1), transcript variant 1, mRNA.
ACCESSION   NM_001415062 XM_039102471
VERSION     NM_001415062.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3728)
  AUTHORS   Hsieh YF, Liu GY, Lee YJ, Yang JJ, Sandor K, Sarang Z, Bononi A,
            Pinton P, Tretter L, Szondy Z and Tsay GJ.
  TITLE     Transglutaminase 2 contributes to apoptosis induction in Jurkat T
            cells by modulating Ca2+ homeostasis via cross-linking RAP1GDS1
  JOURNAL   PLoS One 8 (12), e81516 (2013)
   PUBMED   24349085
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3728)
  AUTHORS   Ravichandran A and Low BC.
  TITLE     SmgGDS antagonizes BPGAP1-induced Ras/ERK activation and
            neuritogenesis in PC12 cell differentiation
  JOURNAL   Mol Biol Cell 24 (2), 145-156 (2013)
   PUBMED   23155002
  REMARK    GeneRIF: SmgGDS, a novel Ras regulator, suppresses
            Ras-BPGAP1-induced Ras/ERK activation.
REFERENCE   3  (bases 1 to 3728)
  AUTHORS   Schonherr C, Yang HL, Vigny M, Palmer RH and Hallberg B.
  TITLE     Anaplastic lymphoma kinase activates the small GTPase Rap1 via the
            Rap1-specific GEF C3G in both neuroblastoma and PC12 cells
  JOURNAL   Oncogene 29 (19), 2817-2830 (2010)
   PUBMED   20190816
  REMARK    GeneRIF: ALK activation of Rap1 via the Rap1-specific GEF C3Gmay
            contribute to cell proliferation and oncogenesis of neuroblastoma.
REFERENCE   4  (bases 1 to 3728)
  AUTHORS   Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta
            R, Wang NS and Knepper MA.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 3728)
  AUTHORS   Thill R, Campbell WB and Williams CL.
  TITLE     Identification and characterization of the unique guanine
            nucleotide exchange factor, SmgGDS, in vascular smooth muscle cells
  JOURNAL   J Cell Biochem 104 (5), 1760-1770 (2008)
   PUBMED   18348285
  REMARK    GeneRIF: These results identify SmgGDS as a novel regulator of
            myosin organization and contraction in vascular smooth muscle
            cells.
REFERENCE   6  (bases 1 to 3728)
  AUTHORS   Shin EY, Lee CS, Cho TG, Kim YG, Song S, Juhnn YS, Park SC, Manser
            E and Kim EG.
  TITLE     betaPak-interacting exchange factor-mediated Rac1 activation
            requires smgGDS guanine nucleotide exchange factor in basic
            fibroblast growth factor-induced neurite outgrowth
  JOURNAL   J Biol Chem 281 (47), 35954-35964 (2006)
   PUBMED   16954223
  REMARK    GeneRIF: betaPak-interacting exchange factor-mediated Rac1
            activation requires smgGDS guanine nucleotide exchange factor in
            basic fibroblast growth factor-induced neurite outgrowth
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000079.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001415062.2.
            
            On Dec 20, 2022 this sequence version replaced XM_039102471.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               JACYVU010000079.1  14744543-14744730   c
            189-296             JACYVU010000079.1  14712411-14712518   c
            297-419             JACYVU010000079.1  14676854-14676976   c
            420-545             JACYVU010000079.1  14671505-14671630   c
            546-692             JACYVU010000079.1  14646027-14646173   c
            693-821             JACYVU010000079.1  14628799-14628927   c
            822-947             JACYVU010000079.1  14626854-14626979   c
            948-1091            JACYVU010000079.1  14622218-14622361   c
            1092-1223           JACYVU010000079.1  14621577-14621708   c
            1224-1358           JACYVU010000079.1  14620447-14620581   c
            1359-1484           JACYVU010000079.1  14619149-14619274   c
            1485-1624           JACYVU010000079.1  14618299-14618438   c
            1625-1751           JACYVU010000079.1  14609537-14609663   c
            1752-1880           JACYVU010000079.1  14605404-14605532   c
            1881-3728           JACYVU010000079.1  14599896-14601743   c
FEATURES             Location/Qualifiers
     source          1..3728
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q44"
     gene            1..3728
                     /gene="Rap1gds1"
                     /note="Rap1 GTPase-GDP dissociation stimulator 1"
                     /db_xref="GeneID:310909"
                     /db_xref="RGD:1308558"
     exon            1..188
                     /gene="Rap1gds1"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..2008
                     /gene="Rap1gds1"
                     /note="isoform 1 is encoded by transcript variant 1; RAP1,
                     GTP-GDP dissociation stimulator 1"
                     /codon_start=1
                     /product="rap1 GTPase-GDP dissociation stimulator 1
                     isoform 1"
                     /protein_id="NP_001401991.1"
                     /db_xref="GeneID:310909"
                     /db_xref="RGD:1308558"
                     /translation="MDNLSDALKKLKITAADKTEGSLEGCLDCLLQALAQNNAETSEK
                     IQGSGILQLFANLLTPQASCTAKVANIIAEVAKNEFMRIPCVDAGLISPLVQLLNSKD
                     QEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCGRADPANEKLLTVFCG
                     MLMNYSNENDSLQAQLINMGVIPTLVKLLGIHCHNAALTEMCLVAFGNLAELESSKEQ
                     FASTNIAEELVKLFKKQIEHDKREMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQ
                     KVDSTKEDDLAELKTASDLMVLLLLGDESMQKLFEGGKGSVFQRVLSWIPSNSQQLQL
                     AGALAIANFARNDGNCIHMVDNGIVEKLMDLLDRHVEDGNVTVQHAALSALRNLAIPV
                     VNKAKMLSAGVTETVLKFLKSEMPPVQFKLLGTLRMLIDAQAEAAEQLGKNAKLVERL
                     VEWCEAKDHAGVMGESNRLLSALIRHSKSKDVIKTIVQSGGIKHLVTMATSEHVIMQN
                     EALVALALIAALELGPAEKDLASAQLVQILHRLLADERSAPEIKYNSMVLICALMGSE
                     ALHKEVQDLAFLDVVSKLRSHENKSVAQQASLTEQRLTVQS"
     exon            189..296
                     /gene="Rap1gds1"
                     /inference="alignment:Splign:2.1.0"
     exon            297..419
                     /gene="Rap1gds1"
                     /inference="alignment:Splign:2.1.0"
     exon            420..545
                     /gene="Rap1gds1"
                     /inference="alignment:Splign:2.1.0"
     exon            546..692
                     /gene="Rap1gds1"
                     /inference="alignment:Splign:2.1.0"
     exon            693..821
                     /gene="Rap1gds1"
                     /inference="alignment:Splign:2.1.0"
     exon            822..947
                     /gene="Rap1gds1"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1091
                     /gene="Rap1gds1"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1223
                     /gene="Rap1gds1"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1358
                     /gene="Rap1gds1"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1484
                     /gene="Rap1gds1"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1624
                     /gene="Rap1gds1"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1751
                     /gene="Rap1gds1"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1880
                     /gene="Rap1gds1"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..3728
                     /gene="Rap1gds1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctcgtctcc gccgcggccg cgccgcccgc agccgcagcc gctgctcctc cccggcggcc
       61 gctccccgcg ggtccctccc tggctgcggg agacgcggag gtagagggag gacgtcgccg
      121 agccgcgccg cccgcacccg aacccttcgc ctcgccctgc cggtcctcac tctgtgggag
      181 gaacatggat aatctcagtg acgcattaaa gaagctgaag ataacagctg ctgacaagac
      241 agagggcagt ttggaaggat gcttggattg tctgcttcaa gccttggctc aaaataatgc
      301 agaaacaagt gaaaaaatac aaggaagtgg aattcttcag ttgtttgcaa acctgttgac
      361 gccacaggcc tcctgcacag ccaaagtagc caacatcata gccgaagtag ccaaaaatga
      421 atttatgcga atcccatgtg tagatgccgg attgatttca ccactggtac agctgttaaa
      481 tagcaaagac caggaagtgc tgcttcaaac tggcagggca ttaggaaaca tatgctatga
      541 tagccatgag ggcagaagtg cagttgacca agcaggtggt gcacagattg taattgacca
      601 tttaaggtcg ctgtgcggta gagcagaccc cgccaatgag aagctcttga ctgtcttttg
      661 tggcatgctg atgaactata gcaatgagaa tgattccctt caggctcagc taatcaatat
      721 gggtgtcatc ccgaccttag tgaagttact gggcatccac tgccacaacg ctgctctgac
      781 agagatgtgc ctcgtggcat ttgggaactt agcagaactc gagtcgagta aagaacagtt
      841 tgctagcaca aacattgccg aagaactggt aaaactattc aagaaacaaa tagagcatga
      901 taaaagagaa atgattttcg aagttctagc tccattggca gaaaatgacg ccattaaact
      961 gcagctggtt gaagcaggtt tggtcgagtg cctcctagag attgttcagc agaaggtgga
     1021 cagtaccaaa gaggatgacc ttgctgagct caaaactgct tcagacctca tggttttatt
     1081 acttcttgga gatgaatcca tgcagaaact ttttgaagga ggaaaaggca gtgtgttcca
     1141 aagggtgctc tcttggattc catcgaatag ccagcagctg cagcttgctg gggcattggc
     1201 cattgcaaat tttgccagga atgatgggaa ttgtattcat atggtagaca atgggattgt
     1261 agaaaaactc atggatttgc tggacagaca cgtagaagac gggaacgtga cggtacagca
     1321 tgcagcactg agcgccctca ggaacctagc cattccagtt gtaaataaag caaagatgtt
     1381 atcagccggg gtcacagaga cggttttgaa gttccttaaa tctgaaatgc ccccagttca
     1441 gttcaaactc ctgggaacgc taagaatgtt aatagatgca caagcagaag ctgctgagca
     1501 actgggaaag aacgctaagt tggtggagcg cttggttgag tggtgtgaag ccaaagatca
     1561 tgccggtgtg atgggcgagt caaacagact gctgtccgct ctcatacgac acagtaaatc
     1621 aaaagatgta attaaaacca ttgtacagag cggtggcatc aagcatctag ttaccatggc
     1681 aactagtgag catgtgataa tgcagaatga ggctctcgtc gcgttggcac taattgcagc
     1741 tttggaattg ggtcctgcgg agaaagatct cgcaagtgct cagcttgtcc agatcctaca
     1801 ccgactgcta gcagatgaga gaagtgcccc ggaaatcaag tataactcca tggttctgat
     1861 ctgtgctctc atgggctctg aagcactaca caaggaagta caagacttgg ccttcctaga
     1921 tgttgtatcc aaacttcgaa gtcatgagaa caaaagtgtt gcccaacagg cctcgctcac
     1981 agagcagaga cttacagtgc aaagctgaga actgcccctt cctggcacca ggcatcatcc
     2041 cagctccgac tcccccactg ttctccatgc agccgctcct gagactccat tctctactac
     2101 gtcacctgtg catgcgtgta atgttccagt accaatggaa gaaccgccgt aggtacctgc
     2161 ctaataagat ttctaaaccc atagttaatg tgaacctgac cgtccaagcc agtctccagc
     2221 cataactgtt agaccctgca ttcccgatgc ctgagctcca ttaagtagaa tgtgcatgtc
     2281 gtactcccat gatgacgtag acttgatgct acatgctgac ttgctcctca cacgcagtaa
     2341 cctacataat aatgtactgg taacttagaa tcaaagactg cagcagggtc tgtccagctt
     2401 atttaaaggt gaaaccgaat gctcagagta gcaccgtggt ttttgttttt gttgttgttt
     2461 tggtttctgg tttatttttt ggtgctggga aagcacggtg atcaaaagaa ctgtgtggct
     2521 gctccttcat tagtctccta ccaacgtcag gcccggtaac acctagagtt gaacagcttt
     2581 agcactcatt ctttccctgc gatttctccc tttttttttt tttttttttt tttttcctct
     2641 gagctgtata ggcagcttgc cagacaccgt gacaaacctt cctggagctc ctcgttccat
     2701 gtttaactga cagcggtaca gaggcccagg gctggaacgt ggttttcagt gtcagcagaa
     2761 tgtaggaagg agttaaaccc tagcacactg aaccactttg gatcctgcct gtacttcaga
     2821 ttccgatttg tttgtagtta acgtctaaac cttcatcagt agccagcatt gtcaacgtgt
     2881 gtctctgcaa cgtccttggc atttgttcag tgaaggaaac ctgaggatgg cttgtttggt
     2941 gcagaacgga cttttttttt ccctctggtt ttcatcattc agggtgaaaa cgggggggct
     3001 tcgtctttca cgctcctttt caatgtgcta attcccgatg aacgtaagag gaaacacgac
     3061 gtaagctagc ctacactaaa gaaaggaagg ccggttttaa aagccatagt agccagtcca
     3121 gtacattctg cagatggcct catagcaatc actgttagag ttcttcacct ccactttccc
     3181 actgagaacc acaataatct cccggctgta agccgggact cgatgtaaag actcttcttg
     3241 gcaaaatgta gtgtgctcat cactgccact taccaccacc acgtgagttt ttagagcttt
     3301 gacacacaat ctttataaat gaatcgggat tccctgtgag ccgcctgcct cctcacaccc
     3361 aagtttgagc cctgctggtg tccaagggag gctgggctct gttacaggaa tggagggcag
     3421 tgagagggct gctgagaggg gaccagctcc ttcctcccca acaggagata catgcatctc
     3481 tgcattctct aagtcagact ttgcttttca cacttttaaa ttcaagaaag atctacctaa
     3541 tttaagtaaa aacccgactg acaattccct ctgatgtcca aataagggaa ctttggtgag
     3601 cgcctgtgct acactcactg taggaacgag ttctttattg tctttctcct gggctggata
     3661 agtggactga tgttgcataa tactgtccat attaataact taataaataa atagtatatg
     3721 aaactaca
//
