LOCUS       NM_001401654            6416 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus RAP1 GTPase activating protein 2 (Rap1gap2),
            mRNA.
ACCESSION   NM_001401654 XM_017597292
VERSION     NM_001401654.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6416)
  AUTHORS   Yasuda,T. and Fukuda,M.
  TITLE     Slp2-a controls renal epithelial cell size through regulation of
            Rap-ezrin signaling independently of Rab27
  JOURNAL   J Cell Sci 127 (Pt 3), 557-570 (2014)
   PUBMED   24284068
REFERENCE   2  (bases 1 to 6416)
  AUTHORS   Sadrian,B., Cheng,T.W., Shull,O. and Gong,Q.
  TITLE     Rap1gap2 regulates axon outgrowth in olfactory sensory neurons
  JOURNAL   Mol Cell Neurosci 50 (3-4), 272-282 (2012)
   PUBMED   22732430
REFERENCE   3  (bases 1 to 6416)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   4  (bases 1 to 6416)
  AUTHORS   Stork,P.J. and Dillon,T.J.
  TITLE     Multiple roles of Rap1 in hematopoietic cells: complementary versus
            antagonistic functions
  JOURNAL   Blood 106 (9), 2952-2961 (2005)
   PUBMED   16076873
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Feb 17, 2022 this sequence version replaced XM_017597292.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1512735.1,
                                           SRR26360172.795599.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-232               JAXUCZ010000010.1  59952156-59952387   c
            233-268             JAXUCZ010000010.1  59930611-59930646   c
            269-353             JAXUCZ010000010.1  59855078-59855162   c
            354-389             JAXUCZ010000010.1  59812675-59812710   c
            390-434             JAXUCZ010000010.1  59809282-59809326   c
            435-467             JAXUCZ010000010.1  59808436-59808468   c
            468-680             JAXUCZ010000010.1  59807883-59808095   c
            681-784             JAXUCZ010000010.1  59806521-59806624   c
            785-863             JAXUCZ010000010.1  59796857-59796935   c
            864-917             JAXUCZ010000010.1  59796105-59796158   c
            918-1001            JAXUCZ010000010.1  59793663-59793746   c
            1002-1102           JAXUCZ010000010.1  59787466-59787566   c
            1103-1232           JAXUCZ010000010.1  59785660-59785789   c
            1233-1388           JAXUCZ010000010.1  59783545-59783700   c
            1389-1460           JAXUCZ010000010.1  59779017-59779088   c
            1461-1547           JAXUCZ010000010.1  59778445-59778531   c
            1548-1682           JAXUCZ010000010.1  59776264-59776398   c
            1683-1820           JAXUCZ010000010.1  59768017-59768154   c
            1821-1939           JAXUCZ010000010.1  59766221-59766339   c
            1940-2053           JAXUCZ010000010.1  59763789-59763902   c
            2054-2171           JAXUCZ010000010.1  59763452-59763569   c
            2172-2298           JAXUCZ010000010.1  59762590-59762716   c
            2299-2375           JAXUCZ010000010.1  59759133-59759209   c
            2376-2414           JAXUCZ010000010.1  59758630-59758668   c
            2415-6416           JAXUCZ010000010.1  59753822-59757823   c
FEATURES             Location/Qualifiers
     source          1..6416
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..6416
                     /gene="Rap1gap2"
                     /gene_synonym="Garnl4"
                     /note="RAP1 GTPase activating protein 2"
                     /db_xref="GeneID:303298"
                     /db_xref="RGD:1304590"
     exon            1..232
                     /gene="Rap1gap2"
                     /gene_synonym="Garnl4"
                     /inference="alignment:Splign:2.1.0"
     exon            233..268
                     /gene="Rap1gap2"
                     /gene_synonym="Garnl4"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..2384
                     /gene="Rap1gap2"
                     /gene_synonym="Garnl4"
                     /note="GTPase activating RANGAP domain-like 4; GTPase
                     activating Rap/RanGAP domain-like 4"
                     /codon_start=1
                     /product="rap1 GTPase-activating protein 2"
                     /protein_id="NP_001388583.1"
                     /db_xref="GeneID:303298"
                     /db_xref="RGD:1304590"
                     /translation="MLAGLKVKKQELANSSDVTLPDRPLSPPLTAPPTMKSAEFFEML
                     EKMQGIKLEEQRPGPQKNKEDYIPYPSIEEVVEKGGPYPQIILPQFGGYWIEDPENVG
                     TPTSLGSSVYEEEEEDSLSPNTFGYKLECRGEARAYRRHFLGKDHLNFYCTGSSLGNL
                     ILSIKCEEAEGIEYLRIILRSKLKTVHERIPLAGLSKLPSVPQIAKAFCDDAVGLKFN
                     PVLYPKASQMIVSYDEHDVNNTFKFGVIYQKARQTLEEELFGNNEESPAFKEFLDLLG
                     DTITLQDFKGFRGGLDVTHGQTGVESVYTTFRDREIMFHVSTKLPFTDGDTQQLQRKR
                     HIGNDIVAIIFQEENTPFVPDMIASNFLHAYIVVQAESTGTETPSYKVSVTAREDVPA
                     FGPPLPSPPVFQKGTEFREFLLTKLTNAENACCKSDKFAKLEDRTRAALLDNLHDELH
                     THTQVMLGMGPEEDKFENGGHGGFLESFKRAIRVRSHSMETMVGSQRKLHGGNIPGSL
                     SGGIVHNSMEVTKTTFSPPVAAATVKNQSRSPIKRRSGLFPRLHSGSEGQGDSRTRCD
                     SASSTPKTPDGGHSSQEIKSETSSNPSSPEICPNKEKPFIKLKENGRANISRSSSSTS
                     SFSSTAGEGEAMEECDSGSSQPSTTSPFKQEVFVYSPSPSSESPSLGAAATPIIMSRS
                     PTDAKSRNSPRSNLKFRFDKLSHASSSAGH"
     exon            269..353
                     /gene="Rap1gap2"
                     /gene_synonym="Garnl4"
                     /inference="alignment:Splign:2.1.0"
     exon            354..389
                     /gene="Rap1gap2"
                     /gene_synonym="Garnl4"
                     /inference="alignment:Splign:2.1.0"
     exon            390..434
                     /gene="Rap1gap2"
                     /gene_synonym="Garnl4"
                     /inference="alignment:Splign:2.1.0"
     exon            435..467
                     /gene="Rap1gap2"
                     /gene_synonym="Garnl4"
                     /inference="alignment:Splign:2.1.0"
     exon            468..680
                     /gene="Rap1gap2"
                     /gene_synonym="Garnl4"
                     /inference="alignment:Splign:2.1.0"
     exon            681..784
                     /gene="Rap1gap2"
                     /gene_synonym="Garnl4"
                     /inference="alignment:Splign:2.1.0"
     exon            785..863
                     /gene="Rap1gap2"
                     /gene_synonym="Garnl4"
                     /inference="alignment:Splign:2.1.0"
     exon            864..917
                     /gene="Rap1gap2"
                     /gene_synonym="Garnl4"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1001
                     /gene="Rap1gap2"
                     /gene_synonym="Garnl4"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1102
                     /gene="Rap1gap2"
                     /gene_synonym="Garnl4"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1232
                     /gene="Rap1gap2"
                     /gene_synonym="Garnl4"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1388
                     /gene="Rap1gap2"
                     /gene_synonym="Garnl4"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1460
                     /gene="Rap1gap2"
                     /gene_synonym="Garnl4"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1547
                     /gene="Rap1gap2"
                     /gene_synonym="Garnl4"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1682
                     /gene="Rap1gap2"
                     /gene_synonym="Garnl4"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1820
                     /gene="Rap1gap2"
                     /gene_synonym="Garnl4"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..1939
                     /gene="Rap1gap2"
                     /gene_synonym="Garnl4"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..2053
                     /gene="Rap1gap2"
                     /gene_synonym="Garnl4"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..2171
                     /gene="Rap1gap2"
                     /gene_synonym="Garnl4"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2298
                     /gene="Rap1gap2"
                     /gene_synonym="Garnl4"
                     /inference="alignment:Splign:2.1.0"
     exon            2299..2375
                     /gene="Rap1gap2"
                     /gene_synonym="Garnl4"
                     /inference="alignment:Splign:2.1.0"
     exon            2376..2414
                     /gene="Rap1gap2"
                     /gene_synonym="Garnl4"
                     /inference="alignment:Splign:2.1.0"
     exon            2415..6416
                     /gene="Rap1gap2"
                     /gene_synonym="Garnl4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcccgccag gtgtgcgagc ggcccggcgc agctttgtgg cggccggtgt gcgcgtgtgc
       61 gcgccgcggt gacggtgcac gcggctgggc gggctgcgag ggaaccccgc gctgaggagg
      121 agggggctca gtcctgatgg agagtcgtgg acgccgcgcc gaccagcgcg cccgttgggt
      181 gagccggcag gactgactat tgacattccg tccacgtcgg gagtgtggga aggatcgaca
      241 agaccatgct ggcgggtctg aaggtcaaga agcaggagct ggccaacagc tcggatgtga
      301 ccctcccaga tcggccactg tcccctcctc tcactgctcc tccaaccatg aagtctgcgg
      361 agttcttcga gatgctggaa aagatgcagg gaatcaagct tgaagagcag aggccaggac
      421 cccagaagaa caaggaggac tatatccctt accccagcat tgaagaggtt gtggagaagg
      481 gaggcccata ccctcagatc atcctgcctc agtttggagg ctactggatt gaggacccag
      541 agaacgtggg tacaccaacg tcactgggca gcagtgttta tgaggaggag gaagaggaca
      601 gcctaagccc caacacgttc ggctacaagc ttgagtgcag aggtgaagcc agagcctacc
      661 gcaggcactt tctaggcaag gatcatctaa acttttactg tactggcagc agcctgggga
      721 atttgatcct gtccatcaaa tgcgaggaag ctgagggcat cgagtacctt cggatcatcc
      781 tcaggtccaa actgaagacg gtgcatgaga gaatcccctt ggctggattg agcaagttgc
      841 ccagcgtccc tcagatcgcc aaggctttct gtgatgatgc agtggggctg aaattcaacc
      901 ctgtcttgta ccccaaggcc tctcagatga ttgtgtccta tgatgagcat gatgtcaaca
      961 acactttcaa gtttggggtt atttatcaga aagccaggca gaccctggaa gaggagctat
     1021 ttgggaacaa tgaggagagc ccagctttca aggagttttt ggatctcttg ggggacacca
     1081 tcacactgca ggatttcaaa ggtttccgag gaggcctgga tgtgacccat ggacagacag
     1141 gggtggagtc ggtgtacacc actttccggg accgggagat catgttccat gtctctacca
     1201 agctgccctt cacggatggt gacacccagc agctgcagag aaagcgacat attgggaatg
     1261 acatcgtggc catcatcttt caagaagaaa acactccatt tgtcccagat atgatcgcat
     1321 caaacttctt acatgcctac attgtcgtcc aggctgaaag cacaggcacg gagaccccat
     1381 cctacaaggt atcagtcact gcgagggaag atgtgcctgc ctttggcccc cctctgccaa
     1441 gcccgcctgt tttccagaag ggcacagaat tccgggagtt tctgctcacc aagctcacga
     1501 atgcagagaa tgcttgctgc aagtcggaca agtttgccaa gctggaggac cggacccggg
     1561 ctgctctcct ggacaacctt cacgatgagc tccacacaca tactcaggtc atgctaggca
     1621 tgggcccaga ggaggacaag tttgagaacg ggggccatgg aggattcctg gagtctttta
     1681 agagagccat ccgagtgcgc agccattcca tggagaccat ggtgggcagc cagaggaagc
     1741 tgcatggtgg gaacattcct ggcagcctca gtggaggtat tgtccacaac agcatggagg
     1801 tcaccaagac caccttctcg cctccagtgg ccgcagcaac cgtgaagaac cagtcacgga
     1861 gccccatcaa gcggcggtcg ggactcttcc cccgcctgca ctcaggctct gaaggccagg
     1921 gggacagccg gacacgatgt gacagtgcct ccagcacccc caaaacccca gatggcggac
     1981 actcttctca ggagataaag tcggagacct cgtcaaatcc cagctctcca gaaatctgtc
     2041 ccaacaaaga gaagcccttc atcaagttga aggagaatgg ccgtgccaac atctcccgct
     2101 cctcctccag caccagcagc ttcagcagca cagcagggga gggcgaggcc atggaggagt
     2161 gtgacagtgg gagcagccag ccgtccacaa cctcgccctt caagcaggag gtgtttgtct
     2221 acagcccgtc ccccagcagc gagagcccca gcctgggggc cgctgccacg cccatcatca
     2281 tgagccggag tcccacagat gccaaaagca gaaactcccc gaggtcaaac ctgaaattcc
     2341 gctttgataa actcagccat gctagctcca gtgcgggtca ctaatgtgaa agtgaaggcc
     2401 ttcccttgtc caagggaagt gtggactttg gtctacagaa ggctcctaat tccagcagct
     2461 tgggggtgcc gtctactact ctgaccgtgt aggcctgctg tctcactggt cgcctgccca
     2521 gcagaccagc tgtctgtccc acgtcctgac ctggccatga ccttgccgga tccttctcca
     2581 gacctgaaag ccccagcctg tacttctgac ctcccgatgt gaccggctct ctgagtcaac
     2641 tatcatgttt tacatgcagg aaaagatttg ggcaaggggg actctgagtc ccagggggct
     2701 cagggagaag ttagggagct cgtctgcccc agagacagaa gggggttgtg tggtggggag
     2761 cagaggtaac tgcagaatgg tgggtgggta ctgtctgtct tgggtcacag tacagtgcct
     2821 tcctgggcat ggtggaaagg ctgctcttcc aggaatatcc cagcatcctc aaggttgaat
     2881 gcctttgcat ttctgacaca tctgctggcc caggcctagg gagctctgtc ccttctgcca
     2941 gggtcctctc aggaggctca ggatgctgga agctccaagt tagagctagg tgttccagga
     3001 cccgggtgca tgctcccttg actgtagtct caaggttttt cctttctaac tctattcaag
     3061 ctgctgatca tctttgtggt tggagaagcc ctggtagtgg gcagccagga gtctggagtc
     3121 cagtgcagga ggactcaggt ctccactttt gtgagatttt ggaaaagaca aagtttaagc
     3181 catctcttag gcgagagaga ggggagtgat gtagcggact tggcaagttt tggtcagtca
     3241 agtatgtggt ggaaacaatc tagtgttctt ccacctccgt ggtcctgtca cctgtgaggg
     3301 ggctgatact gcctagggcc tgcttctagg ctcagtcctc tccagtcttc ttccttccat
     3361 ctccaactgc aggtttctag accactgtcc catctgcagg gctcctggaa gcccagatcc
     3421 cacgagcccg tgctttaaga cacaggccat ctgtattcct tgcatggccg ccttctctgg
     3481 gtgagccggc tcatcccgag gagctgtcct tggctcctca gccttccagg ttcgcagggc
     3541 ttttctgctc ctgggttggg agtagagtat ccaccaggct aaaccctagc tctgcacagc
     3601 agggacttga agatcccagc ccattaggta cacataggtc tgtggcacag gactgcttag
     3661 tcctgggccc ccatttcagt gagcagacga ccagatttcc agccaagtgc tttgtctgca
     3721 taggctccta ttcccaagcc aaagtacaga agggtggggc agcccttggg gctggtattg
     3781 taactgtgtc atctgagcac aatcttgatc cttcattccc catgcactta tgtgcaccca
     3841 ggggaagggg cggtctcccc gccactccac tcggggaaac ctgcttacat gaaatactaa
     3901 tctggtaaga cttgttctag ttagaaggtc aacagaatat ctgtttatct tttattaaaa
     3961 gccagcgtag cagcacccag ggctggaagg aggcgggtgg attctggcag tgttctgctg
     4021 gcaggttcct gctcgaactt gaaaggtcag actgtgtttt ctttgaaact atgacaggac
     4081 tctggctccc ttctcggtgt tggacagctt tacctgctta gtggttctgc tgtgttgtat
     4141 tatggtctgg gtctcccagg ggcttccagg ttgtcccatg ttgtctggaa accttataag
     4201 ctttgtcccc actgcttcgg ctactctgcc tgcaggcgtt acctctgggc cagtggatag
     4261 gatggctgac tgtgtacaga ggcagtgaga ggccctggct gtggtcttca cccttggttt
     4321 gctcctgaga tactctgggc aggatatgag gtgcccctga cctctgctca tgcctctgtc
     4381 tatctagcag gtcaacctgt ggcttccaga gtaggtacca cagccccgct caagttctct
     4441 ctgcttagca ggaggaggat aatggtgggg ctctgcctcc tctcagccct ctgggttgga
     4501 gactgttcct cccacactct gatccagtct tagggctccg agtcttgctg agaccccttc
     4561 atgtgactgg gcttctgtag acaatgcttc tgcttggatt tgggggaacc tttccactgt
     4621 tacctccaca agagattctc ctgtcacaac cgtggaaact gttttgcagg tgttagtagg
     4681 catccagacg cccccagctc tgtggataac ctgaaacaga tgtgggagag ctccgaatag
     4741 aaggccaaag ccagagtttc ctctgcgata atgaatgtcg aatggtgttt cttggaaaac
     4801 aatcccaggc accatttgat acccaagcct tctggcccct gcttgcttct catcagacca
     4861 cgtcatcttc cagaggaaca gaaagaactt gcctgaggcc acacagccgc ctagtggcaa
     4921 agctgttact agacccacaa cagccttggc cctactgcat accaactcta cctactgttg
     4981 gctcagcaag cggttgcatt tcttggagcc tgggttttga ggaagcccaa tagctggggt
     5041 ctctgcattg gcaggagagg tgctgggggt ggagggtatt aatggggcct cagtctctgc
     5101 tgtttcccac catgagaagt cttggtcagc gaggacacag ccagtggctt gggtgaagga
     5161 catggacggg gagggcttac ataaagtgct tctttgggtt ttcagtgact gggacaaagg
     5221 tacctggaca aaagtgtctt tgtcctaaat caggacagaa agtgataaaa tgaactaatt
     5281 ctctggtcta tcttctctcc ctccctctct ccatcccttc cttcctcttt ttttggtggt
     5341 gctggggacg tccccaaggt cttgctcatg ctgagtgaga accctgccac cgagtctagg
     5401 tccagacctc tccagccttt taaaatggag gtgggtaata aaagcccaga tcaggtgtct
     5461 aggcagggca cagccagttt cattttcttt cctttgaccc tttaaggtgc caactcaaac
     5521 atcacctttt gttctttgtt tctcagtctg caaagacagc tgtgttgtgt gtgtgtgtgt
     5581 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgggttgcc cggggttcag
     5641 atagagctta tggtttctgg gccagcagca accaagttag ctccatgctc tggaccccca
     5701 tgctccctcc ccagcttcta gttaccgctc aatcaaaggc aaggttgaca cagagaacaa
     5761 ggctactcct gccacctgga gtggtagagg gcttctgagg catcctacaa agctctggtg
     5821 tctgtttcag caccagctgc atgcccacac caatcccacg tctcttcaca gccaggctat
     5881 gtactccttt gggagaaaga agacaacttc cagagccaag ggtggtctgt agtgagcagc
     5941 agctggggca gtggctttgg cctgggcctt accatctgca ccagatggtg tgcttggctg
     6001 caagactgga attagtcgtc gttgtctttg gttctgtgac attcccatgt gaaagggtgt
     6061 aattcccctt cccactcctt agcgtatgca ccaacttgtg atgtccccgc ccgatctcca
     6121 gctcccaggg tgccggtgtt gccatgtgaa gagataccca tgtggtagaa cctaagaggt
     6181 gtagttggaa gtgacccctg tgacgatgac ttttctttgc ttcctctcag tgaggggggt
     6241 gatttgtaga tcctgactgc ctatgtgatg taaatagtgt acatctaatt tattgctatg
     6301 gtagcacatt gtatttgtta atgtataaaa caaattctaa aaggttgaaa atgtatattt
     6361 tgttgcttaa atgtgtcttt gcagaaattg acaataaata acatattttg tgtcca
//
