LOCUS       NM_001100713            3383 bp    mRNA    linear   ROD 11-AUG-2024
DEFINITION  Rattus norvegicus Rap1 GTPase-activating protein (Rap1gap),
            transcript variant 1, mRNA.
ACCESSION   NM_001100713 XM_001070178 XM_003750062 XM_003750063 XM_003750064
            XM_003754107 XM_003754108 XM_233609
VERSION     NM_001100713.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3383)
  AUTHORS   Han,M., Zhang,D., Ji,J., Zhang,J. and Qin,M.
  TITLE     Downregulating miR-184 relieves calcium oxalate crystal-mediated
            renal cell damage via activating the Rap1 signaling pathway
  JOURNAL   Aging (Albany NY) 15 (24), 14749-14763 (2023)
   PUBMED   38154105
  REMARK    GeneRIF: Downregulating miR-184 relieves calcium oxalate
            crystal-mediated renal cell damage via activating the Rap1
            signaling pathway.
REFERENCE   2  (bases 1 to 3383)
  AUTHORS   Qin,M., Li,Q., Wang,Y., Li,T., Gu,Z., Huang,P. and Ren,L.
  TITLE     Rutin treats myocardial damage caused by pirarubicin via regulating
            miR-22-5p-regulated RAP1/ERK signaling pathway
  JOURNAL   J Biochem Mol Toxicol 35 (1), e22615 (2021)
   PUBMED   32864822
  REMARK    GeneRIF: Rutin treats myocardial damage caused by pirarubicin via
            regulating miR-22-5p-regulated RAP1/ERK signaling pathway.
REFERENCE   3  (bases 1 to 3383)
  AUTHORS   Korayem,A.H., Mujica,P.E., Aramoto,H., Duran,R.G., Nepali,P.R.,
            Kim,D.D., Harris,A.L., Sanchez,F.A. and Duran,W.N.
  TITLE     Endothelial cAMP deactivates ischemia-reperfusion-induced
            microvascular hyperpermeability via Rap1-mediated mechanisms
  JOURNAL   Am J Physiol Heart Circ Physiol 313 (1), H179-H189 (2017)
   PUBMED   28476918
  REMARK    GeneRIF: Here, we demonstrate that 1) stimulation of cAMP
            production deactivates ischemia-reperfusion-induced
            hyperpermeability in muscle and endothelial cells; 2) VEGF mRNA
            expression is not enhanced by brief ischemia, suggesting that VEGF
            mechanisms do not activate immediate postischemic
            hyperpermeability; and 3) deactivation mechanisms operate via
            cAMP-exchange protein activated by cAMP 1-Rap1 to restore integrity
            of the endot
REFERENCE   4  (bases 1 to 3383)
  AUTHORS   DiStefano,P.V., Smrcka,A.V. and Glading,A.J.
  TITLE     Phospholipase Cepsilon Modulates Rap1 Activity and the Endothelial
            Barrier
  JOURNAL   PLoS One 11 (9), e0162338 (2016)
   PUBMED   27612188
  REMARK    GeneRIF: results have shown a novel role of PLCepsilon in the
            maintenance of endothelial barrier function, via its CDC25 GEF
            domain and lipase activity, and subsequent up-regulation of Rap1
            activity
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3383)
  AUTHORS   Le Borgne,M., Chartier,N., Buchet-Poyau,K., Destaing,O.,
            Faurobert,E., Thibert,C., Rouault,J.P., Courchet,J., Negre,D.,
            Bouvard,D., Albiges-Rizo,C., Rousseaux,S., Khochbin,S.,
            Segretain,D., Crepieux,P., Guillou,F., Durand,P., Perrard,M.H. and
            Billaud,M.
  TITLE     The RNA-binding protein Mex3b regulates the spatial organization of
            the Rap1 pathway
  JOURNAL   Development 141 (10), 2096-2107 (2014)
   PUBMED   24803656
REFERENCE   6  (bases 1 to 3383)
  AUTHORS   Valles,A.M., Beuvin,M. and Boyer,B.
  TITLE     Activation of Rac1 by paxillin-Crk-DOCK180 signaling complex is
            antagonized by Rap1 in migrating NBT-II cells
  JOURNAL   J Biol Chem 279 (43), 44490-44496 (2004)
   PUBMED   15308668
  REMARK    GeneRIF: Rac1 activation by paxillin-Crk-DOCK180 signaling complex
            is antagonized by Rap1 in migrating rat cells
REFERENCE   7  (bases 1 to 3383)
  AUTHORS   Daumke,O., Weyand,M., Chakrabarti,P.P., Vetter,I.R. and
            Wittinghofer,A.
  TITLE     The GTPase-activating protein Rap1GAP uses a catalytic asparagine
  JOURNAL   Nature 429 (6988), 197-201 (2004)
   PUBMED   15141215
REFERENCE   8  (bases 1 to 3383)
  AUTHORS   Tsygankova,O.M., Feshchenko,E., Klein,P.S. and Meinkoth,J.L.
  TITLE     Thyroid-stimulating hormone/cAMP and glycogen synthase kinase 3beta
            elicit opposing effects on Rap1GAP stability
  JOURNAL   J Biol Chem 279 (7), 5501-5507 (2004)
   PUBMED   14660640
  REMARK    GeneRIF: Rap1GAP protein levels are tightly regulated and it may
            have a role as a tumor suppressor
REFERENCE   9  (bases 1 to 3383)
  AUTHORS   Meng,J. and Casey,P.J.
  TITLE     Activation of Gz attenuates Rap1-mediated differentiation of PC12
            cells
  JOURNAL   J Biol Chem 277 (45), 43417-43424 (2002)
   PUBMED   12198116
  REMARK    GeneRIF: a model in which activation of G(z) results in recruitment
            of Rap1GAP to the membrane where it can effectively down-regulate
            Rap1 signaling (Rap1)(Rap1GAP)
REFERENCE   10 (bases 1 to 3383)
  AUTHORS   Mochizuki,N., Ohba,Y., Kiyokawa,E., Kurata,T., Murakami,T.,
            Ozaki,T., Kitabatake,A., Nagashima,K. and Matsuda,M.
  TITLE     Activation of the ERK/MAPK pathway by an isoform of rap1GAP
            associated with G alpha(i)
  JOURNAL   Nature 400 (6747), 891-894 (1999)
   PUBMED   10476970
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Jan 5, 2023 this sequence version replaced NM_001100713.1.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.14672.1,
                                           SRR26643285.21085.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               JAXUCZ010000005.1  155175300-155175453
            155-190             JAXUCZ010000005.1  155177253-155177288
            191-284             JAXUCZ010000005.1  155198058-155198151
            285-320             JAXUCZ010000005.1  155204017-155204052
            321-368             JAXUCZ010000005.1  155204793-155204840
            369-407             JAXUCZ010000005.1  155205657-155205695
            408-593             JAXUCZ010000005.1  155206034-155206219
            594-697             JAXUCZ010000005.1  155208974-155209077
            698-776             JAXUCZ010000005.1  155209316-155209394
            777-830             JAXUCZ010000005.1  155209768-155209821
            831-914             JAXUCZ010000005.1  155210623-155210706
            915-1015            JAXUCZ010000005.1  155210893-155210993
            1016-1145           JAXUCZ010000005.1  155211117-155211246
            1146-1301           JAXUCZ010000005.1  155212193-155212348
            1302-1373           JAXUCZ010000005.1  155212609-155212680
            1374-1460           JAXUCZ010000005.1  155213213-155213299
            1461-1598           JAXUCZ010000005.1  155213574-155213711
            1599-1730           JAXUCZ010000005.1  155215178-155215309
            1731-1808           JAXUCZ010000005.1  155217106-155217183
            1809-1918           JAXUCZ010000005.1  155218030-155218139
            1919-2032           JAXUCZ010000005.1  155218826-155218939
            2033-2156           JAXUCZ010000005.1  155219963-155220086
            2157-2259           JAXUCZ010000005.1  155220665-155220767
            2260-2363           JAXUCZ010000005.1  155221031-155221134
            2364-2404           JAXUCZ010000005.1  155221298-155221338
            2405-3383           JAXUCZ010000005.1  155221644-155222622
FEATURES             Location/Qualifiers
     source          1..3383
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3383
                     /gene="Rap1gap"
                     /gene_synonym="Rap1ga1"
                     /note="Rap1 GTPase-activating protein"
                     /db_xref="GeneID:313644"
                     /db_xref="RGD:1309908"
     exon            1..154
                     /gene="Rap1gap"
                     /gene_synonym="Rap1ga1"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..2372
                     /gene="Rap1gap"
                     /gene_synonym="Rap1ga1"
                     /note="isoform 1 is encoded by transcript variant 1; rap1
                     GTPase-activating protein 1"
                     /codon_start=1
                     /product="rap1 GTPase-activating protein 1 isoform 1"
                     /protein_id="NP_001094183.1"
                     /db_xref="GeneID:313644"
                     /db_xref="RGD:1309908"
                     /translation="MSGRKRSFTFGAYGGVDKSFSPRQSVWRSDGQKHSFPQTLNVLL
                     VDSVPSHPASPYPKNTDLFEMIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLG
                     REGPFPLILLPQFGGYWIEGTNHEISSIPETEPLQSPTTKVKLECNPTARIYRKHFLG
                     KEHFNYYSLDTALGHLVFSLKYDVIGDQEHLRLLLRTKCRTYHDVIPISCLTEFPNVV
                     QMAKLVCEDVNVDRFYPVLYPKASRLIVTFDEHVISNNFKFGVIYQKLGQTSEEELFS
                     TNEESPAFVEFLEFLGQKVKLQDFKGFRGGLDVTHGQTGTESVYCNFRNKEIMFHVST
                     KLPYTEGDAQQLQRKRHIGNDIVAVVFQDENTPFVPDMIASNFLHAYVVVQAEGGGPD
                     GPLYKVSVTARDDVPFFGPPLPDPAVFRKGPEFQEFLLTKLINAEYACYKAEKFAKLE
                     ERTRAALLETLYEELHIHSQSMMGLGGDDDKMENGSGGGGFFESFKRVIRSRSQSMDA
                     MGLSNKKPNTVSTSHSGSFTPNNPDLAKAAGISLLIPGKSASRFGRRGSALGIGAVEE
                     SLIVPGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKRESPPAGQKTPDSGHVSQEPKS
                     ENSSTQSSPEMPTTKNRVESAAQRTEVLQGFSRSSSSASSFTSVVEETEGVDGDDTGM
                     ESVSSSGTPHKRDSFLYSTWLDDSVSTTSGGSSPGLTRSPHPDAVKSGDPACPEIKIQ
                     LETSEQHTPQMGC"
     exon            155..190
                     /gene="Rap1gap"
                     /gene_synonym="Rap1ga1"
                     /inference="alignment:Splign:2.1.0"
     exon            191..284
                     /gene="Rap1gap"
                     /gene_synonym="Rap1ga1"
                     /inference="alignment:Splign:2.1.0"
     exon            285..320
                     /gene="Rap1gap"
                     /gene_synonym="Rap1ga1"
                     /inference="alignment:Splign:2.1.0"
     exon            321..368
                     /gene="Rap1gap"
                     /gene_synonym="Rap1ga1"
                     /inference="alignment:Splign:2.1.0"
     exon            369..407
                     /gene="Rap1gap"
                     /gene_synonym="Rap1ga1"
                     /inference="alignment:Splign:2.1.0"
     exon            408..593
                     /gene="Rap1gap"
                     /gene_synonym="Rap1ga1"
                     /inference="alignment:Splign:2.1.0"
     exon            594..697
                     /gene="Rap1gap"
                     /gene_synonym="Rap1ga1"
                     /inference="alignment:Splign:2.1.0"
     exon            698..776
                     /gene="Rap1gap"
                     /gene_synonym="Rap1ga1"
                     /inference="alignment:Splign:2.1.0"
     exon            777..830
                     /gene="Rap1gap"
                     /gene_synonym="Rap1ga1"
                     /inference="alignment:Splign:2.1.0"
     exon            831..914
                     /gene="Rap1gap"
                     /gene_synonym="Rap1ga1"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1015
                     /gene="Rap1gap"
                     /gene_synonym="Rap1ga1"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1145
                     /gene="Rap1gap"
                     /gene_synonym="Rap1ga1"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1301
                     /gene="Rap1gap"
                     /gene_synonym="Rap1ga1"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1373
                     /gene="Rap1gap"
                     /gene_synonym="Rap1ga1"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1460
                     /gene="Rap1gap"
                     /gene_synonym="Rap1ga1"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1598
                     /gene="Rap1gap"
                     /gene_synonym="Rap1ga1"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1730
                     /gene="Rap1gap"
                     /gene_synonym="Rap1ga1"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1808
                     /gene="Rap1gap"
                     /gene_synonym="Rap1ga1"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1918
                     /gene="Rap1gap"
                     /gene_synonym="Rap1ga1"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..2032
                     /gene="Rap1gap"
                     /gene_synonym="Rap1ga1"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2156
                     /gene="Rap1gap"
                     /gene_synonym="Rap1ga1"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..2259
                     /gene="Rap1gap"
                     /gene_synonym="Rap1ga1"
                     /inference="alignment:Splign:2.1.0"
     exon            2260..2363
                     /gene="Rap1gap"
                     /gene_synonym="Rap1ga1"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..2404
                     /gene="Rap1gap"
                     /gene_synonym="Rap1ga1"
                     /inference="alignment:Splign:2.1.0"
     exon            2405..3383
                     /gene="Rap1gap"
                     /gene_synonym="Rap1ga1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtacccggac ctcagctggc gggcggcccg gggcgcacac ggtccgggtt ggggcggcgt
       61 tgccaaggtg accctgcgct gggctggcga cgggcagcgg cgacgatacc atgagcggcc
      121 ggaagcgcag cttcaccttc ggtgcctatg gaggggtgga caaatccttc tctcctcgac
      181 agagtgtgtg gaggagtgat ggacagaaac acagcttccc tcagacactg aacgtgttac
      241 tagtggactc agttccctcc caccctgctt caccctaccc taagaacaca gatctgtttg
      301 agatgattga aaagatgcag ggaagcagga tggatgaaca acgatgctcc ttcccgccac
      361 ccctcaagac ggaggaggac tacattccct acccaagtgt ccatgaggtt ttggggcgag
      421 aagggccctt ccccctcatc ctgctgcccc agtttggggg ctactggatt gaaggcacca
      481 accatgaaat cagcagtatc cccgagacag agccgctgca gtctcccacc accaaggtca
      541 agctggagtg caaccccaca gccagaatct accggaagca ctttctcggc aaggagcact
      601 tcaattacta ctcgctggac actgctctcg gccacctggt cttctcgctc aagtatgatg
      661 tcatcgggga tcaagagcac ctgaggctat tgcttaggac caagtgtcgg acctaccatg
      721 atgtcatccc catctcctgc ctcaccgagt tccccaacgt ggtccagatg gcaaagttgg
      781 tatgtgaaga tgtcaacgtg gatcgattct accccgtgct ttatcctaag gcttccagac
      841 tcatcgtcac ctttgacgag catgttatca gcaataactt caagttcgga gtcatctatc
      901 agaagctggg gcagacatcc gaggaggaac tgttcagcac caacgaggaa agtcctgcct
      961 ttgtggaatt cctcgagttt ctgggccaga aagtcaaact gcaggatttc aaggggttcc
     1021 gaggaggcct ggacgtgact cacgggcaga ccgggaccga gtccgtctac tgcaacttcc
     1081 gcaacaagga gatcatgttt catgtgtcca ccaagctgcc atacacagaa ggggacgccc
     1141 agcagttgca gcggaaacgg cacatcggga acgacatcgt cgccgtggtc ttccaggacg
     1201 aaaacacgcc cttcgtgcca gacatgattg cttccaactt cctgcatgcc tatgtggtgg
     1261 tgcaggcaga ggggggtggc cccgatggcc ccctctacaa ggtctcagtc accgcgagag
     1321 acgatgtgcc ctttttcggg cctcccctcc cagatcctgc tgtgttcagg aaggggcctg
     1381 agttccagga atttcttctg acaaagttga tcaacgctga gtacgcctgc tacaaagcag
     1441 agaagtttgc caaactggag gagcggacac gtgctgccct tctggagaca ctctacgagg
     1501 agctccacat ccacagccag tccatgatgg gcctgggtgg tgacgatgac aagatggaga
     1561 atggcagcgg tgggggtggc ttcttcgagt ctttcaagag ggtcatccgg agccggagcc
     1621 agtccatgga tgccatggga ctgagcaaca agaaacccaa caccgtgtct accagccaca
     1681 gtgggagctt cacccccaac aacccggacc tggccaaggc agctggcata tcattgctta
     1741 ttcccgggaa aagcgcgagt agattcggac gccggggcag cgccttaggc ataggagctg
     1801 tggaagagtc cctgattgtc cctggaaaga gtcccacaag gaagaagtct ggtccatttg
     1861 gctcacgccg cagcagcgcc attggcatcg agaacatcca ggaggtgcag gagaagaggg
     1921 agagccctcc agctggccag aagaccccag acagcgggca tgtctctcag gagcccaagt
     1981 cggagaactc atctactcag agctccccag agatgcccac gaccaagaac agagtggagt
     2041 cggctgccca gagaacggaa gtgctgcaag gcttttccag atcctcctcc agtgccagca
     2101 gcttcaccag cgtggtggag gagacggagg gcgtggatgg agatgataca ggcatggaga
     2161 gcgtgtcgtc ctcaggaacg ccccataagc gggactcctt cctctacagc acatggctgg
     2221 acgacagcgt gagcaccacg agcgggggca gctccccagg cctcacacgg tcaccccacc
     2281 cagacgccgt caagtcgggg gaccctgcgt gtcccgagat caagatccaa ctggaaacat
     2341 ctgagcagca cacaccccag atgggctgct agctgccatc tcatcagcag gcgggactga
     2401 gcagacgagg cctcagaagc acaagaagat gctgcaccac atccaggcag ctggccctct
     2461 gccccacagc caccacccca gcccctggcg cccctccctc caagccctgg gcccacccat
     2521 ctgggctgtc tccgcagggc ggagccatcc agagctctcg aatggatgga tgctgctggc
     2581 atcaccccac ccctactcca ggctggagct ctgggtgtag gaagggactg tggccctgga
     2641 ttgcccccac tggggcctcc gtcacaccgg gttcccgact ggagccatgg ggaacggggt
     2701 aggaaaagga gaaggagcgc cgtgcgcatg cgcgcacccc accgtggaag cagcaggtgc
     2761 ggggtgtgcc gatgagcact gggcagagtc ctgtgtggct tccgcggtga gaccctcatt
     2821 ctctgggcat ctgtgccgca agtggacaag agcatttcag agatcactga agacagattc
     2881 cgtgcacctg ccccaaaaga gggtcgttgt cctaggaccg cctatcacgc tgactgcttc
     2941 ctgaggcccc aggtgggctg aggggccggg gctgctgtac ccatcaccca acttgagtcc
     3001 cccagcttta ccacagagct gccaacgtcc tttcactgtc tccatacgat ggatggccaa
     3061 gtatcctctg ccggggatag ggtcatccct ggctcctcat ccagcaccca gcttaaccct
     3121 gccaccccgc gctcctgggc gtactgggtt gagggggtct cagctggtct ggagtccaga
     3181 cctcgacatc ccctgcccac tattgctgtg gagggggctg ccaggcacag ctgccgtgag
     3241 ccaagtcctt gtgtgtatct gttcactctt aggagccacg cccaaggcga gacttccagc
     3301 cccaacacct actttggaag ccccgtggcc acatgtatgt cagtaagggt tgtacaaaat
     3361 aaattctatt tatcgctatt gta
//
