LOCUS       NM_001412600            2744 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus RAP1B, member of RAS oncogene family (Rap1b),
            transcript variant 2, mRNA.
ACCESSION   NM_001412600 XM_039078356
VERSION     NM_001412600.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2744)
  AUTHORS   Noguchi,H., Ikegami,T., Nagadoi,A., Kamatari,Y.O., Park,S.Y.,
            Tame,J.R. and Unzai,S.
  TITLE     The structure and conformational switching of Rap1B
  JOURNAL   Biochem Biophys Res Commun 462 (1), 46-51 (2015)
   PUBMED   25935485
  REMARK    GeneRIF: Data indicate that mutations at different sites affect the
            ability of rap GTP-Binding Protein Rap1 to activate appropriately.
REFERENCE   2  (bases 1 to 2744)
  AUTHORS   Nakamura,T., Yasuda,S., Nagai,H., Koinuma,S., Morishita,S.,
            Goto,A., Kinashi,T. and Wada,N.
  TITLE     Longest neurite-specific activation of Rap1B in hippocampal neurons
            contributes to polarity formation through RalA and Nore1A in
            addition to PI3-kinase
  JOURNAL   Genes Cells 18 (11), 1020-1031 (2013)
   PUBMED   24165023
  REMARK    GeneRIF: specific activation of Rap1B contributes to neuronal
            polarization via interaction with RalA and Nore1A in addition to
            PI3-kinase.
REFERENCE   3  (bases 1 to 2744)
  AUTHORS   Subramanian,J., Dye,L. and Morozov,A.
  TITLE     Rap1 signaling prevents L-type calcium channel-dependent
            neurotransmitter release
  JOURNAL   J Neurosci 33 (17), 7245-7252 (2013)
   PUBMED   23616533
REFERENCE   4  (bases 1 to 2744)
  AUTHORS   Ahmed,S.M., Theriault,B.L., Uppalapati,M., Chiu,C.W., Gallie,B.L.,
            Sidhu,S.S. and Angers,S.
  TITLE     KIF14 negatively regulates Rap1a-Radil signaling during breast
            cancer progression
  JOURNAL   J Cell Biol 199 (6), 951-967 (2012)
   PUBMED   23209302
REFERENCE   5  (bases 1 to 2744)
  AUTHORS   Gloerich,M., ten Klooster,J.P., Vliem,M.J., Koorman,T.,
            Zwartkruis,F.J., Clevers,H. and Bos,J.L.
  TITLE     Rap2A links intestinal cell polarity to brush border formation
  JOURNAL   Nat Cell Biol 14 (8), 793-801 (2012)
   PUBMED   22797597
REFERENCE   6  (bases 1 to 2744)
  AUTHORS   Weissman,J.T., Ma,J.N., Essex,A., Gao,Y. and Burstein,E.S.
  TITLE     G-protein-coupled receptor-mediated activation of rap GTPases:
            characterization of a novel Galphai regulated pathway
  JOURNAL   Oncogene 23 (1), 241-249 (2004)
   PUBMED   14712229
REFERENCE   7  (bases 1 to 2744)
  AUTHORS   Lou,L., Urbani,J., Ribeiro-Neto,F. and Altschuler,D.L.
  TITLE     cAMP inhibition of Akt is mediated by activated and phosphorylated
            Rap1b
  JOURNAL   J Biol Chem 277 (36), 32799-32806 (2002)
   PUBMED   12089143
  REMARK    GeneRIF: cAMP inhibits Akt via Rap1b
REFERENCE   8  (bases 1 to 2744)
  AUTHORS   Ribeiro-Neto,F., Urbani,J., Lemee,N., Lou,L. and Altschuler,D.L.
  TITLE     On the mitogenic properties of Rap1b: cAMP-induced G(1)/S entry
            requires activated and phosphorylated Rap1b
  JOURNAL   Proc Natl Acad Sci U S A 99 (8), 5418-5423 (2002)
   PUBMED   11959997
  REMARK    GeneRIF: On the mitogenic properties of Rap1b: cAMP-induced G(1)/S
            entry requires activated and phosphorylated Rap1b.
REFERENCE   9  (bases 1 to 2744)
  AUTHORS   McPhee,I., Houslay,M.D. and Yarwood,S.J.
  TITLE     Use of an activation-specific probe to show that Rap1A and Rap1B
            display different sensitivities to activation by forskolin in rat1
            cells
  JOURNAL   FEBS Lett 477 (3), 213-218 (2000)
   PUBMED   10908723
REFERENCE   10 (bases 1 to 2744)
  AUTHORS   Urayama,O., Murakoshi,T., Kubota,M., Hara,Y., Chihara,J. and
            Ikawa,Y.
  TITLE     Coincident induction of K rev-1/rap 1A, rap 1B and H-ras mRNAs in
            the rat spinal cord by noxious stimulation
  JOURNAL   Brain Res Mol Brain Res 45 (2), 331-334 (1997)
   PUBMED   9149109
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Oct 12, 2022 this sequence version replaced XM_039078356.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.30750.1,
                                           SRR26643297.25186.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               JAXUCZ010000007.1  55342071-55342217   c
            148-223             JAXUCZ010000007.1  55336201-55336276   c
            224-305             JAXUCZ010000007.1  55319450-55319531   c
            306-374             JAXUCZ010000007.1  55317850-55317918   c
            375-431             JAXUCZ010000007.1  55316428-55316484   c
            432-572             JAXUCZ010000007.1  55315456-55315596   c
            573-716             JAXUCZ010000007.1  55313504-55313647   c
            717-833             JAXUCZ010000007.1  55312416-55312532   c
            834-2744            JAXUCZ010000007.1  55308922-55310832   c
FEATURES             Location/Qualifiers
     source          1..2744
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..2744
                     /gene="Rap1b"
                     /note="RAP1B, member of RAS oncogene family"
                     /db_xref="GeneID:171337"
                     /db_xref="RGD:620577"
     exon            1..147
                     /gene="Rap1b"
                     /inference="alignment:Splign:2.1.0"
     exon            148..223
                     /gene="Rap1b"
                     /inference="alignment:Splign:2.1.0"
     exon            224..305
                     /gene="Rap1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..803
                     /gene="Rap1b"
                     /EC_number="3.6.5.2"
                     /note="ras-related protein Rap-1b; GTP-binding protein smg
                     p21B; RAS related protein 1b"
                     /codon_start=1
                     /product="ras-related protein Rap-1b precursor"
                     /protein_id="NP_001399529.1"
                     /db_xref="GeneID:171337"
                     /db_xref="RGD:620577"
                     /translation="MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQV
                     EVDAQQCMLEILDTAGTEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILR
                     VKDTDDVPMILVGNKCDLEDERVVGKEQGQNLARQWSNCAFLESSAKSKINVNEIFYD
                     LVRQINRKTPVPGKARKKSSCQLL"
     exon            306..374
                     /gene="Rap1b"
                     /inference="alignment:Splign:2.1.0"
     exon            375..431
                     /gene="Rap1b"
                     /inference="alignment:Splign:2.1.0"
     exon            432..572
                     /gene="Rap1b"
                     /inference="alignment:Splign:2.1.0"
     exon            573..716
                     /gene="Rap1b"
                     /inference="alignment:Splign:2.1.0"
     exon            717..833
                     /gene="Rap1b"
                     /inference="alignment:Splign:2.1.0"
     exon            834..2744
                     /gene="Rap1b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaacctcgcc cagagtcagg cgtggaaagc agcctgagcg gcggcgacgg cggcggcagc
       61 ggcagagacc gccgtggcgc cgggagctga aacccgaagg gaacgcgggg cgacggcgac
      121 ggcggcgacc cggtgacagc gcgagagatc atcagacatc ctcataattc tcactctaga
      181 gcatctcttc tccagcattt cgtaggatcc ttgaaaagca caggtactaa gtgtaacaag
      241 tgtgcatcat gcgtgaatat aagctagtcg ttcttggctc aggaggtgtt gggaagtcgg
      301 ctctgactgt acagtttgtt caaggaattt ttgttgaaaa atatgatcct acgatagaag
      361 attcttatag aaagcaagtt gaagtagatg cacagcagtg tatgcttgaa atcctggata
      421 ctgcaggaac ggagcagttt acagccatga gagatctgta catgaagaac ggacaaggct
      481 ttgcgttggt ttactccatc acagcacagt cgacatttaa tgacttacag gatctaagag
      541 agcagattct tcgggttaaa gacactgacg atgtcccaat gattctggtt ggtaacaaat
      601 gcgacctgga agacgaaaga gttgtcggga aggaacaagg tcagaacctg gcaagacagt
      661 ggagcaactg cgctttctta gagtcctccg ccaagtccaa gataaatgtt aacgagatct
      721 tttatgacct agtgcggcaa attaacagaa aaaccccagt gcctgggaag gcccgcaaaa
      781 agtcatcatg tcagctgctt taatgtactg aatgcattgt agctctgagc caggtctgaa
      841 gaactgttgc ccaattcagc agtgccagca ttccaacttt gttaaaccta ccaacatctt
      901 aaatggactt tcccgtggtg gtaccctgta agaggcggac gaaagctact ctatcagttt
      961 gcacattcta atcactttcc agtatcacga gaggttttga cttatatgat agttctagag
     1021 tatgcagctg gtaaaaccag aggctacatc cagtattact gctaagagac attcttcatc
     1081 caccaatgtt gtacatgtat gaaaatggtg tactgtatac tttaacacac ccatactttg
     1141 tattggagag tacaataatg taaatcctaa aagcaccact attttagcat aataaaagaa
     1201 agtccaaaga gctcctatat agactactcc agataacttt gcttctttga tacttgtagc
     1261 ttactgtaat tttttttaaa ttcaaggtca ttatcattgt attatacaaa ataagcgctt
     1321 tgattaacac agctatatag tttttttaat ttttcaaaaa cctgtggaga cagtgatctt
     1381 gtctttaaaa tatgatagtc ctttcagtat aatgtcttag attaaagacg ttgcctttaa
     1441 tatctgttgg gaaggaaatg tccagacttt tcaaatctcc ttattattat gtttcctttt
     1501 ttgtttacat agggaacaat gtttatagtt gtgtgtacag tgggggtcta caacaagaag
     1561 tgtatatttt caaacagttt tttaatgatt taacaacttt gtaaatcatt ttcaggcttc
     1621 tgcagctgta gattctcact gtgcctccct tgcttgctcg tgcacacgtg tgtctgcaat
     1681 accaaataca caggtttagt atcttcgcct gttagtgact gtttccatgt gtaacgtttt
     1741 ggttgagatg ttaaatggtg gacgagtact gtggatgtga atgtgggaag taattttaat
     1801 catgtgtaat tggtcacaag gctaatctgc agtaactctt gctgttctat ttaacaatgc
     1861 cttgttgctt tgtatgcatt aacgtttggg tgtaaagatt gtgtgtccat ccaacaggga
     1921 gccacagtat ttaaattgac caacctgatg ttacaacttt gaggtggcca aatgtaaact
     1981 aaaagcctta attaaagtgg tgcaattttg tataacttag catccgtagt tcaataaatt
     2041 tggattgccg tgcaagggct tgcattataa ttacttgcca cttgaatgtg ttttgtgtaa
     2101 tgttttaaca gtgctagtaa ataaatatgg gtttaccttt ttaaatgtaa taggtgttat
     2161 tttacacagt gtgatttctt aatttatagc acaggtaaac caaactctga attccaagaa
     2221 tgatgaatga aagatagggt tcggttttgt ttttgttttc ttttctagaa ttgtttgact
     2281 atccacataa aacgaccctt tgaactttct tgagaaagaa tgttagaaat caagcagtat
     2341 tacttaggaa caaatgcctt tggctaggat tcagtaactc tttggggtgg agataggagg
     2401 aaggactcaa atactttggg tactgcacta taattttttt tcaatagaat gcaaatcttt
     2461 ggagaattaa tacacagaaa tttccaccat ttatgcttaa aatattaata tggttataca
     2521 atttttgatg tggattcatg ctacttttct ttttagataa tagatttatc tttgtcttat
     2581 gtgtgctata attgaattct gtgaaattta taaagaagct cttaaacatt ttcatagtac
     2641 tgaccaactg ctggagcact tacttagtgg taccttctag tttgcaggtg tgtgccaatc
     2701 aacacgtgct gtttgaaatg ggacattaaa ggctttcatt ttaa
//
