LOCUS       NM_001005765            2458 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus RAP1A, member of RAS oncogene family (Rap1a),
            mRNA.
ACCESSION   NM_001005765 XM_215669
VERSION     NM_001005765.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2458)
  AUTHORS   Keyes,J., Ganesan,A., Molinar-Inglis,O., Hamidzadeh,A., Zhang,J.,
            Ling,M., Trejo,J., Levchenko,A. and Zhang,J.
  TITLE     Signaling diversity enabled by Rap1-regulated plasma membrane ERK
            with distinct temporal dynamics
  JOURNAL   Elife 9, e57410 (2020)
   PUBMED   32452765
  REMARK    GeneRIF: Signaling diversity enabled by Rap1-regulated plasma
            membrane ERK with distinct temporal dynamics.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2458)
  AUTHORS   Moon,M.Y., Kim,H.J., Kim,M.J., Uhm,S., Park,J.W., Suk,K.T.,
            Park,J.B., Kim,D.J. and Kim,S.E.
  TITLE     Rap1 regulates hepatic stellate cell migration through the
            modulation of RhoA activity in response to TGF-beta1
  JOURNAL   Int J Mol Med 44 (2), 491-502 (2019)
   PUBMED   31173168
  REMARK    GeneRIF: These findings suggest that TGFbeta1 regulates Rap1,
            resulting in the suppression of RhoA, activation of and formation
            of Factin during the migration of hepatic stellate cells.
REFERENCE   3  (bases 1 to 2458)
  AUTHORS   Fang,B., Wei,L., Dong,K., Niu,X., Sui,X. and Zhang,H.
  TITLE     miR-202 modulates the progression of neuropathic pain through
            targeting RAP1A
  JOURNAL   J Cell Biochem 120 (3), 2973-2982 (2019)
   PUBMED   30520098
  REMARK    GeneRIF: that RAP1A was a direct target gene of miR-202 in the PC12
            cell. RAP1A expression was upregulated in the spinal dorsal horn of
            bilateral sciatic nerve chronic constriction injury (bCCI)rat.
REFERENCE   4  (bases 1 to 2458)
  AUTHORS   Yang,Y., Yang,F., Wu,X., Lv,X. and Li,J.
  TITLE     EPAC activation inhibits acetaldehyde-induced activation and
            proliferation of hepatic stellate cell via Rap1
  JOURNAL   Can J Physiol Pharmacol 94 (5), 498-507 (2016)
   PUBMED   26854595
  REMARK    GeneRIF: Data suggest activation of EPAC1/2 (exchange proteins
            activated by cAMP) and Rap1 (RAS-related GTP-binding protein 1) in
            hepatic stellate cells down-regulates proliferation and synthesis
            of a-smooth muscle actin/collagen I/collagen II in an in vitro
            model of alcoholic cirrhosis (AC); in AC, expression of EPAC1 is
            down-regulated but expression of EPAC2 is up-regulated; EPAC1
            activation increases GTP-bound (activated) Rap1.
REFERENCE   5  (bases 1 to 2458)
  AUTHORS   Walkup,W.G. 4th, Washburn,L., Sweredoski,M.J., Carlisle,H.J.,
            Graham,R.L., Hess,S. and Kennedy,M.B.
  TITLE     Phosphorylation of synaptic GTPase-activating protein (synGAP) by
            Ca2+/calmodulin-dependent protein kinase II (CaMKII) and
            cyclin-dependent kinase 5 (CDK5) alters the ratio of its GAP
            activity toward Ras and Rap GTPases
  JOURNAL   J Biol Chem 290 (8), 4908-4927 (2015)
   PUBMED   25533468
  REMARK    GeneRIF: Phosphorylation of synaptic GTPase-activating protein
            (synGAP) by Ca2+/calmodulin-dependent protein kinase II (CaMKII)
            and cyclin-dependent kinase 5 (CDK5) alters the ratio of its GAP
            activity toward Ras and Rap GTPases.
REFERENCE   6  (bases 1 to 2458)
  AUTHORS   Berruti,G.
  TITLE     A novel rap1/B-Raf/14-3-3 theta protein complex is formed in vivo
            during the morphogenetic differentiation of postmeiotic male germ
            cells
  JOURNAL   Exp Cell Res 257 (1), 172-179 (2000)
   PUBMED   10854065
REFERENCE   7  (bases 1 to 2458)
  AUTHORS   York,R.D., Yao,H., Dillon,T., Ellig,C.L., Eckert,S.P.,
            McCleskey,E.W. and Stork,P.J.
  TITLE     Rap1 mediates sustained MAP kinase activation induced by nerve
            growth factor
  JOURNAL   Nature 392 (6676), 622-626 (1998)
   PUBMED   9560161
REFERENCE   8  (bases 1 to 2458)
  AUTHORS   Urayama,O., Murakoshi,T., Kubota,M., Hara,Y., Chihara,J. and
            Ikawa,Y.
  TITLE     Coincident induction of K rev-1/rap 1A, rap 1B and H-ras mRNAs in
            the rat spinal cord by noxious stimulation
  JOURNAL   Brain Res Mol Brain Res 45 (2), 331-334 (1997)
   PUBMED   9149109
REFERENCE   9  (bases 1 to 2458)
  AUTHORS   Cruise,J.L., Rafferty,M.P. and Riehle,M.M.
  TITLE     Cell-cycle regulated expression of Rap1 in regenerating liver
  JOURNAL   Biochem Biophys Res Commun 230 (3), 578-581 (1997)
   PUBMED   9015365
REFERENCE   10 (bases 1 to 2458)
  AUTHORS   Kitayama,H., Sugimoto,Y., Matsuzaki,T., Ikawa,Y. and Noda,M.
  TITLE     A ras-related gene with transformation suppressor activity
  JOURNAL   Cell 56 (1), 77-84 (1989)
   PUBMED   2642744
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083813.1.
            
            On Oct 15, 2004 this sequence version replaced XM_215669.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083813.1, FQ233812.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2458
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..2458
                     /gene="Rap1a"
                     /gene_synonym="rap 1A; RAP-1A"
                     /note="RAP1A, member of RAS oncogene family"
                     /db_xref="GeneID:295347"
                     /db_xref="RGD:1359694"
     exon            1..90
                     /gene="Rap1a"
                     /gene_synonym="rap 1A; RAP-1A"
                     /inference="alignment:Splign:2.1.0"
     exon            91..173
                     /gene="Rap1a"
                     /gene_synonym="rap 1A; RAP-1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..671
                     /gene="Rap1a"
                     /gene_synonym="rap 1A; RAP-1A"
                     /EC_number="3.6.5.2"
                     /note="ras-related protein Krev-1; RAS-related protein 1a"
                     /codon_start=1
                     /product="ras-related protein Rap-1A"
                     /protein_id="NP_001005765.1"
                     /db_xref="GeneID:295347"
                     /db_xref="RGD:1359694"
                     /translation="MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQV
                     EVDCQQCMLEILDTAGTEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILR
                     VKDTEDVPMILVGNKCDLEDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYD
                     LVRQINRKTPVEKKKPKKKSCLLL"
     exon            174..242
                     /gene="Rap1a"
                     /gene_synonym="rap 1A; RAP-1A"
                     /inference="alignment:Splign:2.1.0"
     exon            243..299
                     /gene="Rap1a"
                     /gene_synonym="rap 1A; RAP-1A"
                     /inference="alignment:Splign:2.1.0"
     exon            300..440
                     /gene="Rap1a"
                     /gene_synonym="rap 1A; RAP-1A"
                     /inference="alignment:Splign:2.1.0"
     exon            441..584
                     /gene="Rap1a"
                     /gene_synonym="rap 1A; RAP-1A"
                     /inference="alignment:Splign:2.1.0"
     exon            585..700
                     /gene="Rap1a"
                     /gene_synonym="rap 1A; RAP-1A"
                     /inference="alignment:Splign:2.1.0"
     exon            701..2434
                     /gene="Rap1a"
                     /gene_synonym="rap 1A; RAP-1A"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgctactgc cgccgccgtg cagagcccga gcccgagccg cggccgagag gagggaggag
       61 gaggaggtgg aggaggcgcc gggccgcggg ttgtcaatat ttaaacagac cacatcatgc
      121 gtgagtacaa gctagtggtc cttggttcag gaggcgtggg aaagtctgct ctgacagttc
      181 agtttgttca gggaattttt gttgaaaaat atgacccaac gatagaagat tcctacagaa
      241 agcaagtcga agtagattgc caacagtgta tgctggaaat cctggacacc gcagggacag
      301 agcaatttac agcaatgagg gatttgtata tgaagaatgg ccaagggttt gcactagttt
      361 attcaattac agctcagtct acgtttaatg acttacaaga cttgagagaa cagattttac
      421 gggttaaaga cacagaagat gttccaatga ttttggttgg caataaatgt gatctggaag
      481 atgagcgggt agttggcaaa gaacaaggcc agaatttagc aagacagtgg tgtaactgtg
      541 cctttttaga atcttctgca aagtcaaaga tcaacgttaa tgagatattt tatgacctgg
      601 tcagacagat aaatagaaaa acaccagtgg aaaagaagaa gcctaaaaag aaatcatgtc
      661 tgctgctcta gacctgaagt cagcagcagc tctgagccag attacagaaa tgaagaactg
      721 ttgcctattt ggaaagtgcc agcattccag acttcaaaaa ctaaatctga agaggcttct
      781 cctgttttat atattatgtg aagagtttag atcttatatt ggtttgcaca aattccctgg
      841 agaaaaagtt gctctgtgta tatctcctgg aaataagaca tagtatttct cctttgcaat
      901 agcagttata acagatgtga aataagatac ttgactctaa tacaattata cagaagagca
      961 tggatgcatt tcaaatgtta gatgttacta ctataatcaa atgatttcat attgacgttt
     1021 ttatcatgac tcctccctgc caagcactaa aaagctgaac cgtcatactt tttatctgta
     1081 atgatataga ttatgaaatc tcccctcaaa ctcattgcag cagataactt ttttgagtca
     1141 ttgacttcat tttatattta aaaattatga aaatatcatc tgtcattata ttctaattaa
     1201 aattgtttgt gcataatgct ttggaaaaat gggtctttta tagggaaaca ctgggataac
     1261 tgatttctat ggctttcaaa gctaaaatat atactatact aaaccaactc taatattgct
     1321 tcttgtgttt actgtcagat taaattacag cttttatgga tgattaaatt ttagtacatt
     1381 ttcatttggt ttgtgtcttt ttgttattgt ttgtagactt gagtccttta ctttataaga
     1441 ccactctgtg taaagctctt gctgcctgcc tggattcagc agagcactgg gctttaaact
     1501 gcactaactg gtgatctctc caggaacagg cctcgcactt cctgctctag atagatttat
     1561 tcctactata cagtaaaatg caccacgtga catagactag ttttatatat tttctcgtga
     1621 ccttaaagat tgtatcttac tgaataaatg tcccactctg tattattttt atatgtgaaa
     1681 agataagttt aacactgtat cagggtttga ccttgactat tgcaaatcct gcacagtttg
     1741 taacttcatc cagggaatcc ttgccattgt taatttgctg gtgtgagtcc accaatgaag
     1801 tgttcaatga aaatttcaaa ctggctctct aatagatgga agaacctgag ggcagtggtt
     1861 gcaagttaga acacaaaagt gatgcgtgac ttgactatga gcagtatata taacaggaat
     1921 ggtatgaaga tggttacacc ttagtttgct ggccgtacag aggtgctttt cctttccttc
     1981 ccagttgcat tttacaaagg tggggcttct gtaggtcgtg agcccagggc gagactgctg
     2041 tatgttctcc atggagaaag ggagtggacc cagggtgaga ctgctgtatg ttctccatgg
     2101 agaaagggaa agcaactggc ctgttggcca ggtgcacaca agagaaaaaa gcagacggca
     2161 agattaggaa accctgtgcc ttgtccccga aaatccagga gaccaatcct agaaagtaaa
     2221 tctttgctca gggatctaga tgtggtctcg ttgcagctag gtgtgaaggt gttcacacct
     2281 tgctgagatt tgccaggtgt gtggacagcc cttcagttac taagtcagct ttcaaatgta
     2341 agatccgacc aatctgaaga aatgtcaaaa tatactgttt gaaaatttgg aaattgtatt
     2401 tttttgatac tttaataaac ttagctactt aacaaaaaaa aaaaaaaaaa aaaaaaaa
//
