LOCUS       NM_001105790             827 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus RAN guanine nucleotide release factor (Rangrf),
            mRNA.
ACCESSION   NM_001105790 XM_001078960 XM_213367
VERSION     NM_001105790.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 827)
  AUTHORS   Bao X, Liu H, Liu X, Ruan K, Zhang Y, Zhang Z, Hu Q, Liu Y, Akram
            S, Zhang J, Gong Q, Wang W, Yuan X, Li J, Zhao L, Dou Z, Tian R,
            Yao X, Wu J and Shi Y.
  TITLE     Mitosis-specific acetylation tunes Ran effector binding for
            chromosome segregation
  JOURNAL   J Mol Cell Biol 10 (1), 18-32 (2018)
   PUBMED   29040603
REFERENCE   2  (bases 1 to 827)
  AUTHORS   Chakrabarti S, Wu X, Yang Z, Wu L, Yong SL, Zhang C, Hu K, Wang QK
            and Chen Q.
  TITLE     MOG1 rescues defective trafficking of Na(v)1.5 mutations in Brugada
            syndrome and sick sinus syndrome
  JOURNAL   Circ Arrhythm Electrophysiol 6 (2), 392-401 (2013)
   PUBMED   23420830
REFERENCE   3  (bases 1 to 827)
  AUTHORS   de Mateo S, Castillo J, Estanyol JM, Ballesca JL and Oliva R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   4  (bases 1 to 827)
  AUTHORS   Olesen MS, Jensen NF, Holst AG, Nielsen JB, Tfelt-Hansen J,
            Jespersen T, Sajadieh A, Haunso S, Lund JT, Calloe K, Schmitt N and
            Svendsen JH.
  TITLE     A novel nonsense variant in Nav1.5 cofactor MOG1 eliminates its
            sodium current increasing effect and may increase the risk of
            arrhythmias
  JOURNAL   Can J Cardiol 27 (4), 523 (2011)
   PUBMED   21621375
REFERENCE   5  (bases 1 to 827)
  AUTHORS   Wu L, Yong SL, Fan C, Ni Y, Yoo S, Zhang T, Zhang X, Obejero-Paz
            CA, Rho HJ, Ke T, Szafranski P, Jones SW, Chen Q and Wang QK.
  TITLE     Identification of a new co-factor, MOG1, required for the full
            function of cardiac sodium channel Nav 1.5
  JOURNAL   J Biol Chem 283 (11), 6968-6978 (2008)
   PUBMED   18184654
REFERENCE   6  (bases 1 to 827)
  AUTHORS   Marfatia KA, Harreman MT, Fanara P, Vertino PM and Corbett AH.
  TITLE     Identification and characterization of the human MOG1 gene
  JOURNAL   Gene 266 (1-2), 45-56 (2001)
   PUBMED   11290418
REFERENCE   7  (bases 1 to 827)
  AUTHORS   Steggerda SM and Paschal BM.
  TITLE     The mammalian Mog1 protein is a guanine nucleotide release factor
            for Ran
  JOURNAL   J Biol Chem 275 (30), 23175-23180 (2000)
   PUBMED   10811801
REFERENCE   8  (bases 1 to 827)
  AUTHORS   Adelmann M, Wood J, Benzel I, Fiori P, Lassmann H, Matthieu JM,
            Gardinier MV, Dornmair K and Linington C.
  TITLE     The N-terminal domain of the myelin oligodendrocyte glycoprotein
            (MOG) induces acute demyelinating experimental autoimmune
            encephalomyelitis in the Lewis rat
  JOURNAL   J Neuroimmunol 63 (1), 17-27 (1995)
   PUBMED   8557821
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On or before Oct 3, 2007 this sequence version replaced
            XM_213367.4, XM_001078960.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ228156.1, DV720804.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..827
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..827
                     /gene="Rangrf"
                     /gene_synonym="RGD1563195"
                     /note="RAN guanine nucleotide release factor"
                     /db_xref="GeneID:287419"
                     /db_xref="RGD:1563195"
     exon            1..209
                     /gene="Rangrf"
                     /gene_synonym="RGD1563195"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..690
                     /gene="Rangrf"
                     /gene_synonym="RGD1563195"
                     /codon_start=1
                     /product="ran guanine nucleotide release factor"
                     /protein_id="NP_001099260.1"
                     /db_xref="GeneID:287419"
                     /db_xref="RGD:1563195"
                     /translation="MEPARNCPLFGGAFSAILPRGAIDVSDLRPVPDNQEVFCHPVTD
                     QSLIIELLELQAHVQGEAAARYHFEDVGGVQGARSVHVLSVQPLCLENLSLRGCCQDA
                     WFLSGKQQVAKENQQVAKDVTLHQALLRLPQYQTDLLLTFNQPPCHSRPLGPENLSCP
                     PWSLGNFEQLVTSLTLHDPNLFGPQ"
     exon            210..326
                     /gene="Rangrf"
                     /gene_synonym="RGD1563195"
                     /inference="alignment:Splign:2.1.0"
     exon            327..483
                     /gene="Rangrf"
                     /gene_synonym="RGD1563195"
                     /inference="alignment:Splign:2.1.0"
     exon            484..569
                     /gene="Rangrf"
                     /gene_synonym="RGD1563195"
                     /inference="alignment:Splign:2.1.0"
     exon            570..827
                     /gene="Rangrf"
                     /gene_synonym="RGD1563195"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 taaaggtcca agagcttagt aggaccggag gaggtagtgg ctgctccggg aacaccaggg
       61 gaaatgatgc ctcgaagacc catgtaggtt tctttaaaac ctcgctaatg tccagactca
      121 agtactagat ctatggagcc cgccagaaac tgtccactgt tcggaggcgc cttttccgcc
      181 atcctccccc gaggggccat tgatgtgagt gacctccgac cggtgccaga caaccaagaa
      241 gttttctgcc atcctgtgac cgaccagagt ctgatcatag aacttctgga gctgcaggcc
      301 cacgtgcagg gcgaagcggc tgcgcggtac cattttgagg acgttggcgg ggtgcagggg
      361 gctaggagtg tgcacgtgct atctgtgcag cctctctgtt tggagaactt atccctgaga
      421 ggctgctgtc aagatgcctg gttcctttct ggcaagcagc aggtagctaa agaaaaccaa
      481 caggtagcaa aggatgtcac actgcatcag gccttgcttc ggttgcccca gtatcagact
      541 gatcttttgc tcaccttcaa tcagcccccg tgtcacagca ggcctcttgg ccctgaaaat
      601 ctgtcatgtc caccttggag cctgggtaac tttgagcagc tggtaactag tttgactctt
      661 catgatccca acctctttgg tccccagtaa agatggttga aacacagcgt gctgctgagg
      721 actcaggggc ccagttctga gagggggagt ttctttctgc tgcctccctg gatgtgaaca
      781 taagacacct cctcggcaga aataaacttg ctttatgaag aatataa
//
