LOCUS       NM_001244855            2783 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus RAN GTPase activating protein 1 (Rangap1), mRNA.
ACCESSION   NM_001244855
VERSION     NM_001244855.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2783)
  AUTHORS   Zhang K, Donnelly CJ, Haeusler AR, Grima JC, Machamer JB, Steinwald
            P, Daley EL, Miller SJ, Cunningham KM, Vidensky S, Gupta S, Thomas
            MA, Hong I, Chiu SL, Huganir RL, Ostrow LW, Matunis MJ, Wang J,
            Sattler R, Lloyd TE and Rothstein JD.
  TITLE     The C9orf72 repeat expansion disrupts nucleocytoplasmic transport
  JOURNAL   Nature 525 (7567), 56-61 (2015)
   PUBMED   26308891
REFERENCE   2  (bases 1 to 2783)
  AUTHORS   Guo Z, Neilson LJ, Zhong H, Murray PS, Zanivan S and Zaidel-Bar R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2783)
  AUTHORS   Vorpahl M, Schonhofer-Merl S, Michaelis C, Flotho A, Melchior F and
            Wessely R.
  TITLE     The Ran GTPase-activating protein (RanGAP1) is critically involved
            in smooth muscle cell differentiation, proliferation and migration
            following vascular injury: implications for neointima formation and
            restenosis
  JOURNAL   PLoS One 9 (7), e101519 (2014)
   PUBMED   24988324
  REMARK    GeneRIF: RanGAP1 expression, neointima formation in rat carotid
            arteries was associated with a significant upregulation of RanGAP1
            expression at 3 and 7 days after balloon injury.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2783)
  AUTHORS   Natalizio BJ and Wente SR.
  TITLE     Postage for the messenger: designating routes for nuclear mRNA
            export
  JOURNAL   Trends Cell Biol 23 (8), 365-373 (2013)
   PUBMED   23583578
  REMARK    Review article
REFERENCE   5  (bases 1 to 2783)
  AUTHORS   Hori K, Nagai T, Izumi Y, Kimura M, Hasuike Y, Nakayama Y, Nanami
            M, Tokuyama M, Otaki Y, Kuragano T, Kohda Y, Obinata M, Kawahara K,
            Tanoue A, Tomita K, Nakanishi T and Nonoguchi H.
  TITLE     Vasopressin V1a receptor is required for nucleocytoplasmic
            transport of mineralocorticoid receptor
  JOURNAL   Am J Physiol Renal Physiol 303 (7), F1080-F1088 (2012)
   PUBMED   22811487
REFERENCE   6  (bases 1 to 2783)
  AUTHORS   Yamaguchi T, Sharma P, Athanasiou M, Kumar A, Yamada S and Kuehn
            MR.
  TITLE     Mutation of SENP1/SuPr-2 reveals an essential role for
            desumoylation in mouse development
  JOURNAL   Mol Cell Biol 25 (12), 5171-5182 (2005)
   PUBMED   15923632
REFERENCE   7  (bases 1 to 2783)
  AUTHORS   Takeda E, Hieda M, Katahira J and Yoneda Y.
  TITLE     Phosphorylation of RanGAP1 stabilizes its interaction with Ran and
            RanBP1
  JOURNAL   Cell Struct Funct 30 (2), 69-80 (2005)
   PUBMED   16428860
REFERENCE   8  (bases 1 to 2783)
  AUTHORS   Lee GW, Melchior F, Matunis MJ, Mahajan R, Tian Q and Anderson P.
  TITLE     Modification of Ran GTPase-activating protein by the small
            ubiquitin-related modifier SUMO-1 requires Ubc9, an E2-type
            ubiquitin-conjugating enzyme homologue
  JOURNAL   J Biol Chem 273 (11), 6503-6507 (1998)
   PUBMED   9497385
REFERENCE   9  (bases 1 to 2783)
  AUTHORS   Mahajan R, Delphin C, Guan T, Gerace L and Melchior F.
  TITLE     A small ubiquitin-related polypeptide involved in targeting RanGAP1
            to nuclear pore complex protein RanBP2
  JOURNAL   Cell 88 (1), 97-107 (1997)
   PUBMED   9019411
REFERENCE   10 (bases 1 to 2783)
  AUTHORS   Matunis MJ, Coutavas E and Blobel G.
  TITLE     A novel ubiquitin-like modification modulates the partitioning of
            the Ran-GTPase-activating protein RanGAP1 between the cytosol and
            the nuclear pore complex
  JOURNAL   J Cell Biol 135 (6 Pt 1), 1457-1470 (1996)
   PUBMED   8978815
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CV126932.1, FQ217036.1, DY317647.1, BP492086.1, CX570737.1 and
            CA509531.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ217036.1, SRR8487230.67728.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                CV126932.1         1-16
            17-1126             FQ217036.1         1-1110
            1127-1164           DY317647.1         599-636
            1165-1619           FQ217036.1         1149-1603
            1620-2104           BP492086.1         171-655
            2105-2295           FQ217036.1         2089-2279
            2296-2758           CX570737.1         199-661
            2759-2783           CA509531.1         1-25                c
FEATURES             Location/Qualifiers
     source          1..2783
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..2783
                     /gene="Rangap1"
                     /note="RAN GTPase activating protein 1"
                     /db_xref="GeneID:362965"
                     /db_xref="RGD:1310380"
     exon            1..180
                     /gene="Rangap1"
                     /inference="alignment:Splign:2.1.0"
     exon            181..327
                     /gene="Rangap1"
                     /inference="alignment:Splign:2.1.0"
     CDS             216..1976
                     /gene="Rangap1"
                     /codon_start=1
                     /product="ran GTPase-activating protein 1"
                     /protein_id="NP_001231784.1"
                     /db_xref="GeneID:362965"
                     /db_xref="RGD:1310380"
                     /translation="MASEDIAKLAETLAKTQVAGGQLSFKGKGLKLNTAEDAKDVIKE
                     IEEFDGLEALRLEGNTVGVEAARVIAKALEKKSKLKRCHWSDMFTGRLRSEIPPALIS
                     LGEGLITAGAQLVELDLSDNAFGPDGVRGFEALLKSPACFTLQELKLNNCGMGIGGGK
                     ILAAALTECHRKSSAQGKPLTLKVFVAGRNRLENDGATALAEAFGIIGTLEEVHMPQN
                     GINHPGVTALAQAFAINPLLRVINLNDNTFTEKGGVAMAETLKTLRQVEVINFGDCLV
                     RSKGAVAIADAVRGGLPKLKELNLSFCEIKRDAALVVAEAVADKAELEKLDLNGNALG
                     EEGCEQLQEVLDSFNMAKVLASLSDDEGEDEDEDEEGEDDEDEEDEEEEEEEEEEEEE
                     EEEEPQQRGSGEEPATPSRKILDPNSGEPAPVLSSPPPTDLSTFLSFPSPEKLLRLGP
                     KVSVLIVQQTDTSDPEKVVSAFLKVASVFRDEASVKTAVLDAIDALMKKAFSSSSFNS
                     NTFLTRLLIHMGLLKSEDKIKAIPSLHGPLMVLNHVVQQDYFPKTLAPLLLAFVTKPN
                     GALESCSFARHSLLQTLYSI"
     exon            328..455
                     /gene="Rangap1"
                     /inference="alignment:Splign:2.1.0"
     exon            456..515
                     /gene="Rangap1"
                     /inference="alignment:Splign:2.1.0"
     exon            516..695
                     /gene="Rangap1"
                     /inference="alignment:Splign:2.1.0"
     exon            696..830
                     /gene="Rangap1"
                     /inference="alignment:Splign:2.1.0"
     exon            831..989
                     /gene="Rangap1"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1103
                     /gene="Rangap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1203
                     /gene="Rangap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1288
                     /gene="Rangap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1472
                     /gene="Rangap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1592
                     /gene="Rangap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1695
                     /gene="Rangap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1784
                     /gene="Rangap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1906
                     /gene="Rangap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..2768
                     /gene="Rangap1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggagcagg tggtgtgcac aagctagacg agcagccgcg gcagcgagga caggcgagca
       61 gactggtcac tggaaccgcc gtatagaggc gcggtgaccg gcctggccct cgcgcgggct
      121 ctcaagcagt gaccgacgcg tgcgttccgt ccccccacgc ggcggcgccg ctagtttgag
      181 tttacagacc tccaggggag cccgctgttg tagtcatggc ctctgaagac attgccaaat
      241 tggcagagac cctggccaaa actcaggtag ccggaggaca gctgagtttt aagggcaagg
      301 gtctcaaact aaatactgca gaagatgcta aagatgtgat taaggagatt gaagagtttg
      361 atggcctgga agctctacga ctggagggga acacagtggg cgtggaagcg gccagagtca
      421 tcgccaaggc cttagagaag aagtccaagc tgaagcgatg ccattggagt gacatgttca
      481 ccggaaggct tcggtccgag atcccaccag ctctgatctc actaggggag gggctcatca
      541 ctgcaggagc acagctggtg gagctcgacc tcagtgacaa cgcatttgga cctgatggag
      601 tgcgaggctt cgaggccctc ctcaagagcc cagcctgctt caccctgcag gaactcaagc
      661 ttaacaactg tggcatgggc atcggtggtg gcaagattct ggcagcagct ctgactgagt
      721 gccaccgcaa gtccagtgcc caaggcaagc cactgaccct gaaggtgttt gtggctggca
      781 gaaatcgcct ggagaatgat ggagccactg cactggcaga agcctttggg atcatcggga
      841 ctctggaaga ggtccatatg ccacagaatg gaattaacca ccctggtgtc acagccctgg
      901 cccaggcgtt tgccattaac cccctgctgc gagtcatcaa tctaaacgac aacaccttca
      961 ctgagaaggg tggggtggcc atggctgaga ccctgaagac actgcgacaa gtggaggtga
     1021 tcaattttgg agactgcctg gtgcgctcca agggggcggt cgccatcgca gatgctgtcc
     1081 gtgggggcct gcccaagctg aaggagctga acctgtcatt ctgtgaaatc aagagagatg
     1141 ctgccctggt tgttgccgag gctgtggctg acaaggctga gctggagaag ctggacctca
     1201 atggcaatgc cctaggagaa gagggctgtg agcagcttca ggaggtgctg gacagcttca
     1261 atatggccaa ggtgctggca tccctcagtg atgatgaggg agaggatgag gatgaggatg
     1321 aggaaggaga ggacgatgag gatgaggaag atgaggagga ggaggaggaa gaagaggagg
     1381 aagaggagga agaggaagaa gagccacagc agcgagggtc aggagaggag ccagctacac
     1441 cctcgaggaa gatcctggac cctaacagtg gggagccagc tcccgtgctg tcctccccgc
     1501 ctcccacaga cctgtccacc ttcctgtcat tcccctcccc agagaagctg ctgcggctgg
     1561 gtccaaaggt ctcggtgctg atagtccagc agactgatac ctccgaccct gagaaggttg
     1621 tttcagcctt cctgaaggtg gcatctgtgt tcagggacga agcctcagta aagacagcag
     1681 tgctggatgc catcgatgcc ctcatgaaga aggccttcag ctcctcctct ttcaattcca
     1741 acaccttcct taccaggctg ctcatccaca tgggtctgct caagagtgaa gacaagatca
     1801 aggccattcc tagcctgcat ggccccctga tggtgttgaa ccacgtggta cagcaggact
     1861 atttccccaa gacccttgca ccgctgctgc tggcgtttgt gacaaagccc aatggtgcac
     1921 tggaatcctg ctcctttgcc cgccacagtc tgctgcagac gctgtacagc atctagatct
     1981 aaaaccagct gcttcttgtc cctcaccctg ccccagtgac tgggggactt ggatggactg
     2041 agctcagcca gcatctccat tggataggat tttgaccaga ggcagggaag tgtctttgtc
     2101 cctcgtgtcg tgttggtcct ttgatactat gttggtttgg tgtgtgtggg tatgttcttc
     2161 ctgtctggac tgcagagctt catctccctg ctggactcac cctggtccac tgtagggcat
     2221 tgatgcccag gggaagggct gaaagctgct tagttattaa acttaggcca acttagccat
     2281 aggccctgtt ggctgtcctg ccttcctgtc ccaccaaagc ctggggaatt agtctgtgtg
     2341 ctgtgtcttg ctgtgtccac cgtgcctagg gaacagagac tgtcagagat gggctgcatt
     2401 agaaagtgaa actctggcct taactgtgtg gcttggagga gcagccgggg gccaacccca
     2461 aagagcccag gagtggaata gcctggggta ccctggctct tggacccagt ggaagaagca
     2521 ccttggctgg cccagccctg ttcttcatcc tggggaggga agggcaggtc ccctcatgcc
     2581 tgaaccacat gctgggccta ctctttgagc gttttctgag acagagtgtg tagcagggat
     2641 tgagctgggt gggagatgcc ctgtgacttc caaagtggct gcttggccac ctcctgcttc
     2701 ctgttgtgtc tgtgtctggg ctgcgcctgg gagcgtcaca aataaaagtc acttgtggta
     2761 gttgcagaaa aaaaaaaaaa aaa
//
