LOCUS       NP_001231784             586 aa            linear   ROD 26-FEB-2024
DEFINITION  ran GTPase-activating protein 1 [Rattus norvegicus].
ACCESSION   NP_001231784
VERSION     NP_001231784.1
DBSOURCE    REFSEQ: accession NM_001244855.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 586)
  AUTHORS   Zhang K, Donnelly CJ, Haeusler AR, Grima JC, Machamer JB, Steinwald
            P, Daley EL, Miller SJ, Cunningham KM, Vidensky S, Gupta S, Thomas
            MA, Hong I, Chiu SL, Huganir RL, Ostrow LW, Matunis MJ, Wang J,
            Sattler R, Lloyd TE and Rothstein JD.
  TITLE     The C9orf72 repeat expansion disrupts nucleocytoplasmic transport
  JOURNAL   Nature 525 (7567), 56-61 (2015)
   PUBMED   26308891
REFERENCE   2  (residues 1 to 586)
  AUTHORS   Guo Z, Neilson LJ, Zhong H, Murray PS, Zanivan S and Zaidel-Bar R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 586)
  AUTHORS   Vorpahl M, Schonhofer-Merl S, Michaelis C, Flotho A, Melchior F and
            Wessely R.
  TITLE     The Ran GTPase-activating protein (RanGAP1) is critically involved
            in smooth muscle cell differentiation, proliferation and migration
            following vascular injury: implications for neointima formation and
            restenosis
  JOURNAL   PLoS One 9 (7), e101519 (2014)
   PUBMED   24988324
  REMARK    GeneRIF: RanGAP1 expression, neointima formation in rat carotid
            arteries was associated with a significant upregulation of RanGAP1
            expression at 3 and 7 days after balloon injury.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 586)
  AUTHORS   Natalizio BJ and Wente SR.
  TITLE     Postage for the messenger: designating routes for nuclear mRNA
            export
  JOURNAL   Trends Cell Biol 23 (8), 365-373 (2013)
   PUBMED   23583578
  REMARK    Review article
REFERENCE   5  (residues 1 to 586)
  AUTHORS   Hori K, Nagai T, Izumi Y, Kimura M, Hasuike Y, Nakayama Y, Nanami
            M, Tokuyama M, Otaki Y, Kuragano T, Kohda Y, Obinata M, Kawahara K,
            Tanoue A, Tomita K, Nakanishi T and Nonoguchi H.
  TITLE     Vasopressin V1a receptor is required for nucleocytoplasmic
            transport of mineralocorticoid receptor
  JOURNAL   Am J Physiol Renal Physiol 303 (7), F1080-F1088 (2012)
   PUBMED   22811487
REFERENCE   6  (residues 1 to 586)
  AUTHORS   Yamaguchi T, Sharma P, Athanasiou M, Kumar A, Yamada S and Kuehn
            MR.
  TITLE     Mutation of SENP1/SuPr-2 reveals an essential role for
            desumoylation in mouse development
  JOURNAL   Mol Cell Biol 25 (12), 5171-5182 (2005)
   PUBMED   15923632
REFERENCE   7  (residues 1 to 586)
  AUTHORS   Takeda E, Hieda M, Katahira J and Yoneda Y.
  TITLE     Phosphorylation of RanGAP1 stabilizes its interaction with Ran and
            RanBP1
  JOURNAL   Cell Struct Funct 30 (2), 69-80 (2005)
   PUBMED   16428860
REFERENCE   8  (residues 1 to 586)
  AUTHORS   Lee GW, Melchior F, Matunis MJ, Mahajan R, Tian Q and Anderson P.
  TITLE     Modification of Ran GTPase-activating protein by the small
            ubiquitin-related modifier SUMO-1 requires Ubc9, an E2-type
            ubiquitin-conjugating enzyme homologue
  JOURNAL   J Biol Chem 273 (11), 6503-6507 (1998)
   PUBMED   9497385
REFERENCE   9  (residues 1 to 586)
  AUTHORS   Mahajan R, Delphin C, Guan T, Gerace L and Melchior F.
  TITLE     A small ubiquitin-related polypeptide involved in targeting RanGAP1
            to nuclear pore complex protein RanBP2
  JOURNAL   Cell 88 (1), 97-107 (1997)
   PUBMED   9019411
REFERENCE   10 (residues 1 to 586)
  AUTHORS   Matunis MJ, Coutavas E and Blobel G.
  TITLE     A novel ubiquitin-like modification modulates the partitioning of
            the Ran-GTPase-activating protein RanGAP1 between the cytosol and
            the nuclear pore complex
  JOURNAL   J Cell Biol 135 (6 Pt 1), 1457-1470 (1996)
   PUBMED   8978815
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CV126932.1, FQ217036.1, DY317647.1, BP492086.1, CX570737.1 and
            CA509531.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ217036.1, SRR8487230.67728.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..586
                     /organism="Rattus norvegicus"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     Protein         1..586
                     /product="ran GTPase-activating protein 1"
                     /calculated_mol_wt=63012
     Region          21..358
                     /region_name="LRR_RI"
                     /note="Leucine-rich repeats (LRRs), ribonuclease inhibitor
                     (RI)-like subfamily. LRRs are 20-29 residue sequence
                     motifs present in many proteins that participate in
                     protein-protein interactions and have different functions
                     and cellular locations. LRRs correspond...; cd00116"
                     /db_xref="CDD:238064"
     Site            order(23,25,28,30,51,54,56,59,61,79,82,84,87,89,114,117,
                     119,122,124,144,147,149,152,154,182,185,187,190,192,210,
                     213,215,218,220,238,241,243,246,248,266,269,271,274,276,
                     295,298,300,303,305,323,326,328,331,333,351,354,356)
                     /site_type="active"
                     /note="Leucine-rich repeats [active]"
                     /db_xref="CDD:238064"
     Region          51..81
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            order(57..58,121,189,217,273,299,301,327,355)
                     /site_type="other"
                     /note="Substrate binding site [chemical binding]"
                     /db_xref="CDD:238064"
     Region          82..113
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          114..143
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          144..171
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          182..209
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          210..237
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          238..265
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          266..294
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          405..584
                     /region_name="RanGAP1_C"
                     /note="RanGAP1 C-terminal domain; pfam07834"
                     /db_xref="CDD:462282"
     CDS             1..586
                     /gene="Rangap1"
                     /coded_by="NM_001244855.1:216..1976"
                     /db_xref="GeneID:362965"
                     /db_xref="RGD:1310380"
ORIGIN      
        1 masediakla etlaktqvag gqlsfkgkgl klntaedakd vikeieefdg lealrlegnt
       61 vgveaarvia kalekksklk rchwsdmftg rlrseippal islgeglita gaqlveldls
      121 dnafgpdgvr gfeallkspa cftlqelkln ncgmgigggk ilaaaltech rkssaqgkpl
      181 tlkvfvagrn rlendgatal aeafgiigtl eevhmpqngi nhpgvtalaq afainpllrv
      241 inlndntfte kggvamaetl ktlrqvevin fgdclvrskg avaiadavrg glpklkelnl
      301 sfceikrdaa lvvaeavadk aelekldlng nalgeegceq lqevldsfnm akvlaslsdd
      361 egedededee geddedeede eeeeeeeeee eeeeeepqqr gsgeepatps rkildpnsge
      421 papvlssppp tdlstflsfp spekllrlgp kvsvlivqqt dtsdpekvvs aflkvasvfr
      481 deasvktavl daidalmkka fssssfnsnt fltrllihmg llksedkika ipslhgplmv
      541 lnhvvqqdyf pktlapllla fvtkpngale scsfarhsll qtlysi
//
