LOCUS       NM_001191604           10277 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus RAN binding protein 2 (Ranbp2), mRNA.
ACCESSION   NM_001191604 XM_006223888 XM_215401
VERSION     NM_001191604.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 10277)
  AUTHORS   Lin,M.Y. and Sheng,Z.H.
  TITLE     Regulation of mitochondrial transport in neurons
  JOURNAL   Exp Cell Res 334 (1), 35-44 (2015)
   PUBMED   25612908
  REMARK    Review article
REFERENCE   2  (bases 1 to 10277)
  AUTHORS   Kazyken,D., Kaz,Y., Kiyan,V., Zhylkibayev,A.A., Chen,C.H.,
            Agarwal,N.K. and Sarbassov dos,D.
  TITLE     The nuclear import of ribosomal proteins is regulated by mTOR
  JOURNAL   Oncotarget 5 (20), 9577-9593 (2014)
   PUBMED   25294810
REFERENCE   3  (bases 1 to 10277)
  AUTHORS   Herrold,A.A., Persons,A.L. and Napier,T.C.
  TITLE     Cellular distribution of AMPA receptor subunits and mGlu5 following
            acute and repeated administration of morphine or methamphetamine
  JOURNAL   J Neurochem 126 (4), 503-517 (2013)
   PUBMED   23711322
REFERENCE   4  (bases 1 to 10277)
  AUTHORS   Natalizio,B.J. and Wente,S.R.
  TITLE     Postage for the messenger: designating routes for nuclear mRNA
            export
  JOURNAL   Trends Cell Biol 23 (8), 365-373 (2013)
   PUBMED   23583578
  REMARK    Review article
REFERENCE   5  (bases 1 to 10277)
  AUTHORS   Cho,K.I., Searle,K., Webb,M., Yi,H. and Ferreira,P.A.
  TITLE     Ranbp2 haploinsufficiency mediates distinct cellular and
            biochemical phenotypes in brain and retinal dopaminergic and glia
            cells elicited by the Parkinsonian neurotoxin,
            1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
  JOURNAL   Cell Mol Life Sci 69 (20), 3511-3527 (2012)
   PUBMED   22821000
REFERENCE   6  (bases 1 to 10277)
  AUTHORS   Delphin,C., Guan,T., Melchior,F. and Gerace,L.
  TITLE     RanGTP targets p97 to RanBP2, a filamentous protein localized at
            the cytoplasmic periphery of the nuclear pore complex
  JOURNAL   Mol Biol Cell 8 (12), 2379-2390 (1997)
   PUBMED   9398662
REFERENCE   7  (bases 1 to 10277)
  AUTHORS   Mahajan,R., Delphin,C., Guan,T., Gerace,L. and Melchior,F.
  TITLE     A small ubiquitin-related polypeptide involved in targeting RanGAP1
            to nuclear pore complex protein RanBP2
  JOURNAL   Cell 88 (1), 97-107 (1997)
   PUBMED   9019411
REFERENCE   8  (bases 1 to 10277)
  AUTHORS   Yokoyama,N., Hayashi,N., Seki,T., Pante,N., Ohba,T., Nishii,K.,
            Kuma,K., Hayashida,T., Miyata,T., Aebi,U. et al.
  TITLE     A giant nucleopore protein that binds Ran/TC4
  JOURNAL   Nature 376 (6536), 184-188 (1995)
   PUBMED   7603572
REFERENCE   9  (bases 1 to 10277)
  AUTHORS   Moroianu,J., Hijikata,M., Blobel,G. and Radu,A.
  TITLE     Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers:
            alpha 1 or alpha 2 subunit binds nuclear localization signal and
            beta subunit interacts with peptide repeat-containing nucleoporins
  JOURNAL   Proc Natl Acad Sci U S A 92 (14), 6532-6536 (1995)
   PUBMED   7604027
REFERENCE   10 (bases 1 to 10277)
  AUTHORS   Wu,J., Matunis,M.J., Kraemer,D., Blobel,G. and Coutavas,E.
  TITLE     Nup358, a cytoplasmically exposed nucleoporin with peptide repeats,
            Ran-GTP binding sites, zinc fingers, a cyclophilin A homologous
            domain, and a leucine-rich region
  JOURNAL   J Biol Chem 270 (23), 14209-14213 (1995)
   PUBMED   7775481
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000020.1.
            
            On or before Dec 15, 2013 this sequence version replaced
            XM_006223888.1, XM_215401.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.57707.1,
                                           SRR26643287.37241.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               JAXUCZ010000020.1  26985314-26985457
            145-212             JAXUCZ010000020.1  26991437-26991504
            213-324             JAXUCZ010000020.1  26993532-26993643
            325-477             JAXUCZ010000020.1  26994758-26994910
            478-708             JAXUCZ010000020.1  26995390-26995620
            709-854             JAXUCZ010000020.1  26995904-26996049
            855-1047            JAXUCZ010000020.1  26997937-26998129
            1048-1135           JAXUCZ010000020.1  27001021-27001108
            1136-1345           JAXUCZ010000020.1  27002341-27002550
            1346-1527           JAXUCZ010000020.1  27004570-27004751
            1528-1703           JAXUCZ010000020.1  27004835-27005010
            1704-1827           JAXUCZ010000020.1  27005173-27005296
            1828-1989           JAXUCZ010000020.1  27005797-27005958
            1990-2127           JAXUCZ010000020.1  27006177-27006314
            2128-2274           JAXUCZ010000020.1  27006388-27006534
            2275-2454           JAXUCZ010000020.1  27007272-27007451
            2455-2538           JAXUCZ010000020.1  27007547-27007630
            2539-2674           JAXUCZ010000020.1  27010383-27010518
            2675-2769           JAXUCZ010000020.1  27015021-27015115
            2770-7537           JAXUCZ010000020.1  27015916-27020683
            7538-7708           JAXUCZ010000020.1  27022944-27023114
            7709-7795           JAXUCZ010000020.1  27023822-27023908
            7796-7974           JAXUCZ010000020.1  27024375-27024553
            7975-8176           JAXUCZ010000020.1  27027684-27027885
            8177-8278           JAXUCZ010000020.1  27029727-27029828
            8279-8424           JAXUCZ010000020.1  27031879-27032024
            8425-8698           JAXUCZ010000020.1  27034083-27034356
            8699-9033           JAXUCZ010000020.1  27034483-27034817
            9034-10277          JAXUCZ010000020.1  27035330-27036573
FEATURES             Location/Qualifiers
     source          1..10277
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q11"
     gene            1..10277
                     /gene="Ranbp2"
                     /gene_synonym="RGD1560047"
                     /note="RAN binding protein 2"
                     /db_xref="GeneID:294429"
                     /db_xref="RGD:1560047"
     exon            1..144
                     /gene="Ranbp2"
                     /gene_synonym="RGD1560047"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..9339
                     /gene="Ranbp2"
                     /gene_synonym="RGD1560047"
                     /EC_number="5.2.1.8"
                     /codon_start=1
                     /product="E3 SUMO-protein ligase RanBP2"
                     /protein_id="NP_001178533.1"
                     /db_xref="GeneID:294429"
                     /db_xref="RGD:1560047"
                     /translation="MRRSKAEVERYIASVQGSAPSPREKSMKGFYFAKLYYEAKEYDL
                     AKKYISTYINVQERDPKAHRFLGLLYEIEENTDKAVECYKRSVELNPTQKDLVLKIAE
                     LLCKNDVTDGRAKYWVERAAKLFPGSPAIYKLKEQLLDCKGEDGWNKLFDLIQSELYA
                     RPDDVHVNIRLVELYRSNKRLKDAVAHCHEADRNMALRSSLEWNSCVVQTLKEYLESL
                     QCLDSDKSTWRATNKDLLLAYSNLMLLTLSTRDVQESRELLESFDSALQSVKSSVGGN
                     DELSATFLETKGHFYMHVGSLLLKMGQQSDIQWRALSELAALCYLIAFQVPRPKVKLI
                     KGETGQNLLEMMAHDRLSQSGHMLLNLSRGKQDFLKEVVESFANKSGQSALCDALFSS
                     QSSKDRSFLGNDDIGNLDGQVPDLDDLARYDTGAVRAHSGSLQHLTWLGLQWNSLPTL
                     PAIRKWLKQLFHHLPQETSRLETNAPESICILDLEVFLLGVIYTSHLQLREKSNSHHT
                     SYQPLCLPLPVCRQLCTERQKSWWDAVCTLIHRKALPGTSAKLRLLVQREINSLRGQE
                     KHGLQPALLVHWAQSLQKTGSSLNSFYDQREYIGRSVHYWRKVLPLLKMIRKKNSIPE
                     PIDPLFKHFHSVDIQVSEIGEYEEDAHITFAILDAVNGNIEDAMTAFESIKNVVSYWN
                     LALIFHRKAEDIENDALSPEEQEECKNYLRKTRDYLIKILDDSDSNISVVQKLPVPLE
                     SVKEMLNSVMQELEDYSEGGTLYKNGCFRSADSELKHSTPSPTKYSLSPSKSYKYSPK
                     TPPRWAEDQNSLLKMICQQVEAIKKEMQELKLNSNNSASPHRWPAEHYRQDPVPDGYQ
                     GSQTFHGAPLTVATTGPSVYYSQSPAYNSQYLLRPAANVTPTKGPVYGMNRLPPQQHI
                     YAYSQQMHTPPVQSSSSCMFSQEMYGPPLRFESPATGILSPRGDDYFNYNVQQTSTNP
                     PLPEPGYFTKPPLVAHASRSGESKVIEFGKSNFVQPMQGEVIRPPLATPAHTTQPTPF
                     KFNSNFKSNDGDFTFSSPQVVTQSPSTAYSNSESLLGLLTSDKPLQGDGYSGLKPISA
                     QTGGSRNTFSFGSKSTLTENMGPNQQKNFGFRRSDDMFTFHGPGKSIFTTPTSELANK
                     SHETDGGSAHGDEEDDGPHFEPVVPLPDKIEVKTGEEDEEEFFCNRAKLFRFDGESKE
                     WKERGIGNVKILRHKTSGKIRLLMRREQVLKICANHYISPDMKLTPNAGSDRSFVWHA
                     LDYADELPKPEQLAIRFKTPEEAALFKCKFEEAQNILKALGTNASTAANHTLRIVKEP
                     ATQDNKDICKSDGGNLNFEFQIVKKEGPFWNCNSCSFKNAATATKCVSCQNTKPTNGK
                     ELLGSPLVENGFASKTGPENVQDRFALMTPNKEGHWDCSVCLVRNEPTVSRCIACQNT
                     KSANKNGSSFAQTSFKFGQGDLSKSADSDFRSVFSKKEGQWDCSICLVRNEASSTKCV
                     ACQNPAKQAPVSSPASFKAGTSDVSKTSKSGFDDMFAKKEGQWDCSLCSVRNEANAVK
                     CVACQNPVKPSSSTTVTVLPSFKFGTSEMTKPPRSGFEGMFAKKEGQWDCSLCFVRNE
                     ASASQCIACQNPNKQNQPTSAVSAPASSETSKSPKCGFEGLFTRKEGEWECTVCSVQN
                     ESSSLKCVSCDASKPTHKPIAEAPSAFTVGSKSQLNESAGSQVGTEFKSNFPEKNFKV
                     GISEQKFKFGHVDQEKTPSFTFQGSSNTEFKSIKDGFSFCIPVSADGFKFGIQEKGNQ
                     EKKSEKHLENDPGFQAHDTSGQKNGSGVVFGQTSSTFTFADLAKSTSREGFQFGKKDP
                     NFKGFSGAGEKLFSSQSGKVAEKANTSDLEKDDDAYKTEDSDDIHFEPVVQMPEKVEL
                     VTGEEDEKVLYSQRVKLFRFDAEISQWKERGLGNLKILKNEVNGKLRMLMRREQVLKV
                     CANHWITTTMNLKPLSGSDRAWMWLASDFSDGDAKLEQLAAKFKTPELAEEFKQKFEE
                     CQRLLLDIPLQTPHKLVDTGRAAKLIQRAEEMKSGLKDFKTFLTNDQAKVTEEENTSS
                     GADASSASDTTVKQNPDNTGPALEWDNYDLREDALDDSVSSSSVHASPLASSPVRKNL
                     FRFGESTTGFNFSFKSALSPSKSPAKLNQSGTSVGTDEESDVTQEEERDGQYFEPVVP
                     LPDLIEVSSGEENEQVVFSHRAKLYRYDKDVGQWKERGIGDIKILQNYDNKQVRIVMR
                     RDQVLKLCANHRITPDMTLQTMKGTERVWVWTACDFADGERKIEHLAVRFKLQDVADS
                     FKKIFDEAKTAQEKDCLITPHVSHLSTPRESPCGKIAIAVLEETTRERTDLTQGDEVV
                     DTTSEAGETSSTSETTPKAVVSPPKFVFGSESVKSIFSSEKSKPFAFGNSSATGSLFG
                     FSFNAPLKNSNSEISSIVQSGSEGKVDPDKGELPPNSDIKQSSDGKVKNLIAFSKETS
                     STFKTPEKAREKNKPEDPPSDTDILIVYELTPTPEQKALAEKLLLPSTFFCYKNRPGY
                     VSEEEEDDEDFEMAVKKLNGKLYVDDSEKPLEENLADNDKECVIVWEKKPTVEERAKA
                     DTLKLPPTFFCGVCSDTDEDNGNGEDFQSELRKVQEAQKSQSEKVTNTVGIEQTGETE
                     ATNPDGSKSEEPDSDTKHSSSSPVPGTMDKPVDLSTKKETDMEFPSQGESKTVLFGFG
                     SGTGLSFADLASSNSGDFAFGPKDKNFQWANTGAAVFGTQSTSKDGDDEDGSDEDVVH
                     NEDIHFEPIVSLPEVEVKSGEEDEEVLFKERAKLYRWDRDVSQWKERGIGDIKILWHS
                     VKNYYRILMRRDQVFKVCANHVITKAMELKPLNFSNNALVWTASDYADGEAKIEQLAV
                     RFKTKEITECFKKKIEECQQNIMKLQNGQVSLAAELSKETNPVVFFDVCVDGEPLGRI
                     IMELFSNIVPQTAENFRALCTGEKGFGFKNSIFHRVVPDFICQGGDITKYNGTGGQSI
                     YGDKFDDENFDLKHTGPGLLSMANCGQNTNSSQFFITLKKAEHLDFKHVVFGFVKDGM
                     DTVRKIESFGSPKGSVSRRICITECGQL"
     exon            145..212
                     /gene="Ranbp2"
                     /gene_synonym="RGD1560047"
                     /inference="alignment:Splign:2.1.0"
     exon            213..324
                     /gene="Ranbp2"
                     /gene_synonym="RGD1560047"
                     /inference="alignment:Splign:2.1.0"
     exon            325..477
                     /gene="Ranbp2"
                     /gene_synonym="RGD1560047"
                     /inference="alignment:Splign:2.1.0"
     exon            478..708
                     /gene="Ranbp2"
                     /gene_synonym="RGD1560047"
                     /inference="alignment:Splign:2.1.0"
     exon            709..854
                     /gene="Ranbp2"
                     /gene_synonym="RGD1560047"
                     /inference="alignment:Splign:2.1.0"
     exon            855..1047
                     /gene="Ranbp2"
                     /gene_synonym="RGD1560047"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1135
                     /gene="Ranbp2"
                     /gene_synonym="RGD1560047"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1345
                     /gene="Ranbp2"
                     /gene_synonym="RGD1560047"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1527
                     /gene="Ranbp2"
                     /gene_synonym="RGD1560047"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1703
                     /gene="Ranbp2"
                     /gene_synonym="RGD1560047"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1827
                     /gene="Ranbp2"
                     /gene_synonym="RGD1560047"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..1989
                     /gene="Ranbp2"
                     /gene_synonym="RGD1560047"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..2127
                     /gene="Ranbp2"
                     /gene_synonym="RGD1560047"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..2274
                     /gene="Ranbp2"
                     /gene_synonym="RGD1560047"
                     /inference="alignment:Splign:2.1.0"
     exon            2275..2454
                     /gene="Ranbp2"
                     /gene_synonym="RGD1560047"
                     /inference="alignment:Splign:2.1.0"
     exon            2455..2538
                     /gene="Ranbp2"
                     /gene_synonym="RGD1560047"
                     /inference="alignment:Splign:2.1.0"
     exon            2539..2674
                     /gene="Ranbp2"
                     /gene_synonym="RGD1560047"
                     /inference="alignment:Splign:2.1.0"
     exon            2675..2769
                     /gene="Ranbp2"
                     /gene_synonym="RGD1560047"
                     /inference="alignment:Splign:2.1.0"
     exon            2770..7537
                     /gene="Ranbp2"
                     /gene_synonym="RGD1560047"
                     /inference="alignment:Splign:2.1.0"
     exon            7538..7708
                     /gene="Ranbp2"
                     /gene_synonym="RGD1560047"
                     /inference="alignment:Splign:2.1.0"
     exon            7709..7795
                     /gene="Ranbp2"
                     /gene_synonym="RGD1560047"
                     /inference="alignment:Splign:2.1.0"
     exon            7796..7974
                     /gene="Ranbp2"
                     /gene_synonym="RGD1560047"
                     /inference="alignment:Splign:2.1.0"
     exon            7975..8176
                     /gene="Ranbp2"
                     /gene_synonym="RGD1560047"
                     /inference="alignment:Splign:2.1.0"
     exon            8177..8278
                     /gene="Ranbp2"
                     /gene_synonym="RGD1560047"
                     /inference="alignment:Splign:2.1.0"
     exon            8279..8424
                     /gene="Ranbp2"
                     /gene_synonym="RGD1560047"
                     /inference="alignment:Splign:2.1.0"
     exon            8425..8698
                     /gene="Ranbp2"
                     /gene_synonym="RGD1560047"
                     /inference="alignment:Splign:2.1.0"
     exon            8699..9033
                     /gene="Ranbp2"
                     /gene_synonym="RGD1560047"
                     /inference="alignment:Splign:2.1.0"
     exon            9034..10277
                     /gene="Ranbp2"
                     /gene_synonym="RGD1560047"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcctggaga ccgcagccgc tgtaggcccc agagctggcc tgccgctccc ggggagcctg
       61 gtcggcggca cgatgaggcg cagcaaggcc gaggtggagc ggtacatcgc ctcggtgcag
      121 ggctccgccc cgtcgccccg agagaagtca atgaaaggat tttattttgc aaagctgtac
      181 tatgaagcta aagaatatga tcttgccaaa aaatacattt ctacgtatat taatgtgcaa
      241 gagagggacc ctaaagccca cagatttttg ggtcttcttt atgaaattga agaaaataca
      301 gacaaagctg tagaatgtta taagcgttca gtggaattaa acccaacgca aaaagatctt
      361 gtgttgaaga ttgcagaatt gctttgtaaa aacgatgtga ccgatggaag agcaaagtac
      421 tgggttgaga gagcggccaa actgtttcca ggaagccctg ccatctataa gttaaaggaa
      481 caacttttag actgtaaagg tgaagatgga tggaataaac tttttgactt gattcaatca
      541 gaactttatg caagacctga tgatgttcat gtaaatattc gactagtaga gctttatcgt
      601 tcaaataaaa gattgaagga tgccgtggcc cactgccatg aggcagacag gaacatggct
      661 ttacgttcaa gtttagaatg gaattcatgt gttgtccaga ctcttaagga atatctggaa
      721 tctctgcagt gtttggattc tgataaaagt acttggagag caaccaataa agacttactt
      781 ctagcctatt ccaaccttat gctacttaca ctttccacca gagatgtgca ggaaagtaga
      841 gagctattgg agagttttga tagtgctctt cagtctgtga aatcttctgt gggtggaaat
      901 gacgagctat cagctacgtt cctagaaacg aaaggacatt tctacatgca tgttggctct
      961 ctgcttttga agatggggca gcagagtgac atccagtggc gagctctttc tgagctggct
     1021 gcattgtgct atctcattgc atttcaggtt ccaagaccaa aggttaaatt aataaaagga
     1081 gaaactggac aaaatctact ggaaatgatg gcccacgatc gccttagcca gtcagggcac
     1141 atgttgttaa acttaagtcg tggcaagcaa gactttctga aggaagttgt ggaatctttt
     1201 gctaacaaaa gtggccagtc tgctctctgt gatgctctgt tttctagtca gtcatccaag
     1261 gatagatctt ttcttggtaa cgatgatatt ggaaacctgg atgggcaagt accagaccta
     1321 gatgacttgg ctagatatga tactggagct gttcgagcac atagtggtag tcttcagcac
     1381 cttacctggc ttggcttaca gtggaactca ctgcctactt taccagcaat tcgaaaatgg
     1441 ttaaaacagc tcttccacca tttgcctcag gagacatcaa ggcttgaaac aaatgcacct
     1501 gaatcaatat gtattttaga tcttgaagta ttcttactcg gagtaatata taccagtcac
     1561 ttacaactaa gggagaagag taattctcac cacacttcct atcagccatt gtgtttgcca
     1621 cttccagtgt gcagacagct ttgtacagaa agacagaagt cctggtggga tgcagtttgt
     1681 actctgattc acagaaaggc attacctgga acctcagcaa aattgcgact tctagttcaa
     1741 cgtgaaataa acagtctgag aggccaggaa aagcacggcc tacaacctgc tctgcttgtg
     1801 cattgggcac agagtcttca gaaaacaggc agcagtctta attcttttta tgatcaacgg
     1861 gaatacatag gcagaagtgt tcattattgg aggaaagtct taccattgtt gaagatgatc
     1921 agaaagaaga atagtattcc tgaacctatt gatcctctgt ttaaacattt ccatagtgtg
     1981 gatattcagg tatctgaaat tggcgaatat gaagaagatg cacacataac ttttgctata
     2041 ttggatgctg ttaacggaaa catagaagat gccatgactg cttttgaatc tattaaaaat
     2101 gtagtttctt attggaatct tgcactgatt tttcacagga aagcagaaga tattgaaaat
     2161 gatgccttgt ctcctgaaga acaagaagag tgcaaaaatt atctgagaaa gactagggac
     2221 tacctgataa agattttaga tgatagtgat tcaaatattt ccgtggttca gaaattgcct
     2281 gtcccccttg agtctgtaaa agagatgctg aactcagtta tgcaggaact tgaagactac
     2341 agtgaaggag gtactcttta taaaaatggt tgctttcgaa gtgctgattc agagttaaag
     2401 cattcaacac catctcctac caaatattct ctatcaccaa gtaaaagtta caagtattcg
     2461 ccaaaaacac cacctcgatg ggcagaagat caaaattctt tattgaaaat gatctgccag
     2521 caagtagagg ccattaagaa agaaatgcag gaattgaagc taaatagcaa caattctgca
     2581 tcccctcatc gctggcctgc agaacattac cgacaagacc cagttcctga tgggtatcag
     2641 gggtcacaaa cttttcatgg ggctccacta acagttgcaa ctactggccc ttcagtatat
     2701 tatagtcagt cacctgcata taattcccag tatcttctca gaccagcagc taatgtaact
     2761 cccacaaagg gtccagttta tggcatgaat aggcttccac ctcaacaaca tatttatgca
     2821 tattcacaac agatgcacac accaccagtg caaagttcat cttcttgtat gttctctcag
     2881 gaaatgtatg gtcctccctt gcgttttgag tctcctgcaa caggaattct atcacccagg
     2941 ggtgatgatt actttaatta caatgttcag cagacaagca caaatccacc tttgccagaa
     3001 ccagggtatt tcacaaagcc tccacttgta gctcatgctt caagatcggg agaatcaaag
     3061 gttatagaat ttggaaaatc caattttgtt cagcccatgc agggtgaagt aataaggcca
     3121 cctttggcaa caccagcaca tacaacacag ccaactccct ttaaatttaa ctcaaatttc
     3181 aaatcaaatg acggtgactt cacattttca tcaccacagg tagtgacaca gtctccttca
     3241 acagcttaca gtaacagtga aagtctttta ggtctcctga cctcagataa acctttacaa
     3301 ggagatggct atagtggact aaaaccaata tcagctcaaa ctggtgggtc tcggaataca
     3361 ttcagttttg gaagcaaaag tacacttaca gaaaacatgg gcccaaatca gcagaaaaat
     3421 tttggttttc gtcgaagtga tgatatgttt acttttcacg gtccaggaaa gtccatattt
     3481 acaacaccta cttcagaact ggcaaataaa agtcatgaaa cagatggagg aagtgctcat
     3541 ggagatgaag aggatgatgg tcctcacttt gagcctgtgg tacctcttcc tgacaagata
     3601 gaagtaaaaa cgggtgagga agatgaagaa gaattctttt gcaatcgtgc aaagttgttc
     3661 cgttttgatg gtgaatccaa agaatggaag gaacgtggga taggcaatgt aaaaatacta
     3721 aggcacaaaa catctggtaa aattcgcctt ctgatgagac gagagcaagt attaaagatc
     3781 tgtgcaaatc attatataag ccccgatatg aaactgacac caaatgctgg ctcagataga
     3841 tcttttgtat ggcatgccct tgattatgca gatgaattgc ccaaaccaga acagcttgca
     3901 attagattca aaactcctga ggaagcagca ctatttaagt gtaaatttga agaggcccag
     3961 aacattttaa aagccttagg aacaaatgcc tctacagcag caaatcatac tcttagaatt
     4021 gtcaaagaac ctgcaactca ggataacaag gacatttgca aatctgatgg tggaaacttg
     4081 aactttgaat tccagattgt aaagaaggaa gggcctttct ggaattgtaa cagctgctcg
     4141 tttaagaatg ctgcaactgc tacgaaatgt gtatcatgcc aaaatacaaa accaacgaat
     4201 ggcaaagagc tcctaggttc accattagtt gaaaatggct ttgcttctaa aactggccca
     4261 gaaaatgttc aagatcgatt tgcattgatg actccaaata aagaaggtca ctgggattgc
     4321 agtgtttgtt tagtaagaaa cgaacccact gtatctaggt gcattgcatg tcagaacaca
     4381 aagtctgcta acaaaaatgg gtcttccttt gctcaaactt ctttcaaatt tggccaggga
     4441 gatctttcta agtctgctga cagtgacttc aggtctgtgt tttctaaaaa agaaggtcag
     4501 tgggattgca gtatatgcct agtccgaaat gaagcaagct ctacaaaatg tgttgcttgt
     4561 cagaacccag caaaacaggc tcctgtctca tcacctgctt cttttaaggc tggcacttca
     4621 gatgtaagta aaacttcaaa gagtggattt gatgacatgt ttgctaagaa agaaggacag
     4681 tgggattgta gtttgtgctc agtgagaaat gaagcaaatg ctgtaaagtg tgttgcttgt
     4741 cagaatccag ttaaacccag ttcatctacc actgttacag tacttccctc tttcaagttt
     4801 ggtacctcag agatgactaa gcctcccagg agtggatttg agggcatgtt cgccaagaag
     4861 gaaggacaat gggattgcag cttgtgtttt gtccgaaatg aagcaagtgc ttctcaatgt
     4921 attgcttgtc agaatccaaa taagcagaat cagcctacat ctgctgtatc agctcctgcc
     4981 tcttcagaga caagcaaatc tccaaagtgt ggttttgaag gcttgtttac cagaaaggaa
     5041 ggcgagtggg agtgtactgt ttgttctgta caaaatgaga gctcttccct aaaatgtgtg
     5101 tcttgtgatg cctccaagcc aactcataag cctattgcag aagctccttc agctttcaca
     5161 gtgggctcaa agtcacagtt aaatgaatct gcaggaagtc aagtgggaac agaattcaaa
     5221 agtaactttc cagaaaagaa ttttaaagtt ggcatatcag agcagaaatt taaatttggg
     5281 catgtggatc aagaaaaaac accctccttc acctttcagg gttcttctaa tacagaattt
     5341 aagtcaatca aggatggatt tagtttttgc attcctgtat ctgctgatgg gtttaagttt
     5401 ggcattcagg agaagggaaa tcaagagaag aagagtgaga aacatcttga aaatgatcct
     5461 ggtttccaag ctcatgatac tagtggtcag aagaatggta gtggtgtggt ctttggtcag
     5521 acaagcagca ccttcacctt tgcagatctt gcaaagtcaa cttcaagaga aggatttcag
     5581 tttggcaaga aagaccctaa tttcaaggga ttttcaggtg caggagaaaa attattctca
     5641 tcacaaagtg gcaaagtggc tgagaaagca aatacttctg atcttgagaa agatgacgat
     5701 gcctataaga ccgaggacag cgatgacatc cattttgaac cagtagtgca gatgccggaa
     5761 aaagtggaac ttgtaacagg ggaagaagat gaaaaagttt tgtattctca aagggtgaaa
     5821 ttatttagat ttgatgctga gataagtcag tggaaagaaa gaggtttggg gaacttaaaa
     5881 attctcaaaa atgaagtcaa tggtaaacta agaatgctga tgcgaagaga acaagtacta
     5941 aaagtttgtg ccaatcattg gataaccact acgatgaacc tgaagcctct ctcagggtca
     6001 gatagagcat ggatgtggct agccagtgat ttctcagatg gcgatgctaa actggaacaa
     6061 ttggctgcaa agtttaaaac gccagaacta gctgaagaat tcaagcagaa atttgaggag
     6121 tgtcaaagac ttctcttaga cattccactt cagacacccc ataaacttgt agatactggc
     6181 agggctgcta aattaataca aagagctgag gaaatgaaga gcggactgaa agatttcaaa
     6241 acatttttga caaatgatca agcaaaagtg actgaggaag agaacacaag ttcaggtgca
     6301 gatgcttcca gtgcctcaga cactacagtc aagcaaaacc ctgataacac tgggcccgcc
     6361 ttagaatggg ataactatga cttacgggaa gacgccttgg atgacagtgt cagcagcagc
     6421 tcagttcatg cttctccatt ggcaagcagc cctgtgcgga aaaacctctt ccgctttggt
     6481 gagtcaacta caggatttaa cttcagtttt aaatctgctc tgagtccatc taagtctcct
     6541 gccaagttga accagagtgg aacttcagtt ggcactgatg aagagtctga tgttactcaa
     6601 gaagaagaga gagatggaca gtactttgaa cctgttgttc ccttacctga tctaattgaa
     6661 gtatccagtg gtgaggaaaa tgaacaagtt gtttttagtc acagagcaaa gctctacaga
     6721 tatgataaag atgttggtca gtggaaagaa agaggcattg gagatataaa aattttacag
     6781 aattacgata ataaacaggt tcgcatagtg atgagaaggg accaggtatt aaaactttgt
     6841 gccaatcata ggataactcc agatatgact ttgcaaacta tgaaagggac tgaaagagta
     6901 tgggtgtgga ctgcatgtga ttttgcagat ggagaaagaa aaatagaaca tttagctgtt
     6961 cgttttaaac tacaagatgt tgcagactca tttaagaaaa tttttgatga agcaaaaaca
     7021 gcacaagaaa aagattgttt gataacacct catgtttctc atctgagcac ccctagagag
     7081 tcaccatgtg gcaaaattgc tattgctgtc ttagaagaaa ccacaagaga aaggacagat
     7141 ttaactcaag gagatgaggt agtagataca acttcagagg ctggagaaac atctagcact
     7201 tctgaaacaa caccaaaagc agtagtttct cctcctaagt ttgtatttgg ctctgaatct
     7261 gttaaaagca tttttagtag tgaaaaatca aagccatttg catttggcaa cagttcagcc
     7321 actggttctt tgtttggatt tagttttaat gcacctttga aaaatagcaa tagtgaaatt
     7381 agttcaatag tccagagtgg atctgaaggg aaagtagacc ctgacaaagg cgagctgcca
     7441 ccgaactctg acatcaagca atcttctgat ggcaaagtca agaatctcat tgccttttca
     7501 aaagagacct cttcaacgtt taaaacacca gaaaaggccc gagagaagaa taaacctgaa
     7561 gatcctccct cagatactga tattctcatt gtgtatgaac tcactcccac tcctgagcag
     7621 aaagcccttg cagagaaact tctgcttcct tcaactttct tttgttataa gaataggcca
     7681 ggttatgtta gtgaagaaga ggaggatgat gaagattttg aaatggccgt caagaaactt
     7741 aatggaaaac tctatgtgga tgactcagaa aaaccattgg aagaaaatct agcagataat
     7801 gacaaagaat gtgttattgt ttgggagaag aagccaacag ttgaagagag agcaaaagca
     7861 gatactttaa agcttccgcc tacatttttc tgtggagtct gcagtgacac tgatgaggac
     7921 aatggaaatg gggaggattt tcagtcagag cttcggaaag ttcaggaagc tcagaaatcc
     7981 cagagtgaga aagtgactaa cacagttggt attgagcaga caggtgagac tgaagcaaca
     8041 aaccccgatg gctctaagtc tgaagaaccc gattccgata ccaaacacag tagctcatct
     8101 cctgtccctg ggactatgga caagcctgta gatttgtcca ctaaaaaaga aactgacatg
     8161 gaattcccaa gccaagggga aagcaagact gttttgtttg gatttggaag tggtacaggc
     8221 ctgtcatttg cagacttggc ttcaagtaat tctggagatt ttgcttttgg tcctaaagat
     8281 aaaaatttcc agtgggcaaa cactggagca gctgtgtttg gaacacagtc tacaagtaaa
     8341 gatggtgacg atgaagatgg cagtgatgaa gacgtagttc acaatgagga catccacttt
     8401 gaacccatag tctccttacc agaggtagaa gtgaaatctg gagaagaaga tgaagaagtt
     8461 ttgttcaaag agagagccaa actttataga tgggatagag atgtcagtca gtggaaggag
     8521 agaggtattg gagatataaa gattctttgg cattcagtga agaattatta tcggatccta
     8581 atgagaagag accaagtttt taaagtgtgt gcaaaccatg ttattaccaa agccatggaa
     8641 ttaaaacctt taaatttttc aaacaatgct ttagtttgga ctgcctcaga ttatgctgat
     8701 ggagaagcaa aaatagaaca gcttgcagtg agatttaaga caaaggaaat aactgagtgt
     8761 tttaagaaaa aaattgaaga atgtcaacaa aatataatga aactccagaa tggacaagta
     8821 tcccttgcag cggaattatc taaggagacc aatcctgtgg tgttttttga tgtttgtgtg
     8881 gatggtgaac ctctaggacg gataatcatg gaattatttt caaatattgt tcctcaaact
     8941 gctgagaact tcagagcatt atgcactgga gagaagggct ttggttttaa gaactccatt
     9001 tttcaccgag tagttccaga ttttatttgc caaggaggag atattaccaa atacaatgga
     9061 acaggaggac agtccattta tggagataaa tttgacgatg aaaactttga tctaaaacac
     9121 actggtcctg gcttactatc catggccaat tgcggccaga ataccaacag ttctcagttt
     9181 tttataacac tgaagaaagc agaacatttg gactttaagc atgtagtgtt tgggtttgtt
     9241 aaggatggca tggatactgt gagaaagatt gaatcatttg gttctcctaa agggtctgtt
     9301 agtagaagaa tttgtatcac agaatgtgga cagctataaa ataatttttc acagtggatt
     9361 ttatctatat aagcagttga atttatgctt aattgttaca cagtatagta attatgttca
     9421 ccttttgaaa acagacgttt ctgatgtata aatgtaaaat tgtagcttat agctgttgtc
     9481 actttttagt gtgtaattga tcttgcatgg tgtgaaataa aagtttaaac actggtgtat
     9541 ttcaggtgta cttgttttta tgtactcctg acatatctgt attagaatgg ctaatactaa
     9601 ttttgttaaa agcaatagaa tttcccagac tattgaagga atatgatata tgcaatctta
     9661 ttttaattcc tgttaagata tctggacttc ttgcatggta cttactgaat aaggggacca
     9721 caatgcagat aactttattt tagatttgaa atatatatgt atatatataa aactattcct
     9781 gtgctcatct atgtatagac tcaacttatg aataatagag ccacagaaga tgagagttaa
     9841 ccaaagtgct cttctggaat ttttatgctc ctgtatagtt aaaattaact tttaagtagg
     9901 atactgtctt ttcttaagaa gtgttgtgct cttttgaaga cattaatttt tacattttaa
     9961 ataagtcgat tatttcctta gctagctttc tctccttctt ccttcccatc ctcctttctt
    10021 ctctattttc ttccttcttt ccattcactt ttctgttacc tgtctctact acctcagaaa
    10081 cttcagcttg gtcctgatga tagaattgaa tttttctcta gttcttgtga taaagtatca
    10141 atatttttta aaagatcgat accatgttct ttggttaaag atttgcttta tattagattg
    10201 ttgcagtacc tttttctggt gaattttgta gcagaaataa agtgatgatt gataagtcat
    10261 gacatttaaa acattga
//
