LOCUS       NM_053439               1069 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus RAN, member RAS oncogene family (Ran), mRNA.
ACCESSION   NM_053439
VERSION     NM_053439.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1069)
  AUTHORS   Sobuz,S.U., Sato,Y., Yoshizawa,T., Karim,F., Ono,K., Sawa,T.,
            Miyamoto,Y., Oka,M. and Yamagata,K.
  TITLE     SIRT7 regulates the nuclear export of NF-kappaB p65 by
            deacetylating Ran
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1866 (9), 1355-1367 (2019)
   PUBMED   31075303
REFERENCE   2  (bases 1 to 1069)
  AUTHORS   Bao,X., Liu,H., Liu,X., Ruan,K., Zhang,Y., Zhang,Z., Hu,Q., Liu,Y.,
            Akram,S., Zhang,J., Gong,Q., Wang,W., Yuan,X., Li,J., Zhao,L.,
            Dou,Z., Tian,R., Yao,X., Wu,J. and Shi,Y.
  TITLE     Mitosis-specific acetylation tunes Ran effector binding for
            chromosome segregation
  JOURNAL   J Mol Cell Biol 10 (1), 18-32 (2018)
   PUBMED   29040603
REFERENCE   3  (bases 1 to 1069)
  AUTHORS   Vijayaraghavan,B., Jafferali,M.H., Figueroa,R.A. and Hallberg,E.
  TITLE     Samp1, a RanGTP binding transmembrane protein in the inner nuclear
            membrane
  JOURNAL   Nucleus 7 (4), 415-423 (2016)
   PUBMED   27541860
REFERENCE   4  (bases 1 to 1069)
  AUTHORS   Rudack,T., Jenrich,S., Brucker,S., Vetter,I.R., Gerwert,K. and
            Kotting,C.
  TITLE     Catalysis of GTP hydrolysis by small GTPases at atomic detail by
            integration of X-ray crystallography, experimental, and theoretical
            IR spectroscopy
  JOURNAL   J Biol Chem 290 (40), 24079-24090 (2015)
   PUBMED   26272610
REFERENCE   5  (bases 1 to 1069)
  AUTHORS   Zhang,K., Donnelly,C.J., Haeusler,A.R., Grima,J.C., Machamer,J.B.,
            Steinwald,P., Daley,E.L., Miller,S.J., Cunningham,K.M.,
            Vidensky,S., Gupta,S., Thomas,M.A., Hong,I., Chiu,S.L.,
            Huganir,R.L., Ostrow,L.W., Matunis,M.J., Wang,J., Sattler,R.,
            Lloyd,T.E. and Rothstein,J.D.
  TITLE     The C9orf72 repeat expansion disrupts nucleocytoplasmic transport
  JOURNAL   Nature 525 (7567), 56-61 (2015)
   PUBMED   26308891
REFERENCE   6  (bases 1 to 1069)
  AUTHORS   Percipalle,P., Clarkson,W.D., Kent,H.M., Rhodes,D. and Stewart,M.
  TITLE     Molecular interactions between the importin alpha/beta heterodimer
            and proteins involved in vertebrate nuclear protein import
  JOURNAL   J Mol Biol 266 (4), 722-732 (1997)
   PUBMED   9102465
REFERENCE   7  (bases 1 to 1069)
  AUTHORS   Clarkson,W.D., Kent,H.M. and Stewart,M.
  TITLE     Separate binding sites on nuclear transport factor 2 (NTF2) for
            GDP-Ran and the phenylalanine-rich repeat regions of nucleoporins
            p62 and Nsp1p
  JOURNAL   J Mol Biol 263 (4), 517-524 (1996)
   PUBMED   8918934
REFERENCE   8  (bases 1 to 1069)
  AUTHORS   Bullock,T.L., Clarkson,W.D., Kent,H.M. and Stewart,M.
  TITLE     The 1.6 angstroms resolution crystal structure of nuclear transport
            factor 2 (NTF2)
  JOURNAL   J Mol Biol 260 (3), 422-431 (1996)
   PUBMED   8757804
REFERENCE   9  (bases 1 to 1069)
  AUTHORS   Palacios,I., Weis,K., Klebe,C., Mattaj,I.W. and Dingwall,C.
  TITLE     RAN/TC4 mutants identify a common requirement for snRNP and protein
            import into the nucleus
  JOURNAL   J Cell Biol 133 (3), 485-494 (1996)
   PUBMED   8636225
REFERENCE   10 (bases 1 to 1069)
  AUTHORS   Bischoff,F.R. and Ponstingl,H.
  TITLE     Mitotic regulator protein RCC1 is complexed with a nuclear
            ras-related polypeptide
  JOURNAL   Proc Natl Acad Sci U S A 88 (23), 10830-10834 (1991)
   PUBMED   1961752
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            [WARNING] On Mar 12, 2025 this sequence was replaced by
            NM_053439.3.
            
            On Nov 26, 2020 this sequence version replaced NM_053439.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF306457.1, FQ220799.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676786 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                JAXUCZ010000012.1  33314245-33314290   c
            47-108              JAXUCZ010000012.1  33313966-33314027   c
            109-193             JAXUCZ010000012.1  33313779-33313863   c
            194-319             JAXUCZ010000012.1  33313569-33313694   c
            320-507             JAXUCZ010000012.1  33312306-33312493   c
            508-678             JAXUCZ010000012.1  33311959-33312129   c
            679-1069            JAXUCZ010000012.1  33311155-33311545   c
FEATURES             Location/Qualifiers
     source          1..1069
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q13"
     gene            1..1069
                     /gene="Ran"
                     /note="RAN, member RAS oncogene family"
                     /db_xref="GeneID:84509"
                     /db_xref="RGD:620367"
     exon            1..46
                     /gene="Ran"
                     /inference="alignment:Splign:2.1.0"
     exon            47..108
                     /gene="Ran"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..723
                     /gene="Ran"
                     /note="GTPase Ran; ras-like protein TC4; ras-related
                     nuclear protein"
                     /codon_start=1
                     /product="GTP-binding nuclear protein Ran"
                     /protein_id="NP_445891.1"
                     /db_xref="GeneID:84509"
                     /db_xref="RGD:620367"
                     /translation="MAAQGEPQVQFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLG
                     VEVHPLVFHTNRGPIKFNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVP
                     NWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKP
                     FLWLARKLIGDPNLEFVAMPALAPPEVVMDPALAAQYEHDLEVAQTTALPDEDDDL"
     exon            109..193
                     /gene="Ran"
                     /inference="alignment:Splign:2.1.0"
     exon            194..319
                     /gene="Ran"
                     /inference="alignment:Splign:2.1.0"
     exon            320..507
                     /gene="Ran"
                     /inference="alignment:Splign:2.1.0"
     exon            508..678
                     /gene="Ran"
                     /inference="alignment:Splign:2.1.0"
     exon            679..1069
                     /gene="Ran"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 catctttcca gcttcagtcg gacaggcgcg gagactcttc tggaagccgc tctctcccgc
       61 aggatcgccg cgatggccgc ccagggagag ccgcaggtcc agttcaagct cgtcctggtg
      121 ggcgacggcg gcaccgggaa gacgacgttc gtgaagcgcc acttgacggg cgagtttgag
      181 aagaagtatg tagccaccct gggcgtggag gtgcacccgc tcgtcttcca taccaacaga
      241 ggacccatca agttcaacgt gtgggacaca gccggccagg agaagttcgg gggcctgcgc
      301 gatggctact acatccaagc ccagtgtgcc attataatgt ttgacgtaac atcaagagtt
      361 acttacaaga acgtacctaa ctggcataga gatctggtac gcgtgtgtga aaacatcccc
      421 attgtattgt gtggcaacaa agtggatatt aaagacagga aagtgaaggc aaaatctatt
      481 gtcttccacc gaaagaagaa tcttcagtac tatgacattt ctgccaaaag taactacaac
      541 tttgaaaagc ctttcctctg gcttgccaga aagctcattg gagatcctaa cttggagttc
      601 gttgccatgc ctgctcttgc cccacctgag gtggtcatgg acccagcttt ggcagcacag
      661 tacgagcatg atttagaggt tgctcagacg actgcgctcc cggatgagga tgacgacctg
      721 tgagaaaatg aagctggagc cctgcgtcag aagtctagtt ttataggcaa ctgtcctgtg
      781 atgtcagcgg tgcagcgcgt gtgccacctt atttagctaa gcagatcgtg tacttcattg
      841 ggatgctgaa agatgaatgg gcttcgagtg aatgtggcag ttaaacatac cgtcattttt
      901 tggacttgca tatttagctg tttggaacag agttgtttcc ttcctgaatt tcaaagataa
      961 gactgctgca gtcgcatcac aatattcagt ggtgaaatct tgtttgttac tgtcattccc
     1021 attcttttcg tttagaatca gaataaagtt gtatttcaaa taatctaaa
//
