LOCUS       NM_020100               1234 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Rattus norvegicus receptor activity modifying protein 3 (Ramp3),
            mRNA.
ACCESSION   NM_020100
VERSION     NM_020100.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1234)
  AUTHORS   Meng,Q., Shi,D., Feng,J., Su,Y., Long,Y., He,S., Wang,S., Wang,Y.,
            Zhang,X. and Chen,X.
  TITLE     Hypercholesterolemia Up-Regulates the Expression of Intermedin and
            Its Receptor Components in the Aorta of Rats via Inducing the
            Oxidative Stress
  JOURNAL   Ann Clin Lab Sci 46 (1), 5-17 (2016)
   PUBMED   26927337
  REMARK    GeneRIF: Increased expression of IMD and all its receptor
            components (CRLR, RAMP1, RAMP2, and RAMP3) were displayed within
            the aorta of rats with Hypercholesterolemia.
REFERENCE   2  (bases 1 to 1234)
  AUTHORS   Lenhart,P.M., Broselid,S., Barrick,C.J., Leeb-Lundberg,L.M. and
            Caron,K.M.
  TITLE     G-protein-coupled receptor 30 interacts with receptor
            activity-modifying protein 3 and confers sex-dependent
            cardioprotection
  JOURNAL   J Mol Endocrinol 51 (1), 191-202 (2013)
   PUBMED   23674134
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1234)
  AUTHORS   Fu,W., Ruangkittisakul,A., MacTavish,D., Shi,J.Y., Ballanyi,K. and
            Jhamandas,J.H.
  TITLE     Amyloid beta (Abeta) peptide directly activates amylin-3 receptor
            subtype by triggering multiple intracellular signaling pathways
  JOURNAL   J Biol Chem 287 (22), 18820-18830 (2012)
   PUBMED   22500019
REFERENCE   4  (bases 1 to 1234)
  AUTHORS   Hikosaka,T., Tsuruda,T., Nagata,S., Kuwasako,K., Tsuchiya,K.,
            Hoshiko,S., Inatsu,H., Chijiiwa,K. and Kitamura,K.
  TITLE     Adrenomedullin production is increased in colorectal
            adenocarcinomas; its relation to matrix metalloproteinase-9
  JOURNAL   Peptides 32 (9), 1825-1831 (2011)
   PUBMED   21839130
REFERENCE   5  (bases 1 to 1234)
  AUTHORS   Li,L., Tang,F. and O,W.S.
  TITLE     Coexpression of adrenomedullin and its receptor component proteins
            in the reproductive system of the rat during gestation
  JOURNAL   Reprod Biol Endocrinol 8, 130 (2010)
   PUBMED   21034462
  REMARK    GeneRIF: ADM peptide concentration exhibited a spatio-temporal
            pattern in the rat female reproductive system during gestation and
            this suggests that ADM may play important roles in gestation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1234)
  AUTHORS   Kuwasako,K., Shimekake,Y., Masuda,M., Nakahara,K., Yoshida,T.,
            Kitaura,M., Kitamura,K., Eto,T. and Sakata,T.
  TITLE     Visualization of the calcitonin receptor-like receptor and its
            receptor activity-modifying proteins during internalization and
            recycling
  JOURNAL   J Biol Chem 275 (38), 29602-29609 (2000)
   PUBMED   10882736
REFERENCE   7  (bases 1 to 1234)
  AUTHORS   Husmann,K., Sexton,P.M., Fischer,J.A. and Born,W.
  TITLE     Mouse receptor-activity-modifying proteins 1, -2 and -3: amino acid
            sequence, expression and function
  JOURNAL   Mol Cell Endocrinol 162 (1-2), 35-43 (2000)
   PUBMED   10854696
REFERENCE   8  (bases 1 to 1234)
  AUTHORS   Nagae,T., Mukoyama,M., Sugawara,A., Mori,K., Yahata,K.,
            Kasahara,M., Suganami,T., Makino,H., Fujinaga,Y., Yoshioka,T.,
            Tanaka,I. and Nakao,K.
  TITLE     Rat receptor-activity-modifying proteins (RAMPs) for
            adrenomedullin/CGRP receptor: cloning and upregulation in
            obstructive nephropathy
  JOURNAL   Biochem Biophys Res Commun 270 (1), 89-93 (2000)
   PUBMED   10733909
REFERENCE   9  (bases 1 to 1234)
  AUTHORS   McLatchie,L.M., Fraser,N.J., Main,M.J., Wise,A., Brown,J.,
            Thompson,N., Solari,R., Lee,M.G. and Foord,S.M.
  TITLE     RAMPs regulate the transport and ligand specificity of the
            calcitonin-receptor-like receptor
  JOURNAL   Nature 393 (6683), 333-339 (1998)
   PUBMED   9620797
REFERENCE   10 (bases 1 to 1234)
  AUTHORS   Palmberg,I. and Reuter,M.
  TITLE     Sensory receptors in the head of Stenostomum leucops. I.
            Presumptive photoreceptors
  JOURNAL   Acta Biol Hung 43 (1-4), 259-267 (1992)
   PUBMED   1299115
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF181552.2.
            
            On Jun 4, 2003 this sequence version replaced NM_020100.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF181552.2, FQ220789.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1234
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..1234
                     /gene="Ramp3"
                     /note="receptor activity modifying protein 3"
                     /db_xref="GeneID:56820"
                     /db_xref="RGD:61873"
     exon            1..87
                     /gene="Ramp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..476
                     /gene="Ramp3"
                     /note="receptor (calcitonin) activity modifying protein 3;
                     receptor (G protein-coupled) activity modifying protein 3"
                     /codon_start=1
                     /product="receptor activity-modifying protein 3 precursor"
                     /protein_id="NP_064485.2"
                     /db_xref="GeneID:56820"
                     /db_xref="RGD:61873"
                     /translation="MATPAQRLHLLPLLLLLCGECAQVCGCNETGMLERLPRCGKAFA
                     EMMQKVDVWKWCNLSEFIVYYESFTNCTEMETNIVGCYWPNPLAQSFITGIHRQFFSN
                     CTVDRTHWEDPPDEVLIPLIAVPVLLTVAMAGLVVWRSKRTDRLL"
     exon            88..220
                     /gene="Ramp3"
                     /inference="alignment:Splign:2.1.0"
     exon            221..1225
                     /gene="Ramp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttgctgtaa gccgagtgca tcttagctgg ccatggcgac cccggcacag cggctgcacc
       61 ttctccctct gttgctgctg ctttgtggtg agtgtgccca agtatgcggt tgcaatgaga
      121 caggaatgct ggagaggttg cctcgctgtg ggaaagcctt tgccgaaatg atgcagaagg
      181 tggacgtctg gaagtggtgc aacctgtcgg agttcatcgt gtactacgaa agcttcacta
      241 actgcacgga gatggagaca aacatcgtgg gctgctactg gcccaacccg ctggcccaga
      301 gctttatcac gggtatccat aggcagttct tttccaactg cactgtggac aggacccact
      361 gggaagaccc cccggatgaa gttctcatcc cacttatcgc agttccagtc ttgttgaccg
      421 tggctatggc tgggctggtg gtatggcgta gcaagcgcac tgaccggctt ctgtgagggc
      481 ctgcgggatg gaaggccgtg cctggcaagc tagaagaatg tcgcccagag ctctgagagc
      541 ctgcagactc tgtttctgtc tggtctgcct tggccacacc ctacctggtc gtgtcaaagt
      601 cctcctgact agactgacgt ggcccttgct gtctagcctg ctgcctggtg gggttcaggc
      661 tgccccgaca ggtgcttcac tctttcttgg gctagtggaa gaaagtgaca aacctcacat
      721 ttgtgtacca ggcgtggaaa tcatctcttg ctgagtccca ccctccctgg gctgaattcc
      781 cgagtctcta gacatttctt ggcagagtct ggcccagcct caaccctaac ccaggtcctg
      841 acccatttct atccctgacc ctgacctctg ctacgcttgg ggcagagagg gcaggcaagg
      901 tcatctggaa ggtgtggcgt cccgagcaga aagagagatg agcacattct ctgttggaca
      961 tgaagagtag tcggggggat tggggaatgg agttgttagg agtcatgtgt gacctacgga
     1021 cctgcctgtc ttctaggcga tctgccatga ttctgtgtcc agtgtgggct ggagctgtga
     1081 tttgtttaac ccttcagatc cctaccctga agatagagag tgaacctcct tcctgagggg
     1141 tattcctggg ggtgaggcac gctctgagcg tgctcaaggg ttctgtctgc tgatgtctgc
     1201 tttctgatta aagtgtctcc ttacaaaaaa aaaa
//
