LOCUS       NM_031646                767 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Rattus norvegicus receptor activity modifying protein 2 (Ramp2),
            mRNA.
ACCESSION   NM_031646 XM_001081831
VERSION     NM_031646.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 767)
  AUTHORS   Dai,K., Tanaka,M., Kamiyoshi,A., Sakurai,T., Ichikawa-Shindo,Y.,
            Kawate,H., Cui,N., Wei,Y., Tanaka,M., Kakihara,S., Matsui,S. and
            Shindo,T.
  TITLE     Deficiency of the adrenomedullin-RAMP3 system suppresses metastasis
            through the modification of cancer-associated fibroblasts
  JOURNAL   Oncogene 39 (9), 1914-1930 (2020)
   PUBMED   31754214
REFERENCE   2  (bases 1 to 767)
  AUTHORS   Meng,Q., Shi,D., Feng,J., Su,Y., Long,Y., He,S., Wang,S., Wang,Y.,
            Zhang,X. and Chen,X.
  TITLE     Hypercholesterolemia Up-Regulates the Expression of Intermedin and
            Its Receptor Components in the Aorta of Rats via Inducing the
            Oxidative Stress
  JOURNAL   Ann Clin Lab Sci 46 (1), 5-17 (2016)
   PUBMED   26927337
  REMARK    GeneRIF: Increased expression of IMD and all its receptor
            components (CRLR, RAMP1, RAMP2, and RAMP3) were displayed within
            the aorta of rats with Hypercholesterolemia.
REFERENCE   3  (bases 1 to 767)
  AUTHORS   Gao,H., Liebenthal,D.A., Yallampalli,U. and Yallampalli,C.
  TITLE     Adrenomedullin promotes rat trophoblast stem cell differentiation
  JOURNAL   Biol Reprod 91 (3), 65 (2014)
   PUBMED   25061099
  REMARK    GeneRIF: Data suggest that stimulation of
            adrenomedullin/adrenomedullin receptor signaling enhances
            trophoblast stem cell differentiation; this stimulation involves
            CALCRL (calcitonin receptor-like receptor) and RAMP2 (receptor
            activity-modifying protein 2).
REFERENCE   4  (bases 1 to 767)
  AUTHORS   Uetake,R., Sakurai,T., Kamiyoshi,A., Ichikawa-Shindo,Y., Kawate,H.,
            Iesato,Y., Yoshizawa,T., Koyama,T., Yang,L., Toriyama,Y.,
            Yamauchi,A., Igarashi,K., Tanaka,M., Kuwabara,T., Mori,K.,
            Yanagita,M., Mukoyama,M. and Shindo,T.
  TITLE     Adrenomedullin-RAMP2 system suppresses ER stress-induced tubule
            cell death and is involved in kidney protection
  JOURNAL   PLoS One 9 (2), e87667 (2014)
   PUBMED   24505304
  REMARK    GeneRIF: Adrenomedullin-RAMP2 system suppresses ER stress-induced
            tubule cell death and is involved in kidney protection.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 767)
  AUTHORS   Fu,W., Ruangkittisakul,A., MacTavish,D., Shi,J.Y., Ballanyi,K. and
            Jhamandas,J.H.
  TITLE     Amyloid beta (Abeta) peptide directly activates amylin-3 receptor
            subtype by triggering multiple intracellular signaling pathways
  JOURNAL   J Biol Chem 287 (22), 18820-18830 (2012)
   PUBMED   22500019
REFERENCE   6  (bases 1 to 767)
  AUTHORS   Kuwasako,K., Shimekake,Y., Masuda,M., Nakahara,K., Yoshida,T.,
            Kitaura,M., Kitamura,K., Eto,T. and Sakata,T.
  TITLE     Visualization of the calcitonin receptor-like receptor and its
            receptor activity-modifying proteins during internalization and
            recycling
  JOURNAL   J Biol Chem 275 (38), 29602-29609 (2000)
   PUBMED   10882736
REFERENCE   7  (bases 1 to 767)
  AUTHORS   Husmann,K., Sexton,P.M., Fischer,J.A. and Born,W.
  TITLE     Mouse receptor-activity-modifying proteins 1, -2 and -3: amino acid
            sequence, expression and function
  JOURNAL   Mol Cell Endocrinol 162 (1-2), 35-43 (2000)
   PUBMED   10854696
REFERENCE   8  (bases 1 to 767)
  AUTHORS   Nagae,T., Mukoyama,M., Sugawara,A., Mori,K., Yahata,K.,
            Kasahara,M., Suganami,T., Makino,H., Fujinaga,Y., Yoshioka,T.,
            Tanaka,I. and Nakao,K.
  TITLE     Rat receptor-activity-modifying proteins (RAMPs) for
            adrenomedullin/CGRP receptor: cloning and upregulation in
            obstructive nephropathy
  JOURNAL   Biochem Biophys Res Commun 270 (1), 89-93 (2000)
   PUBMED   10733909
REFERENCE   9  (bases 1 to 767)
  AUTHORS   McLatchie,L.M., Fraser,N.J., Main,M.J., Wise,A., Brown,J.,
            Thompson,N., Solari,R., Lee,M.G. and Foord,S.M.
  TITLE     RAMPs regulate the transport and ligand specificity of the
            calcitonin-receptor-like receptor
  JOURNAL   Nature 393 (6683), 333-339 (1998)
   PUBMED   9620797
REFERENCE   10 (bases 1 to 767)
  AUTHORS   Palmberg,I. and Reuter,M.
  TITLE     Sensory receptors in the head of Stenostomum leucops. I.
            Presumptive photoreceptors
  JOURNAL   Acta Biol Hung 43 (1-4), 259-267 (1992)
   PUBMED   1299115
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVV010000295.1.
            
            On Mar 5, 2021 this sequence version replaced NM_031646.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            a component of the mRatBN7.1 alternate haplotype GenBank assembly
            (GCA_015244455.1) because the reference genome assembly includes
            errors in the coding region of this gene. The genomic coordinates
            used for the transcript record were based on alignments of
            transcripts.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ226087.1, CB782957.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               JACYVV010000295.1  44134-44297
            165-230             JACYVV010000295.1  44772-44837
            231-333             JACYVV010000295.1  45276-45378
            334-767             JACYVV010000295.1  45509-45942
FEATURES             Location/Qualifiers
     source          1..767
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..767
                     /gene="Ramp2"
                     /note="receptor activity modifying protein 2"
                     /db_xref="GeneID:58966"
                     /db_xref="RGD:61872"
     exon            1..164
                     /gene="Ramp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..589
                     /gene="Ramp2"
                     /note="receptor (calcitonin) activity modifying protein 2;
                     receptor (G protein-coupled) activity modifying protein 2"
                     /codon_start=1
                     /product="receptor activity-modifying protein 2 precursor"
                     /protein_id="NP_113834.1"
                     /db_xref="GeneID:58966"
                     /db_xref="RGD:61872"
                     /translation="MAPLRVERAPGGSQLAVTSAQRPAALRLPPLLLLLLLLLLGAVS
                     TSPESLNQSHPTEDSLLSKGKMEDYETNVLPCWYYYKTSMDSVKDWCNWTLISRYYSN
                     LRYCLEYEADKFGLGFPNPLAESIILEAHLIHFANCSLVQPTFSDPPEDVLLAMIIAP
                     ICLIPFLVTLVVWRSKDGDAQA"
     exon            165..230
                     /gene="Ramp2"
                     /inference="alignment:Splign:2.1.0"
     exon            231..333
                     /gene="Ramp2"
                     /inference="alignment:Splign:2.1.0"
     exon            334..767
                     /gene="Ramp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagctccgcc gcccctcctc gccatctcgc ccaaggcgtg atggctccgc tccgggtaga
       61 gcgcgccccg ggtggatcac agctcgctgt gaccagcgcc cagcggcccg cagcgctccg
      121 cctccctccg ctgttactgc tgctgttgct gctgctgctg ggcgctgtct caacctctcc
      181 ggagtccctg aatcaatctc atcctactga ggacagcctt ctgtcaaaag ggaagatgga
      241 ggactacgaa acaaatgtcc taccttgctg gtattattac aagacttcca tggactctgt
      301 caaggactgg tgcaactgga ctttgattag caggtattac agcaacctgc ggtattgctt
      361 ggagtacgag gcagacaagt ttggcctggg cttcccaaat cccttggcag aaagtatcat
      421 ccttgaggct cacctgatac actttgccaa ctgctccttg gtgcagccta ccttctccga
      481 tcccccagag gatgtgcttc tggccatgat catagccccc atctgcctca tccctttcct
      541 cgttacgctt gtggtgtgga ggagtaaaga cggcgatgcg caggcgtagg ctccgcctct
      601 cagcagccat cttttccctg taccctgctg gaaccaggat ctctcctccc ctccctaccc
      661 acttactccc atccttccca cagaccttcg gattggtgga aatggaagaa aggggaactg
      721 atagcacaat gtccgtcgtc tttaaaataa aatatgtttt tgtacaa
//
