LOCUS       NM_031645                810 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Rattus norvegicus receptor activity modifying protein 1 (Ramp1),
            mRNA.
ACCESSION   NM_031645
VERSION     NM_031645.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 810)
  AUTHORS   Meng,Q., Shi,D., Feng,J., Su,Y., Long,Y., He,S., Wang,S., Wang,Y.,
            Zhang,X. and Chen,X.
  TITLE     Hypercholesterolemia Up-Regulates the Expression of Intermedin and
            Its Receptor Components in the Aorta of Rats via Inducing the
            Oxidative Stress
  JOURNAL   Ann Clin Lab Sci 46 (1), 5-17 (2016)
   PUBMED   26927337
  REMARK    GeneRIF: Increased expression of IMD and all its receptor
            components (CRLR, RAMP1, RAMP2, and RAMP3) were displayed within
            the aorta of rats with Hypercholesterolemia.
REFERENCE   2  (bases 1 to 810)
  AUTHORS   Fu,W., Ruangkittisakul,A., MacTavish,D., Shi,J.Y., Ballanyi,K. and
            Jhamandas,J.H.
  TITLE     Amyloid beta (Abeta) peptide directly activates amylin-3 receptor
            subtype by triggering multiple intracellular signaling pathways
  JOURNAL   J Biol Chem 287 (22), 18820-18830 (2012)
   PUBMED   22500019
REFERENCE   3  (bases 1 to 810)
  AUTHORS   Nagayama,T., Seiryu,M., Deguchi,T., Kano,M., Suzuki,T.,
            Takano-Yamamoto,T. and Ichikawa,H.
  TITLE     Increase of CGRP-containing nerve fibers in the rat periodontal
            ligament after luxation
  JOURNAL   Cell Mol Neurobiol 32 (3), 391-397 (2012)
   PUBMED   22038237
  REMARK    GeneRIF: After traumatic injury to periodontal ligament, CGRP nerve
            fibers appear in close vicinity of small and large receptor
            activity modifying protein (RAMP)1 cells at 5-7 days.
REFERENCE   4  (bases 1 to 810)
  AUTHORS   Csati,A., Tajti,J., Tuka,B., Edvinsson,L. and Warfvinge,K.
  TITLE     Calcitonin gene-related peptide and its receptor components in the
            human sphenopalatine ganglion -- interaction with the sensory
            system
  JOURNAL   Brain Res 1435, 29-39 (2012)
   PUBMED   22208649
  REMARK    GeneRIF: The present finding demonstrated that RAMP1
            immunoreactivity was localized in many neurons and phenopalatine
            ganglion.
REFERENCE   5  (bases 1 to 810)
  AUTHORS   Edvinsson,L., Eftekhari,S., Salvatore,C.A. and Warfvinge,K.
  TITLE     Cerebellar distribution of calcitonin gene-related peptide (CGRP)
            and its receptor components calcitonin receptor-like receptor (CLR)
            and receptor activity modifying protein 1 (RAMP1) in rat
  JOURNAL   Mol Cell Neurosci 46 (1), 333-339 (2011)
   PUBMED   21040789
  REMARK    GeneRIF: Data demonstrate that there is a rich expression of
            calcitonin gene-related peptide (CGRP) and its receptor elements
            CLR and RAMP1 in the cerebellum which points towards a functional
            role of CGRP in cerebellar Purkinje cells.
REFERENCE   6  (bases 1 to 810)
  AUTHORS   Husmann,K., Sexton,P.M., Fischer,J.A. and Born,W.
  TITLE     Mouse receptor-activity-modifying proteins 1, -2 and -3: amino acid
            sequence, expression and function
  JOURNAL   Mol Cell Endocrinol 162 (1-2), 35-43 (2000)
   PUBMED   10854696
REFERENCE   7  (bases 1 to 810)
  AUTHORS   Nagae,T., Mukoyama,M., Sugawara,A., Mori,K., Yahata,K.,
            Kasahara,M., Suganami,T., Makino,H., Fujinaga,Y., Yoshioka,T.,
            Tanaka,I. and Nakao,K.
  TITLE     Rat receptor-activity-modifying proteins (RAMPs) for
            adrenomedullin/CGRP receptor: cloning and upregulation in
            obstructive nephropathy
  JOURNAL   Biochem Biophys Res Commun 270 (1), 89-93 (2000)
   PUBMED   10733909
REFERENCE   8  (bases 1 to 810)
  AUTHORS   McLatchie,L.M., Fraser,N.J., Main,M.J., Wise,A., Brown,J.,
            Thompson,N., Solari,R., Lee,M.G. and Foord,S.M.
  TITLE     RAMPs regulate the transport and ligand specificity of the
            calcitonin-receptor-like receptor
  JOURNAL   Nature 393 (6683), 333-339 (1998)
   PUBMED   9620797
REFERENCE   9  (bases 1 to 810)
  AUTHORS   Palmberg,I. and Reuter,M.
  TITLE     Sensory receptors in the head of Stenostomum leucops. I.
            Presumptive photoreceptors
  JOURNAL   Acta Biol Hung 43 (1-4), 259-267 (1992)
   PUBMED   1299115
REFERENCE   10 (bases 1 to 810)
  AUTHORS   Lengvari,I., Csoknya,M., Merchenthaler,I. and Hamori,J.
  TITLE     Immunohistochemical study of the nervous system in earthworm
            (Lumbricus terrestris L.)
  JOURNAL   Acta Biol Hung 43 (1-4), 253-258 (1992)
   PUBMED   1299114
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB042887.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB042887.1, DV720488.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..810
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q36"
     gene            1..810
                     /gene="Ramp1"
                     /note="receptor activity modifying protein 1"
                     /db_xref="GeneID:58965"
                     /db_xref="RGD:61870"
     exon            1..91
                     /gene="Ramp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..486
                     /gene="Ramp1"
                     /note="receptor (calcitonin) activity modifying protein 1;
                     receptor (G protein-coupled) activity modifying protein 1"
                     /codon_start=1
                     /product="receptor activity-modifying protein 1 precursor"
                     /protein_id="NP_113833.1"
                     /db_xref="GeneID:58965"
                     /db_xref="RGD:61870"
                     /translation="MAPGLRGLPRRGLWLLLAHHLFMVTACRDPDYGTLIQELCLSRF
                     KEDMETIGKTLWCDWGKTIGSYGELTHCTKLVANKIGCFWPNPEVDKFFIAVHHRYFS
                     KCPVSGRALRDPPNSILCPFIVLPITVTLLMTALVVWRSKRTEGIV"
     exon            92..230
                     /gene="Ramp1"
                     /inference="alignment:Splign:2.1.0"
     exon            231..808
                     /gene="Ramp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctcggcaa ggcgcaggga cggcggggct ctgcttgcca tggcccccgg cctgcggggc
       61 ctcccgcggc gcggcctctg gctgctgctg gctcatcatc tcttcatggt cactgcctgc
      121 cgggaccctg actatggtac tctcatccag gagctgtgtc tcagccgctt caaagaggac
      181 atggagacca tagggaagac tctgtggtgt gactggggaa agaccatagg gagctatggg
      241 gagctcactc actgcaccaa actcgtggca aacaagattg gctgtttctg gcccaatccg
      301 gaagtggaca agttcttcat tgctgtccac caccgctact tcagcaagtg cccagtctcg
      361 ggcagggccc tgcgggaccc tcccaacagc atcctctgcc ctttcattgt gctccccatt
      421 acggtcacac tgctcatgac tgccctggtg gtctggagga gcaagcgcac agagggcatc
      481 gtgtaggtgt cccaggtgat gggggattgg ggaaccatgg gcctggccca gcaacagcat
      541 cagggacaga ccccacattg catcctgctc tagcctagtt agcacaggat ttgaaagcag
      601 atctgcatta cactaaacct gccccagcca gaggcttcta acaggggagc agggacctgc
      661 ctctgtttac ctctgaaaga gcgctaagcg ccaggtctct ggtatacttc atcaccacca
      721 tcatgtgggc attccgacct ctgaggaaga ctgcacagat gtgtttgtgg atgcatagtt
      781 tgtgattaaa cgagcgttct taaacttgaa
//
