LOCUS       NM_001127451             812 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus RNA guanine-7 methyltransferase activating
            subunit (Ramac), mRNA.
ACCESSION   NM_001127451 XM_001060165 XM_001062455 XM_001062519 XM_214983
VERSION     NM_001127451.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 812)
  AUTHORS   Varshney D, Petit AP, Bueren-Calabuig JA, Jansen C, Fletcher DA,
            Peggie M, Weidlich S, Scullion P, Pisliakov AV and Cowling VH.
  TITLE     Molecular basis of RNA guanine-7 methyltransferase (RNMT)
            activation by RAM
  JOURNAL   Nucleic Acids Res 44 (21), 10423-10436 (2016)
   PUBMED   27422871
REFERENCE   2  (bases 1 to 812)
  AUTHORS   Gonatopoulos-Pournatzis T and Cowling VH.
  TITLE     Cap-binding complex (CBC)
  JOURNAL   Biochem J 457 (2), 231-242 (2014)
   PUBMED   24354960
  REMARK    Review article
            Erratum:[Biochem J. 2014 Feb 15;458(1):185]
REFERENCE   3  (bases 1 to 812)
  AUTHORS   Baltz AG, Munschauer M, Schwanhausser B, Vasile A, Murakawa Y,
            Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E,
            Bonneau R, Selbach M, Dieterich C and Landthaler M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 812)
  AUTHORS   Gonatopoulos-Pournatzis T, Dunn S, Bounds R and Cowling VH.
  TITLE     RAM/Fam103a1 is required for mRNA cap methylation
  JOURNAL   Mol Cell 44 (4), 585-596 (2011)
   PUBMED   22099306
REFERENCE   5  (bases 1 to 812)
  AUTHORS   Farkas RH, Qian J, Goldberg JL, Quigley HA and Zack DJ.
  TITLE     Gene expression profiling of purified rat retinal ganglion cells
  JOURNAL   Invest Ophthalmol Vis Sci 45 (8), 2503-2513 (2004)
   PUBMED   15277470
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF977463.1, DV717487.1 and AA900118.1.
            
            On or before May 21, 2008 this sequence version replaced
            XM_001062455.1, XM_001062519.1, XM_001060165.1, XM_214983.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CF977464.1, FM113783.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-300               CF977463.1         21-320
            301-697             DV717487.1         154-550
            698-812             AA900118.1         1-115               c
FEATURES             Location/Qualifiers
     source          1..812
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..812
                     /gene="Ramac"
                     /gene_synonym="Fam103a1; Rammet; RGD1310022"
                     /note="RNA guanine-7 methyltransferase activating subunit"
                     /db_xref="GeneID:293058"
                     /db_xref="RGD:1310022"
     exon            1..90
                     /gene="Ramac"
                     /gene_synonym="Fam103a1; Rammet; RGD1310022"
                     /inference="alignment:Splign:2.1.0"
     exon            91..287
                     /gene="Ramac"
                     /gene_synonym="Fam103a1; Rammet; RGD1310022"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..477
                     /gene="Ramac"
                     /gene_synonym="Fam103a1; Rammet; RGD1310022"
                     /note="family with sequence similarity 103, member A1;
                     RNMT activating mRNA cap methyltransferase subunit"
                     /codon_start=1
                     /product="RNA guanine-N7 methyltransferase activating
                     subunit"
                     /protein_id="NP_001120923.1"
                     /db_xref="GeneID:293058"
                     /db_xref="RGD:1310022"
                     /translation="MSDTSEAIPIFEEMFANRFTQDDKEYQEYLKRPPESPPIVEEWN
                     SRAGGNQRNRGNWLQDNRQFRGRDNRRGWPSDNRSNQWHGRSWGNNNYPQQRPEPYYQ
                     PNCPQYGHNQRPPYGYY"
     exon            288..798
                     /gene="Ramac"
                     /gene_synonym="Fam103a1; Rammet; RGD1310022"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggattcctg agcgtttggt taccctggag agccgtgtgg agtgctgcag tgtggacgcc
       61 cgaggtctct ccagtacgtc ccgctgaagg atcttaaaaa ttgtacagaa ttttaagatg
      121 agtgatactt ctgaagcgat tccaattttt gaagagatgt ttgcaaacag attcacacag
      181 gatgacaaag aataccagga atacttgaaa cgccctcctg aatcccctcc aattgttgag
      241 gaatggaata gcagagctgg tgggaaccaa agaaacagag gcaactggct gcaagataac
      301 agacaattta gaggtaggga taacagacga ggatggccaa gtgacaatcg gtcaaatcag
      361 tggcatggac ggtcatgggg taacaacaac tacccacagc agagaccaga gccctactat
      421 caaccaaatt gcccacagta tggccacaac cagcggcctc catatggtta ctactgacag
      481 atgttggcag cttttaacaa agacctttta ttttgacaac ctgctaagtg cttgtgtgtc
      541 ttctgttggt catagctttt cattctattt taaagaatgg gttattaatt gtttaaactt
      601 gagacttgaa aaaattaatc ttattagaaa tgtgataatt gatgggaata aacttaccaa
      661 gtgtggatta tattatttga ctttatctta catactgttt tgttttatga tttaatagtg
      721 ttttgagttt ggtctgtttt ccttatttgg actgtaggaa ttctgtctgt atcacagaaa
      781 taaatttttt taattaaaaa aaaaaaaaaa aa
//
