LOCUS       NM_001416483            3607 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus ral guanine nucleotide dissociation stimulator
            (Ralgds), transcript variant 2, mRNA.
ACCESSION   NM_001416483 XM_006233750
VERSION     NM_001416483.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3607)
  AUTHORS   Gloerich,M., ten Klooster,J.P., Vliem,M.J., Koorman,T.,
            Zwartkruis,F.J., Clevers,H. and Bos,J.L.
  TITLE     Rap2A links intestinal cell polarity to brush border formation
  JOURNAL   Nat Cell Biol 14 (8), 793-801 (2012)
   PUBMED   22797597
REFERENCE   2  (bases 1 to 3607)
  AUTHORS   Kawai,M., Kawashima,S., Sakoda,T., Toh,R., Kikuchi,A.,
            Yamauchi-Takihara,K., Kunisada,K. and Yokoyama,M.
  TITLE     Ral GDP dissociation stimulator and Ral GTPase are involved in
            myocardial hypertrophy
  JOURNAL   Hypertension 41 (4), 956-962 (2003)
   PUBMED   12642511
  REMARK    GeneRIF: Ral GDP dissociation stimulator is involved in myocardial
            hypertrophy.
REFERENCE   3  (bases 1 to 3607)
  AUTHORS   Huang,L., Weng,X., Hofer,F., Martin,G.S. and Kim,S.H.
  TITLE     Three-dimensional structure of the Ras-interacting domain of RalGDS
  JOURNAL   Nat Struct Biol 4 (8), 609-615 (1997)
   PUBMED   9253406
  REMARK    Erratum:[Nat Struct Biol 1997 Oct;4(10):840]
REFERENCE   4  (bases 1 to 3607)
  AUTHORS   Hofer,F., Fields,S., Schneider,C. and Martin,G.S.
  TITLE     Activated Ras interacts with the Ral guanine nucleotide
            dissociation stimulator
  JOURNAL   Proc Natl Acad Sci U S A 91 (23), 11089-11093 (1994)
   PUBMED   7972015
REFERENCE   5  (bases 1 to 3607)
  AUTHORS   Albright,C.F., Giddings,B.W., Liu,J., Vito,M. and Weinberg,R.A.
  TITLE     Characterization of a guanine nucleotide dissociation stimulator
            for a ras-related GTPase
  JOURNAL   EMBO J 12 (1), 339-347 (1993)
   PUBMED   8094051
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Feb 3, 2023 this sequence version replaced XM_006233750.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.12099.1,
                                           SRR26643298.14698.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-282               JAXUCZ010000003.1  32257519-32257800
            283-393             JAXUCZ010000003.1  32265407-32265517
            394-587             JAXUCZ010000003.1  32266763-32266956
            588-683             JAXUCZ010000003.1  32267414-32267509
            684-877             JAXUCZ010000003.1  32268194-32268387
            878-1275            JAXUCZ010000003.1  32268635-32269032
            1276-1491           JAXUCZ010000003.1  32269734-32269949
            1492-1595           JAXUCZ010000003.1  32270122-32270225
            1596-1680           JAXUCZ010000003.1  32270588-32270672
            1681-1749           JAXUCZ010000003.1  32271836-32271904
            1750-1836           JAXUCZ010000003.1  32272220-32272306
            1837-1869           JAXUCZ010000003.1  32272753-32272785
            1870-1991           JAXUCZ010000003.1  32273054-32273175
            1992-2087           JAXUCZ010000003.1  32273296-32273391
            2088-2289           JAXUCZ010000003.1  32273595-32273796
            2290-2532           JAXUCZ010000003.1  32273906-32274148
            2533-2647           JAXUCZ010000003.1  32275259-32275373
            2648-3607           JAXUCZ010000003.1  32277075-32278034
FEATURES             Location/Qualifiers
     source          1..3607
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p12"
     gene            1..3607
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /note="ral guanine nucleotide dissociation stimulator"
                     /db_xref="GeneID:29622"
                     /db_xref="RGD:3533"
     exon            1..282
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..2823
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ralGEF; ral guanine nucleotide exchange factor"
                     /codon_start=1
                     /product="ral guanine nucleotide dissociation stimulator
                     isoform 2"
                     /protein_id="NP_001403412.1"
                     /db_xref="GeneID:29622"
                     /db_xref="RGD:3533"
                     /translation="MVQRMWAEASGPIGGAEPLFPGSRRSRSVWDAVRLEVGVPDSCP
                     VVLHSFTQLDPDLPRLESSTQEIGEELINGVIYSISLRKVQLHPGATKGQRWLGCENE
                     SALNLYETCKVRTVKAGTLEKLVEHLVPAFQGSDLSYVTVFLCTYRAFTTTQQVLDLL
                     FKRYGRCDALTASSRYGCILPYSSEDGGPQDQLKNAISSILGTWLDQYSEDFCQPPDF
                     PCLKQLVAYVQLNMPGSDLERRAHLLLAQLEDLEPSEVEPEALSPAPVLSLKPASQLE
                     PAPALLLTPSRAVASTPVREPAPVPVLASSPVVAPASELEPALEPPLDPEPTLAPAPE
                     LDPTVSQSLHLEPAPVPAPALEPSWPLPETTENGLCAKPHLLLFPPDLVAEQFTLMDA
                     ELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVAQFNNVANCVITTCLGDQSMKAS
                     DRARVVEHWIEVARECRVLKNFSSLYAILSALQSNAIHRLKKTWEEVSRGSFRVFQKL
                     SEIFSDENNYSLSRELLIKEGTSKFATLEMNPRRTQRRQKETGVIQGTVPYLGTFLTD
                     LVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIVPEEHFGAWFRAMG
                     RLSEAESYNLSCELEPPSESASNTLRSKKSTAIVKRWSDRQAPSTELSTSSSAHSKSC
                     DQLRCSPYLSSGDITDALSVHSAGSSSSDVEEINMSFVPESPDGQEKKFWESASQSSP
                     ETSGISSASSSTSSSSASTTPVSTTRTHKRSVSGVCSYSSSLPLYNQQVGDCCIIRVS
                     LDVDNGNMYKSILVTSQDKAPTVIRKAMDKHNLDEDEPEDYELLQIISEDHKLKIPEN
                     ANVFYAMNSAANYDFILKKRAFTKGAKVKHGASSTLPRMKQKGLRIARGIF"
     exon            283..393
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            394..587
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            588..683
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            684..877
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1275
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1491
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1595
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1680
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1749
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1836
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..1869
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..1991
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2087
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2289
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            2290..2532
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            2533..2647
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
     exon            2648..3607
                     /gene="Ralgds"
                     /gene_synonym="Rgds"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagagcgca ggcagcgcgg agccgcgccg gccggccctg cgcccacgcc gccccgggtc
       61 tcgcggcccg ccggccaccc gcgccaccgg gagtcgtcca tggtgcagcg catgtgggcc
      121 gaggcgtccg ggcccatagg gggcgccgag ccgttgtttc ccggctcccg gcgcagccgc
      181 agcgtgtggg acgccgtgcg tctggaggtg ggcgtccctg acagctgtcc agtggtgctg
      241 cacagcttca cgcagctcga ccccgatctg ccgcgcctgg agagctctac gcaggagatt
      301 ggggaggagc tgatcaacgg ggtcatctac tccatctccc tgcgcaaggt tcagctacac
      361 ccaggagcca ccaagggcca gcgctggcta gggtgcgaga atgagtcagc tctgaacctc
      421 tacgagactt gcaaggtgcg cacggtgaag gccggtactc tggagaagct ggtggaacac
      481 ctggtgcctg ccttccaggg cagtgacctt tcctacgtca ccgtattcct gtgcacctac
      541 agagccttca caaccactca gcaggtgcta gacctgctgt tcaaaaggta cggtagatgt
      601 gacgccctca cggcctcctc tagatatggc tgcatccttc cctactccag tgaggacggc
      661 ggaccacagg accaactcaa aaatgccatc tcttccatcc tgggcacctg gctggaccaa
      721 tactccgagg acttctgtca acccccggac tttccctgcc tcaagcagct ggtggcttat
      781 gtgcagctca acatgcctgg ctcagacctg gagcgccgtg ctcaccttct cctggcccag
      841 ctggaggacc tggagcccag tgaggttgag cctgaggccc tgtccccagc tccagtgctg
      901 tctctgaaac cagcttcaca gctagaacca gctcccgccc tgcttctgac gcccagccga
      961 gctgtggcat ccactccagt ccgagagcca gccccggtgc cagtactggc atccagcccg
     1021 gtggtggcgc cagcctctga gctagaacca gctctggagc cgcccctaga ccctgagcca
     1081 accctcgcac ctgctccaga gctggacccc actgtctcac agagcctcca cctcgagccc
     1141 gctcccgtgc ccgctcctgc attagagcct tcctggcctc tgcctgaaac cacggagaac
     1201 ggactgtgtg caaagcctca cctactgctg ttccctccag acttggtggc tgaacagttt
     1261 acgctgatgg acgcagagct attcaagaaa gttgtgccct accactgcct gggctccatc
     1321 tggtcccagc gggacaagaa gggcaaggag cacctcgcgc ccaccatccg tgccactgtc
     1381 gcccagttca acaacgtggc caactgtgtc atcaccacct gccttgggga ccagagtatg
     1441 aaagcttcgg acagggcccg ggtggtggaa cactggatcg aggtggccag ggagtgcagg
     1501 gtgctcaaga atttctcctc cctctacgcc atcctctctg ccctacagag caatgccatc
     1561 caccgcctaa agaagacatg ggaagaggtc tccaggggca gctttcgagt gttccagaaa
     1621 ctgtcagaaa tcttctctga tgagaacaac tactccttga gcagagagct gctcatcaag
     1681 gaaggaacct ccaagtttgc cacgctggag atgaacccta ggagaaccca gaggcggcag
     1741 aaggagacag gtgtcatcca gggcactgtc ccctacctgg gcacattcct cactgacctg
     1801 gtgatgctgg acacagccat gaaggactat ctatatggga gactgatcaa ctttgaaaag
     1861 aggaggaagg agttcgaagt catcgcccag atcaagttgc tccagtcggc ctgcaacaac
     1921 tacagcattg ttcccgagga gcactttgga gcctggttcc gagccatggg acggctcagc
     1981 gaggctgaga gctacaacct gtcgtgtgag ctggagcccc cgtctgagtc agccagcaac
     2041 accctgagga gcaagaaaag cacagctatc gtcaagcgct ggagcgaccg ccaggctccc
     2101 agcacggagc tcagcaccag tagcagtgca cactccaagt catgtgacca gctccggtgc
     2161 agcccctacc tcagcagcgg ggacatcacg gacgcactca gtgtgcactc agctggttca
     2221 tccagctctg acgtggagga gatcaacatg agctttgttc cagagtctcc tgatggccag
     2281 gaaaagaagt tctgggagtc agcctcccag tcgtccccag agacctctgg catcagctcg
     2341 gcctccagca gcacctcctc ttcgtcagcc tctaccacac cggtgtctac cacacgcacc
     2401 cacaagcgct ctgtctcagg ggtctgcagc tacagctcct cactgccact ctacaaccag
     2461 caggtgggcg actgctgcat catcagggtc agcctggatg tggacaacgg caacatgtac
     2521 aagagcatcc tggtgaccag ccaggataag gctccgactg tcatccggaa agccatggac
     2581 aaacacaacc tagatgagga cgagcccgag gactatgagc tgctgcagat catctcagag
     2641 gaccacaagc tgaaaattcc agagaacgcc aatgtgttct atgccatgaa ctctgccgcc
     2701 aactatgact tcatcctaaa gaagcgggcc ttcactaagg gggctaaagt caagcatgga
     2761 gccagctcca ctctccctcg aatgaagcag aagggactca ggattgccag aggcatcttc
     2821 taaggacgtc tcccaggggc tggctggctg gctggggact aagcacttac agactagagt
     2881 ggcccaggcc acacaggtac ctctgccctc ctgccagccc aggctactcc cagactccac
     2941 tttcaccccg aacctgtcct gctgccggga ttgacacctg ccactgacag gctgacctgg
     3001 cctccgggga ccgctcaccg ccttaggtgc cttctgctct ctgcaaccag aggactagct
     3061 gactttgcca aggggtgctg ccagctgggc atggagcctc gcctgccctg gacaatgtcc
     3121 accacacttt cctgtcacct ccccaagtgc agatcactgc cacccatgct cccagatgct
     3181 ccaggacacc cacacaccca gcggggctgc caactgcgtt ctctccttgt gcccataggc
     3241 actggcctgg gaccttcatg gaggtcctag cctttcttag gctgcaccaa agattccacc
     3301 ttcagggcct acagagtgag ggagtctcgc ccaccacgag cccaagccct cccatggatc
     3361 agagagagaa gccctctcat ggaccgcctg gttggcattg aaccccatac cactgaaagt
     3421 gccattcacc accgctgcgt cccgggtgta caagactaca tgcaatggga ggtttgtggg
     3481 gagggggaag acgactggat atttgtataa aacgtaaaaa gtttactgat tggggtgggg
     3541 caatatttat ttgttgtaaa tagaaaatgc tagacttgaa tattatatta aaatcccgtt
     3601 tctacta
//
