LOCUS       NP_001408242            1910 aa            linear   ROD 24-JUN-2024
DEFINITION  ral GTPase-activating protein subunit alpha-2 [Rattus norvegicus].
ACCESSION   NP_001408242
VERSION     NP_001408242.1
DBSOURCE    REFSEQ: accession NM_001421313.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1910)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   2  (residues 1 to 1910)
  AUTHORS   Chen,X.W., Leto,D., Xiong,T., Yu,G., Cheng,A., Decker,S. and
            Saltiel,A.R.
  TITLE     A Ral GAP complex links PI 3-kinase/Akt signaling to RalA
            activation in insulin action
  JOURNAL   Mol Biol Cell 22 (1), 141-152 (2011)
   PUBMED   21148297
REFERENCE   3  (residues 1 to 1910)
  AUTHORS   Shirakawa,R., Fukai,S., Kawato,M., Higashi,T., Kondo,H., Ikeda,T.,
            Nakayama,E., Okawa,K., Nureki,O., Kimura,T., Kita,T. and
            Horiuchi,H.
  TITLE     Tuberous sclerosis tumor suppressor complex-like complexes act as
            GTPase-activating proteins for Ral GTPases
  JOURNAL   J Biol Chem 284 (32), 21580-21588 (2009)
   PUBMED   19520869
REFERENCE   4  (residues 1 to 1910)
  AUTHORS   Gridley,S., Chavez,J.A., Lane,W.S. and Lienhard,G.E.
  TITLE     Adipocytes contain a novel complex similar to the tuberous
            sclerosis complex
  JOURNAL   Cell Signal 18 (10), 1626-1632 (2006)
   PUBMED   16490346
REFERENCE   5  (residues 1 to 1910)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1910
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     Protein         1..1910
                     /product="ral GTPase-activating protein subunit alpha-2"
                     /note="Ral GTPase-activating protein alpha subunit 2; Ral
                     GTPase activating protein catalytic alpha subunit 2; Ral
                     GTPase activating protein, alpha subunit 2 (catalytic);
                     250 kDa substrate of Akt"
                     /calculated_mol_wt=214105
     Site            373
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:A3KGS3; propagated from
                     UniProtKB/Swiss-Prot (P86411.1)"
     Site            376
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:A3KGS3; propagated from
                     UniProtKB/Swiss-Prot (P86411.1)"
     Site            379
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:A3KGS3; propagated from
                     UniProtKB/Swiss-Prot (P86411.1)"
     Region          446..481
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P86411.1)"
     Site            486
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P86411.1)"
     Region          534..658
                     /region_name="RALGAPB_N"
                     /note="RALGAPB N-terminal domain; pfam20412"
                     /db_xref="CDD:466561"
     Site            696
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P86411.1)"
     Region          711..730
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P86411.1)"
     Site            715
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by PKB.
                     /evidence=ECO:0000250|UniProtKB:Q2PPJ7; propagated from
                     UniProtKB/Swiss-Prot (P86411.1)"
     Site            857
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P86411.1)"
     Site            858
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P86411.1)"
     Site            1630
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q2PPJ7; propagated from
                     UniProtKB/Swiss-Prot (P86411.1)"
     Region          1702..1874
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     CDS             1..1910
                     /gene="Ralgapa2"
                     /gene_synonym="AS250; p220; RGD1308023"
                     /coded_by="NM_001421313.1:158..5890"
                     /db_xref="GeneID:296211"
                     /db_xref="RGD:1308023"
ORIGIN      
        1 mfsrrshgdv kkstqkvldp kkdvltrlkh lralldnvda sdlkqffetn ysqiyfifye
       61 nfitlenslk lkgnnksqre eldsilflfe kilqflperi ffrwhyqsig stlkkllhtg
      121 nsikircegi rlfllwlqal qtncaeeqvl ifaclvpgfp avlssrgpct letlinpsps
      181 vvdakiypee itpllpavsg ekiaedqtcf flqillkymv iqaaslewkn kenqdtgfkf
      241 lftlfrkyyl phlfpsftkl tniykpvlei phlrpkplyv tvtrdnetiy stkipymaar
      301 vvfikwivtf flekkyltat qntkngvdvl pkiiqtvggg aiqekvpeld gagateqdks
      361 hsnsstlsdr rlsnsslcsi eeehrtvyem vqrillstrg yvnfvnevfr qafllpscei
      421 sitrkvvqvy rkwilqnkpv fmeepdkkdv aeedadklgl setdskevss essghkrsss
      481 wgrtysftsa msrgcvteed ntnvkagaqa mlqvfltnaa nvfllepcve vpmllreqvd
      541 ackavliifr rmimeltmnq ktweqmlqil lriteavmqk pkdklvqdsf arslagllfr
      601 tlivawiran lcvyisrelw ddflrvlssl teweelitew snimdsltav lartvygvem
      661 tnlpldklse qkekkqrgkg cvlepqkgta vgrsfslswr shpdvtepmr frsattsgap
      721 gvekarntvr qkateveefq qaestaaadc dylvvgqqpv prssstsdit erlysdssqg
      781 yspmlphpaf ymasgdlnsg phacttgplp lshlpspgqk vensqnlsss epksvqeskg
      841 hvthehegvt ilvrrssspa eldlkeesqq thgrcrerqk sestgsdmav gysneaelpv
      901 spwqtceedp elstptdava dsdarhwlql sptdasnlte srecladdcs iiaggnltgw
      961 hpdsaavlwr rvlgilgdvn niqspkihak vfsylyelwy klakirdnla isldnqssps
     1021 ppllipplrm faswlfkatt lpneykegkl qayklicamm trrqdvlpns dflvhfylvm
     1081 hlgltsedqd vlntiikncs prffslglpg fsmlvgdfit aaarvlstdm laaprsealt
     1141 llgslvcfpn tyqeipllqs vpevsdvvtg aedvkhylin illknateep necarciaic
     1201 slgvwiceel aqcashpqvk dainvigvtl kfpnkivaqv acdvlqllvs yweklqmfet
     1261 alprkmaeil vatiafllps aeyssvetdk kfivslllcl ldwcmalpvs allhpvstav
     1321 ieelhpsrap lldyiyrvlh ccvcgsstyt qqshytltla dlsstdydpf lplanvrnse
     1381 pvqyhssadl gnlltveeek krrsvelipl tarmvmahlv nhlghyplsg gpavlhslvs
     1441 enhdnahveg telssevfrs pnlqlfvfnd stlisylqtp aegpaggtsg gslsdvrviv
     1501 rdisgkyswd gkvlygpleg rlapsgrnps fqisgwhhht cgpqsnlfhg eegddvldkl
     1561 lenightspe cllpsqlnln epsptpsamn cdqekeiiev ilrqstqede yvqrchsnsa
     1621 vkvtsqgqps pveprgpfyf crlllddlgm nswdrrknfh llkknskllr elknldsrqc
     1681 rethkiavfy iaegqedkcs ilanergsqa yedfvaglgw evdlsthcgf mgglqrngst
     1741 gqtapyyats tvevifhvst rmpsdsddsl tkklrhlgnd evhivwsehs rdyrrgiipt
     1801 afgdvsiiiy pmknhmffit itkkpevpff gplfdgaivs gkllpslica tcinasravk
     1861 cliplyqsfy eeralyleai iqnhrevmtf edfaaqvfsp spsyslsgtd
//
