LOCUS       NP_064468               2035 aa            linear   ROD 29-MAR-2024
DEFINITION  ral GTPase-activating protein subunit alpha-1 [Rattus norvegicus].
ACCESSION   NP_064468
VERSION     NP_064468.4
DBSOURCE    REFSEQ: accession NM_020083.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 2035)
  AUTHORS   Shirakawa,R., Fukai,S., Kawato,M., Higashi,T., Kondo,H., Ikeda,T.,
            Nakayama,E., Okawa,K., Nureki,O., Kimura,T., Kita,T. and
            Horiuchi,H.
  TITLE     Tuberous sclerosis tumor suppressor complex-like complexes act as
            GTPase-activating proteins for Ral GTPases
  JOURNAL   J Biol Chem 284 (32), 21580-21588 (2009)
   PUBMED   19520869
REFERENCE   2  (residues 1 to 2035)
  AUTHORS   Heng,J.I. and Tan,S.S.
  TITLE     Cloning and characterization of GRIPE, a novel interacting partner
            of the transcription factor E12 in developing mouse forebrain
  JOURNAL   J Biol Chem 277 (45), 43152-43159 (2002)
   PUBMED   12200424
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Apr 19, 2021 this sequence version replaced NP_064468.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to correct errors in the reference genome
            assembly. The extent of this transcript is supported by transcript
            alignments and orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.23896.1,
                                           SRR26643298.35612.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2035
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q23"
     Protein         1..2035
                     /product="ral GTPase-activating protein subunit alpha-1"
                     /note="GAP-related-interacting partner to E12;
                     GTPase-activating RapGAP domain-like 1; tuberin-like
                     protein 1; tulip 1; GTPase activating RANGAP domain-like
                     1; GTPase activating Rap/RanGAP domain-like 1; Ral GTPase
                     activating protein, alpha subunit 1 (catalytic); Ral
                     GTPase activating protein catalytic alpha subunit 1"
                     /calculated_mol_wt=229351
     Region          343..384
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O55007.2)"
     Region          549..677
                     /region_name="RALGAPB_N"
                     /note="RALGAPB N-terminal domain; pfam20412"
                     /db_xref="CDD:466561"
     Site            710
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q6GYQ0; propagated from
                     UniProtKB/Swiss-Prot (O55007.2)"
     Region          714..754
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O55007.2)"
     Site            720
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q6GYQ0; propagated from
                     UniProtKB/Swiss-Prot (O55007.2)"
     Site            753
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q6GYQ0; propagated from
                     UniProtKB/Swiss-Prot (O55007.2)"
     Site            772
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q6GYQ0; propagated from
                     UniProtKB/Swiss-Prot (O55007.2)"
     Site            777
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q6GYQ0; propagated from
                     UniProtKB/Swiss-Prot (O55007.2)"
     Site            796
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (O55007.2)"
     Region          807..834
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O55007.2)"
     Region          848..911
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O55007.2)"
     Site            859
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (O55007.2)"
     Site            860
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (O55007.2)"
     Site            863
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (O55007.2)"
     Site            985
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q6GYQ0; propagated from
                     UniProtKB/Swiss-Prot (O55007.2)"
     Region          986..1008
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O55007.2)"
     Site            989
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q6GYQ0; propagated from
                     UniProtKB/Swiss-Prot (O55007.2)"
     Site            993
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q6GYQ0; propagated from
                     UniProtKB/Swiss-Prot (O55007.2)"
     Site            999
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (O55007.2)"
     Site            1001
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (O55007.2)"
     Site            1003
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (O55007.2)"
     Region          1326..2034
                     /region_name="Minimal domain that binds to TCF3/E12.
                     /evidence=ECO:0000250|UniProtKB:Q6GYP7"
                     /note="propagated from UniProtKB/Swiss-Prot (O55007.2)"
     Site            1477
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (O55007.2)"
     Region          1825..1998
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     CDS             1..2035
                     /gene="Ralgapa1"
                     /gene_synonym="Garnl1; GRIPE; p240; Tulip1"
                     /coded_by="NM_020083.4:12..6119"
                     /db_xref="GeneID:56785"
                     /db_xref="RGD:620642"
ORIGIN      
        1 mfskkphgdv kkstqkvldt kkdaltrlkh lrivienads idlkqffdqh fshiyyvffe
       61 nfvtieaslk qkghksqree ldailfifek ilqllperih qrwqfhsigl ilkkllhtgn
      121 slkirregvr lfllwlqalq dncskeqlwm fsclipgfsa pqseygprtl dnlinpplnl
      181 qetqvtieev tplvppqsgd kgqedltsyf leallkyivi qvkslewknk enqergfsfl
      241 fshfkkfylp yifpnlcken slyhpvldip qvrpkphyvm vkkdaetnet iyctkepfiq
      301 arvivirwlv sfwlepkphs gpnipgmege vlpkniqraa aslvsreesk ndtvdkadkt
      361 aepeqshsnt stlterepss sslcsideeh ltdieivrrv fsskrsnvnf vteifrqafl
      421 lpiceaaamr kvvkvyqewi qqegkplfmq epeetvitss dipcsenvtd hdisiedgek
      481 reeengtnis ehvrnstwtk ngsyqeafhv seeateqniq agtqavlqvf iinssnifll
      541 epaneiknll dehtdmckri lniyrymvvq vsmdkktweq mllvllrvte svlkmssqaf
      601 lqfqgkknmt lagrlagplf qtlivawika nlnvyisrel wddllsvlss ltyweelate
      661 wsltmetltk vlarnlysld lsdlpldkls eqkqkkhkgk gvghefqkvs vdksfsrgws
      721 rdqpgqapmr qrsatttgsp gtekarsivr qktvdiddsq ilprstrvrh fsqsedtgne
      781 vfgalheeqp lprssstsdi lepftverak vnkedtspkl pplnsetggs sanvpdlmde
      841 fiaerlrsgn astmtrrgss pgsleipkdl pdilnkqnqm rpvddpgvps ewtspasags
      901 sdlmssdshs dsfsafqceg rkfdnfgfgt digipssadv dsgsghhqst eeqevasltt
      961 lhldsetssl nqqafsaeva tvtgsesasp vhsalgsrsq tpspstlnid hmeqkdlqld
     1021 eklhhsvlqt pddleisefp seccsvmagg tltgwhadva tvmwrrmlgi lgdvnaimdp
     1081 eihaqvfdyl celwqnlaki rdnlgisadn ltspsppvli pplriltpwl fkatmltdky
     1141 kqgklhaykl icntmkrrqd vspnrdflth fynimhcgll hidqdivnti ikhcspqffs
     1201 lglpgatmli mdfiiaagrv assaflnapr veaqvllgsl vcfpnlycel palhpstpdi
     1261 avsqftdvke liiktvlssa rdepsgparc valcslgiwi ceelvheshh pqikealnvi
     1321 cvslkftnkt vahvacnmlh mlvhyaprlq tyqpdsplki iqiliatith llpsteassy
     1381 emdkrlvvsl llclldwima lplktllqsv hstgaenekt eksvlnciyk vlhgcvygaq
     1441 sfshpkyfpi slsdlasvdy dpfmhleslr epeplhspds erssklqpvt evktqmqqgl
     1501 isiaartvit hlvnhlghyp msggpamlts qvcenhdnhy sestelspel fdspniqffv
     1561 lnnttlvsci qirseesvpg gglaaglvsa nsnvriivrd lsgkyswdsa ilygppivsg
     1621 lpeptsfils msyqekpeep ptsnecledi tvkdglslql rrfretvptw stireeedvl
     1681 dellqylgtt speclqrtgi slnvpapqpv cisekqendv inailkqyte ekefvekhfn
     1741 dlnmkaseqd eptpqkpqsa fyycrlllsi lgmnswdkrr sfhllkknek llrelrnlds
     1801 rqcrethkia vfyvaegqed kysiltnigg sqayedfvag lgwevnltnh cgfmgglqkn
     1861 kstglttpyf atstvevifh vstrmpsesd dsltkklrhl gndevhivws ehtrdyrrgi
     1921 iptefgdvli viypmknhmf siqimkkpev pffgplfdga ivngkvlpim vrstainasr
     1981 alksliplyq nfyeeraryl qtivqhhlep ttfedfaaqv fspapyhhfp adadh
//
