LOCUS       NM_032067               3789 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Rattus norvegicus ralA binding protein 1 (Ralbp1), transcript
            variant 1, mRNA.
ACCESSION   NM_032067 XM_039084256
VERSION     NM_032067.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3789)
  AUTHORS   Piao,S.G., Ding,J., Lin,X.J., Nan,Q.Y., Xuan,M.Y., Jiang,Y.J.,
            Zheng,H.L., Jin,J.Z. and Li,C.
  TITLE     Inhibition of RIP1-RIP3-mediated necroptosis attenuates renal
            fibrosis via Wnt3alpha/beta-catenin/GSK-3beta signaling in
            unilateral ureteral obstruction
  JOURNAL   PLoS One 17 (10), e0274116 (2022)
   PUBMED   36223414
  REMARK    GeneRIF: Inhibition of RIP1-RIP3-mediated necroptosis attenuates
            renal fibrosis via Wnt3alpha/beta-catenin/GSK-3beta signaling in
            unilateral ureteral obstruction.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3789)
  AUTHORS   Zhu,Y.M., Lin,L., Wei,C., Guo,Y., Qin,Y., Li,Z.S., Kent,T.A.,
            McCoy,C.E., Wang,Z.X., Ni,Y., Zhou,X.Y. and Zhang,H.L.
  TITLE     The Key Regulator of Necroptosis, RIP1 Kinase, Contributes to the
            Formation of Astrogliosis and Glial Scar in Ischemic Stroke
  JOURNAL   Transl Stroke Res 12 (6), 991-1017 (2021)
   PUBMED   33629276
  REMARK    GeneRIF: The Key Regulator of Necroptosis, RIP1 Kinase, Contributes
            to the Formation of Astrogliosis and Glial Scar in Ischemic Stroke.
REFERENCE   3  (bases 1 to 3789)
  AUTHORS   Stark,K., Goncharov,T., Varfolomeev,E., Xie,L., Ngu,H., Peng,I.,
            Anderson,K.R., Verschueren,E., Choi,M., Kirkpatrick,D.S.,
            Easton,A., Webster,J.D., McKenzie,B.S., Vucic,D. and Bingol,B.
  TITLE     Genetic inactivation of RIP1 kinase activity in rats protects
            against ischemic brain injury
  JOURNAL   Cell Death Dis 12 (4), 379 (2021)
   PUBMED   33828080
  REMARK    GeneRIF: Genetic inactivation of RIP1 kinase activity in rats
            protects against ischemic brain injury.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3789)
  AUTHORS   Zhou,K., Shi,L., Wang,Z., Zhou,J., Manaenko,A., Reis,C., Chen,S.
            and Zhang,J.
  TITLE     RIP1-RIP3-DRP1 pathway regulates NLRP3 inflammasome activation
            following subarachnoid hemorrhage
  JOURNAL   Exp Neurol 295, 116-124 (2017)
   PUBMED   28579326
  REMARK    GeneRIF: subarachnoid hemorrhage led to the upregulation of RIP1,
            RIP3, phosphorylated DRP1 and NLRP3 inflammasome
            Erratum:[Exp Neurol. 2024 Jul;377:114787. doi:
            10.1016/j.expneurol.2024.114787.. PMID: 38653705]
REFERENCE   5  (bases 1 to 3789)
  AUTHORS   Li,B., Cong,M., Zhu,Y., Xiong,Y., Jin,W., Wan,Y., Zhou,Y., Ao,Y.
            and Wang,H.
  TITLE     Indole-3-Carbinol Induces Apoptosis of Hepatic Stellate Cells
            through K63 De-Ubiquitination of RIP1 in Rats
  JOURNAL   Cell Physiol Biochem 41 (4), 1481-1490 (2017)
   PUBMED   28395284
  REMARK    GeneRIF: These results demonstrated that indole-3-carbinol could
            induce apoptosis of hepatic stellate cells through RIP1 K63
            de-ubiquitination by upregulating deubiquitinase CYLD.
REFERENCE   6  (bases 1 to 3789)
  AUTHORS   Iouzalen,N., Camonis,J. and Moreau,J.
  TITLE     Identification and characterization in Xenopus of XsmgGDS, a RalB
            binding protein
  JOURNAL   Biochem Biophys Res Commun 250 (2), 359-363 (1998)
   PUBMED   9753634
REFERENCE   7  (bases 1 to 3789)
  AUTHORS   Ikeda,M., Ishida,O., Hinoi,T., Kishida,S. and Kikuchi,A.
  TITLE     Identification and characterization of a novel protein interacting
            with Ral-binding protein 1, a putative effector protein of Ral
  JOURNAL   J Biol Chem 273 (2), 814-821 (1998)
   PUBMED   9422736
REFERENCE   8  (bases 1 to 3789)
  AUTHORS   Park,S.H. and Weinberg,R.A.
  TITLE     A putative effector of Ral has homology to Rho/Rac GTPase
            activating proteins
  JOURNAL   Oncogene 11 (11), 2349-2355 (1995)
   PUBMED   8570186
REFERENCE   9  (bases 1 to 3789)
  AUTHORS   Jullien-Flores,V., Dorseuil,O., Romero,F., Letourneur,F.,
            Saragosti,S., Berger,R., Tavitian,A., Gacon,G. and Camonis,J.H.
  TITLE     Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with
            CDC42/Rac GTPase-activating protein activity
  JOURNAL   J Biol Chem 270 (38), 22473-22477 (1995)
   PUBMED   7673236
REFERENCE   10 (bases 1 to 3789)
  AUTHORS   Cantor,S.B., Urano,T. and Feig,L.A.
  TITLE     Identification and characterization of Ral-binding protein 1, a
            potential downstream target of Ral GTPases
  JOURNAL   Mol Cell Biol 15 (8), 4578-4584 (1995)
   PUBMED   7623849
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On or before Feb 26, 2021 this sequence version replaced
            XM_039084256.1, NM_032067.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089788.1, U82623.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760434 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-242               JAXUCZ010000009.1  112939418-112939659 c
            243-539             JAXUCZ010000009.1  112922363-112922659 c
            540-998             JAXUCZ010000009.1  112918829-112919287 c
            999-1348            JAXUCZ010000009.1  112915062-112915411 c
            1349-1510           JAXUCZ010000009.1  112913187-112913348 c
            1511-1642           JAXUCZ010000009.1  112911931-112912062 c
            1643-1750           JAXUCZ010000009.1  112909034-112909141 c
            1751-1872           JAXUCZ010000009.1  112907759-112907880 c
            1873-1993           JAXUCZ010000009.1  112907224-112907344 c
            1994-3789           JAXUCZ010000009.1  112903289-112905084 c
FEATURES             Location/Qualifiers
     source          1..3789
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q37"
     gene            1..3789
                     /gene="Ralbp1"
                     /gene_synonym="RIP1; RLIP76"
                     /note="ralA binding protein 1"
                     /db_xref="GeneID:84014"
                     /db_xref="RGD:621134"
     exon            1..242
                     /gene="Ralbp1"
                     /gene_synonym="RIP1; RLIP76"
                     /inference="alignment:Splign:2.1.0"
     exon            243..539
                     /gene="Ralbp1"
                     /gene_synonym="RIP1; RLIP76"
                     /inference="alignment:Splign:2.1.0"
     CDS             296..2239
                     /gene="Ralbp1"
                     /gene_synonym="RIP1; RLIP76"
                     /EC_number="7.6.2.2"
                     /EC_number="7.6.2.3"
                     /note="cytocentrin; DNP-SG ATPase; ral-interacting protein
                     1; dinitrophenyl S-glutathione ATPase"
                     /codon_start=1
                     /product="ralA-binding protein 1"
                     /protein_id="NP_114456.2"
                     /db_xref="GeneID:84014"
                     /db_xref="RGD:621134"
                     /translation="MTECFLPPTSSPSEHRRAEHGSGLTRTPSSEEISPTKFPGLYRT
                     GEPSPPHDILHEPPDIVSDDEKDHGKKKGKFKKKEKRTEGYAAFQEDSSGDEAESPSK
                     MKRSKGIHVFKKPSFSKKKEKDFKIKEKPKEEKHKEEKHKEEKHKEKKCKDLTAADVV
                     KQWKEKKKKKKPTQEPEVPQTDAPSLRPIFGAPLADAVERTMMYDGIRLPAVFRECVD
                     YMEKHGMKCEGIYRVSGIKSKVDELKAAYDREESPNLEEYEPNTVASLLKQYLRDLPE
                     NLLTKELMPRFEEACGRTTEVEKVQEFQRLLRELPEYNHLLLSWLIVHMDHVIAKELE
                     TKMNIQNISIVLSPTVQISNRVLYVLFTHVQELFGTVVLKQVTRPLRWSNMATMPTLP
                     ETQAGIKEEIRRQEFLLNCLHRDLQGGIKDLSKEERLWEVQRILTALKRKLREAKRQE
                     CETKIAQEIASLSKEDVSKEETNENEEVINILLAQENEILTEQEELLAMEQFLRRQIA
                     SEKEEIDRLRAEIAEIQSRQHGRSETEEYSSDSESESEDEEELQIILEDLQRQNEELE
                     IKNNHLNQAVHEEREAIVELRVQLRLLQMLRAKSEQQLQEEEEPERRGGTGPLPCEGV
                     LEVRAAKEQAKPSPSKDRKETPI"
     exon            540..998
                     /gene="Ralbp1"
                     /gene_synonym="RIP1; RLIP76"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1348
                     /gene="Ralbp1"
                     /gene_synonym="RIP1; RLIP76"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1510
                     /gene="Ralbp1"
                     /gene_synonym="RIP1; RLIP76"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1642
                     /gene="Ralbp1"
                     /gene_synonym="RIP1; RLIP76"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1750
                     /gene="Ralbp1"
                     /gene_synonym="RIP1; RLIP76"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1872
                     /gene="Ralbp1"
                     /gene_synonym="RIP1; RLIP76"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..1993
                     /gene="Ralbp1"
                     /gene_synonym="RIP1; RLIP76"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..3789
                     /gene="Ralbp1"
                     /gene_synonym="RIP1; RLIP76"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggccaaggat cggaggaccc gggaagccgg ctgcggcggg aggagggcgt gcgcgtgcgc
       61 gctgggcggc tcgtcctgtt ctgtcccaat cattgtaaac aggcggaggc tgggcggggt
      121 gggaatgggg ctcccgcggc cggccagggg ggcagcgcag gaggcggcgg ttgtagcggc
      181 agcgtgagtg cgaggaggcg gcggctgcag cggagcggac ggtcgctcgg cggcaggcac
      241 tggtgtaatg gataggtaac agaagaccac ttcccttcct cctcagggct tcagcatgac
      301 tgagtgcttc ctgcccccca ccagcagccc tagtgaacac cgcagggccg agcacggcag
      361 cgggctgacc cggaccccca gctccgagga gatcagccct acaaaatttc ctggattgta
      421 ccggacgggt gagccttcac ctccccatga catcctccac gagcctcctg atatcgtgtc
      481 agatgatgag aaagaccatg gaaagaaaaa aggaaaattt aagaaaaagg agaaaaggac
      541 tgaaggctac gctgccttcc aggaagacag ctctggagat gaggctgaaa gtccttccaa
      601 gatgaagagg tccaagggca tccatgtgtt caaaaagccc agcttctcta aaaagaagga
      661 aaaggatttt aaaatcaaag aaaagcccaa agaagaaaag cacaaagaag aaaagcataa
      721 agaggaaaag cataaagaaa agaaatgtaa agacttgacg gccgccgatg ttgttaaaca
      781 gtggaaggaa aagaagaaaa agaagaagcc aactcaggag ccagaggtgc ctcagacgga
      841 cgccccgagt ctcagaccca ttttcggcgc tcccttggct gacgcagtag agaggaccat
      901 gatgtacgac ggcatccggc tgccagctgt cttccgggag tgcgtggact acatggagaa
      961 gcacggcatg aaatgtgaag gcatctaccg agtgtcagga atcaaatcaa aggtagatga
     1021 gctgaaagca gcctatgacc gagaggagtc tccaaacttg gaagaatatg aacctaacac
     1081 tgtagccagc ttgctgaagc agtatctgcg agaccttccc gagaatttgc ttaccaaaga
     1141 gcttatgccc cgatttgaag aggcttgtgg gaggaccaca gaggtggaga aagtgcagga
     1201 gttccagcgc ttgctcaggg aactgccgga gtacaaccat cttctgctct cctggctcat
     1261 tgtgcacatg gaccacgtca tcgcgaagga gctggaaacc aagatgaaca tccagaacat
     1321 ctccatagtg ctgagcccaa ccgtccagat cagcaaccgg gtcctgtatg tgcttttcac
     1381 acacgtgcaa gagctctttg gcaccgtggt cctgaagcaa gtaacgagac ctctgcgttg
     1441 gtccaacatg gccacaatgc ctacactgcc agagacccaa gcaggcatca aggaagaaat
     1501 caggagacag gagttccttt tgaactgttt acatcgagat ctgcagggcg ggataaagga
     1561 cttgtctaaa gaagaaagat tatgggaagt acagaggatt ctgactgccc tcaagagaaa
     1621 gctgagggaa gctaaaagac aagagtgtga gaccaagatt gcacaggaga tagccagcct
     1681 ttcgaaggag gatgtttcca aagaagaaac gaacgaaaac gaggaggtca taaatatcct
     1741 ccttgcccag gagaatgaga tcctgactga gcaggaggag ctcctggcca tggagcagtt
     1801 tctgcgtcgt cagatcgcct cggagaaaga agagattgac cgcctccgag ctgagattgc
     1861 ggagatccag agtcgccagc atggccgcag cgagacagag gagtactcct ctgacagcga
     1921 gagcgagagc gaggatgagg aggagctgca gatcattctg gaagacttac agaggcagaa
     1981 tgaagagtta gaaataaaga acaatcactt gaaccaggca gtccatgaag agcgggaggc
     2041 catcgttgag ctccgagtgc agctccggct gctccagatg ctgcgagcca agtctgagca
     2101 gcagctccag gaggaggagg agcccgagag gcgagggggc acaggcccac taccctgtga
     2161 aggtgtcctc gaggtgagag cagccaagga gcaggcgaag ccctcgccca gcaaagaccg
     2221 gaaggagacg cccatctgaa ctgccccggc cctgtgcatc gtactgtaag cgagagtccg
     2281 ctgcctgtcc tgccgggcag cgttctgtga aggctctcag agacgctcgc tcttgcacac
     2341 gtctgactcc gtgtcaggct caggtcctgg gagagtgaag gggtggacac tcgggggtgg
     2401 ggggcttgca gggaacacag gtatttccag atagtgtcag cttatttgaa aattaatttt
     2461 ctttgttaaa aataactatt ttaacccttg agtggcttct ttttaaacca aaaaactttt
     2521 tgcttttttt tgttgttgtt taaatcacag cagaatcagg atctctttct tatcaaaggg
     2581 tgggaaccaa accaggtcac ttctgcgcct gccttgtgga cgctcgtggt ctcaccagcc
     2641 ctgcagggtc cctggccact cttgcttgtg ccttccacac cttttggtgc agattgttca
     2701 gtggggagct gcctcatatt ctctgactgg ccaaaaaggc tctcgctggg gttccctgta
     2761 cctgccctgt gtgtaccact ttgcttttcc agctccgggt ctgtcagtgt gagtcaggac
     2821 ggcccagttt ggttgcagac ggaggttacc atgcagcctg ccaccagcct gggcagggca
     2881 ggccacccac tcactgccag ggagcagcaa gggcctcttc tcagaggtgg tcagagatga
     2941 ccaccttgac cctgaggttg cacaggacac ttctcacacc agggtccttt tccacactga
     3001 ccttccagga aagtcacctt ccacagtgac ttcagttgct agcttgggct gggataccca
     3061 cacctctgcc aggataagcc atgtagatgc tgtcatgcac aactttcacc tgtccatgtc
     3121 atctcaaggg gctgcttaag gactctgaca gaactgagcg gaaggaagga aagcgtaact
     3181 gtaattgacc ccccctggtg tttgcctcta acctggacga ctgctcccag cggtctggga
     3241 ggccggactc ttaggcaacc ggatttcact gtcagatgag tggcccccag ggaggtcccc
     3301 tgtggctctg aagacaaatc ccacactcta aagtgagcga caaacccaca ggagggctcc
     3361 ggtctactcc tagttagtat ttatttcagc acctgttggt gcgatttttc gttagcctct
     3421 acctattgca ctgttgtgac ttgttggcca ttatttgatt tttgtacgga aaaaaaagct
     3481 ttgttataga aatcagcata ctattttttt aaatctggag agaagatatt atggaaactg
     3541 gaaacgtggt caggtgtcaa atgtaaatgt ataaatgcct tgctgcaccc gtcagatgtg
     3601 caacactcat tctatatttg ctggcaatat tgaggaattc tttttgtttg tgtaaactct
     3661 aatttctatc aaggtatcat gggtttttaa aatttcatta caaatgtctc aatgttggtt
     3721 aactaatttt tgccaggacc attattgatt aaggaaataa actcagcagc catttgagaa
     3781 aaaaaaaaa
//
