LOCUS       NM_053821               2265 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus RAS like proto-oncogene B (Ralb), mRNA.
ACCESSION   NM_053821
VERSION     NM_053821.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2265)
  AUTHORS   Simicek,M., Lievens,S., Laga,M., Guzenko,D., Aushev,V.N., Kalev,P.,
            Baietti,M.F., Strelkov,S.V., Gevaert,K., Tavernier,J. and
            Sablina,A.A.
  TITLE     The deubiquitylase USP33 discriminates between RALB functions in
            autophagy and innate immune response
  JOURNAL   Nat Cell Biol 15 (10), 1220-1230 (2013)
   PUBMED   24056301
REFERENCE   2  (bases 1 to 2265)
  AUTHORS   Martin,T.D., Mitin,N., Cox,A.D., Yeh,J.J. and Der,C.J.
  TITLE     Phosphorylation by protein kinase Calpha regulates RalB small
            GTPase protein activation, subcellular localization, and effector
            utilization
  JOURNAL   J Biol Chem 287 (18), 14827-14836 (2012)
   PUBMED   22393054
  REMARK    GeneRIF: phosphorylation by PKCalpha is critical for RalB-mediated
            vesicle trafficking and exocytosis.
REFERENCE   3  (bases 1 to 2265)
  AUTHORS   Fenwick,R.B., Prasannan,S., Campbell,L.J., Nietlispach,D.,
            Evetts,K.A., Camonis,J., Mott,H.R. and Owen,D.
  TITLE     Solution structure and dynamics of the small GTPase RalB in its
            active conformation: significance for effector protein binding
  JOURNAL   Biochemistry 48 (10), 2192-2206 (2009)
   PUBMED   19166349
REFERENCE   4  (bases 1 to 2265)
  AUTHORS   Cascone,I., Selimoglu,R., Ozdemir,C., Del Nery,E., Yeaman,C.,
            White,M. and Camonis,J.
  TITLE     Distinct roles of RalA and RalB in the progression of cytokinesis
            are supported by distinct RalGEFs
  JOURNAL   EMBO J 27 (18), 2375-2387 (2008)
   PUBMED   18756269
REFERENCE   5  (bases 1 to 2265)
  AUTHORS   Falsetti,S.C., Wang,D.A., Peng,H., Carrico,D., Cox,A.D., Der,C.J.,
            Hamilton,A.D. and Sebti,S.M.
  TITLE     Geranylgeranyltransferase I inhibitors target RalB to inhibit
            anchorage-dependent growth and induce apoptosis and RalA to inhibit
            anchorage-independent growth
  JOURNAL   Mol Cell Biol 27 (22), 8003-8014 (2007)
   PUBMED   17875936
REFERENCE   6  (bases 1 to 2265)
  AUTHORS   Li,G., Han,L., Chou,T.C., Fujita,Y., Arunachalam,L., Xu,A.,
            Wong,A., Chiew,S.K., Wan,Q., Wang,L. and Sugita,S.
  TITLE     RalA and RalB function as the critical GTP sensors for
            GTP-dependent exocytosis
  JOURNAL   J Neurosci 27 (1), 190-202 (2007)
   PUBMED   17202486
  REMARK    GeneRIF: Our results indicate that endogenous RalA and RalB
            function specifically as GTP sensors for the GTP-dependent
            exocytosis of dense core vesicles.
REFERENCE   7  (bases 1 to 2265)
  AUTHORS   Lim,K.H., O'Hayer,K., Adam,S.J., Kendall,S.D., Campbell,P.M.,
            Der,C.J. and Counter,C.M.
  TITLE     Divergent roles for RalA and RalB in malignant growth of human
            pancreatic carcinoma cells
  JOURNAL   Curr Biol 16 (24), 2385-2394 (2006)
   PUBMED   17174914
REFERENCE   8  (bases 1 to 2265)
  AUTHORS   Rosse,C., Hatzoglou,A., Parrini,M.C., White,M.A., Chavrier,P. and
            Camonis,J.
  TITLE     RalB mobilizes the exocyst to drive cell migration
  JOURNAL   Mol Cell Biol 26 (2), 727-734 (2006)
   PUBMED   16382162
  REMARK    GeneRIF: RalB regulation of exocyst function is required for the
            coordinated delivery of secretory vesicles to the sites of dynamic
            plasma membrane expansion that specify directional movement.
REFERENCE   9  (bases 1 to 2265)
  AUTHORS   Lalli,G. and Hall,A.
  TITLE     Ral GTPases regulate neurite branching through GAP-43 and the
            exocyst complex
  JOURNAL   J Cell Biol 171 (5), 857-869 (2005)
   PUBMED   16330713
  REMARK    GeneRIF: The two Ral isoforms, RalA and -B, promote branching
            through distinct pathways, involving the exocyst complex and
            phospholipase D, respectively.
REFERENCE   10 (bases 1 to 2265)
  AUTHORS   Wildey,G.M., Viggeswarapu,M., Rim,S. and Denker,J.K.
  TITLE     Isolation of cDNA clones and tissue expression of rat ral A and ral
            B GTP-binding proteins
  JOURNAL   Biochem Biophys Res Commun 194 (1), 552-559 (1993)
   PUBMED   7687439
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC072505.1.
            
            On Jun 13, 2004 this sequence version replaced NM_053821.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072505.1, CK366097.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760434, SAMN16093049
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2265
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q11"
     gene            1..2265
                     /gene="Ralb"
                     /gene_synonym="dRalb"
                     /note="RAS like proto-oncogene B"
                     /db_xref="GeneID:116546"
                     /db_xref="RGD:619852"
     exon            1..167
                     /gene="Ralb"
                     /gene_synonym="dRalb"
                     /inference="alignment:Splign:2.1.0"
     exon            168..330
                     /gene="Ralb"
                     /gene_synonym="dRalb"
                     /inference="alignment:Splign:2.1.0"
     CDS             217..837
                     /gene="Ralb"
                     /gene_synonym="dRalb"
                     /EC_number="3.6.5.2"
                     /note="v-ral simian leukemia viral oncogene homolog B (ras
                     related); v-ral simian leukemia viral oncogene homolog B
                     (ras related; GTP binding protein); RALB Ras like
                     proto-oncogene B"
                     /codon_start=1
                     /product="ras-related protein Ral-B"
                     /protein_id="NP_446273.1"
                     /db_xref="GeneID:116546"
                     /db_xref="RGD:619852"
                     /translation="MAANKGKSQGSLVLHKVIMVGSGGVGKSALTLQFMYDEFVEDYE
                     PTKADSYRKKVVLDGEEVQIDILDTAGQEDYAAIRDNYFRSGEGFLLVFSITEHESFT
                     ATAEFREQILRVKAEEDKIPLLVVGNKSDLEERRQVPVEEARGKAEEWGVQYVETSAK
                     TRANVDKVFFDLMREIRAKKMSENKDKNGRKSGKSKKSFKERCCLL"
     exon            331..539
                     /gene="Ralb"
                     /gene_synonym="dRalb"
                     /inference="alignment:Splign:2.1.0"
     exon            540..717
                     /gene="Ralb"
                     /gene_synonym="dRalb"
                     /inference="alignment:Splign:2.1.0"
     exon            718..2220
                     /gene="Ralb"
                     /gene_synonym="dRalb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagcgggaac gcgctccggg gggtggggac gcgcgagctc acgactgctc aatgacaaat
       61 cgactgggga cagctggggt ccggccccag gacggggcgg ggcgcgcgtg agagccgcga
      121 gtctggttgt gcacatagcc agagcggcgg tgggacggct ccctcagctc ctcatctggg
      181 ccatctgtcc gtgtgtcgct gcctcagacc agcaggatgg ctgccaacaa aggcaagagc
      241 cagggctccc tggtccttca caaggtcatc atggtcggca gtgggggagt cggcaagtca
      301 gccctgacgc tccagttcat gtatgacgag tttgtagaag actatgagcc caccaaagcc
      361 gacagttaca gaaagaaggt ggttctcgac ggagaagagg ttcagataga catcctggac
      421 acagccggcc aggaggacta tgcggccatc cgtgacaact acttccgaag cggagaaggc
      481 tttctgctgg tgttctccat cacggagcac gagtctttca ccgccacagc tgagttcagg
      541 gaacagatcc tccgagtcaa ggccgaggag gacaaaatcc ctctgctggt cgtgggcaac
      601 aagtctgacc tggaggagcg gaggcaggtg cccgtggagg aggcccgagg caaagcggaa
      661 gagtggggtg tgcagtatgt ggagacatcc gcaaagaccc gagccaacgt ggacaaggtg
      721 ttctttgatc tgatgagaga aatccgggca aaaaagatgt cggaaaacaa ggacaagaac
      781 ggcaggaaaa gcggcaagag caagaagagt ttcaaagagc ggtgctgctt gctgtgagtg
      841 ggccgcggac agagcgagcg gagaaggcca cattgcagcg cgccgagccc aggtggcctc
      901 cccctggctc cccactctcc gcagctgtat tcactatcac ttcttgagat gggacagata
      961 cctgtgcacc agtggctggc aggagaaaga cgccttcgtc tgtgcgtctg tgcgatgcat
     1021 ctgctaacgt tgccaggagc tttgagagtc tgccccctcc caccctccct gaaccgtgac
     1081 tgtcaccagc tctagggtca ggaatctgag ttgtgttgac aagaaagagg attgccacgg
     1141 cggcttgtcc ccccctgttc taggacatgg tcatcttttg ttggaaaatc aaaatgcttc
     1201 acattagcag ggcgtgctgg tgcacccctg tagtcccaga actctagaag gtaaggcagg
     1261 gagggtagcc tgagcccaag gccagcctgg gctacctagc aagaccctgt ctctaaaagg
     1321 aaaaagaact aacatcttat tttcttagat ttaaaaagag ggtctctggc aagacccctc
     1381 gttagttctt atcagtttag aagtagacag ggggcggaaa acctaagctc aggtaatact
     1441 gaaaaagcca aaacaatttg tttttttttt ttttctgttt taaaagataa acttctgtga
     1501 cttggaagca gaattagaaa gatgaacttc acttggtcca gataggctga accaagcctc
     1561 ctggcgtttg tagagaaagt gggacgctgt tcccttcata cttaaatgcc agccaggtgc
     1621 tggctgtggg cttccctccc taacaccctt acttagtagt gaggaaactt tgtgtggggg
     1681 agatgtaggc ctgtgcccca gaacaagctt tcttttttct gactggatca tctcaccttt
     1741 tctggttccc tcccactcca gccataggcc tgttcttttt cttcctttct gaaaaatgtg
     1801 accagttcaa attatgtccc aggacacggg ccagcgccag ctacctctgc agactctaca
     1861 agcggaagag gggaaggctc agaagggagg gccatctcct gtagctcccg gcagttggtt
     1921 ctggtgacac tgacatgaac caggttccag aggctcacac ccactctctg ttaagcctcc
     1981 tctcggggaa ggggactctg ggactggggg ctgccactga gcacacacac tcctcccatt
     2041 ttccagaagt gaacatttca cgttttggtg ccgaatgtga atctgggtgg gaagagcggg
     2101 agcccttcta atggatgttt tttttaacag aggttatgga atccaaggtc tgatccctgg
     2161 aaacttgtgt cacttccaaa gaatcatggg ctttttcgaa ttaaaaaaaa ttacactttt
     2221 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
