LOCUS       NM_001271207            7600 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus retinoic acid induced 1 (Rai1), mRNA.
ACCESSION   NM_001271207 XM_001077437 XM_220520
VERSION     NM_001271207.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7600)
  AUTHORS   Williams,S.R., Zies,D., Mullegama,S.V., Grotewiel,M.S. and
            Elsea,S.H.
  TITLE     Smith-Magenis syndrome results in disruption of CLOCK gene
            transcription and reveals an integral role for RAI1 in the
            maintenance of circadian rhythmicity
  JOURNAL   Am J Hum Genet 90 (6), 941-949 (2012)
   PUBMED   22578325
REFERENCE   2  (bases 1 to 7600)
  AUTHORS   Yan,J., Bi,W. and Lupski,J.R.
  TITLE     Penetrance of craniofacial anomalies in mouse models of
            Smith-Magenis syndrome is modified by genomic sequence surrounding
            Rai1: not all null alleles are alike
  JOURNAL   Am J Hum Genet 80 (3), 518-525 (2007)
   PUBMED   17273973
REFERENCE   3  (bases 1 to 7600)
  AUTHORS   Bi,W., Ohyama,T., Nakamura,H., Yan,J., Visvanathan,J., Justice,M.J.
            and Lupski,J.R.
  TITLE     Inactivation of Rai1 in mice recapitulates phenotypes observed in
            chromosome engineered mouse models for Smith-Magenis syndrome
  JOURNAL   Hum Mol Genet 14 (8), 983-995 (2005)
   PUBMED   15746153
REFERENCE   4  (bases 1 to 7600)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   5  (bases 1 to 7600)
  AUTHORS   Slager,R.E., Newton,T.L., Vlangos,C.N., Finucane,B. and Elsea,S.H.
  TITLE     Mutations in RAI1 associated with Smith-Magenis syndrome
  JOURNAL   Nat Genet 33 (4), 466-468 (2003)
   PUBMED   12652298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On or before Sep 8, 2012 this sequence version replaced
            XM_220520.6, XM_001077437.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            CDS exon combination :: AY724505.1, SRR26643429.36875.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA5760383, SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-290               JAXUCZ010000010.1  45447427-45447716
            291-5370            JAXUCZ010000010.1  45492828-45497907
            5371-5811           JAXUCZ010000010.1  45497908-45498348
            5812-5905           JAXUCZ010000010.1  45501578-45501671
            5906-5955           JAXUCZ010000010.1  45505854-45505903
            5956-7600           JAXUCZ010000010.1  45506103-45507747
FEATURES             Location/Qualifiers
     source          1..7600
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..7600
                     /gene="Rai1"
                     /note="retinoic acid induced 1"
                     /db_xref="GeneID:303188"
                     /db_xref="RGD:1308500"
     exon            1..290
                     /gene="Rai1"
                     /inference="alignment:Splign:2.1.0"
     exon            291..5811
                     /gene="Rai1"
                     /inference="alignment:Splign:2.1.0"
     CDS             307..5970
                     /gene="Rai1"
                     /codon_start=1
                     /product="retinoic acid-induced protein 1"
                     /protein_id="NP_001258136.1"
                     /db_xref="GeneID:303188"
                     /db_xref="RGD:1308500"
                     /translation="MQSFRERCGFHGKQQNYPQTSQETSRLENYRQPGQAGLSCDRQR
                     LLAKDYYNPQPYTGYEGGTGTPAGTVATAAADKYHRGNKSLQGRPAFPSYVQDSSPYP
                     GRYSGEEGLQTWGSPQPPPPQPQPLPGAVSKYEENLMKKTVVPPNRQYPEQGPQLPFR
                     THGLHVPPPQPQQPLAYPKLQRQKPQNDLASPLPFPQGSHFPQHSQSFPTSSTYAPTV
                     QGGGQGAHSYKSCTAPSAQPHDRPMSANASLAPGQRVQNLHAYQPGRLGYEQQQQALQ
                     GRHHTQETLHYQNLAKYQHYGQQGQGYCPADTAVRTPEQYYQTFSPSSSHSPARSVGR
                     SPSYSSTPSPLMPNLENFPYSQQPLSTGAFPTGITDHSHFMPLLNPSPTDAASSVDPQ
                     VSNCKPLQKEKLPDNLLSDLSLQSLTALTSQVENISNTVQQLLLSKATIPQKKGVKNL
                     VSRTPEQHKSQHCSPEGSGYSAEPAGTPLSEPPSSTPQSTHAEPQDTDYLSGSEDPLE
                     RSFLYCSQARGSPARVNSNSKAKPESVSTCSVTSPDDMSTKSDDSFQSLHSTLPLDSF
                     SKFVAGERDCPRLLLSALAQEDLASEILGLQEAIVEKADKAWAEASSLPKDNGKPPFS
                     LENHSTCLDTVAKTSWSQPGEPEALPEPLQLDKGGSTKDFSPGLFEDPSVAFATTDPK
                     KTTSPLSFGTKPLLGTATPDPTTAAFDCFPDTTTASSVDGANPFAWPEENLGDACPRW
                     GLHPGELTKGLEQGAKASDSVGKADAHETSACLGFQEEHAIGKPAAALSGDFKQQEAD
                     GVKEEVGGLLQCPEVGKADQWLEDSRHCCSSADFGDLPLLPPPGRKEDLEAEEEYSSL
                     CELLGSPEQRPSLQDPLSPKAPLICTKEEAEEVLDTKAGWASPCHLSGEPAVLLGPSV
                     GAESKVQSWFESSLSHMKPGEGPELERAPGSASTSQGSLAPKPNTPAVPEGPIAKKEP
                     VPRGKSLRSRRVHRGLPEAEDSPCRAPALPKDLLLPESCTGPPQGQAEGAGAPGRGLS
                     EGLPRMCTRSLTALSEPQTPGPPGLTTTPTPPDKLGGKQRAAFKSGKRVGKPSPKAAS
                     SPSNPAALPVASDSSPMGSKTKEPDSPGMPGKDQRSMVLRSRTKPQQVFHAKRRRPSE
                     SRIPDCRPTKKPPANNHLPTAFKVSSGPQKEGRMSQRGKVPKPGTGSKLSDRPLHTLK
                     RKSAFMAPVPAKKRSLILRSNNGSGVDGREERAESSPGLLRRMASPQRARPRGSGEPP
                     PPPPLEPPAACLGLATQSSLPSAVRTKVLPPRKGRGLKLEAIVQKITSPGLKKLACRV
                     AGAPPGTPRSPALPEKRSGGSPAGAEEGVGGMGAGQMLPAASGADPLCRNPASSRSLK
                     GKLLNSKKLSSAADCPKAEAFMSPETLPSLGTARAPKKRSRKGRTGALGPSKGPLEKR
                     PCPGQALILAPHDRASSTQGGGEDNSSGGGKKPKTEELGLASQPPEGRPCQPQTRAQK
                     QPGQASYSSYSKRKRLSRGRGKATHASPCKGRATRRRQQQVLPLDPAEPEIRLKYISS
                     CKRLRADSRTPAFSPFVRVEKRDAYTTICTVVNSPGDEPKPHWKPSSVASSSTSSSEP
                     AGASLTTFPGGSVLQLRPSLPLSSTMHLGPVVSKALSTSCLVCCLCQNPANFKDLGDL
                     CGPYYPEHCLPKKKPKLKEKVRLEGTLEEASLPLERTLKGLECAASTTAATPTTTTIT
                     TTTTLGRLSRPDGPADPAKQGSLRTSARGLSRRLQSCYCCDGQGDGGEEVAPADKSRK
                     HECSKEAPAEPGGDTQEHWVHEACAVWTSGVYLVAGKLFGLQEAMKVAVDMPCTSCHE
                     SGATISCSYEGCTHTYHYPCANDTGCTFIEENFTLKCPKHKRLPL"
     exon            5812..5905
                     /gene="Rai1"
                     /inference="alignment:Splign:2.1.0"
     exon            5906..5955
                     /gene="Rai1"
                     /inference="alignment:Splign:2.1.0"
     exon            5956..7600
                     /gene="Rai1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctactgag ggcactcgca ggcgctgctg agcaggaagc gaggggctgg agaggcgcgg
       61 cgcgcacggg agcgcgaaaa gagaggaacg agcccagcgc cagcgctcgc ggcgcgcaga
      121 gaaaggaatc gtgtgagcgc tcacatattt ttctcccaag gatctcatct ggcggtcggg
      181 tactggaaga agcgagggga agagcgcacc gttgcagaga gacggcaaga gaaaagggag
      241 actgcgagac gcgccacgcc ggcgccccaa gacccaggag gagcccgcag ataaccagcc
      301 cgagtcatgc agtcttttcg agaaaggtgt ggtttccatg gcaaacagca aaactaccca
      361 cagacctcac aggagacatc gcgtctggag aactacaggc agccgggtca ggctgggcta
      421 agctgtgatc gacagcggct gctggccaag gactattaca accctcagcc ctatacaggc
      481 tatgagggcg gcactggtac acctgcaggc acagtggcca cagcagctgc agacaagtac
      541 caccgaggca acaagtccct gcaggggagg ccagctttcc ccagctatgt tcaagacagc
      601 agcccctacc cagggcgcta ctctggtgag gaggggcttc agacctgggg cagcccacag
      661 ccaccacctc cgcagccaca gcctctgcca ggggcagtga gcaagtacga ggagaacttg
      721 atgaagaaga cagtggtgcc tccaaacagg cagtaccctg agcagggccc ccaacttccc
      781 ttccggactc acggcctgca tgtcccacca ccgcagcctc agcagcccct ggcttacccc
      841 aaactccaaa ggcagaaacc acagaatgac cttgcctccc ctctgccctt cccccagggc
      901 agccactttc cccagcattc ccagtccttc cctacctcct ccacttatgc cccaacagtg
      961 cagggtggtg ggcagggggc ccactcatac aagagctgca cagcaccatc tgcccagcct
     1021 catgacaggc cgatgagtgc caatgcgagc ctggctccag ggcaacgggt ccagaatctt
     1081 cacgcttacc agccgggccg ccttggctat gagcagcagc agcaagcact tcaaggccgg
     1141 caccacaccc aggaaacact ccactaccag aacctcgcca agtaccaaca ctatggacag
     1201 caaggccagg gctactgtcc agcggacaca gctgtcagga ctccggaaca gtattaccag
     1261 accttcagcc ctagctccag ccactcccct gcacgctccg tgggtcgctc cccttcctac
     1321 agctccaccc cgtcaccact gatgcccaat ctggagaact tcccttatag ccagcagccg
     1381 cttagtactg gggccttccc cacaggcatc acagaccaca gccactttat gcccctgctc
     1441 aacccgtccc caacagatgc tgccagctct gtggaccccc aggtcagcaa ctgcaagccc
     1501 ctgcaaaagg agaagcttcc tgacaacttg ctgtcagatc tcagcctgca gagtctcaca
     1561 gcgctcacct cacaggtaga aaacatctcc aatactgtgc aacagctctt gctgtccaaa
     1621 gctaccatac cacagaagaa aggggtcaag aaccttgtgt ctaggactcc agagcagcac
     1681 aaaagccagc attgtagccc agagggcagt ggctactcag ctgagccagc aggcacacca
     1741 ctgtctgagc caccaagtag cacaccacag tccactcatg ctgaaccaca agacactgac
     1801 tacctgagtg gctctgagga cccactagag cgcagcttcc tctactgcag ccaggcccgg
     1861 ggcagtcctg ccagagtcaa cagcaactct aaggccaagc ctgagtctgt gtccacctgt
     1921 tctgtgacct cacctgatga catgtccacc aagtctgacg actctttcca gagcctgcac
     1981 agtactctgc cactggatag cttctccaaa tttgtggcag gcgagcggga ctgtccacgg
     2041 ctgctgctca gtgccctggc acaggaagat ctggcctctg agatcctggg actgcaggaa
     2101 gccattgttg agaaggctga caaggcctgg gctgaggctt ccagcctgcc caaggacaat
     2161 ggcaagccac ccttctcact ggagaaccac agcacttgcc tggacactgt ggctaagaca
     2221 tcatggtcac agccggggga gccagaagcc ctacctgagc ccctgcagct ggacaagggg
     2281 ggcagcacca aggacttcag cccggggcta tttgaagacc cctctgtggc ctttgccacc
     2341 actgacccga agaaaacaac cagtcccctg tcctttggca ccaaaccttt gcttgggact
     2401 gccactcctg accccaccac ggcagcattt gactgctttc cagatacaac cactgccagc
     2461 tcagtggatg gtgccaaccc ctttgcctgg ccagaggaga acctgggcga tgcttgtcct
     2521 cgctggggcc tccaccctgg tgagcttacc aagggcttgg agcagggtgc aaaagcctca
     2581 gacagtgtgg gcaaggcaga tgcacacgag acctctgcct gcttgggctt ccaggaagag
     2641 catgccatcg ggaagccagc agctgcactg tctggggact tcaagcagca ggaggcagat
     2701 ggggtaaaag aggaagtggg tgggttgctg cagtgccccg aggtgggcaa ggccgaccag
     2761 tggctggagg atagccggca ttgctgttcc tccgctgact ttggggacct gccactgttg
     2821 ccaccccctg gcaggaagga ggatctggaa gctgaagagg aatactcttc gctatgtgaa
     2881 ctgctgggga gccctgagca gaggcccagc ctgcaggacc cactgtcccc caaggcccct
     2941 ctgatttgta ccaaggagga agcagaggag gtactagata ccaaggctgg ctgggcctct
     3001 ccgtgccacc tctctgggga gcccgcagtc cttctgggcc cctccgtggg tgccgaatca
     3061 aaggtccaaa gctggtttga atcttccctg tcacatatga agccaggaga agggccagag
     3121 ctggagagag ctccaggtag cgccagcact tcacagggct ccttggcccc aaagcctaac
     3181 acgcccgccg tacccgaggg acccattgcg aagaaagagc ctgtgccacg gggtaaaagt
     3241 ttacggagcc ggcgagtaca ccgggggctg cctgaggcgg aagactctcc atgcagggcg
     3301 ccagcacttc ccaaagacct cttgctccca gagtcctgca cggggccccc acagggtcag
     3361 gcagaggggg ccggggcccc aggccgggga ctgtcagaag ggctccccag aatgtgtacc
     3421 cgttctctca cagctctgag tgagccccaa actcctggac ctccaggcct gactaccacc
     3481 cccacacctc ctgacaaact gggaggaaaa cagcgagctg ccttcaagtc tggtaagcgg
     3541 gtaggaaaac cgtcacccaa ggctgcatcc agccccagca accctgctgc cctgcctgtt
     3601 gcctcagaca gcagccccat gggctccaaa accaaggagc cagactctcc cggcatgcct
     3661 ggcaaggacc agcggtccat ggtcctccgg tctcgcacca aaccccagca ggtcttccat
     3721 gccaaacggc ggcggccctc agagagcagg atcccagact gccgtcccac caagaagccc
     3781 cctgctaaca accatttacc cactgcattc aaggtctcca gtgggcccca gaaggaaggt
     3841 cggatgagcc agcggggcaa agtacccaag cccggtacag ggagcaagct ttcagatagg
     3901 cctctccaca cactcaaaag gaagtcagct ttcatggcac ctgtccctgc caaaaagcgg
     3961 agcctcatcc tgcgaagcaa caatggaagt ggggtagatg ggagggagga aagggctgag
     4021 agctcccctg gcctcttaag gaggatggcc tcaccccaga gggccagacc caggggcagt
     4081 ggggagccac ccccaccccc acccctagag ccacctgctg catgcctggg gttggctaca
     4141 caatcatccc tgcccagtgc tgtgaggacc aaggtgctgc caccccgaaa gggccgtggc
     4201 ctcaagctgg aggccatagt acagaagatc acctcacctg gtctcaagaa acttgcatgc
     4261 agagtggcag gggcccctcc tgggacaccc cggagccctg ccctacctga gaaacgttca
     4321 gggggcagtc cagctggggc agaagagggt gtaggaggaa tgggtgcagg gcaaatgcta
     4381 ccagcagctt cgggagctga cccattgtgc agaaacccag ccagcagcag gtccctaaaa
     4441 ggtaaactct tgaatagtaa gaagctgtcc tctgctgctg actgccccaa agctgaggcc
     4501 ttcatgtccc cggagaccct cccatcccta gggactgccc gggcaccgaa gaaaaggagc
     4561 cggaaaggca ggactggggc cttgggaccc tccaaaggtc cattggagaa gcggccctgt
     4621 cctggccaag ctctgatcct cgctccccac gacagggcca gcagcactca gggcggaggt
     4681 gaggacaact ccagtggagg aggcaagaag ccaaagacag aggagctggg actggcctcc
     4741 cagcccccag aaggccggcc ctgccagccc cagacaaggg cacagaagca gccaggccaa
     4801 gccagctata gcagctattc aaagcggaag cgcctcagcc gtggccgagg aaaggccacc
     4861 catgcttcac cctgtaaagg ccgtgccact cggagaaggc agcagcaggt actgcccctg
     4921 gatcctgcag agcctgaaat ccgactcaaa tacatttctt cttgcaagag gctgagggca
     4981 gacagccgca ccccagcctt ctcgcccttt gtgcgggtgg agaagcgaga tgcatacacc
     5041 accatatgca ctgttgtcaa ctccccaggg gatgagccga agcctcactg gaagccatcc
     5101 tctgttgcct cctcttccac ctcctcctca gaaccagctg gggcttctct gaccacattc
     5161 cctggaggct ctgtgctaca gctgaggccc tccctgcccc tctcctccac catgcatctg
     5221 gggccggtgg tgtccaaggc cctaagtacc tcttgccttg tctgctgcct ctgccaaaac
     5281 ccggccaatt tcaaggacct tggggacctc tgtggtccct actaccctga acactgcctc
     5341 ccaaaaaaga agccaaaact caaggagaag gtacggctgg agggcacctt ggaggaggcc
     5401 tctctgcctc tggagagaac actcaaaggc ctggaatgtg cagccagcac cacggctgcc
     5461 acccctacca caaccaccat cactaccacc acaaccctgg ggaggctgtc caggcctgat
     5521 ggcccagccg accctgccaa gcagggttcc ctgcgcacca gtgcccgggg cctgtcaagg
     5581 cggctgcaga gttgctattg ctgtgatggt cagggggacg ggggtgagga ggtggcccca
     5641 gctgacaaga gccgcaaaca tgaatgcagc aaagaggccc ctgcagaacc tggtggggac
     5701 acccaagagc actgggtaca tgaggcctgt gctgtgtgga ccagcggggt gtacctggtg
     5761 gccgggaagc tctttgggct gcaggaggcc atgaaagtag ctgtggacat gccatgtacc
     5821 agctgtcatg agtccggagc aaccatctcg tgctcctatg aaggctgcac ccacacctac
     5881 cactacccat gtgccaatga cacaggttgc acgttcattg aggagaattt tactttgaag
     5941 tgccccaaac ataagaggct gccgttgtaa tacccgtgtg gccgaaactc cgaggaagag
     6001 gagctgcgcc cacagccggt cctcgatccc atccgggtct aggttccggc tgccttgggc
     6061 actggcgtga ggcctaggtt gcgaagaaaa ccgaggccag gcttggcaaa ggcaggccag
     6121 agagtggcca gacccagggc acagggtctc gggcggggtg caagtcccct gcaagttctg
     6181 gaaaagacgt ggcatgcaag ctgtgcccct gggaagaggc tgggggcgct gctggctcag
     6241 tggacgacgt ggggcagacc caggcctttc ggtagaggcc cagcaatggg gcagcatggc
     6301 ccaagcactt ggcatggatc tgcccagggg cgtggcaggc ggggttcagg ccactctatc
     6361 cctgatgagg gctggcctgg ggtggcaccc tatggcttct ttttgtcccc tttccagtct
     6421 tccaccccac tgttggagcc cggtctggaa gcttgcggag accgggtctg gctaccctct
     6481 agcagatatg cagccgtccc agacatagca ccaacatggg attcagggac tgccactcag
     6541 cttactcgac tcatgggcgg agaccgtgct agattcgtgt acaaacctgt gtacccctct
     6601 atatatatgt tacatagaat gtatatatgt tgggaacatg ctcgcttctg tgtgtcgctg
     6661 ctgtgcgtcc tgtgttccac agcacagagc cctaacctgg ctttggctgg ggtcagagct
     6721 gaagtgatgc tccttcccca gcagatacca ccatcaccac cacggccagc ccccacctgt
     6781 ccgtttgtgt tctcagctgt ccacgcttca ataggcctga tgcagccccc cttcccctgc
     6841 aactttctgt acatatgact gtaaaatggt aaacgtgtgt attatatctg gcctcgttat
     6901 atagtgtata tatatgtata catatacata tatataatat atatgaagac tgtaaatgtt
     6961 aagacaacta gtgttcttat tagtatattg cttcacactg aagattgtgt gtatcgagct
     7021 gtttctaaaa gatgtttatt ttccttaaga gttaaaaaaa aaaaaacagt cattgcattc
     7081 agaaaaaaaa gtcaataaag ataccacgat tgttttggaa gtttgtggcc catggatgcc
     7141 aaccagattc cctaaggggt tgggagtaga gggaggggcc aggggacaca aacagggatc
     7201 ccggattctg ctcctgagtg gaccatgatc cctcacctat gctggtaaca gagagaacca
     7261 gggaactgtg tgtctgtttc caggcacacg ggatatcatt accctgggac ctggtggagg
     7321 gctggaaggc aaagaaacaa ctgatgccat caaggccctt caaggtggag ccacagggta
     7381 gccatgagat tagagggcca ggttggctca acataccgca caaggcagaa gccagcaaac
     7441 acttgtacag catgggaagt ccagcttccc gaaggacaat ccaggaagga tggcaatcag
     7501 atgaggcaaa catccgccta cccagataaa taaaactcaa gttataaata atttcacttt
     7561 ttaattttct gtacaaaatt tctcaaccta tgaaaataaa
//
