LOCUS       NM_053468               6536 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus recombination activating 1 (Rag1), mRNA.
ACCESSION   NM_053468 XM_001079242 XM_230375
VERSION     NM_053468.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6536)
  AUTHORS   Menoret,S., Ouisse,L.H., Tesson,L., Delbos,F., Garnier,D., Remy,S.,
            Usal,C., Concordet,J.P., Giovannangeli,C., Chenouard,V.,
            Brusselle,L., Merieau,E., Nerriere-Daguin,V., Duteille,F.,
            Bellier-Waast,F., Fraichard,A., Nguyen,T.H. and Anegon,I.
  TITLE     Generation of Immunodeficient Rats With Rag1 and Il2rg Gene
            Deletions and Human Tissue Grafting Models
  JOURNAL   Transplantation 102 (8), 1271-1278 (2018)
   PUBMED   29688994
REFERENCE   2  (bases 1 to 6536)
  AUTHORS   Abais-Battad,J.M., Lund,H., Fehrenbach,D.J., Dasinger,J.H. and
            Mattson,D.L.
  TITLE     Rag1-null Dahl SS rats reveal that adaptive immune mechanisms
            exacerbate high protein-induced hypertension and renal injury
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 315 (1), R28-R35 (2018)
   PUBMED   29537860
  REMARK    GeneRIF: Rag1-null Dahl SS rats provide evidence that adaptive
            immune mechanisms contribute to the exacerbation of salt-induced
            hypertension and renal injury mediated by increased dietary protein
            intake.
REFERENCE   3  (bases 1 to 6536)
  AUTHORS   Mattson,D.L., Lund,H., Guo,C., Rudemiller,N., Geurts,A.M. and
            Jacob,H.
  TITLE     Genetic mutation of recombination activating gene 1 in Dahl
            salt-sensitive rats attenuates hypertension and renal damage
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 304 (6), R407-R414 (2013)
   PUBMED   23364523
  REMARK    GeneRIF: The infiltration of T cells into the kidney following
            high-salt intake was significantly blunted in the Rag1-null rats
REFERENCE   4  (bases 1 to 6536)
  AUTHORS   Menoret,S., Fontaniere,S., Jantz,D., Tesson,L., Thinard,R.,
            Remy,S., Usal,C., Ouisse,L.H., Fraichard,A. and Anegon,I.
  TITLE     Generation of Rag1-knockout immunodeficient rats and mice using
            engineered meganucleases
  JOURNAL   FASEB J 27 (2), 703-711 (2013)
   PUBMED   23150522
REFERENCE   5  (bases 1 to 6536)
  AUTHORS   Zschemisch,N.H., Glage,S., Wedekind,D., Weinstein,E.J., Cui,X.,
            Dorsch,M. and Hedrich,H.J.
  TITLE     Zinc-finger nuclease mediated disruption of Rag1 in the LEW/Ztm rat
  JOURNAL   BMC Immunol 13, 60 (2012)
   PUBMED   23136839
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6536)
  AUTHORS   Maraskovsky,E., O'Reilly,L.A., Teepe,M., Corcoran,L.M.,
            Peschon,J.J. and Strasser,A.
  TITLE     Bcl-2 can rescue T lymphocyte development in interleukin-7
            receptor-deficient mice but not in mutant rag-1-/- mice
  JOURNAL   Cell 89 (7), 1011-1019 (1997)
   PUBMED   9215624
REFERENCE   7  (bases 1 to 6536)
  AUTHORS   Schwarz,K., Gauss,G.H., Ludwig,L., Pannicke,U., Li,Z., Lindner,D.,
            Friedrich,W., Seger,R.A., Hansen-Hagge,T.E., Desiderio,S.,
            Lieber,M.R. and Bartram,C.R.
  TITLE     RAG mutations in human B cell-negative SCID
  JOURNAL   Science 274 (5284), 97-99 (1996)
   PUBMED   8810255
REFERENCE   8  (bases 1 to 6536)
  AUTHORS   Sadofsky,M.J., Hesse,J.E., McBlane,J.F. and Gellert,M.
  TITLE     Expression and V(D)J recombination activity of mutated RAG-1
            proteins
  JOURNAL   Nucleic Acids Res 21 (24), 5644-5650 (1993)
   PUBMED   8284210
  REMARK    Erratum:[Nucleic Acids Res. 1994 Feb 11;22(3):550. PMID: 8127702]
REFERENCE   9  (bases 1 to 6536)
  AUTHORS   Mombaerts,P., Iacomini,J., Johnson,R.S., Herrup,K., Tonegawa,S. and
            Papaioannou,V.E.
  TITLE     RAG-1-deficient mice have no mature B and T lymphocytes
  JOURNAL   Cell 68 (5), 869-877 (1992)
   PUBMED   1547488
REFERENCE   10 (bases 1 to 6536)
  AUTHORS   Oettinger,M.A., Schatz,D.G., Gorka,C. and Baltimore,D.
  TITLE     RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J
            recombination
  JOURNAL   Science 248 (4962), 1517-1523 (1990)
   PUBMED   2360047
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 27, 2020 this sequence version replaced NM_053468.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.13478.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680413, SAMN06680422
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                JAXUCZ010000003.1  108383105-108383184 c
            81-6536             JAXUCZ010000003.1  108372087-108378542 c
FEATURES             Location/Qualifiers
     source          1..6536
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q31"
     gene            1..6536
                     /gene="Rag1"
                     /note="recombination activating 1"
                     /db_xref="GeneID:84600"
                     /db_xref="RGD:619790"
     exon            1..80
                     /gene="Rag1"
                     /inference="alignment:Splign:2.1.0"
     exon            81..6536
                     /gene="Rag1"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..3217
                     /gene="Rag1"
                     /EC_number="2.3.2.27"
                     /note="recombination activation protein 1; recombination
                     activating gene 1; recombination-activating protein 1"
                     /codon_start=1
                     /product="V(D)J recombination-activating protein 1"
                     /protein_id="NP_445920.1"
                     /db_xref="GeneID:84600"
                     /db_xref="RGD:619790"
                     /translation="MAVPLPSTLRLSSAPDEIQHPHIKFSEWKFKLFRVRSFEKAPEE
                     AQKEKDSSEGKPCLEQSPVVLDKPGGQNSVLTQRALKLHPKFSKKFHVDGKSSDKAIH
                     QARLRHFCRICGNHFKSDGHNRRYPVHGPVDAKTQSLFRKKEKRVTSWPDLIARVFRI
                     DVKSDVDSIHPTEFCHNCWSIMHRKFGSAHSQVYCPRNVTVEWHPHTPSCDICFTAHR
                     GLKRKRHQPNVQLSKKLKTVLNHARRDRRKRTQARVSSKEVMKKISNCSKIHLSTKLL
                     AVDFPAHFVKSISCQICEHILADPVETTCKHLFCRICILRCLKVMGSYCPSCRYPCFP
                     TDLQSPVKSFLSILNSLMVKCPAQECNEEVSLEKYNHHVSSHKESKETLVHINKGGRP
                     RQHLLSLTRRAQKHRLRELKIQVKEFADKEEGGDVKSVCLTLFLLALRARNEHRQADE
                     LEAIMQGRGSGLQPAVCLAIRVNTFLSCSQYHKMYRTVKAITGRQIFQPLHALRNAEK
                     VLLPGYHPFEWQPPLKNVSSRTDVGIIDGLSGLASSVDEYPVDTIAKRFRYDSALVSA
                     LMDMEEDILDGMRSQDLDDYVSGPFTVVVKESCDGMGDVSEKHGSGPAVPEKAVRFSF
                     TVMRVTVEHGSQNVKIFEEPKPNSELCCKPLCLMLADESDHETLTAILSPLIAEREAM
                     KSSELLLEMGGIPRTFKFIFRGTGYDEKLVREVEGLEASGSVYICTLCDATRLEASQN
                     LVFHSITRSHAENLQRYEVWRSNPYHESVEELRDRVKGVSAKPFIETVPSIDALHCDI
                     GNAAEFYKIFQLEIGEVYKNPNASKEERKRWQATLDKHLRKRMNLKPIMRMNGNFARK
                     LMTQETVDAVCELIPSEERHEALRELMDLYLKMKPVWRSSCPAKECPESLCQYSFNSQ
                     RFAELLSTKFKYRYEGKITNYFHKTLAHVPEIIERDGSIGAWASEGNESGNKLFRRFR
                     KMNARQSKCYEMEDVLKHHWLYTSKYLQKFMNAHNALKNSGFTMNSKETLGDSLDIED
                     SLESQDSMEF"
ORIGIN      
        1 ttgctatctc tgtggcatcg aatattaaca accaaactgc agacattcta acactctggc
       61 cgggaggcct gtggagcaag gtagcttcgc caaaatggct gtccccttgc catctaccct
      121 gagactcagt tctgcacctg atgaaattca gcacccgcac atcaaatttt ccgagtggaa
      181 atttaagctg tttagggtga gatcctttga aaaggcaccc gaagaagcac aaaaagagaa
      241 ggattcctca gaagggaaac cttgtctcga gcagtctcca gtagttctag ataagcctgg
      301 gggtcagaat tcagttctga ctcaacgagc attgaaactc catcctaaat tttcaaagaa
      361 attccatgtt gatgggaagt caagcgacaa agcaattcac caagccaggc ttagacactt
      421 ctgccgcatc tgtggcaatc acttcaagag tgacgggcac aaccggagat acccagtcca
      481 cgggcccgtg gacgctaaaa ctcaaagcct tttccgaaag aaggaaaaaa gagtcacgtc
      541 ctggccagat ctcattgcca gagttttccg gattgatgtg aagtcagatg ttgactccat
      601 ccaccccact gaattctgcc ataactgttg gagcattatg cacaggaagt tcggcagtgc
      661 tcacagtcag gtctactgcc caaggaatgt gaccgtggag tggcaccccc acacaccgtc
      721 ctgtgacatc tgctttactg cccatcgggg actgaagagg aagagacatc agcccaacgt
      781 gcagctcagc aagaaactaa aaactgtgct caaccatgct agacgggacc gtcgcaagag
      841 aactcaggct agggtcagca gcaaggaggt catgaagaag atctccaact gcagtaagat
      901 tcatctcagt accaagcttc ttgcagtaga cttcccagca cactttgtga aatccatctc
      961 ctgccagata tgtgaacaca ttctggccga tccggtggag accacctgta agcacctgtt
     1021 ctgtagaata tgcattctcc ggtgcctcaa ggtcatgggc agctattgtc cctcgtgccg
     1081 atatccatgc ttccctactg acctgcagag tccggtcaag tcctttctga gcatcttgaa
     1141 ttctctgatg gtgaagtgtc ctgcccaaga gtgcaatgag gaagtaagtc tggaaaaata
     1201 taaccaccat gtctcaagcc acaaagaatc taaagagact ttggtgcata ttaataaagg
     1261 gggccggcct cgccagcatc tcctgtcact gacgcgaagg gctcagaaac atcggctgag
     1321 ggagctcaag attcaagtca aagaatttgc agacaaagaa gaaggtggag atgtgaagtc
     1381 tgtgtgcttg acgttgttcc tgctggcact gagggcaagg aatgagcaca gacaagctga
     1441 tgagctcgag gccatcatgc aaggccgggg ctccggtctt caaccagctg tttgcttggc
     1501 catccgtgtc aataccttcc tcagctgtag ccaataccat aagatgtaca ggacggtgaa
     1561 agctatcact gggaggcaga tttttcaacc tttgcacgct cttcgcaatg ctgagaaggt
     1621 cctcctacca ggctaccacc cctttgagtg gcagccccct ctgaagaacg tgtcctccag
     1681 aactgacgtt ggaattattg atgggctctc tggacttgcc tcctccgtag atgaataccc
     1741 agtggacaca attgcaaaga ggttccgcta tgactctgct ttggtgtctg ctttgatgga
     1801 catggaggaa gacatcttgg acggcatgag atcccaagat cttgatgact acgtgagtgg
     1861 tcccttcacc gtggtggtaa aggaatcgtg tgatggaatg ggggatgtga gtgagaagca
     1921 cgggagtggg cccgcagttc cagaaaaggc agttcggttc tctttcaccg tcatgagagt
     1981 tacagtagag catggctctc agaacgtgaa gatatttgag gaacccaagc ccaattctga
     2041 actgtgttgc aagccactgt gccttatgct ggcagatgag tctgaccacg agacacttac
     2101 tgctattctc agccccctca tcgctgagag ggaggccatg aagagcagtg aattgctgct
     2161 ggagatggga ggcatcccca ggacttttaa atttatcttc aggggcactg gatatgacga
     2221 gaaacttgtc agggaagtag aaggcttgga agcttctggc tcagtctaca tttgtacact
     2281 ttgtgatgcc acccgtctgg aagcctccca aaatcttgtc ttccactcca taaccagaag
     2341 ccacgccgag aatctgcagc gctatgaggt ctggcggtcc aatccctatc acgagtcagt
     2401 ggaagaactc cgggaccggg tgaaaggagt ctctgccaaa cctttcatcg agacagtccc
     2461 ttccatagat gcgcttcact gtgacattgg aaatgcagct gaattctata agattttcca
     2521 gctggagata ggggaagtgt ataaaaatcc caatgcctct aaagaggaaa ggaagagatg
     2581 gcaggccacc ttggacaaac atctgcggaa aaggatgaac ttaaaaccaa tcatgaggat
     2641 gaatggcaac tttgcccgga agcttatgac ccaagagact gtggacgcag tttgtgagtt
     2701 aattccttct gaggagaggc acgaagctct cagggagctg atggaccttt acctgaagat
     2761 gaaaccggtg tggcgctcat cgtgtcctgc taaagagtgc ccggagtccc tttgtcagta
     2821 cagtttcaac tcacagcgtt tcgctgagct cctctccacc aagttcaaat acagatacga
     2881 gggcaaaatc accaattact ttcacaaaac cttggcacac gtccctgaaa ttattgaaag
     2941 ggatggctct attggggcat gggcaagtga gggcaatgag tctggtaaca aactgtttag
     3001 gcgcttccgg aaaatgaatg ccaggcagtc caagtgctat gagatggaag atgtcctgaa
     3061 acaccactgg ctgtatactt caaaatacct ccagaagttt atgaatgccc ataatgcatt
     3121 aaaaaactct gggtttacca tgaactcaaa ggagacttta ggggactctt tggacattga
     3181 ggactctctg gaaagccaag attcaatgga gttttaaagt tggtatttgc agatgtgttt
     3241 tcctttgggt tgcagcgagg tcttctctta gcacctagca cattgttgtg tgggtgggtc
     3301 ttatcatcca ggggtgacag gctggagtga gaggccagag gtgctgtcac ctggtcaggg
     3361 attgatagtt gatgagatga gattgcctga gtcgtttagt gaggccagaa gagcaacagg
     3421 agaaatcagt tacttggaag ctcaataact tgggacagcg gtagcttcag gggaccaggg
     3481 atgcacagag atatgtgtgt gcatgccact gcgtgccatg aaaattaaag ccagggctgt
     3541 caaaggacag ccaagcatgc taggaaagaa atttgtcttg ggtatgtctt ttttcttttt
     3601 ttccacctga atttattata ttttatattg agatataatg ctggtttttt ggccatgtca
     3661 tattttgtag aactattatg taaatttcac gtatgttaat ttattctgca agattcgaag
     3721 gagcctttga gttttctcta acaacactct ccatttgtag gacatggtag ccattaccaa
     3781 gggctcttag tgcattgtct tatgtgctac gtttatgcag aaataaatta aatcaagaca
     3841 ggtttcagaa aaacagcctt ttccaggttt aagtggcctc agtattgtca ctttcagtgt
     3901 ctatgaggac atctggtgtc ataaaatttt caatgatgaa ggtagagaac cttttagcta
     3961 cagctaccta ttaagtatga taaactcgtg ttcacttagc tgtctagagc caactctggt
     4021 tgtttatttt tactttttaa ttaagagtaa tttatagtct tggtgttttt ccatgtgatc
     4081 tcaaggttac agatttttaa aatccctatt tccttactgc ctgaaaacag atttaatacc
     4141 tgctgaaaat gtcagatttt tctctatatg aaacatgggt cagtctgagt aagtccaggg
     4201 ttcttaaagg cctctgtttc tgctatgcgt tattattttg attatgatca gttgagtttc
     4261 agtgtgtgca gatcttagta tcggtacagt gctgcacctt ttctatttgt tacatttaga
     4321 tggagtctac ttataataga gtagaggaat gaacatgtgt acattgttta tttccatttt
     4381 atcacttctg gattttttga attgtccctc aaattacagg gatgatcaat acctgatttt
     4441 gaatttaaac ccaagcctgt ctcttaatct gggttcttta tactgtgttt atgttgttca
     4501 tatggtagca ttagaattta tttaggataa ctaaccactg cagcttacaa tcccgagagt
     4561 tatatttttt gggatggaaa gtcatctgtt tgtcttgggc ctttggatag aataaaattg
     4621 ggccaaacct ctaaggaatc cataaaccct ccagtagctg cggttatgtg gaaactattt
     4681 atgtccttag gaattcagcg tttgccaggc accagcaact taagagcagg catgggattt
     4741 tatttgctag tgagtcataa tgatatgtta gcgttaatta gtttttttct tcctttgatt
     4801 ttattggtca taattgtcag tcttcataca cagtatatca aagagctttg taatttagct
     4861 gtcaagtgtg caagagtgac attaccctaa atgacacaca tttggggcaa atgcagggat
     4921 tgcatttaat gctttctact ggaagatgca gccattttct ttgctttctg tttggagcac
     4981 atcgaagaca ttcataattt agttgtcaaa aacatgcaca cgcttaagta ttatcttaaa
     5041 aacccttttt gttttgtcat ttgcaaacca attggttcct aaagcaccgg tcctttcatc
     5101 ccctttaatc tttacagatg tctgtgcact aataaacagc taagttccca ccgtcctcct
     5161 gctccccaga gcatgctggc actgttcggt agccgttttc cccactcact ctgttagtca
     5221 attggcagca ctgtaaatac tgcccaatat taaattcccc ttgctaggat tgtaggacaa
     5281 tttcagaagc atttgactca gggcatgatt tatagcacaa tcttctcccg actctcctaa
     5341 tcagatcata ttctgataaa cctcaagaac acctggccac aggatttcaa tatgtagagt
     5401 gtcccctgtg gctgtttgtt tccctcagtg tggagactgc agtatcctca accctgctct
     5461 agggatactc tacttttatt tttgagaagg cccattgcaa atgcaggcat attcttcagg
     5521 gaaattcacc ccaacgaatg ggggatttcc ccactgctcc ccccaacctc cctccccgcc
     5581 agggctggag aagtgcaata cttttttttc tgttctgaaa cctgaaacct gtttctatag
     5641 gtcttgccag ccttctgcac tgcactgcag ggaccagtga ctgtggctga tgaaaattga
     5701 tgaatggtgg gtgagaggtt aagaagtgtc ttgggattaa taaacatgca cacagatgcc
     5761 agagcagcgg ggaaagatgt ctctcaggtg gataggaatt taattttgtc tcaatgtgtt
     5821 ttcacattgc atggaaataa agattttttt ggggggtggg gtggggttga aaatatgggt
     5881 ttcatatgat ttcacacaga tttcgaattc tacacagcta agaggcagga ttggaggaat
     5941 aagccagggt cttgcacata ctaggcaaat gtatatttga ggaatattcc cagctttctt
     6001 taagcaattt ttgagataag gtctcactat ttgcgcaggt tgatcttgaa tttgagactc
     6061 tccaatgcca gcctttgagc aactaggatg acatatgtgt gcccacttga ctaattttgc
     6121 aagcagttct ttgatacacg tgtatgcctt tagatattgt atgatggttg ttctagtttt
     6181 cctttgttaa gatattttaa gtcaaagttg atactttgta gccatttaaa ttttttttct
     6241 ttctgtaact atctatgtaa gcaaaaccca gaattaatta gttctgggag ataatttgtg
     6301 ggattgtgtt tcactttatt atttttttta catataatga tacattttgt ttaatggctt
     6361 ccaggagtct acttttcctg aggagaggtt tagataccag gatgcattgt actatttgat
     6421 ttaaggacct gtatttccat gttaaatgtt ttcaaatgga agaacatgag ttcgaaactt
     6481 cttttcatat ttgactcttt agcattatga ttattttcat gatttttgtg tttaag
//
