LOCUS       NM_012639               2970 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus Raf-1 proto-oncogene, serine/threonine kinase
            (Raf1), mRNA.
ACCESSION   NM_012639 XM_003749820
VERSION     NM_012639.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2970)
  AUTHORS   Yu,W., Zheng,Z., Wei,W., Li,L., Zhang,Y., Sun,Y., Cao,J., Zang,W.
            and Shao,J.
  TITLE     Raf1 interacts with OIP5 to participate in oxaliplatin-induced
            neuropathic pain
  JOURNAL   Life Sci 281, 119804 (2021)
   PUBMED   34229010
  REMARK    GeneRIF: Raf1 interacts with OIP5 to participate in
            oxaliplatin-induced neuropathic pain.
REFERENCE   2  (bases 1 to 2970)
  AUTHORS   Chen,S., Tang,C., Ding,H., Wang,Z., Liu,X., Chai,Y., Jiang,W.,
            Han,Y. and Zeng,H.
  TITLE     Maf1 Ameliorates Sepsis-Associated Encephalopathy by Suppressing
            the NF-kB/NLRP3 Inflammasome Signaling Pathway
  JOURNAL   Front Immunol 11, 594071 (2020)
   PUBMED   33424842
  REMARK    GeneRIF: Maf1 Ameliorates Sepsis-Associated Encephalopathy by
            Suppressing the NF-kB/NLRP3 Inflammasome Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2970)
  AUTHORS   Feng,D., Sheng-Dong,L., Tong,W. and Zhen-Xian,D.
  TITLE     O-GlcNAcylation of RAF1 increases its stabilization and induces the
            renal fibrosis
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1866 (3), 165556 (2020)
   PUBMED   31521821
  REMARK    GeneRIF: O-GlcNAcylation suppressed the ubiquitination of RAF1.
REFERENCE   4  (bases 1 to 2970)
  AUTHORS   Kamemura,N., Murakami,S., Komatsu,H., Sawanoi,M., Miyamoto,K.,
            Ishidoh,K., Kishimoto,K., Tsuji,A. and Yuasa,K.
  TITLE     Type II cGMP-dependent protein kinase negatively regulates
            fibroblast growth factor signaling by phosphorylating Raf-1 at
            serine 43 in rat chondrosarcoma cells
  JOURNAL   Biochem Biophys Res Commun 483 (1), 82-87 (2017)
   PUBMED   28057484
  REMARK    GeneRIF: Wild-type PKGII phosphorylated Raf-1 at Ser-43 in a
            cGMP-dependent manner, but a PKGII D412A/R415A mutant, which has a
            low affinity for cGMP, did not.
REFERENCE   5  (bases 1 to 2970)
  AUTHORS   Zhang,J., Xu,X., Zhou,D., Li,H., You,W., Wang,Z. and Chen,G.
  TITLE     Possible Role of Raf-1 Kinase in the Development of Cerebral
            Vasospasm and Early Brain Injury After Experimental Subarachnoid
            Hemorrhage in Rats
  JOURNAL   Mol Neurobiol 52 (3), 1527-1539 (2015)
   PUBMED   25367879
  REMARK    GeneRIF: Raf-1 kinase contributes to cerebral vasospasm and early
            brain injury after subarachnoid hemorrhage by enhancing the
            activation of the Raf-1/ERK1/2 and Raf-1/NF-kappaB signaling
            pathways.
            Erratum:[Mol Neurobiol. 2024 Oct;61(10):8490. doi:
            10.1007/s12035-024-04153-0.. PMID: 38625621]
REFERENCE   6  (bases 1 to 2970)
  AUTHORS   York,R.D., Yao,H., Dillon,T., Ellig,C.L., Eckert,S.P.,
            McCleskey,E.W. and Stork,P.J.
  TITLE     Rap1 mediates sustained MAP kinase activation induced by nerve
            growth factor
  JOURNAL   Nature 392 (6676), 622-626 (1998)
   PUBMED   9560161
REFERENCE   7  (bases 1 to 2970)
  AUTHORS   Seko,Y., Tobe,K., Ueki,K., Kadowaki,T. and Yazaki,Y.
  TITLE     Hypoxia and hypoxia/reoxygenation activate Raf-1, mitogen-activated
            protein kinase kinase, mitogen-activated protein kinases, and S6
            kinase in cultured rat cardiac myocytes
  JOURNAL   Circ Res 78 (1), 82-90 (1996)
   PUBMED   8603510
REFERENCE   8  (bases 1 to 2970)
  AUTHORS   Silverman,J.A., Kuhlmann,E.T., Zurlo,J., Yager,J.D. and
            Longnecker,D.S.
  TITLE     Expression of c-myc, c-raf-1, and c-Ki-ras in azaserine-induced
            pancreatic carcinomas and growing pancreas in rats
  JOURNAL   Mol Carcinog 3 (6), 379-386 (1990)
   PUBMED   2278633
REFERENCE   9  (bases 1 to 2970)
  AUTHORS   Ishikawa,F., Takaku,F., Nagao,M. and Sugimura,T.
  TITLE     Rat c-raf oncogene activation by a rearrangement that produces a
            fused protein
  JOURNAL   Mol Cell Biol 7 (3), 1226-1232 (1987)
   PUBMED   3550433
REFERENCE   10 (bases 1 to 2970)
  AUTHORS   Williams,A.F., Barclay,A.N., Letarte-Muirhead,M. and Morris,R.J.
  TITLE     Rat thy-1 antigens from thymus and brain: their tissue
            distribution, purification, and chemical composition
  JOURNAL   Cold Spring Harb Symp Quant Biol 41 Pt 1, 51-61 (1977)
   PUBMED   70317
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC062071.1.
            
            On or before Jun 26, 2012 this sequence version replaced
            XM_003749820.1, NM_012639.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062071.1, SRR8487231.90257.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760434, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2970
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..2970
                     /gene="Raf1"
                     /note="Raf-1 proto-oncogene, serine/threonine kinase"
                     /db_xref="GeneID:24703"
                     /db_xref="RGD:3531"
     exon            1..270
                     /gene="Raf1"
                     /inference="alignment:Splign:2.1.0"
     exon            271..503
                     /gene="Raf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             297..2243
                     /gene="Raf1"
                     /EC_number="2.7.11.1"
                     /note="murine leukemia viral (v-raf-1) oncogene homolog 1
                     (3611-MSV); cRaf; C-RAF; proto-oncogene c-RAF; v-raf-1
                     murine leukemia viral oncogene homolog 1; v-raf-leukemia
                     viral oncogene 1"
                     /codon_start=1
                     /product="RAF proto-oncogene serine/threonine-protein
                     kinase"
                     /protein_id="NP_036771.1"
                     /db_xref="GeneID:24703"
                     /db_xref="RGD:3531"
                     /translation="MEHIQGAWKTISNGFGLKDAVFDGSSCISPTIVQQFGYQRRASD
                     DGKLTDSSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLL
                     QEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLL
                     NGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTASDSGVPAPPSFTMRRMR
                     ESVSRMPASSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRM
                     IEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPGSGTQEKNKIRPRG
                     QRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQLQAFRN
                     EVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIAR
                     QTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGS
                     VLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYA
                     SPDLSRLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPS
                     LHRAAHTEDINACTLTTSPRLPVF"
     exon            504..616
                     /gene="Raf1"
                     /inference="alignment:Splign:2.1.0"
     exon            617..719
                     /gene="Raf1"
                     /inference="alignment:Splign:2.1.0"
     exon            720..877
                     /gene="Raf1"
                     /inference="alignment:Splign:2.1.0"
     exon            878..976
                     /gene="Raf1"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1130
                     /gene="Raf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1158
                     /gene="Raf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1286
                     /gene="Raf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1404
                     /gene="Raf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1489
                     /gene="Raf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1666
                     /gene="Raf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1713
                     /gene="Raf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1832
                     /gene="Raf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..1964
                     /gene="Raf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2099
                     /gene="Raf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2952
                     /gene="Raf1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttgttccg ccatcttaga tggcgggagt tagaacggag cgagcttgaa gcaggaaggc
       61 ttctctgccg ttctccgcag gccctcagac gggccagctg gccgagcttt ggggcgcgtg
      121 ccctgaggcg cggggcgcta gtgcagcgat gcggggcctt cctggggccc cgtcccccgg
      181 gctggggaca cgccgaatgt aaccgcaacc cgttctctca accaccgctg tcgctgcact
      241 acgggacccg gtgctgcccg gctccctcag gtataagtat tgttgaaatt gcatcaatgg
      301 agcacataca gggagcttgg aagacgatca gcaatggttt cggactcaaa gatgctgtgt
      361 ttgatggctc cagttgcatc tcccctacaa ttgttcagca gtttggctat cagcgtcggg
      421 cctctgatga tggcaaactc acggattctt ctaagacaag caatactatc cgggttttct
      481 tgccgaataa gcaaaggact gtggtcaatg tgcggaatgg gatgagcttg cacgactgcc
      541 ttatgaaagc tctgaaggtt agaggcctgc agccagagtg ctgtgcagtg ttcagacttc
      601 ttcaggagca caaaggtaag aaagcacgct tagattggaa caccgacgcc gcctctctga
      661 ttggagaaga actgcaagtg gattttttgg atcacgttcc actcacaact cacaactttg
      721 ctcggaaaac gttcctgaag cttgcattct gtgacatctg tcaaaagttc ctgctaaatg
      781 gatttcgatg tcagacttgt ggctacaagt ttcatgagca ctgtagcacc aaagtaccta
      841 ctatgtgtgt ggactggagt aatatcagac agctcttgct gtttccaaat tccactgcaa
      901 gtgacagtgg agtcccagca ccaccctctt tcacaatgcg tcggatgcga gaatctgttt
      961 cccggatgcc tgctagttcc cagcacagat actccacacc ccatgccttc actttcaaca
     1021 cctccagccc ttcctctgaa ggttccctgt cccagaggca gaggtcaacg tccactccca
     1081 atgtccacat ggtcagcacc accctgcctg tggacagcag gatgattgag gatgcaattc
     1141 gaagtcacag tgaatcagcc tcaccttcag ccctgtccag cagccccaac aacctgagcc
     1201 caacaggctg gtcacagccc aaaacccctg tgccagcaca aagagagagg gcgccaggat
     1261 ctgggaccca ggaaaaaaac aaaattaggc ctcgtgggca gagagattca agttattact
     1321 gggaaataga agccagtgag gtgatgctgt ctactcggat tggctcgggc tcctttggca
     1381 ctgtgtacaa gggcaagtgg catggagatg ttgcagtaaa gatcctaaag gtggttgacc
     1441 caactccaga gcaacttcag gccttcagga acgaggtggc tgttttgcgc aaaacacggc
     1501 atgttaatat cctgctgttc atggggtaca tgacaaagga caacctggcg attgtgaccc
     1561 agtggtgtga aggcagcagt ctctacaaac acctgcatgt ccaggagacc aaattccaga
     1621 tgttccagct aattgacatt gcccggcaga cagctcaggg aatggactat ttacatgcaa
     1681 agaacatcat ccacagagac atgaaatcca acaatatatt tctccatgaa ggcctcacgg
     1741 tgaaaatcgg agattttggt ttggcaacag tgaagtcgcg ctggagtggt tctcagcagg
     1801 ttgaacagcc cactggctct gtgctgtgga tggccccaga agtaatccga atgcaggata
     1861 acaacccgtt cagcttccag tccgatgtct actcctatgg cattgtgctg tatgagctga
     1921 tgactgggga gcttccctac tcccacatca acaaccgaga ccagatcatc ttcatggtgg
     1981 gccgtgggta cgcctcccca gatcttagca ggctctacaa gaactgcccc aaggcaatga
     2041 agaggttggt ggctgactgt gtgaagaaag tcaaagaaga aaggcctttg tttcctcaga
     2101 tcctgtcttc cattgagctg cttcagcact ctctgccgaa aatcaacagg agcgcctctg
     2161 agccttccct gcatcgggca gctcacactg aggacatcaa tgcttgtacg ctgaccacat
     2221 ccccaaggct accagtcttc tagctgacgt tatagctgtt cttaggccac caggggacga
     2281 agaagagtca gcaggcacca ctttctgttt ccttgggggc agaatgcatg tttccggaaa
     2341 agctgctgct aaggacctag actactcaca gggccttaac ttcatattgc cttcttttct
     2401 acccttcctg ccctggaaat ggaagctgtc cgccaagcca gcctgctcca gaggtataca
     2461 agtcagcgag tatttttagg gcaaatggcc ttggagagag aaggcagggc actccggcta
     2521 ctgcagggac atgcagttgg gaacttggct cattgagcct gtacagacag tggtgcagtg
     2581 ccagttttgc acatggagtc ctggccacct gggggagcct gctttggtac tacagaactt
     2641 cactttgtgg acacaccttc ctcttactga gtctaagatg tcctgtgcag aggatgcttt
     2701 ccaagcacgg tgctccacct tctggcagcc tcccacacgc tgaatctgtc ttccaggagc
     2761 tgcccctatg gggtgggctg cagcccagcc ctatctctat agtcacatcc ttgtctgtaa
     2821 gaaagccagg aatacaggtt ttcttaatga ttttgggttt taattttgtt tttattgagc
     2881 ctgataaaat acagttatct gatggttcct caattatgtt attttaataa aataaattaa
     2941 atttaggttt aaaaaaaaaa aaaaaaaaaa
//
