LOCUS       NM_001013063            1436 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus retinoic acid early transcript 1L (Raet1l), mRNA.
ACCESSION   NM_001013063 XM_218058
VERSION     NM_001013063.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1436)
  AUTHORS   Zhuo,M., Fujiki,M., Wang,M., Piard-Ruster,K., Wai,L.E., Wei,L.,
            Martinez,O.M. and Krams,S.M.
  TITLE     Identification of the rat NKG2D ligands, RAE1L and RRLT, and their
            role in allograft rejection
  JOURNAL   Eur J Immunol 40 (6), 1748-1757 (2010)
   PUBMED   20306467
REFERENCE   2  (bases 1 to 1436)
  AUTHORS   Zhi,L., Mans,J., Paskow,M.J., Brown,P.H., Schuck,P., Jonjic,S.,
            Natarajan,K. and Margulies,D.H.
  TITLE     Direct interaction of the mouse cytomegalovirus m152/gp40
            immunoevasin with RAE-1 isoforms
  JOURNAL   Biochemistry 49 (11), 2443-2453 (2010)
   PUBMED   20166740
REFERENCE   3  (bases 1 to 1436)
  AUTHORS   Baba,T., Iwasaki,S., Maruoka,T., Suzuki,A., Tomaru,U., Ikeda,H.,
            Yoshiki,T., Kasahara,M. and Ishizu,A.
  TITLE     Rat CD4+CD8+ macrophages kill tumor cells through an NKG2D- and
            granzyme/perforin-dependent mechanism
  JOURNAL   J Immunol 180 (5), 2999-3006 (2008)
   PUBMED   18292522
  REMARK    GeneRIF: Expression of retinoic acid early transcript 1 (a ligand
            for NKG2D receptor) makes certain tumor cells susceptible to
            killing in vitro by a subset of monocytes/macrophages positive for
            both CD4 and CD8 antigens.
REFERENCE   4  (bases 1 to 1436)
  AUTHORS   Cerwenka,A., Bakker,A.B., McClanahan,T., Wagner,J., Wu,J.,
            Phillips,J.H. and Lanier,L.L.
  TITLE     Retinoic acid early inducible genes define a ligand family for the
            activating NKG2D receptor in mice
  JOURNAL   Immunity 12 (6), 721-727 (2000)
   PUBMED   10894171
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Mar 3, 2021 this sequence version replaced NM_001013063.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079076.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               JAXUCZ010000001.1  3804656-3804799     c
            145-278             JAXUCZ010000001.1  3804230-3804363     c
            279-539             JAXUCZ010000001.1  3802794-3803054     c
            540-803             JAXUCZ010000001.1  3802268-3802531     c
            804-947             JAXUCZ010000001.1  3801558-3801701     c
            948-1089            JAXUCZ010000001.1  3800829-3800970     c
            1090-1436           JAXUCZ010000001.1  3799823-3800169     c
FEATURES             Location/Qualifiers
     source          1..1436
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p13"
     gene            1..1436
                     /gene="Raet1l"
                     /note="retinoic acid early transcript 1L"
                     /db_xref="GeneID:292461"
                     /db_xref="RGD:1308785"
     exon            1..144
                     /gene="Raet1l"
                     /inference="alignment:Splign:2.1.0"
     exon            145..278
                     /gene="Raet1l"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..1156
                     /gene="Raet1l"
                     /codon_start=1
                     /product="retinoic acid early transcript 1L precursor"
                     /protein_id="NP_001013081.2"
                     /db_xref="GeneID:292461"
                     /db_xref="RGD:1308785"
                     /translation="MTMAKRGTTKCNLSLSLGLLLLLNFLGTAMLEDVHSLSCNLIIR
                     SPTKAEPLWYEGQCSMDGIDFLSFNNVNKTMPLGNQEKMANATEVWTCVTQWIDLLGQ
                     DLRDKVSEIKGDTTKTSGHPTLWVTMLSNHSHRHIIGASCVFNISENYSFILDLKTMK
                     WKLINPVPEDIMKEWKDDATLMKHLNLSIAECSQKFNEFLNQHEERTRSRTRAPDIAQ
                     PPPTRQFPYKEVLIPVVLIIFIIFICICVKRMCCTQGGRELQLLKDYYINLHKPQRNE
                     GLEETKGEVPNQSTKMLSQEEDPKTLGGPRRASESVELELQMFSSTGS"
     exon            279..539
                     /gene="Raet1l"
                     /inference="alignment:Splign:2.1.0"
     exon            540..803
                     /gene="Raet1l"
                     /inference="alignment:Splign:2.1.0"
     exon            804..947
                     /gene="Raet1l"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1089
                     /gene="Raet1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1436
                     /gene="Raet1l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagccgccac agctgaagct gcagactgaa acctcaggcc actcagcgcc cgctgactca
       61 tgaatctact gcagaccatc cctggggact ggttattttg tttctttacc ctgttcagga
      121 ggaaccctga gggcgcagct gcagcagctc tggtcgcacc ctaggccgcc tgggctcaga
      181 aatgaccatg gcaaagagag gaaccaccaa gtgcaatctt tctctgagtc tgggcctttt
      241 gctgctgctg aattttctgg ggaccgcgat gctagaagat gtacactctc ttagttgcaa
      301 cttgatcatc aggtctccta ccaaagcaga acctctctgg tatgaaggac agtgttcaat
      361 ggatggaatt gatttccttt cttttaataa tgtgaacaag accatgcctt tgggtaacca
      421 ggagaagatg gcaaatgcca ccgaagtgtg gacatgtgtg acccagtgga tagacctgtt
      481 gggccaggac ttaagggaca aggtgtctga aatcaaaggg gacactacca agaccagtgg
      541 tcaccccact ttatgggtca ccatgctttc taaccacagc catagacata tcattggtgc
      601 ttcctgtgta ttcaacatca gtgagaatta ttccttcatc ttggacctaa agactatgaa
      661 gtggaaactg attaatcctg taccagagga cataatgaaa gaatggaaag atgatgcgac
      721 attaatgaaa catctgaatt tgtccatagc agaatgcagt cagaaattca atgaattctt
      781 aaatcagcac gaggaaagaa caagatcaag aacaagggcc ccagatatcg cccagcctcc
      841 acctaccagg cagtttcctt ataaggaagt attgatccct gtggttctca tcatctttat
      901 tattttcatt tgcatatgtg tgaagaggat gtgttgtacc caaggaggta gagaacttca
      961 gctgctcaag gactactaca tcaacctcca caaaccacag aggaatgagg ggctagagga
     1021 gacaaaagga gaggttccca accagagcac caaaatgttg tcccaggagg aagatcccaa
     1081 gacattggga ggcccaagga gggcatcaga atctgtggaa ctggagttac agatgttttc
     1141 aagtactggg agctgaaccg aggacatctc caagaacagc aagggatctt aactactgag
     1201 ccttcacgcc aaacgataaa tgaatttttc ctttaaaaat gatttttatt ttgtttatgt
     1261 atatgagtac actgtctctg tcttcacaca caccagaggt gggcatcaga tcccatcaca
     1321 gatcgctctg aaccactatg tgttgctgag agttgaactc aggacctctg gagagtgagc
     1381 agttctctta actgcccagc catctcttca gattaataaa tttcttaaaa agaaaa
//
