LOCUS       NM_001134960            2820 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Rattus norvegicus RAD54 like (Rad54l), mRNA.
ACCESSION   NM_001134960
VERSION     NM_001134960.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2820)
  AUTHORS   Li,Z., Xie,L., Zou,L., Xiao,S. and Tao,J.
  TITLE     Overexpression of RAD54L attenuates osteoarthritis by suppressing
            the HIF-1alpha/VEGF signaling pathway: Bioinformatics analysis and
            experimental validation
  JOURNAL   PLoS One 19 (4), e0298575 (2024)
   PUBMED   38593124
  REMARK    GeneRIF: Overexpression of RAD54L attenuates osteoarthritis by
            suppressing the HIF-1alpha/VEGF signaling pathway: Bioinformatics
            analysis and experimental validation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2820)
  AUTHORS   Yuan,J., Ghosal,G. and Chen,J.
  TITLE     The HARP-like domain-containing protein AH2/ZRANB3 binds to PCNA
            and participates in cellular response to replication stress
  JOURNAL   Mol Cell 47 (3), 410-421 (2012)
   PUBMED   22705370
REFERENCE   3  (bases 1 to 2820)
  AUTHORS   Wang,H., Zhang,X., Wang,P., Yu,X., Essers,J., Chen,D., Kanaar,R.,
            Takeda,S. and Wang,Y.
  TITLE     Characteristics of DNA-binding proteins determine the biological
            sensitivity to high-linear energy transfer radiation
  JOURNAL   Nucleic Acids Res 38 (10), 3245-3251 (2010)
   PUBMED   20150414
REFERENCE   4  (bases 1 to 2820)
  AUTHORS   Kirshner,M., Rathavs,M., Nizan,A., Essers,J., Kanaar,R., Shiloh,Y.
            and Barzilai,A.
  TITLE     Analysis of the relationships between ATM and the Rad54 paralogs
            involved in homologous recombination repair
  JOURNAL   DNA Repair (Amst) 8 (2), 253-261 (2009)
   PUBMED   19061978
REFERENCE   5  (bases 1 to 2820)
  AUTHORS   Li,D., Liu,H., Jiao,L., Chang,D.Z., Beinart,G., Wolff,R.A.,
            Evans,D.B., Hassan,M.M. and Abbruzzese,J.L.
  TITLE     Significant effect of homologous recombination DNA repair gene
            polymorphisms on pancreatic cancer survival
  JOURNAL   Cancer Res 66 (6), 3323-3330 (2006)
   PUBMED   16540687
REFERENCE   6  (bases 1 to 2820)
  AUTHORS   Wesoly,J., Agarwal,S., Sigurdsson,S., Bussen,W., Van Komen,S.,
            Qin,J., van Steeg,H., van Benthem,J., Wassenaar,E., Baarends,W.M.,
            Ghazvini,M., Tafel,A.A., Heath,H., Galjart,N., Essers,J.,
            Grootegoed,J.A., Arnheim,N., Bezzubova,O., Buerstedde,J.M., Sung,P.
            and Kanaar,R.
  TITLE     Differential contributions of mammalian Rad54 paralogs to
            recombination, DNA damage repair, and meiosis
  JOURNAL   Mol Cell Biol 26 (3), 976-989 (2006)
   PUBMED   16428451
REFERENCE   7  (bases 1 to 2820)
  AUTHORS   Kovalenko,O.V., Wiese,C. and Schild,D.
  TITLE     RAD51AP2, a novel vertebrate- and meiotic-specific protein, shares
            a conserved RAD51-interacting C-terminal domain with RAD51AP1/PIR51
  JOURNAL   Nucleic Acids Res 34 (18), 5081-5092 (2006)
   PUBMED   16990250
REFERENCE   8  (bases 1 to 2820)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   9  (bases 1 to 2820)
  AUTHORS   Mills,K.D., Ferguson,D.O., Essers,J., Eckersdorff,M., Kanaar,R. and
            Alt,F.W.
  TITLE     Rad54 and DNA Ligase IV cooperate to maintain mammalian chromatid
            stability
  JOURNAL   Genes Dev 18 (11), 1283-1292 (2004)
   PUBMED   15175260
REFERENCE   10 (bases 1 to 2820)
  AUTHORS   Matsuda,M., Miyagawa,K., Takahashi,M., Fukuda,T., Kataoka,T.,
            Asahara,T., Inui,H., Watatani,M., Yasutomi,M., Kamada,N., Dohi,K.
            and Kamiya,K.
  TITLE     Mutations in the RAD54 recombination gene in primary cancers
  JOURNAL   Oncogene 18 (22), 3427-3430 (1999)
   PUBMED   10362365
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC169034.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC169034.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2820
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q35"
     gene            1..2820
                     /gene="Rad54l"
                     /note="RAD54 like"
                     /db_xref="GeneID:298429"
                     /db_xref="RGD:1310600"
     exon            1..173
                     /gene="Rad54l"
                     /inference="alignment:Splign:2.1.0"
     exon            174..417
                     /gene="Rad54l"
                     /inference="alignment:Splign:2.1.0"
     CDS             415..2661
                     /gene="Rad54l"
                     /EC_number="3.6.4.12"
                     /codon_start=1
                     /product="DNA repair and recombination protein RAD54-like"
                     /protein_id="NP_001128432.1"
                     /db_xref="GeneID:298429"
                     /db_xref="RGD:1310600"
                     /translation="MRRSLAPSQLARRKPEDISSDDEDWQPETVTPKKRKSTAETQAQ
                     QCFLSPFRKPLTQLLNRPPCLDSSQHEAFIRSILSKPFKVPIPNYQGPLGSRALGLKR
                     AGVRRALHDPLEEGALVLYEPPPLSVHDQLKLDKEKLPVHVVVDPILSKVLRPHQREG
                     VKFLWECVTSRRIPGSHGCIMADEMGLGKTLQCITLMWTLLRQSPECKPEIEKAVVVS
                     PSSLVKNWYNEVEKWLGGRIQPLAIDGGSKDEIDRKLEGFMNQRGARVPSPILIISYE
                     TFRLHVEVLKKGNVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISGTPIQNDLLE
                     YFSLVHFVNSGILGTAHEFKKHFELPILKSRDAAASEADRQLGEERLRELISIVNRCL
                     IRRTSDILSKYLPVKIEQVVCCRLTPLQTELYKRFLRQAKPEEELHEGKMSVSSLSSI
                     TSLKKLCNHPALIYDKCVAEEDGFEGTLGIFPPGYNSKAVEPQLSGKMLVLDYILAMT
                     RSRSSDKVVLVSNYTQTLDLFEKLCRARRYLYVRLDGTMSIKKRAKVVERFNSPSSPD
                     FVFMLSSKAGGCGLNLIGANRLVMFDPDWNPANDEQAMARVWRDGQKKICYIYRLLSA
                     GTIEEKIFQRQSHKKALSSCVVDEEQDVERHFSLGELKELFTLDEASLSDTHDRLHCR
                     RCVNNRQVWPPPDGSDCTSDLAQWNHNTDKRGLQDEVLQAAWDASSTAITFVFHQRSH
                     EEQRGLHC"
     exon            418..504
                     /gene="Rad54l"
                     /inference="alignment:Splign:2.1.0"
     exon            505..624
                     /gene="Rad54l"
                     /inference="alignment:Splign:2.1.0"
     exon            625..685
                     /gene="Rad54l"
                     /inference="alignment:Splign:2.1.0"
     exon            686..821
                     /gene="Rad54l"
                     /inference="alignment:Splign:2.1.0"
     exon            822..891
                     /gene="Rad54l"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1180
                     /gene="Rad54l"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1305
                     /gene="Rad54l"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1456
                     /gene="Rad54l"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1583
                     /gene="Rad54l"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1658
                     /gene="Rad54l"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1789
                     /gene="Rad54l"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1900
                     /gene="Rad54l"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..2024
                     /gene="Rad54l"
                     /inference="alignment:Splign:2.1.0"
     exon            2025..2103
                     /gene="Rad54l"
                     /inference="alignment:Splign:2.1.0"
     exon            2104..2283
                     /gene="Rad54l"
                     /inference="alignment:Splign:2.1.0"
     exon            2284..2447
                     /gene="Rad54l"
                     /inference="alignment:Splign:2.1.0"
     exon            2448..2795
                     /gene="Rad54l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggaaagat accagagtcg ctctttgccc atcttcggct tctaagattc tcctgcttcc
       61 aacctggatc ttttactggt cctccccggg ttcctgttta acttcccaca aggctttcct
      121 aaagcctctg cttgacctac ctcaggctga ggtttgatgt cagtccagca ctgatttaga
      181 cccggctccg cctggacttg actttgagta acttggggac cgacactccc ggtttggacc
      241 caagccaagt ctcatcccct ggttgcgtcc cctccactca taccgactct tcagacgata
      301 ttttcagtgt gtagcaactt ccttttatag catcctctgg tcctgcattc tctgttgctg
      361 agtgctttta acttagctga tgggtacttg acatttgatg cttctgggtc caggatgagg
      421 aggagcttag ctcccagcca attggccagg aggaaaccag aagacatatc gtctgatgat
      481 gaagactggc agcctgagac agtaacccct aaaaaacgca agtccactgc cgagacccag
      541 gcccagcagt gtttcctgtc tccttttcgg aagcccttga ctcagttact caaccgaccg
      601 ccttgtctgg atagcagtca gcatgaagcg tttatccgaa gtattttgtc aaagcctttc
      661 aaggtcccca ttccaaatta tcaaggtccc ctgggctctc gagcattggg cctgaagagg
      721 gctggcgttc gtcgtgccct gcatgaccct ctggaagaag gtgccttggt cctgtatgag
      781 cctcccccac tgagcgtcca tgaccaactg aagcttgaca aagaaaaact ccctgttcac
      841 gtggttgtag atcctattct cagtaaggtg ttgcgacctc atcagagaga gggagtgaag
      901 ttcctttggg agtgtgtcac cagtcgacga attcctggaa gccatggctg catcatggct
      961 gatgagatgg gcctaggaaa gacactgcag tgcatcacat tgatgtggac acttttgcgc
     1021 cagagcccag agtgcaagcc agaaattgag aaagcagtgg tggtctcacc ttccagcctg
     1081 gtgaagaact ggtacaatga ggttgagaaa tggcttggag ggaggatcca acctctggcc
     1141 atcgacggag gctcaaagga tgagatagac cgaaaactgg aaggattcat gaaccagcgt
     1201 ggagctaggg tgccttcccc catcctcatc atctcctatg agactttccg cctgcatgtt
     1261 gaagttctta aaaaaggaaa cgttggactg gtcatatgtg acgagggcca caggctaaag
     1321 aactctgaga accagactta ccaggctctg gacagtctga ataccagccg gcgggtgctc
     1381 atctccggga cccccatcca gaacgatttg cttgaatatt tcagcttggt gcacttcgtt
     1441 aattcaggca ttttgggaac tgcccatgaa ttcaagaagc attttgaatt accaattttg
     1501 aagagtcgag atgcagctgc cagtgaggca gataggcagc ttggagagga acgtttgcgg
     1561 gagctcatca gtattgtgaa caggtgcctg atacggagaa catctgatat cctctctaag
     1621 tatctgccag tgaagattga gcaggtggtt tgttgtaggc tgacacccct tcaaactgag
     1681 ctatacaaga gatttctaag acaggctaag cctgaagaag aattgcatga gggcaagatg
     1741 agtgtatctt ccctgtcttc tatcacctct ctaaagaagc tgtgtaatca tccagctcta
     1801 atctatgaca agtgtgtggc agaggaggat ggctttgagg gcactttggg tatcttcccc
     1861 cctggttata actctaaagc tgtagaacca cagttgtcgg gtaagatgct ggtccttgac
     1921 tacattctgg ccatgactcg aagccgtagc agtgacaaag tcgtgctggt gtcaaattat
     1981 actcagacat tggatctctt tgaaaagctg tgccgggctc gaaggtactt gtatgttcgc
     2041 ctggatggca cgatgtccat taagaagcga gccaaagttg tggagcgctt caatagccca
     2101 tcgagccctg atttcgtttt catgctgagc agcaaagctg gaggctgtgg gcttaacctc
     2161 attggtgcta accggctggt catgtttgat cctgactgga atccagccaa tgatgaacaa
     2221 gctatggccc gagtctggcg agacggtcaa aagaagatct gctatatcta ccgactgctc
     2281 tctgcaggaa caattgagga aaagatcttt cagcggcaaa gccacaagaa ggctctgagc
     2341 agctgtgtgg tagatgagga gcaggatgtg gaacgtcact tctctcttgg tgagctcaaa
     2401 gagctgttta ccctggatga agccagcctc agtgacactc acgacagact gcattgccgc
     2461 cgttgtgtaa ataaccgcca ggtctggcca ccccctgatg gttctgactg cacttcagac
     2521 ctggctcagt ggaaccataa cacagataaa cgagggctcc aggatgaggt actccaggct
     2581 gcctgggatg cttcatctac agccatcacc ttcgtcttcc accagcgttc ccatgaggag
     2641 cagcggggtc ttcactgcta accagctggt ctggatgagt agcttgggaa aggatacagg
     2701 gaaaaggggg tcctctgtct cacgagtctc tgctcagttt tgttctctgg gagaaaatca
     2761 ccaagaaggg ctgcatgatg tttgcccaaa atttaaaaaa aaaaaaaaaa aaaaaaaaaa
//
