LOCUS       NM_001354109            2032 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus RAD52 homolog, DNA repair protein (Rad52), mRNA.
ACCESSION   NM_001354109 XM_008763236
VERSION     NM_001354109.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2032)
  AUTHORS   Li,M., Chen,R., Ji,B., Fan,C., Wang,G., Yue,C. and Jin,G.
  TITLE     RAD52 variants influence NSCLC risk in the Chinese population in a
            high altitude area
  JOURNAL   Ther Adv Respir Dis 14, 1753466620918192 (2020)
   PUBMED   32401173
REFERENCE   2  (bases 1 to 2032)
  AUTHORS   Li,P., Xu,Y., Zhang,Q., Li,Y., Jia,W., Wang,X., Xie,Z., Liu,J.,
            Zhao,D., Shao,M., Chen,S., Mo,N., Jiang,Z., Li,L., Liu,R.,
            Huang,W., Chang,L., Chen,S., Li,H., Zuo,W., Li,J., Zhang,R. and
            Yang,X.
  TITLE     Evaluating the role of RAD52 and its interactors as novel potential
            molecular targets for hepatocellular carcinoma
  JOURNAL   Cancer Cell Int 19, 279 (2019)
   PUBMED   31719794
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2032)
  AUTHORS   Welty,S., Teng,Y., Liang,Z., Zhao,W., Sanders,L.H.,
            Greenamyre,J.T., Rubio,M.E., Thathiah,A., Kodali,R., Wetzel,R.,
            Levine,A.S. and Lan,L.
  TITLE     RAD52 is required for RNA-templated recombination repair in
            post-mitotic neurons
  JOURNAL   J Biol Chem 293 (4), 1353-1362 (2018)
   PUBMED   29217771
  REMARK    GeneRIF: HR repair protein RAD52 is recruited to sites of DNA DSBs
            in terminally differentiated, post-mitotic neurons. This
            recruitment is dependent on the presence of a nascent mRNA
            generated during active transcription, providing evidence that an
            RNA-templated HR repair mechanism exists in non-dividing,
            terminally differentiated neurons.
REFERENCE   4  (bases 1 to 2032)
  AUTHORS   Zhang,L., Zhang,Y., Tang,C.H. and Su,C.M.
  TITLE     RAD52 gene polymorphisms are associated with risk of colorectal
            cancer in a Chinese Han population
  JOURNAL   Medicine (Baltimore) 96 (49), e8994 (2017)
   PUBMED   29245274
REFERENCE   5  (bases 1 to 2032)
  AUTHORS   Lieberman,R., Pan,J., Zhang,Q. and You,M.
  TITLE     Rad52 deficiency decreases development of lung squamous cell
            carcinomas by enhancing immuno-surveillance
  JOURNAL   Oncotarget 8 (21), 34032-34044 (2017)
   PUBMED   28415565
REFERENCE   6  (bases 1 to 2032)
  AUTHORS   Baynton,K., Otterlei,M., Bjoras,M., von Kobbe,C., Bohr,V.A. and
            Seeberg,E.
  TITLE     WRN interacts physically and functionally with the recombination
            mediator protein RAD52
  JOURNAL   J Biol Chem 278 (38), 36476-36486 (2003)
   PUBMED   12750383
REFERENCE   7  (bases 1 to 2032)
  AUTHORS   Kitao,H. and Yuan,Z.M.
  TITLE     Regulation of ionizing radiation-induced Rad52 nuclear foci
            formation by c-Abl-mediated phosphorylation
  JOURNAL   J Biol Chem 277 (50), 48944-48948 (2002)
   PUBMED   12379650
REFERENCE   8  (bases 1 to 2032)
  AUTHORS   Singleton,M.R., Wentzell,L.M., Liu,Y., West,S.C. and Wigley,D.B.
  TITLE     Structure of the single-strand annealing domain of human RAD52
            protein
  JOURNAL   Proc Natl Acad Sci U S A 99 (21), 13492-13497 (2002)
   PUBMED   12370410
REFERENCE   9  (bases 1 to 2032)
  AUTHORS   Stasiak,A.Z., Larquet,E., Stasiak,A., Muller,S., Engel,A., Van
            Dyck,E., West,S.C. and Egelman,E.H.
  TITLE     The human Rad52 protein exists as a heptameric ring
  JOURNAL   Curr Biol 10 (6), 337-340 (2000)
   PUBMED   10744977
REFERENCE   10 (bases 1 to 2032)
  AUTHORS   Park,M.S., Ludwig,D.L., Stigger,E. and Lee,S.H.
  TITLE     Physical interaction between human RAD52 and RPA is required for
            homologous recombination in mammalian cells
  JOURNAL   J Biol Chem 271 (31), 18996-19000 (1996)
   PUBMED   8702565
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Aug 5, 2017 this sequence version replaced XM_008763236.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1753083.1,
                                           SRR26643292.19512.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               JAXUCZ010000004.1  154778320-154778495
            177-270             JAXUCZ010000004.1  154785889-154785982
            271-372             JAXUCZ010000004.1  154788807-154788908
            373-466             JAXUCZ010000004.1  154789856-154789949
            467-534             JAXUCZ010000004.1  154790114-154790181
            535-653             JAXUCZ010000004.1  154791366-154791484
            654-729             JAXUCZ010000004.1  154792215-154792290
            730-932             JAXUCZ010000004.1  154795489-154795691
            933-1084            JAXUCZ010000004.1  154795834-154795985
            1085-1165           JAXUCZ010000004.1  154796986-154797066
            1166-1399           JAXUCZ010000004.1  154797703-154797936
            1400-2032           JAXUCZ010000004.1  154798985-154799617
FEATURES             Location/Qualifiers
     source          1..2032
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..2032
                     /gene="Rad52"
                     /note="RAD52 homolog, DNA repair protein"
                     /db_xref="GeneID:297561"
                     /db_xref="RGD:1304975"
     exon            1..176
                     /gene="Rad52"
                     /inference="alignment:Splign:2.1.0"
     exon            177..270
                     /gene="Rad52"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..1461
                     /gene="Rad52"
                     /codon_start=1
                     /product="DNA repair protein RAD52 homolog"
                     /protein_id="NP_001341038.1"
                     /db_xref="GeneID:297561"
                     /db_xref="RGD:1304975"
                     /translation="MAGAEEAVHGGCDCRPPFVGGKSVLLFGQSQYTADEYQAIQKAL
                     RQRLGPEYISSRMAGGGQKVCYIEGHRVINLANEMFGYNGWAHSVTQQNVDFVDLNNG
                     KFYVGVCAFVRVQLKDGSYHEDVGYGVSEGLRSKALSLEKARKEAVTDGLKRALRSFG
                     NALGNCILDKDYLKSLNRLPRQLPLEVDLTTTKREDFEPSVEQARYNSCRQDKASGLP
                     KPQEAASPCRPSHPHDSNIKLQGAKDSSSSSCSLATTSESDATHQRKLRKLRQKQLQQ
                     QFREQMEAHRLSHAPAEEVEAKREAALPAPPKHSTPVPAASACLREKAVLPDNLEENL
                     EMWDLTPDLEDIIKPLCRTEPPQTSVTRTLNNQAVIQDSVPHIHCHQKVQEKPGPGHL
                     QTCSTNQHVLGSRENSESHRKSQDLKKRKLDPS"
     exon            271..372
                     /gene="Rad52"
                     /inference="alignment:Splign:2.1.0"
     exon            373..466
                     /gene="Rad52"
                     /inference="alignment:Splign:2.1.0"
     exon            467..534
                     /gene="Rad52"
                     /inference="alignment:Splign:2.1.0"
     exon            535..653
                     /gene="Rad52"
                     /inference="alignment:Splign:2.1.0"
     exon            654..729
                     /gene="Rad52"
                     /inference="alignment:Splign:2.1.0"
     exon            730..932
                     /gene="Rad52"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1084
                     /gene="Rad52"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1165
                     /gene="Rad52"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1399
                     /gene="Rad52"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..2032
                     /gene="Rad52"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcggctttg ctgctctcgt cgacttcgga cttgacttac ggctcctctt ctgttattct
       61 ttgggctcag accttcttcc cagcgttccc tgagcttgcg cctcgatctc ttctgcgagg
      121 ccctctccag cctcccagca cccaggaccg agctcctgcg tgcaccgcgt tccgagagtc
      181 aatatggctg gggctgaaga agcggtccat ggaggctgtg actgccgtcc tccgtttgtt
      241 ggtgggaagt ctgtgcttct ctttggacag agccaataca cagcagatga ataccaggcc
      301 atccagaaag ccctgaggca gaggctgggg ccagagtaca ttagcagccg catggcggga
      361 ggaggtcaga aggtgtgtta tattgaaggt caccgggtaa ttaatctggc caatgagatg
      421 tttggttaca atggctgggc acactccgtc acccagcaga atgtggattt tgttgacctc
      481 aacaatggca agttctacgt gggagtctgt gcatttgtaa gggtgcagtt aaaggatggt
      541 tcctaccatg aggatgtggg ctatggagtt agtgagggcc tcagatcgaa ggctttgtca
      601 ctggagaagg ccaggaagga ggctgtgact gacgggctga aacgggcact caggagtttt
      661 gggaatgcac ttggaaactg cattctggat aaagactatc tgaagtcgct gaataggctg
      721 cctcggcagc tcccacttga agtggattta actacaacaa agagagaaga ttttgaacca
      781 tctgtagaac aggcaagata taacagctgc cgacaggata aagcatcggg gctccccaaa
      841 ccacaggaag cagcttctcc ttgcagacca agccacccac atgattcgaa cattaagcta
      901 cagggggcta aggacagcag cagcagctcc tgcagtctgg ccaccacctc agagagtgat
      961 gccactcacc agaggaagct ccggaagctc cggcagaagc agttacagca gcagttccgg
     1021 gaacagatgg aggctcaccg gcttagccac gcacctgccg aagaggtgga agccaagcgt
     1081 gaggcagcac ttccagcccc tccaaaacac agcacccccg tacctgcagc ctcggcatgc
     1141 ctcagggaga aagccgtcct tccagataac ctagaagaga accttgaaat gtgggacctt
     1201 actccagact tagaggacat cattaagccc ttgtgtagaa cagaaccacc ccaaacctct
     1261 gtcacccgaa ccctcaacaa ccaggcggtg atccaggaca gtgtcccaca tatccattgc
     1321 caccagaaag tacaagaaaa acctggacct gggcacctgc agacctgcag cactaatcag
     1381 catgtcctag gtagcagaga aaactctgaa tctcatagga agagccagga cctgaagaaa
     1441 aggaaactag atccatcctg aagctcaata agttactaga ttctgccaca aaaggacttt
     1501 ggaaaatgca gtttggtcac caaattattc ccatcttggt tcatgctgaa ctctttagag
     1561 cctactgtag aggaagctga ctacaagagg ttgttgtacc ctgtgatggg aaagaggcca
     1621 acagatgctt taactttttt cagtattgct tactcctaag ccaatgcatt gagattctag
     1681 gaaggctgcc ttccgtttta acgatgtagc tcaccaaacc cagtttcatt gccacctaca
     1741 ttaaatcacg tgtgaccttg cctttccttt ggcttcaggt ttttaatgtt ttccactggg
     1801 tgctatcaac aaggtcacgg ttagttcagg actatgcatg gatccacaga gtagcctccc
     1861 tttatctaga gatgtgccaa cacttaaatg gggcacttaa gacttccgtc ctctccatgg
     1921 catttctttt agtgtttttg ttttttgtgt agtcctggcc gtcctgggtc ttgcacctgc
     1981 cccctccctc cctcccttca gagtgctggg attaaaggag tggctcctgt ca
//
