LOCUS       NM_001129777            1927 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus RAD51 paralog C (Rad51c), mRNA.
ACCESSION   NM_001129777 XM_001081158 XM_573171
VERSION     NM_001129777.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1927)
  AUTHORS   Rodrigue,A., Coulombe,Y., Jacquet,K., Gagne,J.P., Roques,C.,
            Gobeil,S., Poirier,G. and Masson,J.Y.
  TITLE     The RAD51 paralogs ensure cellular protection against mitotic
            defects and aneuploidy
  JOURNAL   J Cell Sci 126 (Pt 1), 348-359 (2013)
   PUBMED   23108668
REFERENCE   2  (bases 1 to 1927)
  AUTHORS   Chun,J., Buechelmaier,E.S. and Powell,S.N.
  TITLE     Rad51 paralog complexes BCDX2 and CX3 act at different stages in
            the BRCA1-BRCA2-dependent homologous recombination pathway
  JOURNAL   Mol Cell Biol 33 (2), 387-395 (2013)
   PUBMED   23149936
REFERENCE   3  (bases 1 to 1927)
  AUTHORS   Badie,S., Escandell,J.M., Bouwman,P., Carlos,A.R., Thanasoula,M.,
            Gallardo,M.M., Suram,A., Jaco,I., Benitez,J., Herbig,U.,
            Blasco,M.A., Jonkers,J. and Tarsounas,M.
  TITLE     BRCA2 acts as a RAD51 loader to facilitate telomere replication and
            capping
  JOURNAL   Nat Struct Mol Biol 17 (12), 1461-1469 (2010)
   PUBMED   21076401
REFERENCE   4  (bases 1 to 1927)
  AUTHORS   Sage,J.M., Gildemeister,O.S. and Knight,K.L.
  TITLE     Discovery of a novel function for human Rad51: maintenance of the
            mitochondrial genome
  JOURNAL   J Biol Chem 285 (25), 18984-18990 (2010)
   PUBMED   20413593
REFERENCE   5  (bases 1 to 1927)
  AUTHORS   Heyer,W.D., Ehmsen,K.T. and Liu,J.
  TITLE     Regulation of homologous recombination in eukaryotes
  JOURNAL   Annu Rev Genet 44, 113-139 (2010)
   PUBMED   20690856
  REMARK    Review article
REFERENCE   6  (bases 1 to 1927)
  AUTHORS   Kuznetsov,S., Pellegrini,M., Shuda,K., Fernandez-Capetillo,O.,
            Liu,Y., Martin,B.K., Burkett,S., Southon,E., Pati,D.,
            Tessarollo,L., West,S.C., Donovan,P.J., Nussenzweig,A. and
            Sharan,S.K.
  TITLE     RAD51C deficiency in mice results in early prophase I arrest in
            males and sister chromatid separation at metaphase II in females
  JOURNAL   J Cell Biol 176 (5), 581-592 (2007)
   PUBMED   17312021
REFERENCE   7  (bases 1 to 1927)
  AUTHORS   Bennett,B.T. and Knight,K.L.
  TITLE     Cellular localization of human Rad51C and regulation of
            ubiquitin-mediated proteolysis of Rad51
  JOURNAL   J Cell Biochem 96 (6), 1095-1109 (2005)
   PUBMED   16215984
REFERENCE   8  (bases 1 to 1927)
  AUTHORS   Liu,Y., Masson,J.Y., Shah,R., O'Regan,P. and West,S.C.
  TITLE     RAD51C is required for Holliday junction processing in mammalian
            cells
  JOURNAL   Science 303 (5655), 243-246 (2004)
   PUBMED   14716019
REFERENCE   9  (bases 1 to 1927)
  AUTHORS   French,C.A., Tambini,C.E. and Thacker,J.
  TITLE     Identification of functional domains in the RAD51L2 (RAD51C)
            protein and its requirement for gene conversion
  JOURNAL   J Biol Chem 278 (46), 45445-45450 (2003)
   PUBMED   12966089
REFERENCE   10 (bases 1 to 1927)
  AUTHORS   Masson,J.Y., Tarsounas,M.C., Stasiak,A.Z., Stasiak,A., Shah,R.,
            McIlwraith,M.J., Benson,F.E. and West,S.C.
  TITLE     Identification and purification of two distinct complexes
            containing the five RAD51 paralogs
  JOURNAL   Genes Dev 15 (24), 3296-3307 (2001)
   PUBMED   11751635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On or before Nov 23, 2008 this sequence version replaced
            XM_573171.2, XM_001081158.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166862.1, SRR26643297.35395.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               JAXUCZ010000010.1  72728317-72728464   c
            149-407             JAXUCZ010000010.1  72727036-72727294   c
            408-574             JAXUCZ010000010.1  72726064-72726230   c
            575-708             JAXUCZ010000010.1  72722263-72722396   c
            709-840             JAXUCZ010000010.1  72719856-72719987   c
            841-907             JAXUCZ010000010.1  72714656-72714722   c
            908-968             JAXUCZ010000010.1  72713727-72713787   c
            969-1029            JAXUCZ010000010.1  72706861-72706921   c
            1030-1927           JAXUCZ010000010.1  72702299-72703196   c
FEATURES             Location/Qualifiers
     source          1..1927
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..1927
                     /gene="Rad51c"
                     /gene_synonym="RGD1563765"
                     /note="RAD51 paralog C"
                     /db_xref="GeneID:497976"
                     /db_xref="RGD:1563765"
     exon            1..148
                     /gene="Rad51c"
                     /gene_synonym="RGD1563765"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..1131
                     /gene="Rad51c"
                     /gene_synonym="RGD1563765"
                     /note="Rad51 homolog c"
                     /codon_start=1
                     /product="DNA repair protein RAD51 homolog 3"
                     /protein_id="NP_001123249.1"
                     /db_xref="GeneID:497976"
                     /db_xref="RGD:1563765"
                     /translation="MQRELVGFPLSPAVRVKLVAAGFQTAEDVLEVKPSELSKEVGIS
                     KEEALETLQILRRECLTNKPRCAGTSVANKKCTALELLEQEHTQGFIITFCSALDNIL
                     GGGIPLMKTTEVCGVPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVDRV
                     VSLATACIQHLHLIAGTHTEEEQQKALKDFTLENILSHIYYFRCHDYTELLAQVYLLP
                     DFLSDHSKVQLVIIDGIAFPFRHDLDDLFLRTRLLNGLAQQLISLANKHRLAVILTNQ
                     MTTKIDKNQASLVPALGESWGHAATIRLIFHWEQKQRFATLYKSPSQKESTVPFQITP
                     QGFRDAVVTAASSQTESSLNFRKRSREPEEEC"
     exon            149..407
                     /gene="Rad51c"
                     /gene_synonym="RGD1563765"
                     /inference="alignment:Splign:2.1.0"
     exon            408..574
                     /gene="Rad51c"
                     /gene_synonym="RGD1563765"
                     /inference="alignment:Splign:2.1.0"
     exon            575..708
                     /gene="Rad51c"
                     /gene_synonym="RGD1563765"
                     /inference="alignment:Splign:2.1.0"
     exon            709..840
                     /gene="Rad51c"
                     /gene_synonym="RGD1563765"
                     /inference="alignment:Splign:2.1.0"
     exon            841..907
                     /gene="Rad51c"
                     /gene_synonym="RGD1563765"
                     /inference="alignment:Splign:2.1.0"
     exon            908..968
                     /gene="Rad51c"
                     /gene_synonym="RGD1563765"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1029
                     /gene="Rad51c"
                     /gene_synonym="RGD1563765"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1927
                     /gene="Rad51c"
                     /gene_synonym="RGD1563765"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cactacgcgc gtaggcgccg agctttcaaa atgcagaggg aattggtggg ttttccgctg
       61 tctcccgcgg tgcgcgtgaa gctggtggct gcgggttttc agactgccga ggacgtcctg
      121 gaggtgaagc cctccgagct tagcaaagaa gttgggatat ccaaagagga agccttggaa
      181 actctccaaa ttctaagaag agaatgtctc acaaataaac caagatgtgc tggtacatct
      241 gtggcaaaca agaagtgcac agcactggaa cttctagagc aagagcacac ccagggcttc
      301 ataatcacct tctgttcagc actagataac attcttgggg gtggaatacc cctaatgaaa
      361 acgacagaag tttgtggtgt accaggtgtt ggaaaaacac agttatgtat gcaattagca
      421 gtagatgtgc aaattccaga atgttttgga ggagtggccg gtgaagcagt atttattgat
      481 acggagggaa gttttatggt tgatagggtg gtaagccttg ccactgcctg cattcagcac
      541 cttcatctca tagcaggaac acacacggaa gaagaacagc agaaagcctt gaaggatttt
      601 actcttgaaa atattctgtc ccatatttat tattttcgtt gtcacgatta cactgagctg
      661 ctggcacaag tctatctcct tccagatttc ctttcagatc attcaaaggt gcagttagtg
      721 ataatagatg gaattgcttt tccctttcgt catgacctcg atgatctttt ccttcgtact
      781 cgattactaa atggccttgc ccaacaattg atcagcctcg caaataagca cagactagct
      841 gttattttaa cgaatcagat gacaacaaag attgataaaa atcaagcttc gcttgttcct
      901 gcgttagggg aaagctgggg acatgctgct acaataaggc taatttttca ctgggaacaa
      961 aaacaaagat ttgcaacatt gtacaaatca ccaagccaga aggagtccac agtaccattt
     1021 cagatcacac ctcagggatt tagagatgct gttgtcactg ctgcctcatc acagacagaa
     1081 agttctttga acttccggaa acggtcacga gaaccagagg aagaatgctg accaaataat
     1141 aatgttaatg catcagttaa ctgattatgt gctatccagt atataatgga tgtatgtatg
     1201 tgcactgtgt ttgtgctggt gcctacagaa gcgagctggg gtggtggatc ttgtggaact
     1261 ggagttacaa gtgaaactga gccaccatga aggtgctcgg agccagaacc tagtcttccg
     1321 caaggaccaa aatgttccca gctgctgggc cattcctcca gcctgtctct gagacaggcc
     1381 attcctccag cccctccacc ctgtctctga ggcaggtctt cttgtttggt ctcttcacac
     1441 tccaggtcca cacactttgg ctacttctgg ttttgcctcc tgtctcacta gggacactgg
     1501 gatacgggtg tgcagcaaca cgtgtgggct ctgggaattg aactcaggtt gtcaggtttg
     1561 cttaacaaat gcttttatcc agtgagcatc tttccaggcc ctccacctta aattttaaga
     1621 aagagatatc ttactgaaca tgagttcact gactcagagg gccacctgtc tgccccaccc
     1681 accccaaggt gcacaaatgc actgtagggc accagccttt atatgcagtc ttcatgcctg
     1741 catttcccta gctcctgaaa agattttctg aagcactgtt ctataattat attttaatgt
     1801 gtttttattt tgagtaatgt ggaaagctga ccttatgtta cctatctgca tttaccatcc
     1861 agagtgggaa acttctttgt caattgccta aaaaataata caaataaaac attgtaatgc
     1921 attttaa
//
