LOCUS       NM_001109204            2167 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus RAD51 recombinase (Rad51), mRNA.
ACCESSION   NM_001109204 XM_001075212 XM_575211
VERSION     NM_001109204.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2167)
  AUTHORS   Ding YC, Adamson AW, Steele L, Bailis AM, John EM, Tomlinson G and
            Neuhausen SL.
  TITLE     Discovery of mutations in homologous recombination genes in
            African-American women with breast cancer
  JOURNAL   Fam Cancer 17 (2), 187-195 (2018)
   PUBMED   28864920
REFERENCE   2  (bases 1 to 2167)
  AUTHORS   Finsterbusch F, Ravindranathan R, Dereli I, Stanzione M, Trankner D
            and Toth A.
  TITLE     Alignment of Homologous Chromosomes and Effective Repair of
            Programmed DNA Double-Strand Breaks during Mouse Meiosis Require
            the Minichromosome Maintenance Domain Containing 2 (MCMDC2) Protein
  JOURNAL   PLoS Genet 12 (10), e1006393 (2016)
   PUBMED   27760146
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2167)
  AUTHORS   Sun X, Brieno-Enriquez MA, Cornelius A, Modzelewski AJ, Maley TT,
            Campbell-Peterson KM, Holloway JK and Cohen PE.
  TITLE     FancJ (Brip1) loss-of-function allele results in spermatogonial
            cell depletion during embryogenesis and altered processing of
            crossover sites during meiotic prophase I in mice
  JOURNAL   Chromosoma 125 (2), 237-252 (2016)
   PUBMED   26490168
REFERENCE   4  (bases 1 to 2167)
  AUTHORS   Ameziane N, May P, Haitjema A, van de Vrugt HJ, van Rossum-Fikkert
            SE, Ristic D, Williams GJ, Balk J, Rockx D, Li H, Rooimans MA,
            Oostra AB, Velleuer E, Dietrich R, Bleijerveld OB, Maarten Altelaar
            AF, Meijers-Heijboer H, Joenje H, Glusman G, Roach J, Hood L, Galas
            D, Wyman C, Balling R, den Dunnen J, de Winter JP, Kanaar R,
            Gelinas R and Dorsman JC.
  TITLE     A novel Fanconi anaemia subtype associated with a dominant-negative
            mutation in RAD51
  JOURNAL   Nat Commun 6, 8829 (2015)
   PUBMED   26681308
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2167)
  AUTHORS   Parplys AC, Zhao W, Sharma N, Groesser T, Liang F, Maranon DG,
            Leung SG, Grundt K, Dray E, Idate R, Ostvold AC, Schild D, Sung P
            and Wiese C.
  TITLE     NUCKS1 is a novel RAD51AP1 paralog important for homologous
            recombination and genome stability
  JOURNAL   Nucleic Acids Res 43 (20), 9817-9834 (2015)
   PUBMED   26323318
REFERENCE   6  (bases 1 to 2167)
  AUTHORS   Kovalenko OV, Golub EI, Bray-Ward P, Ward DC and Radding CM.
  TITLE     A novel nucleic acid-binding protein that interacts with human
            rad51 recombinase
  JOURNAL   Nucleic Acids Res 25 (24), 4946-4953 (1997)
   PUBMED   9396801
REFERENCE   7  (bases 1 to 2167)
  AUTHORS   Moens PB, Chen DJ, Shen Z, Kolas N, Tarsounas M, Heng HH and
            Spyropoulos B.
  TITLE     Rad51 immunocytology in rat and mouse spermatocytes and oocytes
  JOURNAL   Chromosoma 106 (4), 207-215 (1997)
   PUBMED   9254722
REFERENCE   8  (bases 1 to 2167)
  AUTHORS   Baumann P, Benson FE and West SC.
  TITLE     Human Rad51 protein promotes ATP-dependent homologous pairing and
            strand transfer reactions in vitro
  JOURNAL   Cell 87 (4), 757-766 (1996)
   PUBMED   8929543
REFERENCE   9  (bases 1 to 2167)
  AUTHORS   Li MJ, Peakman MC, Golub EI, Reddy G, Ward DC, Radding CM and
            Maizels N.
  TITLE     Rad51 expression and localization in B cells carrying out class
            switch recombination
  JOURNAL   Proc Natl Acad Sci U S A 93 (19), 10222-10227 (1996)
   PUBMED   8816780
REFERENCE   10 (bases 1 to 2167)
  AUTHORS   Benson FE, Stasiak A and West SC.
  TITLE     Purification and characterization of the human Rad51 protein, an
            analogue of E. coli RecA
  JOURNAL   EMBO J 13 (23), 5764-5771 (1994)
   PUBMED   7988572
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473949.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_575211.2, XM_001075212.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168875.1, SRR8487231.180683.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2167
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..2167
                     /gene="Rad51"
                     /gene_synonym="RGD1563603"
                     /note="RAD51 recombinase"
                     /db_xref="GeneID:499870"
                     /db_xref="RGD:1563603"
     exon            1..215
                     /gene="Rad51"
                     /gene_synonym="RGD1563603"
                     /inference="alignment:Splign:2.1.0"
     exon            216..304
                     /gene="Rad51"
                     /gene_synonym="RGD1563603"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..1237
                     /gene="Rad51"
                     /gene_synonym="RGD1563603"
                     /note="RAD51 homolog"
                     /codon_start=1
                     /product="DNA repair protein RAD51 homolog 1"
                     /protein_id="NP_001102674.1"
                     /db_xref="GeneID:499870"
                     /db_xref="RGD:1563603"
                     /translation="MAMQMQLEANADTSVEEESFGPQPISRLEQCGINANDVKKLEEA
                     GYHTVEAVAYAPKKELINIKGISEAKADKILAEAAKLVPMGFTTATEFHQRRSEIIQI
                     TTGSKELDKLLQGGIETGSITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYI
                     DTEGTFRPERLLAVAERYGLSGSDVLDNVAYARGFNTDHQTQLLYQASAMMVESRYAL
                     LIVDSATALYRTDYSGRGELSARQMHLARFLRMLLRLADEFGVAVVITNQVVAQVDGA
                     AMFAADPKKPIGGNIIAHASTTRLYLRKGRGETRICKIYDSPCLPEAEAMFAINADGV
                     GDAKD"
     exon            305..442
                     /gene="Rad51"
                     /gene_synonym="RGD1563603"
                     /inference="alignment:Splign:2.1.0"
     exon            443..560
                     /gene="Rad51"
                     /gene_synonym="RGD1563603"
                     /inference="alignment:Splign:2.1.0"
     exon            561..652
                     /gene="Rad51"
                     /gene_synonym="RGD1563603"
                     /inference="alignment:Splign:2.1.0"
     exon            653..747
                     /gene="Rad51"
                     /gene_synonym="RGD1563603"
                     /inference="alignment:Splign:2.1.0"
     exon            748..861
                     /gene="Rad51"
                     /gene_synonym="RGD1563603"
                     /inference="alignment:Splign:2.1.0"
     exon            862..991
                     /gene="Rad51"
                     /gene_synonym="RGD1563603"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1113
                     /gene="Rad51"
                     /gene_synonym="RGD1563603"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..2167
                     /gene="Rad51"
                     /gene_synonym="RGD1563603"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggatttggc gggatttctg aaagtcgcgc gcccatcgcg tatctgcgcc tgggcaaagc
       61 tgaggcgttc ccagaagtgt ggttaggaga actgaaactt tcatagaaga actgacagga
      121 gctgcgaagt gtgtttgagc cgtgtgacgg gagtgagcgt ggtgtgtgca gaaccgactg
      181 ccggaaggag cgagcggccc acggctgcga gacagtaatg gctatgcaaa tgcagcttga
      241 agcaaatgca gatacttcag tggaagaaga aagctttggt ccacagccta tttctcggtt
      301 agagcaatgt ggcataaatg ccaatgatgt gaagaaatta gaagaagctg gttaccacac
      361 ggtggaggct gttgcttatg caccaaagaa ggaactgata aatattaaag gaattagtga
      421 agccaaagct gacaaaatcc tggctgaggc agcgaaatta gttccaatgg gtttcaccac
      481 tgcaaccgaa tttcaccaac gccggtcaga aatcatccag attactactg gctccaaaga
      541 gcttgacaaa ctacttcaag gtggaattga gactgggtct atcacagaga tgtttggaga
      601 attccgaact gggaagacac agatctgtca tacattggct gtaacatgcc agctccccat
      661 tgaccgaggt ggaggtgaag ggaaagcaat gtacattgac accgagggca cctttaggcc
      721 ggagcggctg ctggcggtag ctgagagata cggcctctct ggaagtgacg tcctcgataa
      781 tgtagcatac gctcgagggt tcaacacaga ccaccagacc cagctccttt accaagcgtc
      841 agccatgatg gtagaatcca ggtatgcact gcttattgta gacagtgcta ctgcccttta
      901 cagaacagac tactcaggtc ggggagagct ttcagccagg caaatgcatt tggccagatt
      961 tctaaggatg ctgcttcgac ttgctgatga gtttggtgta gcagtggtaa tcaccaacca
     1021 ggtggtagcc caagtggatg gagcagccat gtttgctgca gatccgaaaa aacccattgg
     1081 aggaaacatc atcgctcatg catcaaccac caggctatac ctgaggaaag gaagagggga
     1141 aaccagaatc tgcaaaatct acgactctcc ctgtctccct gaagctgaag ccatgtttgc
     1201 cattaatgca gatggagtgg gagatgccaa agactgagtc actgagtccc tgtcctgtga
     1261 gaagtctcta aatgctgcat tgctaatgga caggactgcc attgggccgc ttcacaggct
     1321 catgtctgac tgactgccgg gagggcttcc aggaaaacaa ggatggtgtc agctgatagc
     1381 agaaacaggt ctgattggag atgtcaatct cttcttactg tactaataac ttctgtatta
     1441 ataacttctt actgtattag taactgattc ctttggtttt ggaggagagg taggaaatga
     1501 caggtgtggg acagtcttat gtcttcaaaa gaagcaaact agaaagacct gagtactctt
     1561 ttcacttctc aagaatggta aaataatgcc tgaggctctg taagtgggaa tgggtgttta
     1621 ctcgttcttt ttctctgtaa gtaagatgca aacttagaaa ttatatgcct gaactgtcac
     1681 atatttaaaa tttatttttt ggttgaggag tcttgacatg tggcatgtta ggctaacagc
     1741 cctccagttg catgcttgtt cttttaatta ctgagacttc acctaagcga gtttattctg
     1801 ctgctgctaa gtagttgtgt gcagtggatg tgttgtttgc tggagatatt ctagtgcaaa
     1861 ctgagtactg caaagcagcg cttccagaac agctctccct actgtgcagc tatggtcagc
     1921 tgctatagtc gtaagctgtg aaccctaaag aaagctctac actcaggtta ctgcattgta
     1981 tcctttaacc taagaataag aattccaggc tgatttaccg tatcgttcct gtgctctttg
     2041 ttcttattgt ataagttttg tgttgcagag gtctgacatt atccaaacaa ctcactttgg
     2101 gagtatttcc aaaaactgtg gtctcctttt gagtcgttga gtctcattaa taaaagaatt
     2161 tcaaaac
//
