LOCUS       NM_022246               4443 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus RAD50 double strand break repair protein (Rad50),
            mRNA.
ACCESSION   NM_022246
VERSION     NM_022246.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4443)
  AUTHORS   Park,Y.B., Hohl,M., Padjasek,M., Jeong,E., Jin,K.S., Krezel,A.,
            Petrini,J.H. and Cho,Y.
  TITLE     Eukaryotic Rad50 functions as a rod-shaped dimer
  JOURNAL   Nat Struct Mol Biol 24 (3), 248-257 (2017)
   PUBMED   28134932
REFERENCE   2  (bases 1 to 4443)
  AUTHORS   Agca,C., Yakan,A. and Agca,Y.
  TITLE     Estrus synchronization and ovarian hyper-stimulation treatments
            have negligible effects on cumulus oocyte complex gene expression
            whereas induction of ovulation causes major expression changes
  JOURNAL   Mol Reprod Dev 80 (2), 102-117 (2013)
   PUBMED   23239112
REFERENCE   3  (bases 1 to 4443)
  AUTHORS   Grolimund,L., Aeby,E., Hamelin,R., Armand,F., Chiappe,D.,
            Moniatte,M. and Lingner,J.
  TITLE     A quantitative telomeric chromatin isolation protocol identifies
            different telomeric states
  JOURNAL   Nat Commun 4, 2848 (2013)
   PUBMED   24270157
REFERENCE   4  (bases 1 to 4443)
  AUTHORS   Lovric,J., Mano,M., Zentilin,L., Eulalio,A., Zacchigna,S. and
            Giacca,M.
  TITLE     Terminal differentiation of cardiac and skeletal myocytes induces
            permissivity to AAV transduction by relieving inhibition imposed by
            DNA damage response proteins
  JOURNAL   Mol Ther 20 (11), 2087-2097 (2012)
   PUBMED   22850678
REFERENCE   5  (bases 1 to 4443)
  AUTHORS   Labeikyte,D., Borutinskaite,V., Legzdins,N. and Sjakste,N.
  TITLE     Tightly-bound to DNA proteins in rat experimental hepatomas and
            normal liver cells
  JOURNAL   Exp Oncol 33 (3), 121-125 (2011)
   PUBMED   21956462
REFERENCE   6  (bases 1 to 4443)
  AUTHORS   Zhu,X.D., Kuster,B., Mann,M., Petrini,J.H. and de Lange,T.
  TITLE     Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and
            human telomeres
  JOURNAL   Nat Genet 25 (3), 347-352 (2000)
   PUBMED   10888888
REFERENCE   7  (bases 1 to 4443)
  AUTHORS   Eijpe,M., Offenberg,H., Goedecke,W. and Heyting,C.
  TITLE     Localisation of RAD50 and MRE11 in spermatocyte nuclei of mouse and
            rat
  JOURNAL   Chromosoma 109 (1-2), 123-132 (2000)
   PUBMED   10855503
REFERENCE   8  (bases 1 to 4443)
  AUTHORS   Trujillo,K.M., Yuan,S.S., Lee,E.Y. and Sung,P.
  TITLE     Nuclease activities in a complex of human recombination and DNA
            repair factors Rad50, Mre11, and p95
  JOURNAL   J Biol Chem 273 (34), 21447-21450 (1998)
   PUBMED   9705271
REFERENCE   9  (bases 1 to 4443)
  AUTHORS   Carney,J.P., Maser,R.S., Olivares,H., Davis,E.M., Le Beau,M.,
            Yates,J.R. 3rd, Hays,L., Morgan,W.F. and Petrini,J.H.
  TITLE     The hMre11/hRad50 protein complex and Nijmegen breakage syndrome:
            linkage of double-strand break repair to the cellular DNA damage
            response
  JOURNAL   Cell 93 (3), 477-486 (1998)
   PUBMED   9590181
REFERENCE   10 (bases 1 to 4443)
  AUTHORS   Dolganov,G.M., Maser,R.S., Novikov,A., Tosto,L., Chong,S.,
            Bressan,D.A. and Petrini,J.H.
  TITLE     Human Rad50 is physically associated with human Mre11:
            identification of a conserved multiprotein complex implicated in
            recombinational DNA repair
  JOURNAL   Mol Cell Biol 16 (9), 4832-4841 (1996)
   PUBMED   8756642
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 26, 2020 this sequence version replaced NM_022246.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF218576.1, SRR26360176.1690231.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-283               JAXUCZ010000010.1  38361818-38362100   c
            284-367             JAXUCZ010000010.1  38360884-38360967   c
            368-519             JAXUCZ010000010.1  38357630-38357781   c
            520-705             JAXUCZ010000010.1  38355251-38355436   c
            706-910             JAXUCZ010000010.1  38354421-38354625   c
            911-1039            JAXUCZ010000010.1  38351564-38351692   c
            1040-1205           JAXUCZ010000010.1  38351183-38351348   c
            1206-1399           JAXUCZ010000010.1  38348641-38348834   c
            1400-1606           JAXUCZ010000010.1  38348059-38348265   c
            1607-1789           JAXUCZ010000010.1  38346581-38346763   c
            1790-1947           JAXUCZ010000010.1  38345241-38345398   c
            1948-2123           JAXUCZ010000010.1  38343001-38343176   c
            2124-2361           JAXUCZ010000010.1  38342100-38342337   c
            2362-2551           JAXUCZ010000010.1  38339055-38339244   c
            2552-2678           JAXUCZ010000010.1  38338200-38338326   c
            2679-2872           JAXUCZ010000010.1  38337670-38337863   c
            2873-2983           JAXUCZ010000010.1  38335073-38335183   c
            2984-3076           JAXUCZ010000010.1  38334296-38334388   c
            3077-3190           JAXUCZ010000010.1  38334102-38334215   c
            3191-3318           JAXUCZ010000010.1  38329070-38329197   c
            3319-3543           JAXUCZ010000010.1  38327453-38327677   c
            3544-3629           JAXUCZ010000010.1  38315457-38315542   c
            3630-3772           JAXUCZ010000010.1  38314801-38314943   c
            3773-3906           JAXUCZ010000010.1  38312113-38312246   c
            3907-4443           JAXUCZ010000010.1  38310147-38310683   c
FEATURES             Location/Qualifiers
     source          1..4443
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..4443
                     /gene="Rad50"
                     /note="RAD50 double strand break repair protein"
                     /db_xref="GeneID:64012"
                     /db_xref="RGD:621542"
     exon            1..283
                     /gene="Rad50"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..4093
                     /gene="Rad50"
                     /note="RAD50 homolog, double strand break repair protein"
                     /codon_start=1
                     /product="DNA repair protein RAD50"
                     /protein_id="NP_071582.2"
                     /db_xref="GeneID:64012"
                     /db_xref="RGD:621542"
                     /translation="MSRIEKMSILGVRSFGIEDKDKQIISFFSPLTILVGPNGAGKTT
                     IIECLKYICTGDFPPGTKGNTFVHDPKVAQETDVRAQIRLQFRDVNGEMVLVQRSMLC
                     SQKSKKTEFKTLEGVITRIKHGEKVSLSSKCAEIDREMISCLGVSKSVLNNVIFCHQE
                     DSNWPLSEGKALKQKFDEIFSATRYIKALDTLRQVRQTQGQKVKECQTELKYLRQNKE
                     KACEIRDQITSKEAQLASSREIVKAYENELEPLKNRLKEIEHNLSKIMRLDNEIKALD
                     SRKKQMEKDNSELEQKMEKVFQGTDEQLNDLYHNHQRTVREKERRLVDCQRELEKLSK
                     EARLLNQERAELLVEQGRLQLQADRHQEHIRARDSLIQSLAAHLELDGFERGPFSERQ
                     IKNFHELVRERQEREAKTASQLLSDLTDKEALKQRQMDEMRDKKSGLGRMIELKTEIL
                     TKKQTELRNVRNELQQLEGSSDRILELDQELTKAERELSKAEKNSSIETLKAEILNLQ
                     SEKADLDRNLRKLDQEMEQLNHHTTTRTQMEMLTKDKTDKDEQIRKIKSRHSDELTSL
                     LGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASAEQNKNHINNELKKKEEQLSS
                     YEDKLFDVCGSQDFESDLDRLKEDIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCP
                     VCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKERRRDEMLGLVPMRQSII
                     DLKEKEIPELRNRLQSVNRDIQRLKNDIEEQETLLGTVMPEEESAKVCLTDVTIMERF
                     QMELKDVERKIAQQAAKLQGVDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQ
                     QEQIQHLKSKTNELKSEKLQIATNLQRRQQMEEQTVELSTEVQSLNREIKDAKEQINP
                     LEIALEKLQQEKEELIHRKNTSNKMAQDKINDIKEKVKNIHGYMKDIENYIQDGKDDY
                     KKQKETELNEVVIQLNECDKHKEKINKEMGTMRQDIDTQKIQERWLQDNLTLRKRREE
                     LKEVEEERKQHLKEMGQMQVLQMKNEHQKLEENIDTIKRNHSLALGRQKGYEEEILHF
                     KKELREPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDHAIMKFHSMKMEEINKI
                     IRDLWRSTYRGQDIEYIEIRSDADENVSASDKRRNYNYRVVMLKGDTALDMRGRCSAG
                     QKVLASLIIRLALAETFCLNCGILALDEPTTNLDRENIESLAHALVEIIKSRSQQRNF
                     QLLVITHDEDFVELLGRSEYVEKFYRVKKNIDQCSEIVKSSINSLGSYVH"
     exon            284..367
                     /gene="Rad50"
                     /inference="alignment:Splign:2.1.0"
     exon            368..519
                     /gene="Rad50"
                     /inference="alignment:Splign:2.1.0"
     exon            520..705
                     /gene="Rad50"
                     /inference="alignment:Splign:2.1.0"
     exon            706..910
                     /gene="Rad50"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1039
                     /gene="Rad50"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1205
                     /gene="Rad50"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1399
                     /gene="Rad50"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1606
                     /gene="Rad50"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1789
                     /gene="Rad50"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1947
                     /gene="Rad50"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2123
                     /gene="Rad50"
                     /inference="alignment:Splign:2.1.0"
     exon            2124..2361
                     /gene="Rad50"
                     /inference="alignment:Splign:2.1.0"
     exon            2362..2551
                     /gene="Rad50"
                     /inference="alignment:Splign:2.1.0"
     exon            2552..2678
                     /gene="Rad50"
                     /inference="alignment:Splign:2.1.0"
     exon            2679..2872
                     /gene="Rad50"
                     /inference="alignment:Splign:2.1.0"
     exon            2873..2983
                     /gene="Rad50"
                     /inference="alignment:Splign:2.1.0"
     exon            2984..3076
                     /gene="Rad50"
                     /inference="alignment:Splign:2.1.0"
     exon            3077..3190
                     /gene="Rad50"
                     /inference="alignment:Splign:2.1.0"
     exon            3191..3318
                     /gene="Rad50"
                     /inference="alignment:Splign:2.1.0"
     exon            3319..3543
                     /gene="Rad50"
                     /inference="alignment:Splign:2.1.0"
     exon            3544..3629
                     /gene="Rad50"
                     /inference="alignment:Splign:2.1.0"
     exon            3630..3772
                     /gene="Rad50"
                     /inference="alignment:Splign:2.1.0"
     exon            3773..3906
                     /gene="Rad50"
                     /inference="alignment:Splign:2.1.0"
     exon            3907..4443
                     /gene="Rad50"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggtaccgg aagtgttctc gccgccggag ctcccactcg cagctcgggt tcggaacttt
       61 cgggtcctct cgtggcgtcc cttcccggct tgcccagctt ccgcttcgag gttaaactgg
      121 tccctggcag tgagataaga agcgtggtgc aaacatgtcc cggatcgaaa agatgagcat
      181 tctgggcgtg cgaagttttg ggatagagga taaagataag caaattatct ctttcttcag
      241 ccccctcaca attttggttg gacccaatgg ggcggggaag acgaccatca ttgaatgtct
      301 aaagtatatt tgtactggag atttccctcc tggaaccaaa ggaaatacat ttgttcatga
      361 tcccaaggtt gctcaagaaa cagatgtgcg tgcccaaatt cgcctgcagt ttcgtgatgt
      421 caatggagag atggtacttg tgcagaggtc catgctttgc agtcagaaaa gtaaaaaaac
      481 cgaatttaaa accctggaag gagtcattac tagaataaag cacggtgaaa aagtcagtct
      541 cagctccaaa tgtgcagaaa tcgaccgaga aatgataagt tgtcttgggg tttccaagtc
      601 tgtgctaaac aatgttattt tctgccacca agaagactca aattggcctc taagtgaagg
      661 aaaggctctg aagcagaaat ttgatgagat tttttcagca acaaggtaca ttaaagccct
      721 agatacgctt cgacaggtac gacagacaca aggtcagaaa gtaaaagaat gtcaaacaga
      781 attgaaatat ctgaggcaaa ataaggagaa agcttgtgag atccgagatc agatcactag
      841 taaggaagcc cagttagcat cttcacggga aattgtcaaa gcctatgaga atgagcttga
      901 gccattgaag aatcgcctga aagagattga acataacctc tctaaaataa tgagacttga
      961 caatgaaatt aaagccttgg atagcagaaa gaagcaaatg gaaaaagata acagtgaatt
     1021 agaacagaag atggaaaagg tttttcaagg gactgatgag cagctaaatg acttgtatca
     1081 caatcaccag agaactgtaa gggagaaaga aaggcgcttg gtagactgtc agcgtgaact
     1141 ggagaagctg agtaaagaag ctcggctcct caaccaggaa agagcagagc tgcttgtgga
     1201 gcagggtcgt ctacaactac aggcagatcg acatcaagag catatccgag ccagagactc
     1261 actgattcag tctttggcag cacatcttga attggatggt tttgagcgtg gaccattcag
     1321 tgaaagacag attaaaaact ttcatgaact tgtgagagag agacaggaga gagaagctaa
     1381 aactgccagc cagctcttga gcgaccttac agacaaagaa gcgctgaagc agagacagat
     1441 ggatgagatg agggacaaga agagcgggct ggggaggatg attgagctga agaccgagat
     1501 cctgacgaag aagcagactg agctgaggaa cgtgaggaat gagctgcagc agctggaggg
     1561 ctcctcggac aggattctgg agctggacca ggagctcaca aaagcggaac gtgaactaag
     1621 caaggctgag aaaaatagca gcatagaaac cctaaaagca gaaatactaa acctccaaag
     1681 tgagaaagcg gacctggaca ggaacctgcg gaaactggat caggagatgg agcagttaaa
     1741 ccatcataca acaacccgca cacagatgga gatgcttacc aaagacaaaa ctgacaaaga
     1801 tgaacagatc agaaaaataa agtccaggca cagtgatgaa ctaacttcac tgttgggata
     1861 ttttcctaac aaaaaacagc ttgaagactg gcttcattct aaatccaaag agattaatca
     1921 gaccagggac agacttgcca aactgaacaa agaactagct tcagccgaac aaaataaaaa
     1981 tcatataaat aatgagctaa agaaaaagga agagcagctg tctagttatg aagataaact
     2041 gtttgatgtt tgtggtagcc aagattttga aagtgactta gacagactta aagaagatat
     2101 tgaaaaatcc tcaaagcagc gagccatgct ggctggagcc acagcagttt actcccagtt
     2161 catcactcag ctgacagatg aaaaccagtc ctgttgccca gtctgtcaga gagtatttca
     2221 gacggaagct gaattacagg aagtcatcag tgacttgcag tccaagctga ggcttgctcc
     2281 agataaactc aagtcaacag aatcagaact aaaaaaaaaa gaacggcgcc gtgatgaaat
     2341 gctggggctt gtgcccatga ggcaaagcat aattgatttg aaggaaaagg aaataccaga
     2401 attaagaaac agactgcaga gtgtcaatag agacatacag cgcctaaaga atgacataga
     2461 ggagcaggag acactcttgg gtacagtgat gcccgaagag gaaagtgcta aagtgtgcct
     2521 gacagacgtc acgatcatgg agaggttcca gatggagcta aaagacgttg aaaggaaaat
     2581 tgcacagcag gcagctaagc tgcagggggt agacttggat cggactgtcc agcaggttaa
     2641 ccaggaaaaa caagaaaaac aacacaaact ggatacagtt tccagtaaga ttgaattgaa
     2701 ccgtaagctt atacaggacc agcaggaaca aattcagcac ctgaaaagta aaacaaatga
     2761 gctgaaatca gagaaactgc agatagccac caatttgcaa cggcgtcagc aaatggagga
     2821 gcagactgtg gaattatcca ctgaagttca gtctttgaac agagaaataa aggatgctaa
     2881 agagcaaata aaccctttgg agatagcact ggaaaagttg cagcaggaaa aagaagaatt
     2941 gatccacaga aaaaatacaa gtaacaaaat ggctcaggat aagatcaatg atatcaaaga
     3001 gaaagttaaa aatattcatg gttacatgaa agacatagag aattatattc aagatggaaa
     3061 agatgactat aagaagcaaa aagaaactga acttaatgaa gttgtcattc aactaaatga
     3121 atgtgacaaa cacaaagaaa agataaataa agaaatggga accatgaggc aagatattga
     3181 cacacagaag atacaggaaa ggtggttaca ggataacctt acactgagaa aaagaagaga
     3241 ggaactaaaa gaagttgaag aggaacgaaa gcaacatttg aaggagatgg gacagatgca
     3301 agttttacag atgaaaaatg agcaccagaa gttggaagag aacatagaca cgataaagag
     3361 aaatcacagt ttggcattgg ggcgacagaa aggctatgaa gaagaaattc ttcactttaa
     3421 gaaggagctc cgagaacctc agtttcggga tgcagaggag aagtacagag aaatgatgat
     3481 tgtcatgaga accacagagc tggtgaataa ggacctggac atctactaca aaactcttga
     3541 tcacgcaata atgaaatttc acagtatgaa aatggaagaa atcaacaaaa ttattcgtga
     3601 tctttggcgg agtacctatc gtgggcaaga tattgaatac atagaaattc gatccgatgc
     3661 tgatgaaaat gtatcagctt ctgataaaag gcgaaattac aactaccgag tggtgatgct
     3721 gaagggggat acagccttgg acatgcgcgg acgatgcagt gctggacaga aggtgctggc
     3781 ctctctcatc atccgcctgg cactggccga aaccttctgt ctgaactgcg gcatccttgc
     3841 cttggatgag cctacaacaa acctggaccg agaaaacatc gagtctctgg cacatgcttt
     3901 ggttgagatt ataaaaagtc gctcgcagca gcgcaacttc cagcttctgg tcatcactca
     3961 cgatgaagat tttgtggagc tcctaggacg atctgagtat gtggagaaat tctacagagt
     4021 gaagaagaac atcgaccagt gctcagagat tgtcaagagc agcatcaact ctctgggctc
     4081 ttatgttcac tgacttgttt tgggagggat gtggattggg tgaagggaac tgtgtatggc
     4141 aggtttgaga gttcctgaga tcgtgaggtt gccttgaatg aagactgaac acagttccca
     4201 caggcctagc aacctcccag ttctgctcag ctgtttattt cctgcctact gaatgtcacc
     4261 cagataaaca gtgctcttga gagcagtgct gacaggagtg gtgagcattt caaagtgttg
     4321 ctgttttctc tgaagcttag agtgatattt agtaagtggc cctgctttaa catgaatcca
     4381 tgcacacaac ctgtctgtcc gagcctaggt cttccctgaa gccacagtca ttgaacggag
     4441 gct
//
