LOCUS       NM_001025701            3582 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus RAD21 cohesin complex component (Rad21), mRNA.
ACCESSION   NM_001025701 XM_235267
VERSION     NM_001025701.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3582)
  AUTHORS   Jiao Y, Ren S, Wang L and Wu G.
  TITLE     PPARgamma/RAD21 alleviates peripheral secondary brain injury in rat
            cerebral hemorrhage model through promoting M2 polarization of
            microglial cells
  JOURNAL   Int Immunopharmacol 114, 109572 (2023)
   PUBMED   36538854
  REMARK    GeneRIF: PPARgamma/RAD21 alleviates peripheral secondary brain
            injury in rat cerebral hemorrhage model through promoting M2
            polarization of microglial cells.
REFERENCE   2  (bases 1 to 3582)
  AUTHORS   Li D, Yang T, Shao C, Cao Z and Zhang H.
  TITLE     LncRNA MIAT activates vascular endothelial growth factor A through
            RAD21 to promote nerve injury repair in acute spinal cord injury
  JOURNAL   Mol Cell Endocrinol 528, 111244 (2021)
   PUBMED   33741460
  REMARK    GeneRIF: LncRNA MIAT activates vascular endothelial growth factor A
            through RAD21 to promote nerve injury repair in acute spinal cord
            injury.
REFERENCE   3  (bases 1 to 3582)
  AUTHORS   Wang J, Zhao H, Yu J, Xu X, Jing H, Li N, Tang Y, Wang S, Li Y, Cai
            J and Jin J.
  TITLE     MiR-320b/RAD21 axis affects hepatocellular carcinoma
            radiosensitivity to ionizing radiation treatment through DNA damage
            repair signaling
  JOURNAL   Cancer Sci 112 (2), 575-588 (2021)
   PUBMED   33251678
REFERENCE   4  (bases 1 to 3582)
  AUTHORS   Liping X, Jia L, Qi C, Liang Y, Dongen L and Jianshuai J.
  TITLE     Cell Cycle Genes Are Potential Diagnostic and Prognostic Biomarkers
            in Hepatocellular Carcinoma
  JOURNAL   Biomed Res Int 2020, 6206157 (2020)
   PUBMED   32596342
  REMARK    Erratum:[Biomed Res Int. 2020 Nov 21;2020:8679532. PMID: 33354571]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3582)
  AUTHORS   Zhou B and Guo R.
  TITLE     Genomic and regulatory characteristics of significant transcription
            factors in colorectal cancer metastasis
  JOURNAL   Sci Rep 8 (1), 17836 (2018)
   PUBMED   30546056
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3582)
  AUTHORS   Liu J, Zhang Z, Bando M, Itoh T, Deardorff MA, Clark D, Kaur M,
            Tandy S, Kondoh T, Rappaport E, Spinner NB, Vega H, Jackson LG,
            Shirahige K and Krantz ID.
  TITLE     Transcriptional dysregulation in NIPBL and cohesin mutant human
            cells
  JOURNAL   PLoS Biol 7 (5), e1000119 (2009)
   PUBMED   19468298
REFERENCE   7  (bases 1 to 3582)
  AUTHORS   Farina A, Shin JH, Kim DH, Bermudez VP, Kelman Z, Seo YS and
            Hurwitz J.
  TITLE     Studies with the human cohesin establishment factor, ChlR1.
            Association of ChlR1 with Ctf18-RFC and Fen1
  JOURNAL   J Biol Chem 283 (30), 20925-20936 (2008)
   PUBMED   18499658
REFERENCE   8  (bases 1 to 3582)
  AUTHORS   Yamamoto G, Irie T, Aida T, Nagoshi Y, Tsuchiya R and Tachikawa T.
  TITLE     Correlation of invasion and metastasis of cancer cells, and
            expression of the RAD21 gene in oral squamous cell carcinoma
  JOURNAL   Virchows Arch 448 (4), 435-441 (2006)
   PUBMED   16416296
REFERENCE   9  (bases 1 to 3582)
  AUTHORS   Gregson HC, Schmiesing JA, Kim JS, Kobayashi T, Zhou S and Yokomori
            K.
  TITLE     A potential role for human cohesin in mitotic spindle aster
            assembly
  JOURNAL   J Biol Chem 276 (50), 47575-47582 (2001)
   PUBMED   11590136
REFERENCE   10 (bases 1 to 3582)
  AUTHORS   Darwiche N, Freeman LA and Strunnikov A.
  TITLE     Characterization of the components of the putative mammalian sister
            chromatid cohesion complex
  JOURNAL   Gene 233 (1-2), 39-47 (1999)
   PUBMED   10375619
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC099200.1.
            
            On Jul 22, 2005 this sequence version replaced XM_235267.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099200.1, SRR8487227.334677.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760433 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3582
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q31"
     gene            1..3582
                     /gene="Rad21"
                     /note="RAD21 cohesin complex component"
                     /db_xref="GeneID:314949"
                     /db_xref="RGD:1594529"
     exon            1..174
                     /gene="Rad21"
                     /inference="alignment:Splign:2.1.0"
     exon            175..349
                     /gene="Rad21"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..2113
                     /gene="Rad21"
                     /note="RAD21 homolog"
                     /codon_start=1
                     /product="double-strand-break repair protein rad21
                     homolog"
                     /protein_id="NP_001020872.1"
                     /db_xref="GeneID:314949"
                     /db_xref="RGD:1594529"
                     /translation="MFYAHFVLSKRGPLAKIWLAAHWDKKLTKAHVFECNLESSVESI
                     ISPKVKMALRTSGHLLLGVVRIYHRKAKYLLADCNEAFIKIKMAFRPGVVDLPEENRE
                     AAYNAITLPEEFHDFDQPLPDLDDIDVAQQFSLNQSRVEEITMREEVGNISILQENDF
                     GDFGMDDREIMREGSAFEDDDMLVSTSASNLLLEPEQSTSNLNEKINHLEYEDQYKDD
                     NFGEGNDGGILDDKLISNNDGGIFDDPPALSETGVMLPEQPAHDDMDEDDNGSLGGPD
                     SPDSVDPVEPMPTMTDQTTLVPNEEEAFALEPIDITVKETKAKRKRKLIVDSVKELDS
                     KTIRAQLSDYSDIVTTLDLAPPTKKLMMWKETGGVEKLFSLPAQPLWNNRLLKLFTRC
                     LTPLVPEDLRKRRKGGEADNLDEFLKEFENPEVPREEQQPQPQQQQAQRDVIDEPIIE
                     EPSRLQDSVMEASRTNIEESAMPPPPPQGVKRKAGQVDPEPAIPPQQVEQMEIPPVEL
                     PPEEPPNICQLIPELELLPEKEKEKEKEKEEEEEEEDEDASGGDQDQEERRWNKRTQQ
                     MLHGLQRALAKTGAESISLLELCRNTNRKQAAAKFYSFLVLKKQQAIELTQEEPYSDI
                     IATPGPRFHII"
     exon            350..479
                     /gene="Rad21"
                     /inference="alignment:Splign:2.1.0"
     exon            480..579
                     /gene="Rad21"
                     /inference="alignment:Splign:2.1.0"
     exon            580..686
                     /gene="Rad21"
                     /inference="alignment:Splign:2.1.0"
     exon            687..893
                     /gene="Rad21"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1019
                     /gene="Rad21"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1142
                     /gene="Rad21"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1366
                     /gene="Rad21"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1538
                     /gene="Rad21"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1687
                     /gene="Rad21"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1837
                     /gene="Rad21"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..1921
                     /gene="Rad21"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..3557
                     /gene="Rad21"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcagccat cttgtttgtt tgagtgaatc ggaaaggagg cggcggccgt ggcggtggcg
       61 ggagcaactc cgaggctaca ccgcacaagg gctccccctt tccccgcccc ctcccccgac
      121 cctttccccc ctccccgggc cacccacccc tcccagctcc ccgcagagat acaggtttct
      181 ttttatttca tagcaaataa gaaaaatgtt ctacgcacat tttgtcctca gcaaacgagg
      241 gcctctggcc aaaatttggc tggcggccca ttgggacaag aagctaacca aagcccatgt
      301 gtttgagtgt aacttagaaa gcagtgtgga aagtatcatc tcacctaagg tgaagatggc
      361 gctgcggacg tcaggacacc tcctcctggg cgtagtccgc atctatcaca ggaaagccaa
      421 atacctcctc gcggactgta atgaagcatt tattaaaata aagatggctt ttcggccagg
      481 tgttgtcgat ctacctgagg aaaatcggga agcggcttat aatgccatta ctttacctga
      541 ggaatttcac gattttgacc agccactgcc agacttagat gacattgacg tcgcccagca
      601 gttcagcttg aaccagagca gagtagaaga gataaccatg agagaagaag ttgggaacat
      661 cagtatccta caggaaaatg acttcggtga ctttggaatg gatgaccgtg aaatcatgag
      721 agaaggcagt gctttcgagg atgacgacat gttagtgagc accagtgctt ccaacctcct
      781 cctagagcct gagcagagca ccagcaacct gaatgaaaag attaaccatt tagagtatga
      841 ggaccagtac aaagatgata actttggaga aggcaatgat ggtggtatat tggacgacaa
      901 acttataagt aataatgacg gtggcatctt tgacgacccc cctgccttgt ctgagacggg
      961 ggtcatgttg ccagagcagc ctgcacacga tgatatggat gaggatgaca atggctcgtt
     1021 gggtgggcct gatagtcctg actctgtgga tcctgttgaa ccaatgccaa ccatgactga
     1081 tcagacaaca ctcgtcccaa atgaggaaga agcttttgca ttggagccca ttgatataac
     1141 tgtcaaagaa acaaaagcca agaggaagag gaagctgatt gttgacagtg tcaaggaatt
     1201 ggatagtaag acaattagag cccaactcag tgattactct gatattgtta caactctgga
     1261 cctggccccg cccaccaaga agctgatgat gtggaaagag acgggagggg tggagaagct
     1321 cttctcctta ccagcgcagc cattgtggaa taaccgacta ctgaagctct ttacacgctg
     1381 ccttactcca cttgtaccag aagaccttag gaaaagaagg aaagggggag aggcagataa
     1441 tctggatgag ttcctcaaag agttcgagaa cccagaggtc ccccgagagg agcagcagcc
     1501 gcagccacag cagcagcagg cgcagcgtga cgtcattgat gagcccatta tagaagagcc
     1561 aagccgcctt caggactcag tgatggaggc cagcagaaca aacatagaag agtcggccat
     1621 gcctccacca ccccctcagg gagttaagcg aaaagccggg caagtagacc cggagcctgc
     1681 gattcctcct cagcaggtag agcaaatgga aataccacca gtagaacttc ccccagaaga
     1741 acctcccaat atctgtcagc tgataccgga gttagagctt ctaccagaaa aggagaagga
     1801 gaaagagaag gagaaggagg aggaagaaga ggaggaggat gaagatgctt cagggggtga
     1861 tcaggatcaa gaggaaagga gatggaacaa aaggactcag cagatgcttc atggtcttca
     1921 gcgagctctt gctaaaactg gagcagagtc gatcagtttg cttgagctat gtcgaaacac
     1981 aaaccgaaag caggcagcag caaagttcta cagctttttg gttcttaaaa agcagcaagc
     2041 catcgagctc acacaggaag agccgtacag tgacatcatt gcaacacctg gaccaaggtt
     2101 ccacatcatc tgaggagcta gacgctttag agctagtgtt aactcactag gacgtacaaa
     2161 ttgccccatg tgtagggcac cagaaccctt taaggaagtt tttagatttt tgtttgtaca
     2221 aaatctttgc cttttctttc ttcatttttt tcccccagtg tttctaattt tgtcgaccat
     2281 cttttaaggg aaactgctta tttgggttgg gtttgtattc ctggagaaga cagtaccccc
     2341 aagaacccag aagactttta acagttcaga gcagatgtgt gcaatattgg tgcatgtaag
     2401 aatatggagt aacagtcaaa agtccccatt tttatgttag ttttccatta ctttgtttaa
     2461 aagaaaaacc tgcctaggaa aatgcctgac actttaagaa ctgtggtttg agtcccttga
     2521 caggaagaga aaaatgtctt cccatcagtg aaaccaacag tctggttaac cactgtacct
     2581 ggggatagta tgtgaggcat cgtgcttgtc ttcttgatca tgttttaaag taagtcagtt
     2641 cataatgagc aagaacttgt gagtttgtgc tgactgatcc tcttcgacta ttatgttctg
     2701 aaatcattcc gtgactctta ggaactctga cgctagtgca gctcagaatg acagacttct
     2761 gcagtggcgg gactcctcaa gggctgcaga tcgctttctc aaaggtgtct ggatgtttgc
     2821 ttgagtaatg agatcatgaa aatagaaatt cccctgcctg ctgaagggca aaccaatgag
     2881 aaactacccc agattgactt cctttaagca aacagtgctg taaaaactaa tggcttctct
     2941 gatatttatt ataaatgtta gtactgagct tccaatgctg cacactcctg tgtttgaaac
     3001 tattttaata actttgcaac tgtaatcctg tatcagtttc ctataattta aatggaaaaa
     3061 aacatcctaa taaaggcttt attattaaca gaccagatag taccagaaat tatgtgacta
     3121 tataaatatc aaaacgtgtt cactttgtag gacaaaatta tgttgaaagt tctagcttaa
     3181 gtgttggcac ttttatgggg gggaaatcag ttttaaaact aagacttcca tgtataccca
     3241 gtaatttaaa attatgtgaa atattttaaa tttgtgaact cgtaattact attttaatga
     3301 ttgagcttct cgagaatggt aagtgtatag atgctcttgc ggtttctttt cagtaagacg
     3361 tgcctggaaa ccatggatcc cctttgtaaa aagacactgt agataattga atgttgatta
     3421 tagaaaggcc attagtttct tgttacacat tttgttagtc cagtttttgt cgcttattgg
     3481 gtttaatatt gttcttgaaa atagtcaatg ctatgttatg tataactttt ctaataaaag
     3541 ttgtgtttca agctgtaaaa aaaaaaaaaa aaaaaaaaaa aa
//
