LOCUS       NM_001077673            1737 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus RAD18 E3 ubiquitin protein ligase (Rad18), mRNA.
ACCESSION   NM_001077673 XM_001078594 XM_342734
VERSION     NM_001077673.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1737)
  AUTHORS   Raschle M, Smeenk G, Hansen RK, Temu T, Oka Y, Hein MY, Nagaraj N,
            Long DT, Walter JC, Hofmann K, Storchova Z, Cox J, Bekker-Jensen S,
            Mailand N and Mann M.
  TITLE     DNA repair. Proteomics reveals dynamic assembly of repair complexes
            during bypass of DNA cross-links
  JOURNAL   Science 348 (6234), 1253671 (2015)
   PUBMED   25931565
REFERENCE   2  (bases 1 to 1737)
  AUTHORS   Zeman MK, Lin JR, Freire R and Cimprich KA.
  TITLE     DNA damage-specific deubiquitination regulates Rad18 functions to
            suppress mutagenesis
  JOURNAL   J Cell Biol 206 (2), 183-197 (2014)
   PUBMED   25023518
REFERENCE   3  (bases 1 to 1737)
  AUTHORS   Panier S, Ichijima Y, Fradet-Turcotte A, Leung CC, Kaustov L,
            Arrowsmith CH and Durocher D.
  TITLE     Tandem protein interaction modules organize the ubiquitin-dependent
            response to DNA double-strand breaks
  JOURNAL   Mol Cell 47 (3), 383-395 (2012)
   PUBMED   22742833
REFERENCE   4  (bases 1 to 1737)
  AUTHORS   Liu T, Chen H, Kim H, Huen MS, Chen J and Huang J.
  TITLE     RAD18-BRCTx interaction is required for efficient repair of
            UV-induced DNA damage
  JOURNAL   DNA Repair (Amst) 11 (2), 131-138 (2012)
   PUBMED   22036607
REFERENCE   5  (bases 1 to 1737)
  AUTHORS   Sun J, Yomogida K, Sakao S, Yamamoto H, Yoshida K, Watanabe K,
            Morita T, Araki K, Yamamura K and Tateishi S.
  TITLE     Rad18 is required for long-term maintenance of spermatogenesis in
            mouse testes
  JOURNAL   Mech Dev 126 (3-4), 173-183 (2009)
   PUBMED   19068231
REFERENCE   6  (bases 1 to 1737)
  AUTHORS   van der Laan R, Uringa EJ, Wassenaar E, Hoogerbrugge JW, Sleddens
            E, Odijk H, Roest HP, de Boer P, Hoeijmakers JH, Grootegoed JA and
            Baarends WM.
  TITLE     Ubiquitin ligase Rad18Sc localizes to the XY body and to other
            chromosomal regions that are unpaired and transcriptionally
            silenced during male meiotic prophase
  JOURNAL   J Cell Sci 117 (Pt 21), 5023-5033 (2004)
   PUBMED   15383616
REFERENCE   7  (bases 1 to 1737)
  AUTHORS   Tateishi S, Niwa H, Miyazaki J, Fujimoto S, Inoue H and Yamaizumi
            M.
  TITLE     Enhanced genomic instability and defective postreplication repair
            in RAD18 knockout mouse embryonic stem cells
  JOURNAL   Mol Cell Biol 23 (2), 474-481 (2003)
   PUBMED   12509447
REFERENCE   8  (bases 1 to 1737)
  AUTHORS   van der Laan R, Roest HP, Hoogerbrugge JW, Smit EM, Slater R,
            Baarends WM, Hoeijmakers JH and Grootegoed JA.
  TITLE     Characterization of mRAD18Sc, a mouse homolog of the yeast
            postreplication repair gene RAD18
  JOURNAL   Genomics 69 (1), 86-94 (2000)
   PUBMED   11013078
REFERENCE   9  (bases 1 to 1737)
  AUTHORS   Xin H, Lin W, Sumanasekera W, Zhang Y, Wu X and Wang Z.
  TITLE     The human RAD18 gene product interacts with HHR6A and HHR6B
  JOURNAL   Nucleic Acids Res 28 (14), 2847-2854 (2000)
   PUBMED   10908344
REFERENCE   10 (bases 1 to 1737)
  AUTHORS   Wood PL, Hawkinson JE and Goodnough DB.
  TITLE     Formation of D-serine from L-phosphoserine in brain synaptosomes
  JOURNAL   J Neurochem 67 (4), 1485-1490 (1996)
   PUBMED   8858931
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC127510.1.
            
            On or before Nov 15, 2006 this sequence version replaced
            XM_342734.3, XM_001078594.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC127510.1, EF395817.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1737
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1737
                     /gene="Rad18"
                     /note="RAD18 E3 ubiquitin protein ligase"
                     /db_xref="GeneID:362412"
                     /db_xref="RGD:1306993"
     exon            1..101
                     /gene="Rad18"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..1535
                     /gene="Rad18"
                     /EC_number="2.3.2.27"
                     /note="RAD18 homolog"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RAD18"
                     /protein_id="NP_001071141.1"
                     /db_xref="GeneID:362412"
                     /db_xref="RGD:1306993"
                     /translation="MEDLAEPRWPPGLAMMKTIDDLLRCGICFEYFNIAVIIPQCSHN
                     YCSLCIRKFLSYKTQCPTCCVAVTEPDLRNNRLLDELVKSMSFARTRLLQFALESPPI
                     SPVSSTSKKVVVKVHNVEATQHPVKQGNRLMDKFLIRETGDCVSELLGKENERKFSPQ
                     KEISTSADIKETSLLGKTALGLSDANGPVTPSTSTLKLDTKVSCPVCGVSIPENHINK
                     HLDSCLSREEKKESLRSSAHKRKPLPKTVYNLLSDRDLKKKLKQHGLSIQGNKQQLIK
                     RHQEFVHMYNAQCDALHPKSAAEIVQEIENMEKTRMRLEASKLNENVMVFTKNQTEKE
                     IEEIHSKYRKKHQNEFQLLVDQAKKGYKKTGRMSKAAVMRKDEPAETLPSERMAQEDN
                     VSFSDTVSVTKHFPQSKVDSPGLSEPERPDDSSSCTDILLSSESDSCNSSSSDIIRDL
                     LEEEEAWEAAHKNDQNKEVSPQQNRRTRATERAEIEPRNKRNKN"
     exon            102..183
                     /gene="Rad18"
                     /inference="alignment:Splign:2.1.0"
     exon            184..245
                     /gene="Rad18"
                     /inference="alignment:Splign:2.1.0"
     exon            246..316
                     /gene="Rad18"
                     /inference="alignment:Splign:2.1.0"
     exon            317..654
                     /gene="Rad18"
                     /inference="alignment:Splign:2.1.0"
     exon            655..754
                     /gene="Rad18"
                     /inference="alignment:Splign:2.1.0"
     exon            755..939
                     /gene="Rad18"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1016
                     /gene="Rad18"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1077
                     /gene="Rad18"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1212
                     /gene="Rad18"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1372
                     /gene="Rad18"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1435
                     /gene="Rad18"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1719
                     /gene="Rad18"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaggaactg cgtggcaggc cggtagctgg tggtctcgtc aagtgcgacc atggaggacc
       61 tggccgagcc acggtggcct ccggggttgg cgatgatgaa gacaatagat gacttgctgc
      121 gctgtgggat ttgctttgag tatttcaaca ttgcagtgat aatcccccag tgctctcaca
      181 actattgttc tctctgtata agaaaatttt tgtcctataa aactcagtgc ccaacttgtt
      241 gcgtggcagt aacagagcca gacctgagaa ataatcgcct cttagatgaa ctggtaaaaa
      301 gcatgagttt tgcacggact cgcctgctgc agtttgcctt agagtcacca cctatatctc
      361 ctgtgtcttc cacctcaaag aaggttgtag ttaaggtaca taatgttgaa gccacccaac
      421 accctgtcaa acaggggaac aggttaatgg ataagttcct gattagagaa actggtgatt
      481 gtgtatccga gttgttggga aaagaaaatg agaggaaatt cagccctcaa aaagagataa
      541 gcacctctgc tgatattaaa gagacaagtc tcctaggaaa gacggcactt ggtctctcgg
      601 atgctaatgg tcctgtgaca ccctctacat ccactctgaa actggatact aaagtgtctt
      661 gtcctgtttg tggggtcagc attccagaaa atcacatcaa taagcattta gacagttgtt
      721 tatcacggga agagaaaaag gagagcctta gaagttctgc tcacaaaagg aagccattgc
      781 ccaaaactgt gtataacttg ctctctgatc gtgatttaaa gaaaaagctg aaacagcatg
      841 gcttatctat tcaaggaaac aaacagcagc ttattaaaag gcatcaggaa tttgtgcaca
      901 tgtataatgc ccagtgcgat gctttgcatc ctaaatcagc tgctgaaatc gtccaagaaa
      961 ttgagaacat ggagaagacc aggatgcgcc ttgaagcaag taaactcaat gaaaatgtta
     1021 tggtttttac aaagaaccaa acagagaagg aaatagagga aattcacagt aaatatcgaa
     1081 aaaagcacca gaatgaattc cagcttctgg tggatcaggc caaaaaagga tacaagaaaa
     1141 ctggcagaat gtcaaaagct gcagtaatga ggaaagatga acctgcagag acactgccat
     1201 ctgaacgtat ggcacaagaa gataatgtga gcttctcaga tactgtctca gtaacaaagc
     1261 actttcctca gtccaaggtg gactccccag ggctgtcgga gcccgagaga ccagacgatt
     1321 cttctagttg tactgatatt cttctctcct cagaatcaga ttcgtgcaat agttccagtt
     1381 cggacatcat aagagatctc ctggaagaag aggaagcctg ggaagcagct cacaaaaatg
     1441 atcaaaacaa agaagtaagc ccacaacaga atcgtcgcac tagagccact gaacgtgctg
     1501 agattgaacc aagaaacaag cggaataaga attagtatgg ccttttgcca gtttttctga
     1561 acggtgacct gagtatgata tttttattgc catgtgtggt ttcatattta gcaatatcca
     1621 aggaagattt ttttaagtct aaatgcaata gttaatttat tttcattctt ctttgccttc
     1681 ctgaacaaca gcaacaacaa caaaaaaaaa acaaaaaaaa aaaaaaaaaa aaaaaaa
//
