LOCUS       NM_001024778            2790 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus RAD17 checkpoint clamp loader component (Rad17),
            mRNA.
ACCESSION   NM_001024778 XM_226718
VERSION     NM_001024778.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2790)
  AUTHORS   Tsao CC, Geisen C and Abraham RT.
  TITLE     Interaction between human MCM7 and Rad17 proteins is required for
            replication checkpoint signaling
  JOURNAL   EMBO J 23 (23), 4660-4669 (2004)
   PUBMED   15538388
REFERENCE   2  (bases 1 to 2790)
  AUTHORS   Budzowska M, Jaspers I, Essers J, de Waard H, van Drunen E, Hanada
            K, Beverloo B, Hendriks RW, de Klein A, Kanaar R, Hoeijmakers JH
            and Maas A.
  TITLE     Mutation of the mouse Rad17 gene leads to embryonic lethality and
            reveals a role in DNA damage-dependent recombination
  JOURNAL   EMBO J 23 (17), 3548-3558 (2004)
   PUBMED   15297881
REFERENCE   3  (bases 1 to 2790)
  AUTHORS   Herbig U, Jobling WA, Chen BP, Chen DJ and Sedivy JM.
  TITLE     Telomere shortening triggers senescence of human cells through a
            pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)
  JOURNAL   Mol Cell 14 (4), 501-513 (2004)
   PUBMED   15149599
REFERENCE   4  (bases 1 to 2790)
  AUTHORS   Wang Y and Qin J.
  TITLE     MSH2 and ATR form a signaling module and regulate two branches of
            the damage response to DNA methylation
  JOURNAL   Proc Natl Acad Sci U S A 100 (26), 15387-15392 (2003)
   PUBMED   14657349
REFERENCE   5  (bases 1 to 2790)
  AUTHORS   Chang MS, Sasaki H, Campbell MS, Kraeft SK, Sutherland R, Yang CY,
            Liu Y, Auclair D, Hao L, Sonoda H, Ferland LH and Chen LB.
  TITLE     HRad17 colocalizes with NHP2L1 in the nucleolus and redistributes
            after UV irradiation
  JOURNAL   J Biol Chem 274 (51), 36544-36549 (1999)
   PUBMED   10593953
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098057.1.
            
            On Jun 10, 2005 this sequence version replaced XM_226718.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098057.1, SRR8487227.69387.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2790
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q12"
     gene            1..2790
                     /gene="Rad17"
                     /note="RAD17 checkpoint clamp loader component"
                     /db_xref="GeneID:310034"
                     /db_xref="RGD:1309515"
     exon            1..149
                     /gene="Rad17"
                     /inference="alignment:Splign:2.1.0"
     exon            150..253
                     /gene="Rad17"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..2272
                     /gene="Rad17"
                     /note="RAD17 homolog"
                     /codon_start=1
                     /product="cell cycle checkpoint protein RAD17"
                     /protein_id="NP_001019949.1"
                     /db_xref="GeneID:310034"
                     /db_xref="RGD:1309515"
                     /translation="MSETFLRPKVSSTKVTDWVDPAFDDFSANTAVTTITVSSLSLNN
                     SSHRRKYLPSTLESNRLSARKRGRLPLEQTNGLETSKEYLSDDEPWVDKYKPETQHEL
                     AVHKKKIEEVETWLKTQVLEVKPKHGGSILLITGPPGCGKTTTIKILSKELGIQVQEW
                     VNPILQDFQKDDYKELFNSESNFSVIPYQSQIAVFNDFLLRATKYNKLQMLGDALTTD
                     KKIILVEDLPNQFYRDANALHEILRKYVHIGRCPLVFIVSDSVSGDSNHRLLFPKNIQ
                     EECSVSNISFNPVAPTIMMKFLNRIVTIEASKNGEKITVPNKASLELLCQGCSGDIRS
                     AINSLQFSSSKGENSSWSKKKKMSLKSDASISKAKQKRKHNSTLENQEIQAIGGKDVS
                     LFLFRALGKILYCKRAPLTELASPRLPAHLSEHDRDTLLVQPEEIVEMSHMPGEFFNL
                     YLHQNYIDFFTDVDDLVRASEFLSFADILGGDWNTRSSLRDYSTSIAARGVMHSNTSR
                     RFAHCQGGGSSFRPLHKPQWFLIQKKYRENCLAAKALFCDFCLPAVCLQTQLLPYLAL
                     LTIPMRNKAQISFIQDIGRLPLKRNFGRLKMEALTDRELGLIDPDSGDELLHSGGQPA
                     QEAQGQPAQTADPETWSLPLSQNSGSDLPASQPRPFSSKVDLEEEEEEEEDIVIEDYD
                     SDEA"
     exon            254..508
                     /gene="Rad17"
                     /inference="alignment:Splign:2.1.0"
     exon            509..592
                     /gene="Rad17"
                     /inference="alignment:Splign:2.1.0"
     exon            593..749
                     /gene="Rad17"
                     /inference="alignment:Splign:2.1.0"
     exon            750..886
                     /gene="Rad17"
                     /inference="alignment:Splign:2.1.0"
     exon            887..939
                     /gene="Rad17"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1065
                     /gene="Rad17"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1135
                     /gene="Rad17"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1247
                     /gene="Rad17"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1430
                     /gene="Rad17"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1516
                     /gene="Rad17"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1663
                     /gene="Rad17"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1813
                     /gene="Rad17"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..1934
                     /gene="Rad17"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..1992
                     /gene="Rad17"
                     /inference="alignment:Splign:2.1.0"
     exon            1993..2764
                     /gene="Rad17"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtaagcgccc gcagtaagga aggtccccag gaggcgggcc gccctagaag cctgcggctg
       61 agctgggagg gctgggcggt tacccttcca cactacagcc tggcctcctt cacatctttc
      121 cgcccgcgag gggacgcagc tcccagaaag tgaattatac ttcaatatac tctaaattgt
      181 atgctactga tgggaactgt taaagtttat aatgtcagaa actttcctta gaccaaaggt
      241 gtcttctaca aaggtaacag actgggtaga tccggcattt gatgactttt cagcgaacac
      301 tgctgtcacc accatcaccg tttcatctct aagtttgaat aactccagtc acagaagaaa
      361 atacttgccc tccacattag aaagtaacag attgtctgct aggaaaagag gaaggctgcc
      421 tttagaacag actaatggtc tagaaacgtc aaaagaatat ctgtctgacg atgagccatg
      481 ggtggataag tataaaccag aaactcagca tgagcttgct gtccataaaa agaaaattga
      541 agaagttgaa acctggttaa aaactcaagt cttagaagtg aagccgaaac acggtgggtc
      601 tattttatta ataacaggtc ctccaggatg tggaaagaca actactataa aaatactgtc
      661 aaaggagctt gggattcaag tacaagaatg ggttaatccc attttacaag acttccaaaa
      721 agatgattac aaggagttat ttaattcaga gtcaaacttc tctgtcattc cataccaatc
      781 tcagatagca gtcttcaatg actttctgtt aagagccacc aagtacaaca aattgcagat
      841 gcttggagat gccctgacaa cagataagaa gataattctg gttgaggatc tacctaacca
      901 attttatcga gatgctaatg ctttacacga aattctaagg aagtatgtgc acatcggccg
      961 gtgtcctctt gtatttatag tctctgacag tgtcagtgga gatagtaatc atcggttact
     1021 ctttcccaaa aacattcaag aagagtgttc tgtttcaaat attagtttca accctgtggc
     1081 accaacaatt atgatgaaat ttcttaatcg aattgtgact atagaagcta gtaagaatgg
     1141 agaaaaaatt actgttccta ataaagcttc tttggagttg ctctgtcaag gatgttctgg
     1201 tgatatcaga agtgcaataa acagcctgca gttttcttct tcaaaaggag agaacagttc
     1261 atggtcaaag aagaaaaaga tgtcattgaa atcagatgct tcgatttcaa aagcaaagca
     1321 gaaaaggaaa cataatagta ctttggaaaa tcaggagatt caagctattg gtggaaaaga
     1381 tgtctctctt tttctcttca gagctttggg gaaaattctg tactgtaaaa gagcaccttt
     1441 aacagagctc gcctcgcctc gcctgccggc tcacttgtca gagcatgacc gggatacttt
     1501 gcttgttcag cccgaggaaa tagtagaaat gtcacacatg ccaggagaat tttttaattt
     1561 gtaccttcac caaaactaca tagatttctt caccgacgta gatgaccttg tgagagccag
     1621 tgagtttctg agttttgcag atatcctcgg tggtgactgg aatacgcgct cttcactcag
     1681 ggactatagt acatctatag ctgcaagagg tgtgatgcat tccaatacat ctcggagatt
     1741 cgctcattgc caaggagggg gatccagctt tcgaccctta cataagcccc aatggtttct
     1801 aatacagaaa aagtatcggg aaaattgcct ggcagcgaaa gcactcttct gtgacttctg
     1861 cctacccgct gtgtgtctgc agactcagct cttgccttat cttgctcttc tgaccattcc
     1921 aatgcgaaac aaagctcaga tttcttttat ccaagatatt ggaagacttc ctttgaagcg
     1981 aaactttggg aggttgaaaa tggaggccct gactgaccga gagctcgggc tcatagaccc
     2041 tgacagcggg gatgaattgc tgcacagtgg aggacagcct gctcaggagg ctcagggcca
     2101 gcccgcccag actgctgacc cagaaacctg gtctctccct ttgagtcaga acagtgggag
     2161 cgatctgcct gccagccagc ctcggccctt ttcctccaaa gtggacctgg aagaggagga
     2221 ggaggaagag gaagacatag taatagagga ctatgacagc gatgaggcat agagaacagc
     2281 ccgccaatca gactgctgcg tgagagtcat cggtttaagt ctattcagtg gtacttgagc
     2341 agcattcaca ggtctctgaa ggaccagctt tgttaattgc tcagttcctg atagtaatca
     2401 tcacggcagc tgccgcctgt catcttgaag taaagcaggt ctcaagtact cagtgctcag
     2461 tatttattta gtcttgtgta tggtttaagg agaggtcacg gtgtgaagaa tgtatggatg
     2521 ttgtgctaaa tatcagagaa tgtgaaggaa taatccagaa catacagact ttatggggcg
     2581 ttgtaaattt gatttataaa accttttagg atgcaattat gagtataaat aaactttgtg
     2641 ccttattcac agtttgcatc tagcatctcg ggtaccgttt tggtatgttg tacagtgaaa
     2701 tattttagat acttctggaa agtatttaca taatttatat cgaaattaaa aatgttggat
     2761 ttcaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
