LOCUS       NM_001106419            1321 bp    mRNA    linear   ROD 04-JUN-2023
DEFINITION  Rattus norvegicus RAD1 checkpoint DNA exonuclease (Rad1), mRNA.
ACCESSION   NM_001106419 XM_001060140 XM_215497
VERSION     NM_001106419.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1321)
  AUTHORS   Tong X, Li D, Liu N, Huang W, Zhao X, Zhang D, Xue X and Fu J.
  TITLE     Rad1 attenuates DNA double-strand breaks and cell cycle arrest in
            type II alveolar epithelial cells of rats with bronchopulmonary
            dysplasia
  JOURNAL   Mol Med 29 (1), 70 (2023)
   PUBMED   37226090
  REMARK    GeneRIF: Rad1 attenuates DNA double-strand breaks and cell cycle
            arrest in type II alveolar epithelial cells of rats with
            bronchopulmonary dysplasia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1321)
  AUTHORS   Chen S, Lu FF, Seeman P and Liu F.
  TITLE     Quantitative proteomic analysis of human substantia nigra in
            Alzheimer's disease, Huntington's disease and Multiple sclerosis
  JOURNAL   Neurochem Res 37 (12), 2805-2813 (2012)
   PUBMED   22926577
REFERENCE   3  (bases 1 to 1321)
  AUTHORS   Cotta-Ramusino C, McDonald ER 3rd, Hurov K, Sowa ME, Harper JW and
            Elledge SJ.
  TITLE     A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1
            interacting protein required for ATR signaling
  JOURNAL   Science 332 (6035), 1313-1317 (2011)
   PUBMED   21659603
REFERENCE   4  (bases 1 to 1321)
  AUTHORS   Freire R, Murguia JR, Tarsounas M, Lowndes NF, Moens PB and Jackson
            SP.
  TITLE     Human and mouse homologs of Schizosaccharomyces pombe rad1(+) and
            Saccharomyces cerevisiae RAD17: linkage to checkpoint control and
            mammalian meiosis
  JOURNAL   Genes Dev 12 (16), 2560-2573 (1998)
   PUBMED   9716408
REFERENCE   5  (bases 1 to 1321)
  AUTHORS   Parker AE, Van de Weyer I, Laus MC, Oostveen I, Yon J, Verhasselt P
            and Luyten WH.
  TITLE     A human homologue of the Schizosaccharomyces pombe rad1+ checkpoint
            gene encodes an exonuclease
  JOURNAL   J Biol Chem 273 (29), 18332-18339 (1998)
   PUBMED   9660799
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474058.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001060140.1, XM_215497.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1321
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q16"
     gene            1..1321
                     /gene="Rad1"
                     /note="RAD1 checkpoint DNA exonuclease"
                     /db_xref="GeneID:294800"
                     /db_xref="RGD:1306496"
     exon            1..245
                     /gene="Rad1"
                     /inference="alignment:Splign:2.1.0"
     exon            246..508
                     /gene="Rad1"
                     /inference="alignment:Splign:2.1.0"
     CDS             311..1153
                     /gene="Rad1"
                     /EC_number="3.1.11.2"
                     /note="RAD1 homolog"
                     /codon_start=1
                     /product="cell cycle checkpoint protein RAD1"
                     /protein_id="NP_001099889.1"
                     /db_xref="GeneID:294800"
                     /db_xref="RGD:1306496"
                     /translation="MPLLTQYNEDEYEQYCLVASLDNVRNLSTVLKAIHFKEHATCFA
                     TKNGIKVTVENAKCVQANAFIQADVFQEFIIQEESVTFRINLTILLDCLSIFGSSPTP
                     GTLTALRMCYQGYGHPLMLFLEEGGVVTVCKITTQEPEDTLDFDFCSTNVMNKIILQS
                     EGLREAFSELDMTGDVLQITVSPDKPYFRLSTFGNAGNSHLDYPKDSDLVEAFHCNKT
                     QINRYKLSLLKPSTKALALSCKVSIRTDNRGFLSLQYMIRNEDGQICFVEYYCCPDEE
                     VPES"
     exon            509..617
                     /gene="Rad1"
                     /inference="alignment:Splign:2.1.0"
     exon            618..876
                     /gene="Rad1"
                     /inference="alignment:Splign:2.1.0"
     exon            877..975
                     /gene="Rad1"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1321
                     /gene="Rad1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacggtggcc tggttggctg cgggtctgaa cagtggcggg agctgtttgc caggcttgct
       61 ggcttctgga ttctcagggt gttcttcttg gggctaggct gacaagggct ttacgggatc
      121 ggacgtcacc tcaaaggcag gggcctggcg cccggggctc cccttagtgg ccgctgtgcg
      181 gcgagcgggc tggtgagctg ggtgacggtc ggcgccgcgg tctaaggtgt ctgtggcggg
      241 ctaaggtttt cggagatctt ccggaagagg agcatccttc tctctgagct gaacgtacag
      301 tggtccaccc atgcctctcc taacccagta caatgaggat gagtacgaac agtactgctt
      361 agtggccagc cttgacaacg ttaggaatct ctccactgtc ttgaaagcca ttcacttcaa
      421 agaacacgcc acgtgttttg ctactaaaaa tggaatcaag gttaccgtgg aaaatgcaaa
      481 gtgtgtgcaa gccaatgcct ttattcaggc tgatgtattt caagaattta tcattcagga
      541 agaatccgtt acttttcgaa ttaacttaac tatcctttta gactgtttat ctatttttgg
      601 atcaagtcct acaccaggga ctttaactgc acttcggatg tgttaccaag gttatggtca
      661 cccactgatg ctatttctag aagaaggagg agtagtgacg gtctgcaaaa ttaccactca
      721 ggagcctgag gacacactgg attttgattt ctgcagcacc aatgttatga ataaaattat
      781 cctgcagtcc gagggactcc gggaagcctt ttctgagttg gacatgacag gtgatgtcct
      841 acagatcacc gtgtctcctg acaagcccta cttcaggttg tctacttttg gaaatgcagg
      901 aaactcccat cttgactatc ccaaagattc ggatttggtg gaagcatttc actgtaataa
      961 gacccagatc aacagataca aactttcttt actgaaacct tctacaaagg cattagcttt
     1021 atcttgtaaa gtgtctattc ggacagataa tcgaggattc ctctcattac agtacatgat
     1081 tagaaatgag gatgggcaaa tatgctttgt ggaatattac tgctgccctg atgaagaagt
     1141 ccctgagtct tgaataattc actgtgaata tttgtgtctc tgtagttggt gttgtcactc
     1201 tgactgtata atcctgatga tttcatattg gattatatac agagatgcat ggagaagata
     1261 gggccaaggt cccattctgt aaatagtgtt tattttgtga ataaattttt catgtggcca
     1321 g
//
