LOCUS       NM_130734               1209 bp    mRNA    linear   ROD 12-AUG-2024
DEFINITION  Rattus norvegicus receptor for activated C kinase 1 (Rack1), mRNA.
ACCESSION   NM_130734
VERSION     NM_130734.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1209)
  AUTHORS   Zhao,L., Chen,Y., Li,H., Ding,X. and Li,J.
  TITLE     Deciphering the neuroprotective mechanisms of RACK1 in cerebral
            ischemia-reperfusion injury: Pioneering insights into mitochondrial
            autophagy and the PINK1/Parkin axis
  JOURNAL   CNS Neurosci Ther 30 (8), e14836 (2024)
   PUBMED   39097918
  REMARK    GeneRIF: Deciphering the neuroprotective mechanisms of RACK1 in
            cerebral ischemia-reperfusion injury: Pioneering insights into
            mitochondrial autophagy and the PINK1/Parkin axis.
REFERENCE   2  (bases 1 to 1209)
  AUTHORS   Wang,C.Y., Li,M.Y., Li,S.Y., Wei,X.G., Dong,N.X., Liu,S.T.,
            Yuan,Z.W., Li,B., Pierro,A., Tang,X.B. and Bai,Y.Z.
  TITLE     Rack1-mediated ferroptosis affects hindgut development in rats with
            anorectal malformations: Spatial transcriptome insights
  JOURNAL   Cell Prolif 57 (7), e13618 (2024)
   PUBMED   38523594
  REMARK    GeneRIF: Rack1-mediated ferroptosis affects hindgut development in
            rats with anorectal malformations: Spatial transcriptome insights.
REFERENCE   3  (bases 1 to 1209)
  AUTHORS   Ni,H., Kan,X., Rui,Q., Zhang,Y., Zhai,W., Zhang,B. and Yu,Z.
  TITLE     RACK1 promotes autophagy via the PERK signaling pathway to protect
            against traumatic brain injury in rats
  JOURNAL   CNS Neurosci Ther 30 (3), e14691 (2024)
   PUBMED   38532543
  REMARK    GeneRIF: RACK1 promotes autophagy via the PERK signaling pathway to
            protect against traumatic brain injury in rats.
REFERENCE   4  (bases 1 to 1209)
  AUTHORS   Sun,C., Peng,S., Lv,Z., Guo,T. and Zhang,L.
  TITLE     Research of STEAP3 interaction with Rab7A and RACK1 to modulate the
            MAPK and JAK/STAT signaling in Osteoarthritis
  JOURNAL   Int Immunopharmacol 124 (Pt B), 111034 (2023)
   PUBMED   37820423
  REMARK    GeneRIF: Research of STEAP3 interaction with Rab7A and RACK1 to
            modulate the MAPK and JAK/STAT signaling in Osteoarthritis.
REFERENCE   5  (bases 1 to 1209)
  AUTHORS   do Canto,A.M., Vieira,A.S., H B Matos,A., Carvalho,B.S.,
            Henning,B., Norwood,B.A., Bauer,S., Rosenow,F., Gilioli,R.,
            Cendes,F. and Lopes-Cendes,I.
  TITLE     Laser microdissection-based microproteomics of the hippocampus of a
            rat epilepsy model reveals regional differences in protein
            abundances
  JOURNAL   Sci Rep 10 (1), 4412 (2020)
   PUBMED   32157145
  REMARK    GeneRIF: Laser microdissection-based microproteomics of the
            hippocampus of a rat epilepsy model reveals regional differences in
            protein abundances.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1209)
  AUTHORS   Chang,B.Y., Chiang,M. and Cartwright,C.A.
  TITLE     The interaction of Src and RACK1 is enhanced by activation of
            protein kinase C and tyrosine phosphorylation of RACK1
  JOURNAL   J Biol Chem 276 (23), 20346-20356 (2001)
   PUBMED   11279199
REFERENCE   7  (bases 1 to 1209)
  AUTHORS   Mourton,T., Hellberg,C.B., Burden-Gulley,S.M., Hinman,J., Rhee,A.
            and Brady-Kalnay,S.M.
  TITLE     The PTPmu protein-tyrosine phosphatase binds and recruits the
            scaffolding protein RACK1 to cell-cell contacts
  JOURNAL   J Biol Chem 276 (18), 14896-14901 (2001)
   PUBMED   11278757
REFERENCE   8  (bases 1 to 1209)
  AUTHORS   Baumann,M., Gires,O., Kolch,W., Mischak,H., Zeidler,R., Pich,D. and
            Hammerschmidt,W.
  TITLE     The PKC targeting protein RACK1 interacts with the Epstein-Barr
            virus activator protein BZLF1
  JOURNAL   Eur J Biochem 267 (12), 3891-3901 (2000)
   PUBMED   10849009
REFERENCE   9  (bases 1 to 1209)
  AUTHORS   Chang,B.Y., Conroy,K.B., Machleder,E.M. and Cartwright,C.A.
  TITLE     RACK1, a receptor for activated C kinase and a homolog of the beta
            subunit of G proteins, inhibits activity of src tyrosine kinases
            and growth of NIH 3T3 cells
  JOURNAL   Mol Cell Biol 18 (6), 3245-3256 (1998)
   PUBMED   9584165
REFERENCE   10 (bases 1 to 1209)
  AUTHORS   Ron,D., Chen,C.H., Caldwell,J., Jamieson,L., Orr,E. and
            Mochly-Rosen,D.
  TITLE     Cloning of an intracellular receptor for protein kinase C: a
            homolog of the beta subunit of G proteins
  JOURNAL   Proc Natl Acad Sci U S A 91 (3), 839-843 (1994)
   PUBMED   8302854
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1995 Feb 28;92(5):2016]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Sep 20, 2012 this sequence version replaced NM_130734.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ219900.1, FQ229633.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-242               JAXUCZ010000010.1  33670550-33670791
            243-414             JAXUCZ010000010.1  33671814-33671985
            415-562             JAXUCZ010000010.1  33672463-33672610
            563-658             JAXUCZ010000010.1  33673523-33673618
            659-769             JAXUCZ010000010.1  33673922-33674032
            770-910             JAXUCZ010000010.1  33674251-33674391
            911-1021            JAXUCZ010000010.1  33675463-33675573
            1022-1209           JAXUCZ010000010.1  33675844-33676031
FEATURES             Location/Qualifiers
     source          1..1209
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q21"
     gene            1..1209
                     /gene="Rack1"
                     /gene_synonym="Gnb2l1"
                     /note="receptor for activated C kinase 1"
                     /db_xref="GeneID:83427"
                     /db_xref="RGD:69229"
     exon            1..242
                     /gene="Rack1"
                     /gene_synonym="Gnb2l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1087
                     /gene="Rack1"
                     /gene_synonym="Gnb2l1"
                     /note="guanine nucleotide binding protein (G protein),
                     beta polypeptide 2-like 1; guanine nucleotide-binding
                     protein subunit beta-2-like 1; receptor of activated
                     protein kinase C 1; guanine nucleotide binding protein,
                     beta polypeptide 2-like 1; guanine nucleotide binding
                     protein (G protein) beta polypeptide 2-like 1; protein
                     kinase C receptor; receptor for activated protein kinase
                     C; receptor of activated protein C kinase 1"
                     /codon_start=1
                     /product="small ribosomal subunit protein RACK1"
                     /protein_id="NP_570090.2"
                     /db_xref="GeneID:83427"
                     /db_xref="RGD:69229"
                     /translation="MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWK
                     LTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFV
                     GHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNS
                     SNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAML
                     WDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVIS
                     TSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR"
     exon            243..414
                     /gene="Rack1"
                     /gene_synonym="Gnb2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            415..562
                     /gene="Rack1"
                     /gene_synonym="Gnb2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            563..658
                     /gene="Rack1"
                     /gene_synonym="Gnb2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            659..769
                     /gene="Rack1"
                     /gene_synonym="Gnb2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            770..910
                     /gene="Rack1"
                     /gene_synonym="Gnb2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1021
                     /gene="Rack1"
                     /gene_synonym="Gnb2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1209
                     /gene="Rack1"
                     /gene_synonym="Gnb2l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atttccggtt ccggcggagg ccgctctttc tttttctccg cagggtcgcg gtggcagccg
       61 ctgcggtgct tggctcccta agctatccgg tgccatcctt gtcgctgcgg cgacactcgc
      121 aacatctgca gccatgaccg agcaaatgac ccttcgtggg accctcaagg gccataatgg
      181 atgggttaca cagatcgcca ccactccgca gttcccggac atgatcctgt cggcgtctcg
      241 agacaagacc atcatcatgt ggaagctgac cagggatgag accaactacg gcataccaca
      301 acgtgctctt cgaggtcact cccactttgt tagcgatgtt gtcatctcct ctgatggcca
      361 gtttgccctc tcaggctcct gggatggaac cctacgcctc tgggatctca caacgggcac
      421 taccacgaga cgatttgtcg gccacaccaa ggatgtgctg agcgtggctt tctcctctga
      481 caaccggcag attgtctctg ggtcccgaga caagaccatt aagttatgga atactctggg
      541 tgtctgcaag tacactgtcc aggatgagag tcattcagaa tgggtgtctt gtgtccgctt
      601 ctccccgaac agcagcaacc ctatcatcgt ctcctgcgga tgggacaagc tggtcaaggt
      661 gtggaatctg gctaactgca agctaaagac caaccacatt ggccacactg gctatctgaa
      721 cacagtgact gtctctccag atggatccct ctgtgcttct ggaggcaagg atggccaggc
      781 tatgctgtgg gatctcaatg aaggcaagca cctttacaca ttagatggtg gagacatcat
      841 caatgccttg tgcttcagcc ccaaccgcta ctggctctgt gctgccactg gccccagtat
      901 caagatctgg gacttggagg gcaagatcat tgtagatgaa ctgaagcaag aggttatcag
      961 caccagcagc aaggcagagc caccccagtg tacctctttg gcttggtctg ctgatggcca
     1021 gactctgttt gctggctata ccgacaactt ggtgcgtgta tggcaggtga ctattggtac
     1081 ccgctaaaag tttatgacag actcttagaa ataaactggc tttctgaaat tggcctctat
     1141 atgtgagtcc tgggagctga gccctgtttt acaagagcac cccatgctct gaaccactga
     1201 aacatcttt
//
