LOCUS       NM_001108112            2474 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Rattus norvegicus Rac GTPase-activating protein 1 (Racgap1), mRNA.
ACCESSION   NM_001108112 XM_001062413 XM_235650
VERSION     NM_001108112.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2474)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 2474)
  AUTHORS   Lekomtsev,S., Su,K.C., Pye,V.E., Blight,K., Sundaramoorthy,S.,
            Takaki,T., Collinson,L.M., Cherepanov,P., Divecha,N. and
            Petronczki,M.
  TITLE     Centralspindlin links the mitotic spindle to the plasma membrane
            during cytokinesis
  JOURNAL   Nature 492 (7428), 276-279 (2012)
   PUBMED   23235882
REFERENCE   3  (bases 1 to 2474)
  AUTHORS   Burkard,M.E., Maciejowski,J., Rodriguez-Bravo,V., Repka,M.,
            Lowery,D.M., Clauser,K.R., Zhang,C., Shokat,K.M., Carr,S.A.,
            Yaffe,M.B. and Jallepalli,P.V.
  TITLE     Plk1 self-organization and priming phosphorylation of HsCYK-4 at
            the spindle midzone regulate the onset of division in human cells
  JOURNAL   PLoS Biol 7 (5), e1000111 (2009)
   PUBMED   19468302
REFERENCE   4  (bases 1 to 2474)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   5  (bases 1 to 2474)
  AUTHORS   Simon,G.C., Schonteich,E., Wu,C.C., Piekny,A., Ekiert,D., Yu,X.,
            Gould,G.W., Glotzer,M. and Prekeris,R.
  TITLE     Sequential Cyk-4 binding to ECT2 and FIP3 regulates cleavage furrow
            ingression and abscission during cytokinesis
  JOURNAL   EMBO J 27 (13), 1791-1803 (2008)
   PUBMED   18511905
REFERENCE   6  (bases 1 to 2474)
  AUTHORS   Toure,A., Morin,L., Pineau,C., Becq,F., Dorseuil,O. and Gacon,G.
  TITLE     Tat1, a novel sulfate transporter specifically expressed in human
            male germ cells and potentially linked to rhogtpase signaling
  JOURNAL   J Biol Chem 276 (23), 20309-20315 (2001)
   PUBMED   11278976
REFERENCE   7  (bases 1 to 2474)
  AUTHORS   Van de Putte,T., Zwijsen,A., Lonnoy,O., Rybin,V., Cozijnsen,M.,
            Francis,A., Baekelandt,V., Kozak,C.A., Zerial,M. and Huylebroeck,D.
  TITLE     Mice with a homozygous gene trap vector insertion in mgcRacGAP die
            during pre-implantation development
  JOURNAL   Mech Dev 102 (1-2), 33-44 (2001)
   PUBMED   11287179
REFERENCE   8  (bases 1 to 2474)
  AUTHORS   Hirose,K., Kawashima,T., Iwamoto,I., Nosaka,T. and Kitamura,T.
  TITLE     MgcRacGAP is involved in cytokinesis through associating with
            mitotic spindle and midbody
  JOURNAL   J Biol Chem 276 (8), 5821-5828 (2001)
   PUBMED   11085985
REFERENCE   9  (bases 1 to 2474)
  AUTHORS   Kawashima,T., Hirose,K., Satoh,T., Kaneko,A., Ikeda,Y., Kaziro,Y.,
            Nosaka,T. and Kitamura,T.
  TITLE     MgcRacGAP is involved in the control of growth and differentiation
            of hematopoietic cells
  JOURNAL   Blood 96 (6), 2116-2124 (2000)
   PUBMED   10979956
REFERENCE   10 (bases 1 to 2474)
  AUTHORS   Arar,C., Ott,M.O., Toure,A. and Gacon,G.
  TITLE     Structure and expression of murine mgcRacGAP: its developmental
            regulation suggests a role for the Rac/MgcRacGAP signalling pathway
            in neurogenesis
  JOURNAL   Biochem J 343 Pt 1 (Pt 1), 225-230 (1999)
   PUBMED   10493933
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474035.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_235650.4, XM_001062413.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2474
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..2474
                     /gene="Racgap1"
                     /note="Rac GTPase-activating protein 1"
                     /db_xref="GeneID:315298"
                     /db_xref="RGD:1305912"
     exon            1..177
                     /gene="Racgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            178..266
                     /gene="Racgap1"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..2062
                     /gene="Racgap1"
                     /note="rac GTPase-activating protein 1-like"
                     /codon_start=1
                     /product="rac GTPase-activating protein 1"
                     /protein_id="NP_001101582.1"
                     /db_xref="GeneID:315298"
                     /db_xref="RGD:1305912"
                     /translation="MDTTMVNLWTLFEQLVRRLEIINEGNESIEFIQVVKDFEDFRKK
                     CQRTNQELEKFKDLLLKAETGRSALDVKLKHARNQVDVEIKRRQRAEAECAKLEQQIQ
                     LIRDILMCDTTGSIQLSEEQKSALAFLNRGQASSGNAGNNRLSTIDESGSILSDISFD
                     KTDESLDWDSSLKNFKMKKREKRRSSSRQFIDGPPGPVKKTCSIGSTIDQANESIVAK
                     TTVTVPSDGGPIEAVSTIETLPCWTRSRGKSGPLQPVNSDSALNSRPLEPRTETDAVG
                     TPQNNGMRLHDFVSKTVIKPESCVPCGKRIKFGKLSLKCRDCRLVSHPECRDRCPLPC
                     IPPLVGTPVKIGEGMLADFVSQTSPMIPAIVVSCVNEIEQRGLTEAGLYRISGCDRTV
                     KELKEKFLKVKTVPLLSKVDDIHAICSLLKDFLRNLKEPLLTFWLSKAFMEAAEITDE
                     DNSTAAMYQAVSELPQANRDTLAFLMIHLQRVAQSPSTKMDVVNLAKIFGPTIVAHTV
                     PNPDPVTMFQDIKRQLKVVERLLSLPLEYWNQFMMVEQENMDCHRGNGSSTPRTPDIK
                     VSLLGPVTTPEFQLVKTPSSNSLSQRLYNLSKSTPRFGNKSKSATNLGQQGKFFPAPY
                     LK"
     exon            267..472
                     /gene="Racgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            473..609
                     /gene="Racgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            610..679
                     /gene="Racgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            680..730
                     /gene="Racgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            731..811
                     /gene="Racgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            812..929
                     /gene="Racgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1057
                     /gene="Racgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1222
                     /gene="Racgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1318
                     /gene="Racgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1517
                     /gene="Racgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1623
                     /gene="Racgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1756
                     /gene="Racgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1880
                     /gene="Racgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..1986
                     /gene="Racgap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2474
                     /gene="Racgap1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgatctcct ctgtgattgg ctgctgcgcg attttgaacc ggatccggcg gcgcggtttt
       61 acactgccgt tagtgaggcg cgcagctggt ggacagcagc cctcctgggg cgcggcggcc
      121 ggagagtaag cgccgcgggc cgaacagggt tgcgtgtgcg cggggccggg agcctcgaaa
      181 gatggatact acaatggtga atctgtggac tctgtttgag cagcttgtgc gccggctgga
      241 gattatcaat gaaggaaatg aaagcattga attcatccag gttgtaaagg acttcgagga
      301 cttccgaaag aaatgtcaaa gaaccaacca ggagctggag aaattcaaag atctgttgtt
      361 gaaggcagag actgggcgga gtgccctgga cgtcaagctg aagcacgccc gtaaccaagt
      421 ggatgtggag atcaaacgga ggcaacgagc tgaggccgag tgtgcgaagc tggaacaaca
      481 gattcagctg attcgagata tactcatgtg tgacacaact ggcagcatcc agctaagcga
      541 ggaacaaaaa tcagctctgg cttttctcaa ccgaggccaa gcatccagtg gcaacgctgg
      601 gaacaataga ctgtcaacga ttgatgaatc tggctccatt ttatcagata tcagctttga
      661 caagactgat gaatcactgg actgggattc ttctttgaag aatttcaaaa tgaagaaacg
      721 agaaaagagg cgctccagca gtagacagtt catcgatggc cctcctgggc ctgtgaagaa
      781 aacgtgttcc attggctcta caatagacca ggcaaatgaa tcaatagttg ctaaaacaac
      841 ggtgactgtc cccagtgacg gtgggcccat tgaagccgtg tccactatcg agacattgcc
      901 gtgttggacc aggagtcgag ggaaatcagg acctttacaa cctgtgaaca gcgactctgc
      961 tctcaatagc aggccactgg agccaagaac tgagacagac gctgtgggca caccccagaa
     1021 taatggcatg cgcttacacg actttgtctc aaagacggtt attaagcctg aatcttgtgt
     1081 cccgtgtggg aagcggatca agtttggcaa gctgtctctg aagtgtcggg actgtcgttt
     1141 ggtctctcat ccagaatgcc gggaccgatg tccccttccc tgcattcctc ccctggtggg
     1201 aacccccgtg aagattggag agggaatgct ggcagatttt gtgtcgcaga cttccccaat
     1261 gattcctgct attgttgtca gctgtgtgaa tgagattgag cagcgaggcc tgactgaggc
     1321 aggcttatac aggatctcag gctgtgaccg gacagtaaag gagctgaaag agaaattcct
     1381 taaagtgaaa accgtgcccc tcctcagcaa agtggacgac atccatgcca tctgcagcct
     1441 cctgaaagac ttccttcgaa acctcaagga accccttctg accttttggc taagcaaagc
     1501 gttcatggag gcagcagaga taacggatga agacaacagc acagccgcca tgtaccaggc
     1561 tgtcagtgag ctgccccagg ccaacaggga cacgctagcc ttcctcatga tccacctcca
     1621 gagagtggct cagagtccga gcactaagat ggacgttgtc aatctggcta aaatcttcgg
     1681 ccctacgata gttgcccaca ctgtgcccaa tccagatcca gtgacgatgt tccaggacat
     1741 caaacgccag ctcaaggtgg tggagcgcct gctctctctg cccctggagt actggaatca
     1801 gttcatgatg gtggaacaag agaacatgga ctgccaccgc ggcaatggga gctcaacacc
     1861 acggacacca gacattaaag tgagcttatt ggggcctgtg accactcctg aattccagct
     1921 tgtcaagact ccttcatcaa attccctgtc acagagattg tacaacctct ccaagagcac
     1981 acccagattt gggaacaaga gcaagtctgc caccaactta ggtcaacagg gcaaattttt
     2041 ccctgctccg tacctcaagt aaagctgttt ctgcctactg tctgcctact gcaggagaca
     2101 cacctgttcg ctcctcagct cctgtgtaat tactactttt agcattttcc aggctttaaa
     2161 taaagtttaa tgtatatgag agtttgatta ttacatagct ccctctcacc tggtgaccta
     2221 gcacctcgta gagttgttgg gagctttaaa atggagcttt ctgcagggta gaaggacaac
     2281 gggaatcgac tatggctctt ctgggggggg agggggatct cttaggctta aagccagata
     2341 cagctcgtga aatgactggt cctgtggtgt ctcttagaca gtgacagaaa ctgtgcctct
     2401 taggtaaacc tgaattatct cgggacaaga ggttttggga caagataaag aactacacag
     2461 aggccacagg atgg
//
