LOCUS       NM_001398954            1037 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus Rac family small GTPase 3 (Rac3), mRNA.
ACCESSION   NM_001398954 XM_039087551
VERSION     NM_001398954.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1037)
  AUTHORS   White,J.J., Mazzeu,J.F., Coban-Akdemir,Z., Bayram,Y.,
            Bahrambeigi,V., Hoischen,A., van Bon,B.W.M., Gezdirici,A.,
            Gulec,E.Y., Ramond,F., Touraine,R., Thevenon,J., Shinawi,M.,
            Beaver,E., Heeley,J., Hoover-Fong,J., Durmaz,C.D., Karabulut,H.G.,
            Marzioglu-Ozdemir,E., Cayir,A., Duz,M.B., Seven,M., Price,S.,
            Ferreira,B.M., Vianna-Morgante,A.M., Ellard,S., Parrish,A.,
            Stals,K., Flores-Daboub,J., Jhangiani,S.N., Gibbs,R.A.,
            Brunner,H.G., Sutton,V.R., Lupski,J.R. and Carvalho,C.M.B.
  CONSRTM   Baylor-Hopkins Center for Mendelian Genomics
  TITLE     WNT Signaling Perturbations Underlie the Genetic Heterogeneity of
            Robinow Syndrome
  JOURNAL   Am J Hum Genet 102 (1), 27-43 (2018)
   PUBMED   29276006
REFERENCE   2  (bases 1 to 1037)
  AUTHORS   Donnelly,S.K., Cabrera,R., Mao,S.P.H., Christin,J.R., Wu,B.,
            Guo,W., Bravo-Cordero,J.J., Condeelis,J.S., Segall,J.E. and
            Hodgson,L.
  TITLE     Rac3 regulates breast cancer invasion and metastasis by controlling
            adhesion and matrix degradation
  JOURNAL   J Cell Biol 216 (12), 4331-4349 (2017)
   PUBMED   29061650
  REMARK    GeneRIF: Rac3 regulates breast cancer invasion and metastasis by
            controlling adhesion and matrix degradation.
REFERENCE   3  (bases 1 to 1037)
  AUTHORS   Vaghi,V., Pennucci,R., Talpo,F., Corbetta,S., Montinaro,V.,
            Barone,C., Croci,L., Spaiardi,P., Consalez,G.G., Biella,G. and de
            Curtis,I.
  TITLE     Rac1 and rac3 GTPases control synergistically the development of
            cortical and hippocampal GABAergic interneurons
  JOURNAL   Cereb Cortex 24 (5), 1247-1258 (2014)
   PUBMED   23258346
REFERENCE   4  (bases 1 to 1037)
  AUTHORS   Orioli,D., Colaluca,I.N., Stefanini,M., Riva,S., Dotti,C.G. and
            Peverali,F.A.
  TITLE     Rac3-induced neuritogenesis requires binding to Neurabin I
  JOURNAL   Mol Biol Cell 17 (5), 2391-2400 (2006)
   PUBMED   16525025
REFERENCE   5  (bases 1 to 1037)
  AUTHORS   Corbetta,S., Gualdoni,S., Albertinazzi,C., Paris,S., Croci,L.,
            Consalez,G.G. and de Curtis,I.
  TITLE     Generation and characterization of Rac3 knockout mice
  JOURNAL   Mol Cell Biol 25 (13), 5763-5776 (2005)
   PUBMED   15964829
REFERENCE   6  (bases 1 to 1037)
  AUTHORS   De Langhe,S., Haataja,L., Senadheera,D., Groffen,J. and
            Heisterkamp,N.
  TITLE     Interaction of the small GTPase Rac3 with NRBP, a protein with a
            kinase-homology domain
  JOURNAL   Int J Mol Med 9 (5), 451-459 (2002)
   PUBMED   11956649
REFERENCE   7  (bases 1 to 1037)
  AUTHORS   Haataja,L., Kaartinen,V., Groffen,J. and Heisterkamp,N.
  TITLE     The small GTPase Rac3 interacts with the integrin-binding protein
            CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and
            spreading
  JOURNAL   J Biol Chem 277 (10), 8321-8328 (2002)
   PUBMED   11756406
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Dec 28, 2021 this sequence version replaced XM_039087551.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DV716463.1, SRR22582424.1641603.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               JAXUCZ010000010.1  106501135-106501267
            134-205             JAXUCZ010000010.1  106501857-106501928
            206-323             JAXUCZ010000010.1  106502137-106502254
            324-386             JAXUCZ010000010.1  106502377-106502439
            387-546             JAXUCZ010000010.1  106502780-106502939
            547-1037            JAXUCZ010000010.1  106503079-106503569
FEATURES             Location/Qualifiers
     source          1..1037
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.3"
     gene            1..1037
                     /gene="Rac3"
                     /note="Rac family small GTPase 3"
                     /db_xref="GeneID:688319"
                     /db_xref="RGD:1590052"
     exon            1..133
                     /gene="Rac3"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..677
                     /gene="Rac3"
                     /EC_number="3.6.5.2"
                     /note="ras-related C3 botulinum toxin substrate 3 (rho
                     family, small GTP binding protein Rac3)"
                     /codon_start=1
                     /product="ras-related C3 botulinum toxin substrate 3"
                     /protein_id="NP_001385883.1"
                     /db_xref="GeneID:688319"
                     /db_xref="RGD:1590052"
                     /translation="MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANV
                     MVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVR
                     HHCPHTPILLVGTKLDLRDDKDTIERLRDKKLAPITYPQGLAMAREIGSVKYLECSAL
                     TQRGLKTVFDEAIRAVLCPPPVKKPGKKCTVF"
     exon            134..205
                     /gene="Rac3"
                     /inference="alignment:Splign:2.1.0"
     exon            206..323
                     /gene="Rac3"
                     /inference="alignment:Splign:2.1.0"
     exon            324..386
                     /gene="Rac3"
                     /inference="alignment:Splign:2.1.0"
     exon            387..546
                     /gene="Rac3"
                     /inference="alignment:Splign:2.1.0"
     exon            547..1037
                     /gene="Rac3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgctcgctc ggcgttcggg tccgcggccg ctgcggcgcc gggcatttct ccgcagctcg
       61 gctcgcggcc gcgcccgccg ccgcccggcc ccgcgcccat gcaggccatc aagtgcgtgg
      121 tggttggcga tggagccgtg gggaagactt gcctgctgat cagctacacg accaacgcct
      181 tcccaggaga atatatcccc acagttttcg acaactactc agccaacgtg atggtggatg
      241 ggaagccggt caacctgggg ctatgggaca ctgctggcca ggaagactac gataggcttc
      301 ggccactctc ctatcctcaa actgacgtct tcctgatctg cttctccctg gtgagcccgg
      361 cgtcctttga gaacgtccgt gccaagtggt acccagaggt gcggcaccac tgcccacaca
      421 cacccatcct tctggtgggc accaagctgg acctccgtga tgacaaggac acaattgaac
      481 ggctgcggga caagaagctg gcacctatca cctaccccca aggtctggcc atggcccgag
      541 agatcggttc tgtcaagtac ctggagtgct cagccctgac ccagagaggt ctgaagacag
      601 tgttcgacga ggccatccgg gctgtgctct gcccacctcc agtgaaaaag ccaggcaaga
      661 agtgcactgt gttctagagc cttgtccggc cggcctggct gcagagcgct ggctcaagtg
      721 tgcccttctg ttgagctgtc tgatgtccct gagtctgccg tgggaagtgg tgtgggtggg
      781 agaagcatgg ggacaaggct ggggtgatgg ggtcctgtcc cctattcctc ctttttctgg
      841 gatatagccc cagccttccc tggtccctat gggaggccag gagggagcgg ggtctccctc
      901 agggtttcag gggtgggtcc agggcagccc caggatgggc ttccctgggg ggaagggtgg
      961 gggtggtttt gttcatccat cgtgtcccag gaaagggcgg ccccttctta ttttatacaa
     1021 taaacattca ccacctc
//
